citalopram and Dyspepsia studies

Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.

Research Excerpts

Excerpt	Relevance	Reference
"The Functional Dyspepsia Treatment Trial reported that amitriptyline (AMI) was associated with adequate relief of functional dyspepsia (FD) symptoms, but the pharmacogenetics of antidepressant response in FD are not known."	5.24	Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial. ( Abraham, BP; Almazar, AE; Bouras, EP; Camilleri, M; DiBaise, JK; El-Serag, HB; Hamilton, FA; Herrick, LM; Howden, CW; Lacy, BE; Locke, GR; Moayyedi, P; Prather, CM; Saito, YA; Schleck, CD; Szarka, LA; Talley, NJ; Tilkes, KE; Zinsmeister, AR, 2017)
"Objective: To assess the efficacy of selective serotonin reuptake inhibitor (SSRI) escitalopram in patients with functional dyspepsia (FD)."	5.19	[Psychopharmacological approach with the usage of selective serotonin reuptake inhibitors in functional dyspepsia treatment]. ( Korendovych, IV; Maliarov, SO; Revenok, KM; Svintsits'kyĭ, AS, 2014)
"The Functional Dyspepsia Treatment Trial (FDTT) aims to test whether treatment with an antidepressant (amitriptyline or escitalopram) leads to improvement of symptoms in patients with moderate to severe FD."	5.16	Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. ( Abraham, BP; Bouras, EP; Brenner, DM; DiBaise, JK; El-Serag, HB; Herrick, LM; Howden, CW; Lacy, BE; Locke, GR; Moayyedi, P; Prather, CM; Silvernail, VM; Talley, NJ; Zinsmeister, AR, 2012)
"While this study does not rule out a beneficial effect of tricyclics or selective serotonin reuptake inhibitors in functional dyspepsia, neither desipramine nor escitalopram significantly altered the nutrient volume ingested or symptoms induced by the nutrient drink test in healthy volunteers."	5.11	Effects of desipramine and escitalopram on postprandial symptoms induced by the nutrient drink test in healthy volunteers: a randomized, double-blind, placebo-controlled study. ( Bouras, E; Burton, D; Camilleri, M; Chitkara, DK; Locke, GR; Rucker, MJ; Talley, NJ; Thapa, P; Zinsmeister, AR, 2005)

Research

Studies (15)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Gastric Emptying Half-Time (T1/2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (6.67)	29.6817
2010's	14 (93.33)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Luo, L	1
Du, L	1
Shen, J	1
Cen, M	1
Dai, N	1
Cooper, TE	1
Heathcote, LC	1
Clinch, J	1
Gold, JI	1
Howard, R	1
Lord, SM	1
Schechter, N	1
Wood, C	1
Wiffen, PJ	1
Herrick, LM	5
Camilleri, M	5
Schleck, CD	3
Zinsmeister, AR	6
Saito, YA	4
Talley, NJ	8
Lacy, BE	4
Bouras, E	2
DiBaise, JK	4
Szarka, LA	3
Tilkes, K	1
Korendovych, IV	1
Svintsits'kyĭ, AS	1
Revenok, KM	1
Maliarov, SO	1
Locke, GR	5
Almazar, AE	2
Bouras, EP	3
Howden, CW	3
Prather, CM	3
Abraham, BP	3
El-Serag, HB	3
Moayyedi, P	3
Hamilton, FA	2
Tilkes, KE	2
Hasler, WL	1
Koch, KL	1
Naumann, J	1
Saito, Y	1
Zinsmeister, A	1
Jo, Y	1
Herrick, L	1
Berriozabal Diaz, L	1
Zubiaurre Lizarralde, L	1
Castiella Eguzkiza, A	1
Zapata Morcillo, E	1
Silvernail, VM	1
Brenner, DM	1
Chitkara, DK	1
Burton, D	1
Rucker, MJ	1
Thapa, P	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Short-term and Low-dose Application of Neuromodulators Increases Treatment Efficacy and Minimizes Antidepressant Discontinuation Syndrome in Refractory Functional Dyspepsia[NCT05099913]		220 participants (Anticipated)	Interventional	2020-08-01	Recruiting
Antidepressant Therapy for Functional Dyspepsia[NCT00248651]	Phase 2/Phase 3	292 participants (Actual)	Interventional	2006-10-31	Completed
A Prospective, Randomized, Investigator Blinded, Controlled Trial to Evaluate the Effectiveness of Dietary Modification in Patients With Functional Dyspepsia[NCT02863822]		0 participants (Actual)	Interventional	2016-09-30	Withdrawn (stopped due to no patients enrolled)
Effect and Mechanism of Acupuncture on Patients With Functional Dyspepsia: a Protocol for a Randomized, Assessor-blind, Sham-controlled Trial[NCT02358486]		70 participants (Anticipated)	Interventional	2015-01-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The time for half of the ingested solids or liquids to leave the stomach. (NCT00248651)
Timeframe: 12 weeks

Maximum Tolerated Volume by Nutrient Drink Test

Intervention	minutes (Mean)
Amitriptyline	117
Escitalopram	108
Placebo	115

The nutrient drink test for meal-induced satiety had subjects drink 120 ml of ENSURE every four minutes. Satiety scores were measured on a scale graded 0-5 (1, no symptoms; 5, maximum satiety). When a score of 5 was reached, the maximum tolerated volume intake was measured. Abnormal satiety was defined as inability to consume > 800 ml of Ensure. (NCT00248651)
Timeframe: 12 weeks

Self-Report of Adequate Relief of Dyspepsia (Yes/No) For at Least 50% of Weeks 3 -12 of Treatment

Intervention	ml (Mean)
Amitriptyline	764
Escitalopram	823
Placebo	839

The first two weeks of treatment were excluded to allow for establishment of steady state drug levels. (NCT00248651)
Timeframe: 3 weeks through 12 weeks

Dyspepsia-Specific Quality of Life

Intervention	percentage of participants (Number)
Amitriptyline	53
Escitalopram	38
Placebo	40

The Nepean Dyspepsia Index (NDI) assessed quality of life. NDI scores are summarized into overall quality of life and 5 subscales: Interference, Knowledge/Control, Eating/Drinking, Sleep Disturbance, Work/Study. The scale consists of 25 items, yielding 5 sub-scales. Range 0-100, higher numbers indicate a greater quality of life. (NCT00248651)
Timeframe: 12 Weeks

Intervention	units on a scale (Mean)
	Overall Quality of Life	Interference Subscale	Knowledge/Control Subscale	Eat/Drink Subscale	Sleep Disturbance Subscale	Work/Study Subscale
Amitriptyline	80.6	83.2	78.2	72.4	86.3	86.9
Escitalopram	82.8	82.8	76.2	70.6	80.8	87.2
Placebo	73.5	76.2	72.9	64.8	76.4	79.7

Article	Year
Effects of Amitriptyline and Escitalopram on Sleep and Mood in Patients With Functional Dyspepsia. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2018, Volume: 16, Issue:3 Topics: Adult; Affect; Amitriptyline; Antidepressive Agents; Citalopram; Dyspepsia; Female; Humans; Male; Ne	2018
Effects of Antidepressants on Gastric Function in Patients with Functional Dyspepsia. The American journal of gastroenterology, 2018, Volume: 113, Issue:2 Topics: Adult; Amitriptyline; Antidepressive Agents; Citalopram; Dyspepsia; Female; Gastric Emptying; Gastro	2018
[Psychopharmacological approach with the usage of selective serotonin reuptake inhibitors in functional dyspepsia treatment]. Likars'ka sprava, 2014, Issue:11 Topics: Adolescent; Adult; Anti-Bacterial Agents; Anxiety; Citalopram; Depression; Drug Therapy, Combination	2014
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Gastroenterology, 2015, Volume: 149, Issue:2 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Drinking; D	2015
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Gastroenterology, 2015, Volume: 149, Issue:2 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Drinking; D	2015
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Gastroenterology, 2015, Volume: 149, Issue:2 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Drinking; D	2015
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Gastroenterology, 2015, Volume: 149, Issue:2 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Drinking; D	2015
Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial. The American journal of gastroenterology, 2017, Volume: 112, Issue:6 Topics: Adult; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bi	2017
Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. Contemporary clinical trials, 2012, Volume: 33, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra	2012
Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. Contemporary clinical trials, 2012, Volume: 33, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra	2012
Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. Contemporary clinical trials, 2012, Volume: 33, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra	2012
Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. Contemporary clinical trials, 2012, Volume: 33, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra	2012
Effects of desipramine and escitalopram on postprandial symptoms induced by the nutrient drink test in healthy volunteers: a randomized, double-blind, placebo-controlled study. Digestion, 2005, Volume: 72, Issue:2-3 Topics: Adult; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyc	2005

Article	Year
Benefit of small dose antidepressants for functional dyspepsia: Experience from a tertiary center in eastern China. Medicine, 2019, Volume: 98, Issue:41 Topics: Anthracenes; Antidepressive Agents; China; Citalopram; Drug Combinations; Dyspepsia; Female; Fluoxet	2019
Amitriptyline for Functional Dyspepsia: Importance of Symptom Profile and Making a Case for Gastric Emptying Testing. Gastroenterology, 2015, Volume: 149, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Female; Humans; Male; Qualit	2015
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia. Gastroenterology, 2016, Volume: 150, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Female; Humans; Male; Qualit	2016
Reply. Gastroenterology, 2016, Volume: 150, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Female; Humans; Male; Qualit	2016
[Effect of Amitriptyline in Patients with Functional Dyspepsia]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2015, Volume: 66, Issue:4 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Female; Humans; Male; Qualit	2015
Antidepressants in functional dyspepsia. Expert review of gastroenterology & hepatology, 2010, Volume: 4, Issue:1 Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Human	2010
[Parkinsonism due to clebopride]. Revista espanola de enfermedades digestivas, 2011, Volume: 103, Issue:3 Topics: Aged; Antidepressive Agents; Antiemetics; Benzamides; Citalopram; Depression; Dyspepsia; Female; Hum	2011

citalopram and Dyspepsia