citalopram has been researched along with Cocaine-Related Disorders in 14 studies
Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Depression and substance cocaine abuse are disorders with a high frequency of comorbidity." | 3.85 | Effects of escitalopram and imipramine on cocaine reinforcement and drug-seeking behaviors in a rat model of depression. ( Filip, M; Frankowska, M; Jastrzębska, J; Nowak, E; Przegaliński, E; Suder, A; Wydra, K, 2017) |
| "A secondary data analysis of a previously published, double-blind, randomized controlled trial examines the interaction of decision-making, as measured by the Iowa Gambling Task, and citalopram in increasing longest sustained abstinence from cocaine use." | 3.75 | Evaluation of heterogeneity in pharmacotherapy trials for drug dependence: a Bayesian approach. ( Carbonari, JP; Green, CE; Lane, SD; Lasky, RE; Lucke, JF; Moeller, FG; Schmitz, JM; Swann, AC, 2009) |
| "Citalopram treated subjects showed a significant reduction in cocaine-positive urines during treatment compared to placebo treated subjects." | 2.73 | Citalopram combined with behavioral therapy reduces cocaine use: a double-blind, placebo-controlled trial. ( Grabowski, J; Green, CM; Lai, LY; Moeller, FG; Reist, C; Schmitz, JM; Steinberg, JL; Swann, AC, 2007) |
| " Moreover, chronic administration of psychostimulants can cause enduring changes in neurobiology reflected in dysregulation of monoamine neurochemistry and behavior." | 2.50 | Monoamine transporter inhibitors and substrates as treatments for stimulant abuse. ( Howell, LL; Negus, SS, 2014) |
| "0 mg/kg) attenuated the priming effects of cocaine, shifting the cocaine dose-response function rightward and downward." | 1.36 | Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms. ( Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Spealman, RD, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Snyder, AD | 1 |
| Zuniga, E | 1 |
| Ma, L | 1 |
| Steinberg, JL | 3 |
| Woisard, K | 1 |
| Narayana, PA | 1 |
| Lane, S | 1 |
| Schmitz, J | 1 |
| Moeller, FG | 5 |
| Pélissier-Alicot, AL | 1 |
| Deveaux, M | 1 |
| Sastre, C | 1 |
| Baillif-Couniou, V | 1 |
| Christia, MA | 1 |
| Champeaux-Fesquet, C | 1 |
| Leonetti, G | 1 |
| Jastrzębska, J | 1 |
| Frankowska, M | 1 |
| Suder, A | 1 |
| Wydra, K | 1 |
| Nowak, E | 1 |
| Filip, M | 1 |
| Przegaliński, E | 1 |
| Liu, S | 1 |
| Lane, SD | 3 |
| Schmitz, JM | 4 |
| Cunningham, KA | 1 |
| John, VP | 1 |
| Howell, LL | 1 |
| Negus, SS | 1 |
| Green, CE | 2 |
| Lucke, JF | 1 |
| Swann, AC | 3 |
| Lasky, RE | 1 |
| Carbonari, JP | 1 |
| Rüedi-Bettschen, D | 1 |
| Rowlett, JK | 1 |
| Spealman, RD | 1 |
| Platt, DM | 1 |
| Mooney, ME | 1 |
| Kalechstein, AD | 1 |
| Mahoney, JJ | 1 |
| Yoon, JH | 1 |
| Bennett, R | 1 |
| De la Garza, R | 1 |
| Stein, MD | 1 |
| Herman, DS | 1 |
| Solomon, DA | 1 |
| Anthony, JL | 1 |
| Anderson, BJ | 1 |
| Ramsey, SE | 1 |
| Miller, IW | 1 |
| Kim, DI | 1 |
| Deutsch, HM | 1 |
| Ye, X | 1 |
| Schweri, MM | 1 |
| Green, CM | 1 |
| Reist, C | 1 |
| Lai, LY | 1 |
| Grabowski, J | 1 |
| Zhang, XM | 1 |
| Yan, SQ | 1 |
| Yan, QS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Project 1: Clinical Neurobiology of Serotonin and Addiction[NCT00732901] | Phase 2/Phase 3 | 160 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Impulsivity, Brain Function and Substance Abuse Treatment[NCT00217997] | 192 participants (Actual) | Observational | 2005-09-30 | Completed | |||
| Antidepressant Treatment to Reduce HIV Risk Among IDUs[NCT00183768] | Phase 3 | 175 participants | Interventional | 1999-09-30 | Completed | ||
| Motivational Interviewing to Reduce Substance Use Among Depression Patients[NCT02420561] | 307 participants (Actual) | Interventional | 2010-10-31 | Completed | |||
| Serotonin, Impulsivity, and Cocaine Dependence Treatment[NCT00297505] | Phase 2 | 120 participants | Interventional | 2001-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of urine drug screens positive for cocaine metabolite benzoylecgonine. (NCT00732901)
Timeframe: 5 weeks of treatment
| Intervention | Positive urine drug screens (Number) |
|---|---|
| A (Escitalopram) | 9 |
| B (Placebo) | 8 |
Attentional bias is the difference in reaction time to cocaine related words and neutral words. A slower reaction time indicates greater attentional bias. (NCT00732901)
Timeframe: 5 weeks of treatment
| Intervention | milliseconds (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline | Acute | Chronic Day 1 | Chronic Day 2 | Chronic Day 3 | Chronic Day 4 | |
| A (Escitalopram) | 90.2 | -8.6 | 56.4 | 45.0 | 23.4 | 63.6 |
| B (Placebo) | 45.9 | 37.4 | 35.4 | 15.4 | -11.3 | 4.4 |
2 reviews available for citalopram and Cocaine-Related Disorders
| Article | Year |
|---|---|
Monoamine transporter inhibitors and substrates as treatments for stimulant abuse.
Topics: Animals; Central Nervous System Stimulants; Citalopram; Cocaine-Related Disorders; Dose-Response Rel | 2014 |
[The research progress on 5-hydroxytryptamine transporter].
Topics: Animals; Carrier Proteins; Citalopram; Cloning, Molecular; Cocaine-Related Disorders; Humans; Membra | 1997 |
5 trials available for citalopram and Cocaine-Related Disorders
| Article | Year |
|---|---|
Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects.
Topics: Adult; Attention; Citalopram; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Drug Users; F | 2013 |
Baseline neurocognitive profiles differentiate abstainers and non-abstainers in a cocaine clinical trial.
Topics: Adult; Citalopram; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Data Collection; Decisio | 2009 |
Modafinil, but not escitalopram, improves working memory and sustained attention in long-term, high-dose cocaine users.
Topics: Adult; Benzhydryl Compounds; Black or African American; Citalopram; Cocaine-Related Disorders; Cogni | 2013 |
Adherence to treatment of depression in active injection drug users: the minerva study.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Citalopram; Cocaine-Related Disorders; Cognitive Beh | 2004 |
Adherence to treatment of depression in active injection drug users: the minerva study.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Citalopram; Cocaine-Related Disorders; Cognitive Beh | 2004 |
Adherence to treatment of depression in active injection drug users: the minerva study.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Citalopram; Cocaine-Related Disorders; Cognitive Beh | 2004 |
Adherence to treatment of depression in active injection drug users: the minerva study.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Citalopram; Cocaine-Related Disorders; Cognitive Beh | 2004 |
Citalopram combined with behavioral therapy reduces cocaine use: a double-blind, placebo-controlled trial.
Topics: Adult; Behavior Therapy; Citalopram; Cocaine-Related Disorders; Double-Blind Method; Female; Humans; | 2007 |
7 other studies available for citalopram and Cocaine-Related Disorders
| Article | Year |
|---|---|
Examination of preliminary behavioral and effective connectivity findings from treatment response to citalopram in cocaine use disorder: A dynamic causal modeling study.
Topics: Adult; Citalopram; Cocaine-Related Disorders; Corpus Striatum; Female; Humans; Impulsive Behavior; M | 2020 |
Planned complex suicide involving combined drug intoxication and femoral catheterization.
Topics: Adult; Antidepressive Agents, Second-Generation; Catheterization; Chromatography, Liquid; Citalopram | 2021 |
Effects of escitalopram and imipramine on cocaine reinforcement and drug-seeking behaviors in a rat model of depression.
Topics: Animals; Citalopram; Cocaine; Cocaine-Related Disorders; Cues; Depressive Disorder; Disease Models, | 2017 |
Evaluation of heterogeneity in pharmacotherapy trials for drug dependence: a Bayesian approach.
Topics: Bayes Theorem; Citalopram; Cocaine-Related Disorders; Decision Making; Double-Blind Method; Gambling | 2009 |
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms.
Topics: Animals; Benzofurans; Citalopram; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Fluox | 2010 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Cocaine; Cocaine-Related Disord | 2007 |
Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.
Topics: Animals; Animals, Newborn; Citalopram; Cocaine; Cocaine-Related Disorders; Electric Stimulation; Fem | 2002 |