citalopram has been researched along with Chemical and Drug Induced Liver Injury in 15 studies
Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Even though citalopram is commonly used in psychiatry, there are several reports on its toxic effects." | 1.46 | In vitro and in vivo evaluation of the mechanisms of citalopram-induced hepatotoxicity. ( Ahmadian, E; Babaei, H; Eftekhari, A; Eghbal, MA; Fard, JK; Mohammadnejad, D; Nayebi, AM, 2017) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 11 (73.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Glitho, S | 1 |
| Boukari, L | 1 |
| Mekinian, A | 1 |
| Fain, O | 1 |
| Gessel, L | 1 |
| Alcorn, J | 1 |
| Ma, L | 1 |
| Wen, C | 1 |
| Chen, C | 1 |
| Shen, S | 1 |
| Yang, J | 1 |
| Ahmadian, E | 1 |
| Eftekhari, A | 1 |
| Fard, JK | 1 |
| Babaei, H | 1 |
| Nayebi, AM | 1 |
| Mohammadnejad, D | 1 |
| Eghbal, MA | 1 |
| Del Val Antoñana, A | 1 |
| Ortiz Polo, I | 1 |
| Roselló Sastre, E | 1 |
| Moreno-Osset, E | 1 |
| Merino, MI | 1 |
| Carrero, AA | 1 |
| García, JF | 1 |
| Martínez, JA | 1 |
| López-Torres, E | 1 |
| Lucena, MI | 1 |
| Seoane, J | 1 |
| Verge, C | 1 |
| Andrade, RJ | 1 |
| Solomons, K | 1 |
| Gooch, S | 1 |
| Wong, A | 1 |
| Neumann, H | 1 |
| Csepregi, A | 1 |
| Evert, M | 1 |
| Malfertheiner, P | 1 |
1 review available for citalopram and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
14 other studies available for citalopram and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
[Dermatomyositis].
Topics: Aged; Antidepressive Agents, Second-Generation; Chemical and Drug Induced Liver Injury; Citalopram; | 2013 |
When Good Medications Go Bad, Don't DILI Dally.
Topics: Aged; Antidepressive Agents, Second-Generation; Chemical and Drug Induced Liver Injury; Citalopram; | 2016 |
Hepatotoxicity Associated with Donepezil in an Individual Taking Citalopram.
Topics: Aged, 80 and over; Alzheimer Disease; Antidepressive Agents, Second-Generation; Chemical and Drug In | 2016 |
In vitro and in vivo evaluation of the mechanisms of citalopram-induced hepatotoxicity.
Topics: Animals; Antioxidants; Cell Death; Chemical and Drug Induced Liver Injury; Citalopram; Glutathione; | 2017 |
[Hepatotoxicity related to escitalopram].
Topics: Chemical and Drug Induced Liver Injury; Citalopram; Female; Humans; Middle Aged; Selective Serotonin | 2008 |
[Citalopram hepatotoxicity].
Topics: Aged, 80 and over; Chemical and Drug Induced Liver Injury; Citalopram; Humans; Male; Selective Serot | 2011 |
Hepatotoxicity related to citalopram.
Topics: Adult; Chemical and Drug Induced Liver Injury; Citalopram; Depressive Disorder; Humans; Liver; Liver | 2004 |
Toxicity with selective serotonin reuptake inhibitors.
Topics: Adult; Chemical and Drug Induced Liver Injury; Citalopram; Depressive Disorder; Female; Fluvoxamine; | 2005 |
Drug-induced liver disease related to citalopram.
Topics: Chemical and Drug Induced Liver Injury; Citalopram; Dose-Response Relationship, Drug; Female; Humans | 2008 |