citalopram has been researched along with Brain Injuries in 14 studies
Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Citalopram was tolerated without adverse effects." | 2.69 | Paroxetine versus citalopram treatment of pathological crying after brain injury. ( Bauer-Wittmund, T; Müller, U; Murai, T; von Cramon, DY, 1999) |
| "Intracranial stab wounds are low-velocity, penetrating injuries to the brain and fatality and outcome significantly depend on route, depth and location of cranial penetration." | 1.39 | Self-inflicted trans-oral intracranial stab wound. ( Han, ZA; Kim, JH; Kim, SW, 2013) |
| "Citalopram prevented the increase in sucrose consumption in the PCA+CVS rats, and in 5-HT-depleted animals blocked the increase in struggling and reduced the number of defecations in the forced swim test." | 1.35 | Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: effects of citalopram. ( Eller, M; Häidkind, R; Harro, J; Kõiv, K; Mällo, T; Tõnissaar, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Madani, Y | 1 |
| Azad, S | 1 |
| Nachev, P | 1 |
| Collas, D | 1 |
| Kim, SW | 1 |
| Kim, JH | 1 |
| Han, ZA | 1 |
| Silver, JM | 1 |
| McAllister, TW | 1 |
| Arciniegas, DB | 1 |
| Pandey, DK | 2 |
| Yadav, SK | 1 |
| Mahesh, R | 2 |
| Rajkumar, R | 1 |
| Rapoport, MJ | 3 |
| Mitchell, RA | 1 |
| McCullagh, S | 3 |
| Herrmann, N | 3 |
| Chan, F | 3 |
| Kiss, A | 2 |
| Feinstein, A | 3 |
| Lanctôt, KL | 2 |
| Rajaram, RD | 1 |
| Strauss, J | 1 |
| Sicard, T | 1 |
| Kennedy, JL | 1 |
| Bassett, AS | 1 |
| Katiyar, S | 1 |
| Kukade, G | 1 |
| Viyogi, S | 1 |
| Rudra, A | 1 |
| Tõnissaar, M | 1 |
| Mällo, T | 1 |
| Eller, M | 1 |
| Häidkind, R | 1 |
| Kõiv, K | 1 |
| Harro, J | 1 |
| Lanctot, K | 1 |
| Daniels, JP | 1 |
| Felde, A | 1 |
| Andersen, G | 1 |
| Stylsvig, M | 1 |
| Sunde, N | 1 |
| Müller, U | 1 |
| Murai, T | 1 |
| Bauer-Wittmund, T | 1 |
| von Cramon, DY | 1 |
| Perino, C | 1 |
| Rago, R | 1 |
| Cicolini, A | 1 |
| Torta, R | 1 |
| Monaco, F | 1 |
| Zafonte, RD | 1 |
| Cullen, N | 1 |
| Lexell, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury[NCT00162916] | Phase 4 | 21 participants (Actual) | Interventional | 2005-05-31 | Active, not recruiting | ||
| A Double-Blind Controlled, Multicenter Phase II/III Study to Assess the Safety and Efficacy of AVP-923 (Dextromethorphan/Quinidine) in the Treatment of Pseudobulbar Affect in Patients With Amyotrophic Lateral Sclerosis[NCT00021697] | Phase 3 | 100 participants | Interventional | 2001-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for citalopram and Brain Injuries
| Article | Year |
|---|---|
Depression and cognitive complaints following mild traumatic brain injury.
Topics: Antidepressive Agents, Tricyclic; Brain; Brain Injuries; Central Nervous System Stimulants; Choline; | 2009 |
Serotonin agents in the treatment of acquired brain injury.
Topics: Brain Injuries; Citalopram; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Adminis | 2002 |
2 trials available for citalopram and Brain Injuries
| Article | Year |
|---|---|
A randomized controlled trial of antidepressant continuation for major depression following traumatic brain injury.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Brain Injuries; Citalopram | 2010 |
Paroxetine versus citalopram treatment of pathological crying after brain injury.
Topics: Adult; Aged; Brain Damage, Chronic; Brain Injuries; Citalopram; Crying; Dose-Response Relationship, | 1999 |
10 other studies available for citalopram and Brain Injuries
| Article | Year |
|---|---|
Laughing at funerals.
Topics: Brain Injuries; Citalopram; Humans; Laughter; Male; Middle Aged; Selective Serotonin Reuptake Inhibi | 2013 |
Self-inflicted trans-oral intracranial stab wound.
Topics: Amines; Analgesics; Antidepressive Agents; Brain Injuries; Cerebellum; Citalopram; Cyclohexanecarbox | 2013 |
Depression-like and anxiety-like behavioural aftermaths of impact accelerated traumatic brain injury in rats: a model of comorbid depression and anxiety?
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety Disorders; Brain Injuries; Citalopram; Co | 2009 |
Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury.
Topics: Adult; Antidepressive Agents, Second-Generation; Brain Injuries; Brain-Derived Neurotrophic Factor; | 2010 |
Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats.
Topics: Acceleration; Amitriptyline; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brain Injuri | 2010 |
Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: effects of citalopram.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Brain Injuries; Cital | 2008 |
An open-label study of citalopram for major depression following traumatic brain injury.
Topics: Adult; Aged; Aged, 80 and over; Brain Injuries; Citalopram; Depressive Disorder, Major; Female; Huma | 2008 |
Quetiapine treatment for mania secondary to brain injury in 2 patients.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Brain Injuries; Citalopram; Dibenzothiazepines; Drug | 2008 |
Citalopram treatment of traumatic brain damage in a 6-year-old boy.
Topics: Basal Ganglia; Behavioral Symptoms; Brain Injuries; Child; Citalopram; Crying; Humans; Male; Selecti | 1999 |
Mood and behavioural disorders following traumatic brain injury: clinical evaluation and pharmacological management.
Topics: Adult; Antidepressive Agents; Brain Injuries; Brief Psychiatric Rating Scale; Carbamazepine; Citalop | 2001 |