citalopram has been researched along with Amyloid Deposits in 4 studies
Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed in vivo microdialysis and in vivo 2-photon imaging to assess changes in brain interstitial fluid (ISF) Aβ and Aβ plaque size over time, respectively, in the APP/presenilin 1 mouse model of Alzheimer disease treated with vehicle or escitalopram." | 3.96 | Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model. ( Cirrito, JR; Davis, TA; Doherty, BM; Gardiner, WD; King, D; Lee, JM; Sheline, YI; Wallace, CE; Yan, P; Yuede, CM, 2020) |
| " In healthy human volunteers, citalopram's effects on Aβ production and Aβ concentrations in cerebrospinal fluid (CSF) were measured prospectively using stable isotope labeling kinetics, with CSF sampling during acute dosing of citalopram." | 2.79 | An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice. ( Bateman, RJ; Chott, R; Cirrito, JR; Ficker, WD; Fisher, JR; Frederiksen, C; Grzelak, MV; Jasielec, MS; Lee, JM; Mintun, MA; Morris, JC; Sheline, YI; Swarm, R; West, T; Xiong, C; Yan, P; Yarasheski, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cirrito, JR | 2 |
| Wallace, CE | 1 |
| Yan, P | 2 |
| Davis, TA | 1 |
| Gardiner, WD | 1 |
| Doherty, BM | 1 |
| King, D | 1 |
| Yuede, CM | 1 |
| Lee, JM | 2 |
| Sheline, YI | 2 |
| Zhang, Q | 1 |
| Yang, C | 1 |
| Liu, T | 1 |
| Liu, L | 1 |
| Li, F | 1 |
| Cai, Y | 1 |
| Lv, K | 1 |
| Li, X | 1 |
| Gao, J | 1 |
| Sun, D | 1 |
| Xu, H | 1 |
| Yang, Q | 1 |
| Fan, X | 1 |
| West, T | 1 |
| Yarasheski, K | 1 |
| Swarm, R | 1 |
| Jasielec, MS | 1 |
| Fisher, JR | 1 |
| Ficker, WD | 1 |
| Xiong, C | 1 |
| Frederiksen, C | 1 |
| Grzelak, MV | 1 |
| Chott, R | 1 |
| Bateman, RJ | 1 |
| Morris, JC | 1 |
| Mintun, MA | 1 |
| Holm, P | 1 |
| Ettrup, A | 1 |
| Klein, AB | 1 |
| Santini, MA | 1 |
| El-Sayed, M | 1 |
| Elvang, AB | 1 |
| Stensbøl, TB | 1 |
| Mikkelsen, JD | 1 |
| Knudsen, GM | 1 |
| Aznar, S | 1 |
1 trial available for citalopram and Amyloid Deposits
| Article | Year |
|---|---|
An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice.
Topics: Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antidepressive Agents; Brain; Cit | 2014 |
3 other studies available for citalopram and Amyloid Deposits
| Article | Year |
|---|---|
Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Citalopram | 2020 |
Citalopram restores short-term memory deficit and non-cognitive behaviors in APP/PS1 mice while halting the advance of Alzheimer's disease-like pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; | 2018 |
Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice.
Topics: Aging; Amphetamines; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Ci | 2010 |