Page last updated: 2024-10-25

citalopram and Aggression

citalopram has been researched along with Aggression in 43 studies

Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
" The authors assessed the heterogeneity of response to citalopram in the Citalopram for Agitation in Alzheimer Disease (CitAD) study to identify individuals who may be helped or harmed."9.22Heterogeneity of Treatment Response to Citalopram for Patients With Alzheimer's Disease With Aggression or Agitation: The CitAD Randomized Clinical Trial. ( Devanand, DP; Drye, LT; Frangakis, C; Lyketsos, CG; Marano, CM; Mintzer, J; Mulsant, BH; Munro, CA; Newell, JA; Pawluczyk, S; Pelton, G; Pollock, BG; Porsteinsson, AP; Rabins, PV; Rein, L; Rosenberg, PB; Schneider, LS; Shade, D; Weintraub, D; Yesavage, J, 2016)
" citalopram induced delirium."7.79Delirium during i. v. citalopram treatment: a case report. ( Delić, M; Pregelj, P, 2013)
" Therefore, aggression was tested in male CFW mice to determine whether repeated citalopram (CIT) administration reduces alcohol-heightened aggression."7.74Long-term citalopram maintenance in mice: selective reduction of alcohol-heightened aggression. ( Caldwell, EE; Miczek, KA, 2008)
"To assess the short-term effect and safety of citalopram in the reduction of impulsive aggression in children and adolescents."7.71Citalopram treatment for impulsive aggression in children and adolescents: an open pilot study. ( Armenteros, JL; Lewis, JE, 2002)
" The authors assessed the heterogeneity of response to citalopram in the Citalopram for Agitation in Alzheimer Disease (CitAD) study to identify individuals who may be helped or harmed."5.22Heterogeneity of Treatment Response to Citalopram for Patients With Alzheimer's Disease With Aggression or Agitation: The CitAD Randomized Clinical Trial. ( Devanand, DP; Drye, LT; Frangakis, C; Lyketsos, CG; Marano, CM; Mintzer, J; Mulsant, BH; Munro, CA; Newell, JA; Pawluczyk, S; Pelton, G; Pollock, BG; Porsteinsson, AP; Rabins, PV; Rein, L; Rosenberg, PB; Schneider, LS; Shade, D; Weintraub, D; Yesavage, J, 2016)
"Since aggression after citalopram treatment decreased in a subgroup of animals and increased in the other, future research should focus on other possible predictors to support treatment strategies in aggressive patients."3.88Searching for neural and behavioral parameters that predict anti-aggressive effects of chronic SSRI treatment in rats. ( de Boer, SF; Gerrits, D; Homberg, JR; Peeters, D; Rietdijk, J; Rijpkema, M; Verkes, RJ, 2018)
" citalopram induced delirium."3.79Delirium during i. v. citalopram treatment: a case report. ( Delić, M; Pregelj, P, 2013)
" Therefore, aggression was tested in male CFW mice to determine whether repeated citalopram (CIT) administration reduces alcohol-heightened aggression."3.74Long-term citalopram maintenance in mice: selective reduction of alcohol-heightened aggression. ( Caldwell, EE; Miczek, KA, 2008)
"Citalopram was the most widely used antidepressant medication (32."1.62Use of psychotropic agents to treat agitation and aggression in Brazilian patients with Alzheimer's disease: A naturalistic and multicenter study. ( Camargos, EF; Machado, FV; Martini, LLL; Novaes, MRCG; Oliveira, LF, 2021)
"Citalopram is an antidepressant drug, which acts by inhibiting the re-uptake of serotonin from the synaptic cleft into the pre-synaptic nerve ending."1.43Waterborne citalopram has anxiolytic effects and increases locomotor activity in the three-spine stickleback (Gasterosteus aculeatus). ( Hallgren, S; Hansen, SH; Kellner, M; Olsén, KH; Porsch-Hällström, I; Porseryd, T, 2016)
"Citalopram was the most preferred antidepressant and Carbamazepine, the most preferred mood stabilizer/antiepileptic."1.35Use of medication for the management of behavior problems among adults with intellectual disabilities: a clinicians' consensus survey. ( Deb, S; Unwin, GL, 2008)
"Escitalopram is a very selective 5-HT reuptake inhibitor."1.32Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. ( Bergqvist, PB; Brennum, LT; Gupta, S; Hogg, S; Larsen, A; Sánchez, C; Wiborg, O, 2003)
" The dose-response curve was biphasic for citalopram with a maximum of 64% inhibition."1.30Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike? ( Meier, E; Sánchez, C, 1997)
"Citalopram was well tolerated by 13 of the patients, and 9 had a clinically impressive response."1.30An open pilot study of citalopram for behavioral disturbances of dementia. Plasma levels and real-time observations. ( Burgio, LD; Kirshner, MA; Mulsant, BH; Pollock, BG; Rosen, J; Shuster, K; Sweet, R, 1997)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.65)18.7374
1990's9 (20.93)18.2507
2000's14 (32.56)29.6817
2010's15 (34.88)24.3611
2020's3 (6.98)2.80

Authors

AuthorsStudies
Richard, R1
Boren, B1
Becker, J1
Kellner, M2
Olsén, KH2
Oliveira, LF1
Camargos, EF1
Martini, LLL1
Machado, FV1
Novaes, MRCG1
Peeters, D1
Rietdijk, J1
Gerrits, D1
Rijpkema, M1
de Boer, SF1
Verkes, RJ1
Homberg, JR1
Wise, J1
Crockett, MJ1
Siegel, JZ1
Kurth-Nelson, Z1
Ousdal, OT1
Story, G1
Frieband, C1
Grosse-Rueskamp, JM1
Dayan, P1
Dolan, RJ1
Dorfman, HM1
Buckholtz, JW1
Rosenberg, PB2
Drye, LT2
Porsteinsson, AP2
Pollock, BG3
Devanand, DP2
Frangakis, C2
Ismail, Z1
Marano, C1
Meinert, CL1
Mintzer, JE1
Munro, CA2
Pelton, G2
Rabins, PV2
Schneider, LS2
Shade, DM1
Weintraub, D2
Newell, J1
Yesavage, J2
Lyketsos, CG2
Žmuc Veranič, L1
Pregelj, P2
Jerin, A1
Marano, CM1
Mintzer, J1
Mulsant, BH2
Newell, JA1
Pawluczyk, S1
Rein, L1
Shade, D1
Porseryd, T1
Hallgren, S1
Porsch-Hällström, I1
Hansen, SH1
Schindler, EA1
Guo, XM1
Schrag, M1
Ghoshal, S1
Schilsky, ML1
Beslow, LA1
Herrmann, N1
Kamarck, TW2
Haskett, RF2
Muldoon, M1
Flory, JD2
Anderson, B1
Bies, R1
Pollock, B1
Manuck, SB2
Kuepper, Y1
Alexander, N1
Osinsky, R1
Mueller, E1
Schmitz, A1
Netter, P2
Hennig, J2
Holmberg, A1
Fogel, J1
Albertsson, E1
Fick, J1
Brown, JN1
Paxéus, N1
Förlin, L1
Johnsson, JI1
Larsson, DG1
Muldoon, MF1
Cheong, J1
Vella, E1
Knorr, U1
Vinberg, M1
Gether, U1
Winkel, P1
Gluud, C1
Wetterslev, J1
Kessing, LV1
Delić, M1
Reist, C1
Nakamura, K1
Sagart, E1
Sokolski, KN1
Fujimoto, KA1
Sánchez, C3
Bergqvist, PB1
Brennum, LT1
Gupta, S1
Hogg, S2
Larsen, A1
Wiborg, O1
Hadi, F1
Franco, K1
Hermida, T1
Douton, K1
Zarko, R1
Reuter, M1
Burk, C1
Landt, O1
Peremans, K1
Audenaert, K1
Hoybergs, Y1
Otte, A1
Goethals, I1
Gielen, I1
Blankaert, P1
Vervaet, M1
van Heeringen, C1
Dierckx, R1
Lepage, O1
Larson, ET1
Mayer, I1
Winberg, S1
Lindberg, N1
Tani, P1
Takala, P1
Sailas, E1
Putkonen, H1
Eronen, M1
Virkkunen, M2
Caldwell, EE1
Miczek, KA1
Unwin, GL1
Deb, S1
Maj, J1
Rogóz, Z1
Skuza, G1
Sowińska, H1
Vartiainen, H1
Tiihonen, J1
Putkonen, A1
Koponen, H1
Hakola, P1
Lehto, H1
Hyttel, J1
Meier, E1
Sweet, R1
Burgio, LD1
Kirshner, MA1
Shuster, K1
Rosen, J1
Matto, V3
Allikmets, L3
Skrebuhhova, T3
Rudissaar, R1
Pruus, K1
Keeney, AJ1
Manhães de Castro, R1
Barreto Medeiros, JM1
Mendes da Silva, C1
Ferreira, LM1
Guedes, RC1
Cabral Filho, JE1
Costa, JA2
Rilke, O1
Will, K1
Jähkel, M1
Oehler, J1
Medeiros, JM1
Silva, CM1
Sougey, EB1
Castro, CM1
Castro, RM1
Armenteros, JL1
Lewis, JE1
Datla, KP1
Mitra, SK1
Bhattacharya, SK1
Molina, V1
Ciesielski, L1
Gobaille, S1
Isel, F1
Mandel, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00217828]0 participants Interventional2002-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

9 trials available for citalopram and Aggression

ArticleYear
Dissociable Effects of Serotonin and Dopamine on the Valuation of Harm in Moral Decision Making.
    Current biology : CB, 2015, Jul-20, Volume: 25, Issue:14

    Topics: Adolescent; Adult; Aggression; Altruism; Citalopram; Decision Making; Dopamine; Dopamine Agents; Dou

2015
Change in agitation in Alzheimer's disease in the placebo arm of a nine-week controlled trial.
    International psychogeriatrics, 2015, Volume: 27, Issue:12

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Antidepressive A

2015
Heterogeneity of Treatment Response to Citalopram for Patients With Alzheimer's Disease With Aggression or Agitation: The CitAD Randomized Clinical Trial.
    The American journal of psychiatry, 2016, May-01, Volume: 173, Issue:5

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Antidepressive Agents, Second-Generation; Ci

2016
Citalopram intervention for hostility: results of a randomized clinical trial.
    Journal of consulting and clinical psychology, 2009, Volume: 77, Issue:1

    Topics: Adult; Aggression; Cardiovascular Diseases; Citalopram; Drug Administration Schedule; Female; Hostil

2009
Citalopram improves metabolic risk factors among high hostile adults: results of a placebo-controlled intervention.
    Psychoneuroendocrinology, 2011, Volume: 36, Issue:7

    Topics: Adult; Aggression; Algorithms; Antidepressive Agents; Citalopram; Female; Health Behavior; Hostility

2011
The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial.
    Psychiatry research, 2012, Dec-30, Volume: 200, Issue:2-3

    Topics: Adult; Aggression; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder; Family

2012
Impulsive aggressive behavior: open-label treatment with citalopram.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:1

    Topics: Adult; Aggression; Citalopram; Disruptive, Impulse Control, and Conduct Disorders; Female; Humans; M

2003
Two types of aggression are differentially related to serotonergic activity and the A779C TPH polymorphism.
    Behavioral neuroscience, 2005, Volume: 119, Issue:1

    Topics: Adult; Aggression; Citalopram; Genotype; Humans; Hydrocortisone; Male; Polymorphism, Genetic; Psychi

2005
Citalopram, a selective serotonin reuptake inhibitor, in the treatment of aggression in schizophrenia.
    Acta psychiatrica Scandinavica, 1995, Volume: 91, Issue:5

    Topics: Adolescent; Adult; Aged; Aggression; Citalopram; Double-Blind Method; Female; Humans; Male; Middle A

1995

Other Studies

34 other studies available for citalopram and Aggression

ArticleYear
THE USE OF CITALOPRAM HYDROBROMIDE TO MANAGE AGGRESSION IN A MALE CHIMPANZEE (
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2020, Jan-09, Volume: 50, Issue:4

    Topics: Aggression; Animals; Citalopram; Male; Pan troglodytes; Selective Serotonin Reuptake Inhibitors

2020
Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus).
    Archives of environmental contamination and toxicology, 2020, Volume: 79, Issue:4

    Topics: Aggression; Animals; Behavior, Animal; Citalopram; Feeding Behavior; Female; Male; Selective Seroton

2020
Use of psychotropic agents to treat agitation and aggression in Brazilian patients with Alzheimer's disease: A naturalistic and multicenter study.
    Psychiatry research, 2021, Volume: 295

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Antidepressive Agents; Antipsychotic Agents;

2021
Searching for neural and behavioral parameters that predict anti-aggressive effects of chronic SSRI treatment in rats.
    Neuropharmacology, 2018, Volume: 143

    Topics: Aggression; Animals; Animals, Outbred Strains; Anxiety; Brain; Citalopram; Cross-Over Studies; Indiv

2018
Common drugs can affect moral decision making, study finds.
    BMJ (Clinical research ed.), 2015, Jul-02, Volume: 351

    Topics: Aggression; Citalopram; Dopamine Agents; Female; Humans; Levodopa; Male; Selective Serotonin Reuptak

2015
Social Behavior: A Penny for Your Shocks.
    Current biology : CB, 2015, Jul-20, Volume: 25, Issue:14

    Topics: Aggression; Citalopram; Dopamine Agents; Female; Humans; Levodopa; Male; Selective Serotonin Reuptak

2015
Treating agitation and aggression in patients with Alzheimer's disease with escitalopram.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2016, Volume: 16, Issue:6

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Antidepressive Agents, Second-Generation; Ci

2016
Waterborne citalopram has anxiolytic effects and increases locomotor activity in the three-spine stickleback (Gasterosteus aculeatus).
    Aquatic toxicology (Amsterdam, Netherlands), 2016, Volume: 173

    Topics: Aggression; Animals; Anti-Anxiety Agents; Citalopram; Female; Motor Activity; Smegmamorpha; Swimming

2016
Neuropsychiatric Presentation of Wilson Disease in an Adolescent Male.
    Neuropediatrics, 2016, Volume: 47, Issue:5

    Topics: Adenosine Triphosphatases; Adolescent; Aggression; Antidepressive Agents; Antipsychotic Agents; Arip

2016
Lack of clinically useful response predictors for treating aggression and agitation in Alzheimer's disease with citalopram.
    Evidence-based mental health, 2016, Volume: 19, Issue:4

    Topics: Aggression; Alzheimer Disease; Citalopram; Humans; Psychomotor Agitation

2016
Aggression--interactions of serotonin and testosterone in healthy men and women.
    Behavioural brain research, 2010, Jan-05, Volume: 206, Issue:1

    Topics: Adult; Aggression; Analysis of Variance; Citalopram; Female; Humans; Hydrocortisone; Male; Personali

2010
Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy?
    Journal of hazardous materials, 2011, Mar-15, Volume: 187, Issue:1-3

    Topics: Aggression; Animals; Citalopram; Female; Oncorhynchus mykiss; Poecilia; Selective Serotonin Reuptake

2011
Delirium during i. v. citalopram treatment: a case report.
    Pharmacopsychiatry, 2013, Volume: 46, Issue:1

    Topics: Aged; Aggression; Citalopram; Delirium; Delusions; Depressive Disorder, Major; Humans; Injections, I

2013
Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities.
    Psychopharmacology, 2003, Volume: 167, Issue:4

    Topics: Action Potentials; Aggression; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generatio

2003
Citalopram for impulsive aggression.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2003, Volume: 42, Issue:7

    Topics: Aggression; Child; Citalopram; Disruptive, Impulse Control, and Conduct Disorders; Drug Administrati

2003
The effect of citalopram hydrobromide on 5-HT2A receptors in the impulsive-aggressive dog, as measured with 123I-5-I-R91150 SPECT.
    European journal of nuclear medicine and molecular imaging, 2005, Volume: 32, Issue:6

    Topics: Aggression; Animals; Behavior, Animal; Brain; Citalopram; Dogs; Impulsive Behavior; Piperidines; Rad

2005
Serotonin, but not melatonin, plays a role in shaping dominant-subordinate relationships and aggression in rainbow trout.
    Hormones and behavior, 2005, Volume: 48, Issue:2

    Topics: Aggression; Animals; Citalopram; Diet; Dominance-Subordination; Drug Implants; Female; Hydrocortison

2005
Increased deep sleep in a medication-free, detoxified female offender with schizophrenia, alcoholism and a history of attempted homicide: effect of concomitant administration of quetiapine and citalopram.
    Criminal behaviour and mental health : CBMH, 2006, Volume: 16, Issue:1

    Topics: Adult; Aggression; Alcoholism; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Antis

2006
Long-term citalopram maintenance in mice: selective reduction of alcohol-heightened aggression.
    Psychopharmacology, 2008, Volume: 196, Issue:3

    Topics: Aggression; Animals; Behavior, Animal; Central Nervous System Depressants; Citalopram; Conditioning,

2008
Use of medication for the management of behavior problems among adults with intellectual disabilities: a clinicians' consensus survey.
    American journal of mental retardation : AJMR, 2008, Volume: 113, Issue:1

    Topics: Adult; Aggression; Antipsychotic Agents; Attitude of Health Personnel; Autistic Disorder; Carbamazep

2008
Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in mice.
    Journal of neural transmission, 1982, Volume: 55, Issue:1

    Topics: Aggression; Animals; Antidepressive Agents; Citalopram; Clonidine; Drug Interactions; Fluoxetine; Fl

1982
Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors.
    European journal of pharmacology, 1994, Nov-03, Volume: 264, Issue:3

    Topics: 1-Naphthylamine; 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Analysis o

1994
Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike?
    Psychopharmacology, 1997, Volume: 129, Issue:3

    Topics: 1-Naphthylamine; Aggression; Animals; Anxiety; Binding, Competitive; Citalopram; Depression; Fluoxet

1997
An open pilot study of citalopram for behavioral disturbances of dementia. Plasma levels and real-time observations.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 1997,Winter, Volume: 5, Issue:1

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Biological Availability; Citalopram; Female;

1997
Apomorphine-induced aggressiveness and [3H]citalopram binding after antidepressant treatment in rats.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:3

    Topics: Aggression; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Binding Sites; Buspirone;

1998
The effect of antidepressants on rat aggressive behavior in the electric footshock and apomorphine-induced aggressiveness paradigms.
    Methods and findings in experimental and clinical pharmacology, 1998, Volume: 20, Issue:4

    Topics: Aggression; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive

1998
Modulatory role of 5-HT3 receptors in mediation of apomorphine-induced aggressive behaviour in male rats.
    Behavioural brain research, 1999, Volume: 106, Issue:1-2

    Topics: Aggression; Animals; Apomorphine; Behavior, Animal; Benzylamines; Biguanides; Citalopram; Dopamine A

1999
Behavioural consequences of repeated social defeat in the mouse: preliminary evaluation of a potential animal model of depression.
    Behavioural pharmacology, 1999, Volume: 10, Issue:8

    Topics: Aggression; Alcohol Drinking; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; B

1999
Reduction of intraspecific aggression in adult rats by neonatal treatment with a selective serotonin reuptake inhibitor.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2001, Volume: 34, Issue:1

    Topics: Aggression; Animals; Animals, Newborn; Body Weight; Citalopram; Male; Random Allocation; Rats; Rats,

2001
Behavioral and neurochemical effects of anpirtoline and citalopram in isolated and group housed mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2001, Volume: 25, Issue:5

    Topics: Aggression; Animals; Citalopram; Dopamine; Housing, Animal; Male; Mice; Piperidines; Pyridines; Rece

2001
Action of selective serotonin reuptake inhibitor on aggressive behavior in adult rat submitted to the neonatal malnutrition.
    Arquivos de neuro-psiquiatria, 2001, Volume: 59, Issue:3-A

    Topics: Aggression; Animals; Animals, Suckling; Behavior, Animal; Body Weight; Brain; Citalopram; Diet; Fema

2001
Citalopram treatment for impulsive aggression in children and adolescents: an open pilot study.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:5

    Topics: Adolescent; Aggression; Ambulatory Care; Child; Citalopram; Female; Humans; Impulsive Behavior; Male

2002
Serotonergic modulation of footshock induced aggression in paired rats.
    Indian journal of experimental biology, 1991, Volume: 29, Issue:7

    Topics: 5-Hydroxytryptophan; Aggression; Agonistic Behavior; Animals; Apomorphine; Citalopram; Clorgyline; D

1991
Inhibition of mouse killing behavior by serotonin-mimetic drugs: effects of partial alterations of serotonin neurotransmission.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 27, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Citalopram; Fenclonine; Fluoxetine; Hyd

1987