citalopram has been researched along with Age-Related Memory Disorders in 20 studies
Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The obtained results suggest that ADs may enhance the antipsychotic-like effect of aripiprazole in the animal tests used for evaluation of some positive and cognitive symptoms of schizophrenia." | 7.88 | Combined treatment with aripiprazole and antidepressants reversed some MK-801-induced schizophrenia-like symptoms in mice. ( Lorenc-Koci, E; Rogóż, Z; Wąsik, A, 2018) |
| "The obtained results suggest that ADs may enhance the antipsychotic-like effect of aripiprazole in the animal tests used for evaluation of some positive and cognitive symptoms of schizophrenia." | 3.88 | Combined treatment with aripiprazole and antidepressants reversed some MK-801-induced schizophrenia-like symptoms in mice. ( Lorenc-Koci, E; Rogóż, Z; Wąsik, A, 2018) |
| " Low dose citalopram reversed both scopolamine- and THC-induced impairment of spatial memory, suppressed ECS-induced immobilization reversed the THC-induced decrease of acetylcholine (ACh) release in the dorsal hippocampus in vivo microdialysis, and enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist." | 3.73 | Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization. ( Egashira, N; Fujioka, M; Fujiwara, M; Iwasaki, K; Matsumoto, Y; Matsushita, M; Mishima, K; Nishimura, R; Shoyama, Y, 2006) |
| "Vortioxetine (VOR) is a multimodal antidepressant drug with pro-cognitive actions in animal models and MDD patients." | 1.56 | Sub-chronic vortioxetine (but not escitalopram) normalizes brain rhythm alterations and memory deficits induced by serotonin depletion in rats. ( Artigas, F; Celada, P; Riga, MS; Sanchez, C, 2020) |
| "Rapid eye movement (REM) sleep deprivation (SD) decreases cerebral sigma-1 receptor expression and causes cognitive deficits." | 1.42 | Cutamesine Overcomes REM Sleep Deprivation-Induced Memory Loss: Relationship to Sigma-1 Receptor Occupancy. ( Dierckx, RA; Elsinga, PH; Ishiwata, K; Luurtsema, G; Nyakas, CJ; Ramakrishnan, NK; Schepers, M; van Waarde, A, 2015) |
| "The melatonin level was decreased in SI group compared with group housed (GH) group, and citalopram could partly restore the level of melatonin." | 1.42 | Citalopram attenuates tau hyperphosphorylation and spatial memory deficit induced by social isolation rearing in middle-aged rats. ( Gong, WG; Ren, QG; Wang, YJ; Zhang, ZJ; Zhou, QD, 2015) |
| "Depression during pregnancy has been linked to in utero stress and is associated with long-lasting symptoms in offspring, including anxiety, helplessness, attentional deficits, and social withdrawal." | 1.42 | Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats. ( Bourke, CH; Ehrlich, DE; Hazra, R; Jairam, N; Neigh, GN; Nemeth, CL; Owens, MJ; Rainnie, DG; Rowson, S; Ryan, SJ; Sholar, CA; Stowe, ZN, 2015) |
| "Escitalopram is an antidepressant drug shown to reverse the depressive-like features caused by this stress model." | 1.38 | Escitalopram improves memory deficits induced by maternal separation in the rat. ( Batalha, VL; Couto, FS; Data-Franca, J; Lopes, LV; Ribeiro, JA; Valadas, JS, 2012) |
| "Escitalopram (ESC) is a novel selective serotonin reuptake inhibitor that seems to have a favorable side effect profile." | 1.35 | The safety of the electroconvulsive therapy-escitalopram combination. ( Florakis, A; Markatou, M; Masdrakis, VG; Oulis, P; Papadimitriou, GN; Valamoutopoulos, T, 2008) |
| "Hypersexuality in Alzheimer's disease (AD) has been rarely investigated." | 1.35 | Effect of citalopram in treating hypersexuality in an Alzheimer's disease case. ( Bruno, G; Lenzi, GL; Talarico, G; Tosto, G, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 15 (75.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hereta, M | 1 |
| Kamińska, K | 2 |
| Białoń, M | 1 |
| Wąsik, A | 2 |
| Lorenc-Koci, E | 2 |
| Rogóż, Z | 3 |
| Riga, MS | 1 |
| Sanchez, C | 2 |
| Celada, P | 1 |
| Artigas, F | 1 |
| Zhang, Q | 1 |
| Yang, C | 1 |
| Liu, T | 1 |
| Liu, L | 1 |
| Li, F | 1 |
| Cai, Y | 1 |
| Lv, K | 1 |
| Li, X | 1 |
| Gao, J | 1 |
| Sun, D | 1 |
| Xu, H | 1 |
| Yang, Q | 1 |
| Fan, X | 1 |
| Misrani, A | 1 |
| Tabassum, S | 1 |
| Chen, X | 1 |
| Tan, SY | 1 |
| Wang, JC | 1 |
| Yang, L | 1 |
| Long, C | 1 |
| Jensen, JB | 1 |
| du Jardin, KG | 1 |
| Song, D | 1 |
| Budac, D | 1 |
| Smagin, G | 1 |
| Pehrson, AL | 1 |
| Ramakrishnan, NK | 1 |
| Schepers, M | 1 |
| Luurtsema, G | 1 |
| Nyakas, CJ | 1 |
| Elsinga, PH | 1 |
| Ishiwata, K | 1 |
| Dierckx, RA | 1 |
| van Waarde, A | 1 |
| Sambeth, A | 1 |
| Riedel, WJ | 1 |
| Klinkenberg, I | 1 |
| Kähkönen, S | 1 |
| Blokland, A | 1 |
| Ren, QG | 3 |
| Gong, WG | 3 |
| Wang, YJ | 3 |
| Zhou, QD | 1 |
| Zhang, ZJ | 3 |
| Ehrlich, DE | 1 |
| Neigh, GN | 1 |
| Bourke, CH | 1 |
| Nemeth, CL | 1 |
| Hazra, R | 1 |
| Ryan, SJ | 1 |
| Rowson, S | 1 |
| Jairam, N | 1 |
| Sholar, CA | 1 |
| Rainnie, DG | 1 |
| Stowe, ZN | 1 |
| Owens, MJ | 1 |
| Xu, L | 1 |
| Zhou, H | 1 |
| Li, XL | 1 |
| Bai, F | 1 |
| Tao, C | 1 |
| Yan, W | 1 |
| Li, Y | 1 |
| Lu, X | 1 |
| Masdrakis, VG | 1 |
| Oulis, P | 1 |
| Florakis, A | 1 |
| Valamoutopoulos, T | 1 |
| Markatou, M | 1 |
| Papadimitriou, GN | 1 |
| Tosto, G | 1 |
| Talarico, G | 1 |
| Lenzi, GL | 1 |
| Bruno, G | 1 |
| Eriksson, TM | 1 |
| Delagrange, P | 1 |
| Spedding, M | 1 |
| Popoli, M | 1 |
| Mathé, AA | 1 |
| Ögren, SO | 1 |
| Svenningsson, P | 1 |
| Kalechstein, AD | 1 |
| Mahoney, JJ | 1 |
| Yoon, JH | 1 |
| Bennett, R | 1 |
| De la Garza, R | 1 |
| Couto, FS | 1 |
| Batalha, VL | 1 |
| Valadas, JS | 1 |
| Data-Franca, J | 1 |
| Ribeiro, JA | 1 |
| Lopes, LV | 1 |
| Egashira, N | 1 |
| Matsumoto, Y | 1 |
| Mishima, K | 1 |
| Iwasaki, K | 1 |
| Fujioka, M | 1 |
| Matsushita, M | 1 |
| Shoyama, Y | 1 |
| Nishimura, R | 1 |
| Fujiwara, M | 1 |
2 trials available for citalopram and Age-Related Memory Disorders
| Article | Year |
|---|---|
Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram.
Topics: Adult; Alzheimer Disease; Attention; Biperiden; Citalopram; Cross-Over Studies; Double-Blind Method; | 2015 |
Modafinil, but not escitalopram, improves working memory and sustained attention in long-term, high-dose cocaine users.
Topics: Adult; Benzhydryl Compounds; Black or African American; Citalopram; Cocaine-Related Disorders; Cogni | 2013 |
18 other studies available for citalopram and Age-Related Memory Disorders
| Article | Year |
|---|---|
Effect of combined treatment with aripiprazole and antidepressants on the MK-801-induced deficits in recognition memory in novel recognition test and on the release of monoamines in the rat frontal cortex.
Topics: Animals; Antidepressive Agents; Aripiprazole; Benzazepines; Biogenic Monoamines; Citalopram; Dizocil | 2020 |
Sub-chronic vortioxetine (but not escitalopram) normalizes brain rhythm alterations and memory deficits induced by serotonin depletion in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Circadian Rhythm; Citalopram; Fenclonine; | 2020 |
Citalopram restores short-term memory deficit and non-cognitive behaviors in APP/PS1 mice while halting the advance of Alzheimer's disease-like pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; | 2018 |
Combined treatment with aripiprazole and antidepressants reversed some MK-801-induced schizophrenia-like symptoms in mice.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Citalopram; Disease Models, Anim | 2018 |
Differential effects of citalopram on sleep-deprivation-induced depressive-like behavior and memory impairments in mice.
Topics: Animals; Antidepressive Agents, Second-Generation; Citalopram; CREB-Binding Protein; Depression; Dis | 2019 |
Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation.
Topics: 5-Hydroxytryptophan; Animals; Carbidopa; Citalopram; Disease Models, Animal; Dose-Response Relations | 2014 |
Cutamesine Overcomes REM Sleep Deprivation-Induced Memory Loss: Relationship to Sigma-1 Receptor Occupancy.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Citalopram; Cognition; Male; Mass Spectrometry | 2015 |
Citalopram attenuates tau hyperphosphorylation and spatial memory deficit induced by social isolation rearing in middle-aged rats.
Topics: Animals; Brain; Citalopram; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Melat | 2015 |
Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats.
Topics: Amygdala; Animals; Anxiety; Citalopram; Corticosterone; Disease Models, Animal; Estradiol; Female; g | 2015 |
Escitalopram Ameliorates Tau Hyperphosphorylation and Spatial Memory Deficits Induced by Protein Kinase A Activation in Sprague Dawley Rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Citalopram; Colforsin; Disease Models, Animal; En | 2015 |
The effect of combined treatment with escitalopram and risperidone on the MK-801-induced changes in the object recognition test in mice.
Topics: Animals; Antipsychotic Agents; Citalopram; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dr | 2016 |
Citalopram Ameliorates Synaptic Plasticity Deficits in Different Cognition-Associated Brain Regions Induced by Social Isolation in Middle-Aged Rats.
Topics: Age Factors; Animals; Brain; Citalopram; Cognition; Cognition Disorders; Male; Maze Learning; Memory | 2017 |
Effect of antidepressants on spatial memory deficit induced by dizocilpine.
Topics: Animals; Antidepressive Agents; Cell Count; Citalopram; Cognition; Cognitive Dysfunction; Dizocilpin | 2016 |
The safety of the electroconvulsive therapy-escitalopram combination.
Topics: Aged; Bipolar Disorder; Citalopram; Combined Modality Therapy; Depressive Disorder, Major; Electroco | 2008 |
Effect of citalopram in treating hypersexuality in an Alzheimer's disease case.
Topics: Alzheimer Disease; Brain; Citalopram; Cognition Disorders; Disease Progression; Donepezil; Fluorodeo | 2008 |
Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration.
Topics: AIDS-Related Complex; Analysis of Variance; Animals; Avoidance Learning; Benzopyrans; Brain-Derived | 2012 |
Escitalopram improves memory deficits induced by maternal separation in the rat.
Topics: Animals; Antidepressive Agents; Anxiety, Separation; Behavior, Animal; Citalopram; Cognition; Female | 2012 |
Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization.
Topics: Animals; Brain Chemistry; Citalopram; Dronabinol; Electroshock; Hallucinogens; Male; Memory Disorder | 2006 |