Page last updated: 2024-10-25

citalopram and ADDH

citalopram has been researched along with ADDH in 8 studies

Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.

Research Excerpts

ExcerptRelevanceReference
" In the present study, we have examined the effect of lisdexamfetamine dimesylate (LDX), an amphetamine pro-drug that is approved for the treatment of ADHD on acetylcholine and histamine efflux in pre-frontal cortex and hippocampus alone and in combination with the anti-depressant s-citalopram."1.42Effects of lisdexamfetamine alone and in combination with s-citalopram on acetylcholine and histamine efflux in the rat pre-frontal cortex and ventral hippocampus. ( Folgering, JH; Heins, MS; Hutson, PH, 2015)
"Citalopram was being investigated in three ongoing clinical trials lasting 8-24 weeks in 423 patients aged 7-18 years."1.35Opening the white boxes: the licensing documentation of efficacy and safety of psychotropic medicines for children. ( Aagaard, L; Hansen, EH; Thirstrup, S, 2009)
"Thirty youth with major depressive disorder (MDD) and 23 control youth reported on caffeine use, sleep, and affect in their natural environment using ecological momentary assessment at baseline and over 8 weeks, while MDD youth received treatment."1.35Caffeine consumption, sleep, and affect in the natural environments of depressed youth and healthy controls. ( Axelson, DA; Birmaher, B; Dahl, RE; Forbes, EE; Ryan, ND; Semel, M; Silk, JS; Whalen, DJ, 2008)
"The diagnoses of ADHD and tic disorder were based on clinical observations and standardized rating scales."1.34Tic exacerbation and precipitation during atomoxetine treatment in two children with attention-deficit hyperactivity disorder. ( Harris, DK; Párraga, HC; Párraga, MI, 2007)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chon, MW1
Lee, J1
Chung, S1
Kim, Y1
Kim, HW1
Santos-Cubiñá, J1
Torres-Rodríguez, A1
Castaing-Lespier, PA1
Sabaté, N1
Torres-Martin, A1
Carlo, S1
Hutson, PH1
Heins, MS1
Folgering, JH1
Aagaard, L1
Thirstrup, S1
Hansen, EH1
Herrera-Guzmán, I1
Herrera-Abarca, JE1
Gudayol-Ferré, E1
Herrera-Guzmán, D1
Gómez-Carbajal, L1
Peña-Olvira, M1
Villuendas-González, E1
Joan, GO1
Woolley, JB1
Heyman, I1
Whalen, DJ1
Silk, JS1
Semel, M1
Forbes, EE1
Ryan, ND1
Axelson, DA1
Birmaher, B1
Dahl, RE1
Párraga, HC1
Párraga, MI1
Harris, DK1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Single Blind, Controlled, Longitudinal Study of the Effects of Venlafaxine Hydrochloride Capsules on the Language Function of Stroke Patients With Subcortical Aphasia Using fMRI[NCT03588572]43 participants (Actual)Interventional2018-08-01Completed
The Language Functional Reorganization Following Subcortical Cerebral Infarction: A Longitudinal fMRI Study[NCT03668132]80 participants (Actual)Observational2016-01-19Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

A Change of Outcome Measure:Picture Naming Test(PNT)

This test mainly assesses the ability of picture name of participants.we used a program for displaying named pictures on a computer screen (60 photos in total, of which 20 were Chinese celebrity faces). Each image was displayed in 3 seconds, and 1 point was correctly named for an image.The faces of celebrities were selected from the picture database of Chinese celebrities in the State Key Laboratory of Cognitive Neuroscience and Learning at Beijing Normal University.Score fluctuation is 0-60 points, the higher the score, the better the ability of picture name. (NCT03588572)
Timeframe: This is an outcome measure to assess the improvement of language function from onset to 3 months after treatment. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group38.3143.3148.31
Venlafaxine Group39.1946.7552.25

A Change of Outcome Measure:Spontaneous Language Frequency Test(SLFT)

This test mainly assesses spontaneous speech fluency of participants.It requires participants name as many food names as possible within one minute, and each correct one to give one point.The higher the score, the better the language function. (NCT03588572)
Timeframe: This is an outcome measure to assess the improvement of language function from onset to 3 months after treatment. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group5.758.1310.81
Venlafaxine Group5.319.3112.69

A Change of Outcome Measure:the Chinese Version of Western Aphasia Battery(WAB)

The main outcome measure for this scale is Aphasia Quotient(AQ) which mainly tests the ability of spontaneous speech, oral comprehension, repetition, and naming, and reflects the severity of aphasia, and can be used as a reliable indicator to evaluate the improvement and deterioration of aphasia. Score fluctuation is 0-100 points, the normal value is 98.4-100 points, AQ<93.8 can be judged as language dysfunction. (NCT03588572)
Timeframe: This is an outcome measure to assess the improvement of language function from onset to 3 months after treatment. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group78.6083.5188.55
Venlafaxine Group78.1688.2494.23

Follow-up Measurement: Hamilton Anxiety Rating Scale (HAMA)

The Hamilton Anxiety Rating Scale (HAMA) is a widely used and well-validated tool for measuring the severity of a patient's anxiety. The HAMA is composed of 14 items and takes 15-20 minutes to complete the interview and score the results. Each item is scored on a 5-point scale, ranging from 0=not present to 4=severe.HAMA Scoring Instructions:0-8=Normal, 8-13= Possible Anxiety, 14-17 = Mild Anxiety, 18-24 = Moderate Anxiety, 25-30 = Severe Anxiety(i.e.,the higher the score, the greater the likelihood of anxiety). (NCT03588572)
Timeframe: We must determine that the participant is not in anxiety at each follow-up. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group4.634.003.25
Venlafaxine Group4.884.133.56

Follow-up Measurement: Hamilton Depression Rating Scale (HAMD)

The Hamilton Depression Rating Scale (HAMD) has proven useful for many years as a way of determining a patient's level of depression before, during, and after treatment. It generally takes 15-20 minutes to complete the interview and score the results. Eight items are scored on a 5-point scale, ranging from 0 = not present to 4 = severe. Nine items are scored from 0-2. HAMD Scoring Instructions:0-7=Normal, 8-13 = Mild Depression, 14-18 = Moderate Depression, 19-22 = Severe Depression, ≥ 23 = Very Severe Depression(i.e.,Minimum 0 points and maximum 50 points, the higher the score, the greater the likelihood of depression). (NCT03588572)
Timeframe: We must determine that the participant is not in depression at each follow-up. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group5.254.633.88
Venlafaxine Group5.634.944.06

Follow-up Measurement: Mini-Mental State Examination (MMSE)

The Mini-Mental State Examination (MMSE) is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment. Administration of the test takes between 5 and 10 minutes. The MMSE test includes simple questions and problems in a number of areas: the time and place of the test, repeating lists of words, arithmetic such as the serial sevens, language use and comprehension, and basic motor skills. Any score greater than or equal to 24 points (out of 30) indicates a normal cognition. Below this, scores can indicate severe (≤9 points), moderate (10-18 points) or mild (19-23 points) cognitive impairment.The raw score may also need to be corrected for educational attainment and age. (NCT03588572)
Timeframe: We must determine that the participant is not in moderate or more cognitive impairment at each follow-up. Thus, participates will undergo this assessment on the first days (V1), 28±3 days (V2), and 90±3 days (V3) after randomization.

,
Interventionscore on a scale (Mean)
Visitation 1Visitation 2Visitation 3
Controlled Group23.8825.0026.19
Venlafaxine Group23.8125.3826.38

Other Studies

8 other studies available for citalopram and ADDH

ArticleYear
Prescription Pattern of Antidepressants for Children and Adolescents in Korea Based on Nationwide Data.
    Journal of Korean medical science, 2017, Volume: 32, Issue:10

    Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Child; Citalopram;

2017
Exacerbation of mood symptoms associated to primary and secondary carnitine deficiency: a case report.
    Boletin de la Asociacion Medica de Puerto Rico, 2013, Volume: 105, Issue:3

    Topics: Adult; Antidepressive Agents; Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Benzo

2013
Effects of lisdexamfetamine alone and in combination with s-citalopram on acetylcholine and histamine efflux in the rat pre-frontal cortex and ventral hippocampus.
    Journal of neurochemistry, 2015, Volume: 134, Issue:4

    Topics: Acetylcholine; Animals; Antidepressive Agents, Second-Generation; Attention Deficit Disorder with Hy

2015
Opening the white boxes: the licensing documentation of efficacy and safety of psychotropic medicines for children.
    Pharmacoepidemiology and drug safety, 2009, Volume: 18, Issue:5

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Citalopra

2009
Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on attention and executive functions in patients with major depressive disorder.
    Psychiatry research, 2010, May-30, Volume: 177, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Adult; Attention Deficit Disorder with Hyperactivity; Citalopram; Cogn

2010
Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on attention and executive functions in patients with major depressive disorder.
    Psychiatry research, 2010, May-30, Volume: 177, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Adult; Attention Deficit Disorder with Hyperactivity; Citalopram; Cogn

2010
Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on attention and executive functions in patients with major depressive disorder.
    Psychiatry research, 2010, May-30, Volume: 177, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Adult; Attention Deficit Disorder with Hyperactivity; Citalopram; Cogn

2010
Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on attention and executive functions in patients with major depressive disorder.
    Psychiatry research, 2010, May-30, Volume: 177, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Adult; Attention Deficit Disorder with Hyperactivity; Citalopram; Cogn

2010
Dexamphetamine for obsessive-compulsive disorder.
    The American journal of psychiatry, 2003, Volume: 160, Issue:1

    Topics: Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2003
Caffeine consumption, sleep, and affect in the natural environments of depressed youth and healthy controls.
    Journal of pediatric psychology, 2008, Volume: 33, Issue:4

    Topics: Adolescent; Affect; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Beverages; Caf

2008
Tic exacerbation and precipitation during atomoxetine treatment in two children with attention-deficit hyperactivity disorder.
    International journal of psychiatry in medicine, 2007, Volume: 37, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Antipsychotic Agents; Anxiety Disorders; Atomoxetine Hydrochloride; At

2007