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cisapride and Ventricular Fibrillation

cisapride has been researched along with Ventricular Fibrillation in 2 studies

Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.

Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the risk of serious ventricular arrhythmia (SVA) with cisapride use in the United States."7.71Serious ventricular arrhythmias among users of cisapride and other QT-prolonging agents in the United States. ( Cali, C; Enger, C; Walker, AM, 2002)
"The FDA analyzed reports of patients who developed QT prolongation, torsades de pointes, and ventricular arrhythmia in association with the use of cisapride to assess probable etiology and risk factors."7.71Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions. ( Corken, A; Gallo-Torres, H; Rodriguez, EM; Talarico, L; Wysowski, DK, 2001)
"To evaluate the risk of serious ventricular arrhythmia (SVA) with cisapride use in the United States."3.71Serious ventricular arrhythmias among users of cisapride and other QT-prolonging agents in the United States. ( Cali, C; Enger, C; Walker, AM, 2002)
"The FDA analyzed reports of patients who developed QT prolongation, torsades de pointes, and ventricular arrhythmia in association with the use of cisapride to assess probable etiology and risk factors."3.71Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions. ( Corken, A; Gallo-Torres, H; Rodriguez, EM; Talarico, L; Wysowski, DK, 2001)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Enger, C1
Cali, C1
Walker, AM1
Wysowski, DK1
Corken, A1
Gallo-Torres, H1
Talarico, L1
Rodriguez, EM1

Other Studies

2 other studies available for cisapride and Ventricular Fibrillation

ArticleYear
Serious ventricular arrhythmias among users of cisapride and other QT-prolonging agents in the United States.
    Pharmacoepidemiology and drug safety, 2002, Volume: 11, Issue:6

    Topics: Adolescent; Adult; Age Distribution; Age Factors; Arrhythmias, Cardiac; Child; Child, Preschool; Cis

2002
Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions.
    The American journal of gastroenterology, 2001, Volume: 96, Issue:6

    Topics: Adverse Drug Reaction Reporting Systems; Arrhythmias, Cardiac; Cisapride; Contraindications; Drug an

2001