cisapride has been researched along with Pyrosis in 19 studies
Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As cisapride can inhibit similar channels in other tissues and is an effective treatment for nocturnal heartburn, we examined the effects of cisapride on gastric and oesophageal acidity, gastric emptying and heartburn severity in subjects with gastro-oesophageal reflux disease." | 9.10 | Cisapride inhibits meal-stimulated gastric acid secretion and post-prandial gastric acidity in subjects with gastro-oesophageal reflux disease. ( Gardner, JD; Miner, PB; Robinson, M; Rodriguez-Stanley, S, 2002) |
| "Enhanced gastric functioning and reduction in heartburn suggest that cisapride is efficacious in the treatment of older adults with symptomatic GERD, and that gastric dysrhythmias and postprandial fullness are resolved with cisapride treatment." | 9.09 | Gastric myoelectric activity in older adults treated with cisapride for gastro-oesophageal reflux disease. ( Chen, JD; McClanahan, J; Orr, WC; Sloan, S; Zhang, M, 2000) |
| "We were unable to show major differences in the short-term efficacy of cisapride and placebo in functional dyspepsia." | 9.08 | Efficacy of cisapride therapy in functional dyspepsia. ( Cowan, H; Eckstein, RP; Höschl, R; Kellow, JE; Lam, SK; Lunzer, MR; Riley, JW; Shuter, B, 1995) |
| "Although cisapride and ranitidine both improved the symptoms of functional dyspepsia, cisapride was superior to ranitidine, particularly on the combined evaluation of the response to treatment and the recurrence of symptoms." | 9.08 | Cisapride compared with ranitidine in the treatment of functional dyspepsia. ( Carvalhinhos, A; Fidalgo, P; Freire, A; Matos, L, 1995) |
| "Cisapride 10 mg significantly reduced daytime and nighttime heartburn at 4 wk compared with placebo." | 9.08 | Cisapride for gastroesophageal reflux disease: a placebo-controlled, double-blind study. ( Long, JF; Richter, JE, 1995) |
| "Omeprazole 20 or 10 mg once daily is significantly more effective than cisapride in the resolution of heartburn, regardless of the presence of erosive oesophagitis, and this is accompanied by an improvement in patient quality of life." | 9.08 | Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride. ( Barthelemy, P; Galmiche, JP; Hamelin, B, 1997) |
| "We evaluated the efficacy and safety of a twice-daily dosage regimen of cisapride 20 mg in relieving the symptoms of mild-moderate gastroesophageal reflux disease (GERD) in patients with moderate intensity heartburn and no history of erosive esophagitis." | 9.08 | Cisapride 20 mg b.i.d. provides symptomatic relief of heartburn and related symptoms of chronic mild to moderate gastroesophageal reflux disease. CIS-USA-52 Investigator Group. ( Castell, DO; Clyde, C; Hasner, D; Lambert, R; Patterson, D; Sigmund, C; Zeldis, JB, 1998) |
| "Cisapride has well-documented prokinetic effects and may be well suited for long-term therapy of GORD, but its effectiveness in purely symptomatic treatment is unknown." | 6.68 | The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux disease. ( Carling, L; Hatlebakk, JG; Johnsson, F; Thøgersen, T; Vilien, M; Wetterhus, S, 1997) |
| " As cisapride can inhibit similar channels in other tissues and is an effective treatment for nocturnal heartburn, we examined the effects of cisapride on gastric and oesophageal acidity, gastric emptying and heartburn severity in subjects with gastro-oesophageal reflux disease." | 5.10 | Cisapride inhibits meal-stimulated gastric acid secretion and post-prandial gastric acidity in subjects with gastro-oesophageal reflux disease. ( Gardner, JD; Miner, PB; Robinson, M; Rodriguez-Stanley, S, 2002) |
| "Heartburn was prevented in a significantly higher percentage of cisapride-treated patients (40%; 24 out of 60) than placebo-treated patients (21%; 12 out of 58) after the repeat provocative meal at the end of the double-blind phase (P = 0." | 5.09 | Cisapride 20 mg b.d. for preventing symptoms of GERD induced by a provocative meal. The CIS-USA-89 Study Group. ( Castell, D; Jokubaitis, L; Littlejohn, T; Napolitano, J; Oleka, N; Orr, W; Silvers, D, 1999) |
| "To compare the effects and tolerability of omeprazole and cisapride with that of placebo for control of heartburn in primary care patients." | 5.09 | Heartburn treatment in primary care: randomised, double blind study for 8 weeks. ( Bernklev, T; Berstad, A; Hatlebakk, JG; Hyggen, A; Madsen, PH; Mowinckel, P; Schulz, T; Walle, PO, 1999) |
| "Enhanced gastric functioning and reduction in heartburn suggest that cisapride is efficacious in the treatment of older adults with symptomatic GERD, and that gastric dysrhythmias and postprandial fullness are resolved with cisapride treatment." | 5.09 | Gastric myoelectric activity in older adults treated with cisapride for gastro-oesophageal reflux disease. ( Chen, JD; McClanahan, J; Orr, WC; Sloan, S; Zhang, M, 2000) |
| "We were unable to show major differences in the short-term efficacy of cisapride and placebo in functional dyspepsia." | 5.08 | Efficacy of cisapride therapy in functional dyspepsia. ( Cowan, H; Eckstein, RP; Höschl, R; Kellow, JE; Lam, SK; Lunzer, MR; Riley, JW; Shuter, B, 1995) |
| "Although cisapride and ranitidine both improved the symptoms of functional dyspepsia, cisapride was superior to ranitidine, particularly on the combined evaluation of the response to treatment and the recurrence of symptoms." | 5.08 | Cisapride compared with ranitidine in the treatment of functional dyspepsia. ( Carvalhinhos, A; Fidalgo, P; Freire, A; Matos, L, 1995) |
| "Cisapride 10 mg significantly reduced daytime and nighttime heartburn at 4 wk compared with placebo." | 5.08 | Cisapride for gastroesophageal reflux disease: a placebo-controlled, double-blind study. ( Long, JF; Richter, JE, 1995) |
| "Omeprazole 20 or 10 mg once daily is significantly more effective than cisapride in the resolution of heartburn, regardless of the presence of erosive oesophagitis, and this is accompanied by an improvement in patient quality of life." | 5.08 | Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride. ( Barthelemy, P; Galmiche, JP; Hamelin, B, 1997) |
| "We evaluated the efficacy and safety of a twice-daily dosage regimen of cisapride 20 mg in relieving the symptoms of mild-moderate gastroesophageal reflux disease (GERD) in patients with moderate intensity heartburn and no history of erosive esophagitis." | 5.08 | Cisapride 20 mg b.i.d. provides symptomatic relief of heartburn and related symptoms of chronic mild to moderate gastroesophageal reflux disease. CIS-USA-52 Investigator Group. ( Castell, DO; Clyde, C; Hasner, D; Lambert, R; Patterson, D; Sigmund, C; Zeldis, JB, 1998) |
| "The withdrawal of cisapride from the market will present challenges for physicians treating patients with nocturnal heartburn, gastroparesis, and dyspepsia." | 4.80 | Cisapride: limited access and alternatives. ( Richter, JE, 2000) |
| "Cisapride has well-documented prokinetic effects and may be well suited for long-term therapy of GORD, but its effectiveness in purely symptomatic treatment is unknown." | 2.68 | The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux disease. ( Carling, L; Hatlebakk, JG; Johnsson, F; Thøgersen, T; Vilien, M; Wetterhus, S, 1997) |
| "Heartburn is a normal consequence of pregnancy." | 2.43 | Review article: the management of heartburn in pregnancy. ( Richter, JE, 2005) |
| "Only surgery improved regurgitation." | 1.30 | The effect of medical therapy and antireflux surgery on dysphagia in patients with gastroesophageal reflux disease without esophageal stricture. ( Gadenstaetter, M; Glaser, K; Hinder, RA; Profanter, C; Wetscher, GJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 13 (68.42) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gardner, JD | 1 |
| Rodriguez-Stanley, S | 1 |
| Robinson, M | 1 |
| Miner, PB | 1 |
| Richter, JE | 3 |
| Kellow, JE | 1 |
| Cowan, H | 1 |
| Shuter, B | 1 |
| Riley, JW | 1 |
| Lunzer, MR | 1 |
| Eckstein, RP | 1 |
| Höschl, R | 1 |
| Lam, SK | 1 |
| Carvalhinhos, A | 1 |
| Fidalgo, P | 1 |
| Freire, A | 1 |
| Matos, L | 1 |
| Long, JF | 1 |
| Galmiche, JP | 2 |
| Barthelemy, P | 1 |
| Hamelin, B | 1 |
| Hatlebakk, JG | 2 |
| Johnsson, F | 1 |
| Vilien, M | 1 |
| Carling, L | 1 |
| Wetterhus, S | 1 |
| Thøgersen, T | 1 |
| Castell, DO | 1 |
| Sigmund, C | 1 |
| Patterson, D | 1 |
| Lambert, R | 1 |
| Hasner, D | 1 |
| Clyde, C | 1 |
| Zeldis, JB | 1 |
| Shibata, Y | 1 |
| Nimura, Y | 1 |
| Toyoda, S | 1 |
| Yasui, A | 1 |
| Kawamura, T | 1 |
| Josefson, D | 1 |
| Wetscher, GJ | 1 |
| Glaser, K | 1 |
| Gadenstaetter, M | 1 |
| Profanter, C | 1 |
| Hinder, RA | 1 |
| Castell, D | 1 |
| Silvers, D | 1 |
| Littlejohn, T | 1 |
| Orr, W | 1 |
| Napolitano, J | 1 |
| Oleka, N | 1 |
| Jokubaitis, L | 1 |
| Hyggen, A | 1 |
| Madsen, PH | 1 |
| Walle, PO | 1 |
| Schulz, T | 1 |
| Mowinckel, P | 1 |
| Bernklev, T | 1 |
| Berstad, A | 1 |
| Orr, WC | 1 |
| Zhang, M | 1 |
| McClanahan, J | 1 |
| Sloan, S | 1 |
| Chen, JD | 1 |
| Dent, J | 1 |
| Brandstätter, G | 1 |
| Evreux, M | 1 |
| Hentschel, E | 1 |
| Kerstan, E | 1 |
| Kratochvil, P | 1 |
| Reichel, W | 1 |
| Schütze, K | 1 |
| Soule, JC | 1 |
| Vitaux, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Efficacy of Alginate-based Reflux Suppressant and Magnesium-aluminium Antacid Gel for Treatment of Heartburn in Pregnancy : A Randomized Double-Blind Controlled Trial[NCT02470117] | Phase 4 | 100 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for cisapride and Pyrosis
| Article | Year |
|---|---|
Review article: the management of heartburn in pregnancy.
Topics: Antacids; Anti-Ulcer Agents; Cisapride; Female; Gastroesophageal Reflux; Gastrointestinal Motility; | 2005 |
Cisapride: limited access and alternatives.
Topics: Anti-Ulcer Agents; Arrhythmias, Cardiac; Cisapride; Drug and Narcotic Control; Dyspepsia; Female; Ga | 2000 |
Heartburn--lifting the veil of mythology.
Topics: Antacids; Cisapride; Esophagus; Gastroesophageal Reflux; Heartburn; Histamine H2 Antagonists; Humans | 1992 |
11 trials available for cisapride and Pyrosis
| Article | Year |
|---|---|
Cisapride inhibits meal-stimulated gastric acid secretion and post-prandial gastric acidity in subjects with gastro-oesophageal reflux disease.
Topics: Adult; Cisapride; Cross-Over Studies; Female; Gastric Acid; Gastric Acidity Determination; Gastric E | 2002 |
Efficacy of cisapride therapy in functional dyspepsia.
Topics: Adult; Anti-Ulcer Agents; Cisapride; Double-Blind Method; Dyspepsia; Eructation; Female; Gastric Emp | 1995 |
Cisapride compared with ranitidine in the treatment of functional dyspepsia.
Topics: Adult; Antacids; Anti-Ulcer Agents; Cisapride; Double-Blind Method; Dyspepsia; Eructation; Female; F | 1995 |
Cisapride for gastroesophageal reflux disease: a placebo-controlled, double-blind study.
Topics: Aluminum Hydroxide; Antacids; Anti-Ulcer Agents; Cisapride; Double-Blind Method; Drug Administration | 1995 |
Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride.
Topics: Adult; Anti-Ulcer Agents; Cisapride; Double-Blind Method; Enzyme Inhibitors; Esophagitis; Female; Ga | 1997 |
The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux disease.
Topics: Abdominal Pain; Cisapride; Constipation; Diarrhea; Drug Administration Schedule; Endoscopy; Esophagi | 1997 |
Cisapride 20 mg b.i.d. provides symptomatic relief of heartburn and related symptoms of chronic mild to moderate gastroesophageal reflux disease. CIS-USA-52 Investigator Group.
Topics: Adolescent; Adult; Aged; Antacids; Cisapride; Eructation; Female; Gastroesophageal Reflux; Gastroint | 1998 |
Cisapride 20 mg b.d. for preventing symptoms of GERD induced by a provocative meal. The CIS-USA-89 Study Group.
Topics: Adult; Aged; Cisapride; Double-Blind Method; Drug Administration Schedule; Female; Gastroesophageal | 1999 |
Heartburn treatment in primary care: randomised, double blind study for 8 weeks.
Topics: Anti-Ulcer Agents; Cisapride; Double-Blind Method; Female; Heartburn; Humans; Male; Middle Aged; Nor | 1999 |
Gastric myoelectric activity in older adults treated with cisapride for gastro-oesophageal reflux disease.
Topics: Aged; Aged, 80 and over; Cisapride; Female; Gastric Acid; Gastroesophageal Reflux; Heartburn; Humans | 2000 |
Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial.
Topics: Adult; Aged; Cimetidine; Cisapride; Clinical Trials as Topic; Double-Blind Method; Drug Combinations | 1988 |
5 other studies available for cisapride and Pyrosis
| Article | Year |
|---|---|
[With evidence-based phytotherapy. Takes away gastric and intestinal irritation].
Topics: Antiemetics; Cisapride; Clinical Trials as Topic; Dopamine Antagonists; Evidence-Based Medicine; Gas | 2003 |
Cisapride for nocturnal heartburn.
Topics: Cisapride; Clinical Trials as Topic; Esophagitis, Peptic; Gastroesophageal Reflux; Heartburn; Humans | 1994 |
Acid reflux test for gastroesophageal reflux after distal gastrectomy: diagnosis and clinical effect of cisapride.
Topics: Adult; Aged; Anti-Ulcer Agents; Barium Sulfate; Chest Pain; Cisapride; Contrast Media; Esophagitis, | 1998 |
FDA warns about heartburn drug.
Topics: Cisapride; Gastrointestinal Agents; Heartburn; Humans; Piperidines; United States; United States Foo | 1998 |
The effect of medical therapy and antireflux surgery on dysphagia in patients with gastroesophageal reflux disease without esophageal stricture.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Ulcer Agents; Benzimidazoles; Cisapride; | 1999 |