cisapride has been researched along with Intestinal Obstruction in 24 studies
Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.
Intestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind, placebo-controlled, crossover trial, we investigated the effects of the prokinetic drug cisapride in patients with cystic fibrosis and chronic recurrent distal intestinal obstruction syndrome (DIOS)." | 9.06 | Effects of cisapride in patients with cystic fibrosis and distal intestinal obstruction syndrome. ( Corey, M; Durie, PR; Ellis, L; Koletzko, S; Spino, M; Stringer, DA, 1990) |
| "Cisapride was effective in reducing the delayed intestinal transit time to within the normal range (delta solids = -115 +/- 25 min; delta liquids = -146 +/- 71 min; p less than 0." | 5.27 | Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride. ( Brown, ML; Camilleri, M; Malagelada, JR, 1986) |
| "In a double-blind, placebo-controlled, crossover trial, we investigated the effects of the prokinetic drug cisapride in patients with cystic fibrosis and chronic recurrent distal intestinal obstruction syndrome (DIOS)." | 5.06 | Effects of cisapride in patients with cystic fibrosis and distal intestinal obstruction syndrome. ( Corey, M; Durie, PR; Ellis, L; Koletzko, S; Spino, M; Stringer, DA, 1990) |
| "This paper provides a comprehensive review of the current knowledge on cisapride in different clinical conditions in children: different manifestations of gastro-oesophageal reflux, such as (excessive) regurgitation, oesophagitis, chronic respiratory disease or uncontrolled asthma, cystic fibrosis, chronic dyspepsia, constipation and pseudo-obstruction, and as an aid to small bowel capsule-biopsy." | 4.80 | Clinical use of cisapride and its risk-benefit in paediatric patients. ( Vandenplas, Y, 1998) |
| "Treatment with cisapride did not shorten the duration of postoperative ileus after either upper gastrointestinal or colonic surgery." | 2.67 | Cisapride in the treatment of post-operative ileus. ( Bergman, B; Bong, H; Ekström, P; Glise, H; Hallerbäck, B; Lundgren, K; Risberg, O, 1991) |
| "Cisapride was significantly effective: bowel sounds were present in 43% and 50% within 1 hour after the first and second injection of 4 mg, respectively, and flatus in 36% and 43%." | 2.66 | Placebo-controlled trial of cisapride in postoperative ileus. ( Boghaert, A; Haesaert, G; Mourisse, P; Verlinden, M, 1987) |
| "A 46-year-old man with achalasia-like syndrome developed CREST syndrome 4 years later." | 1.29 | Achalasia-like syndrome as the first manifestation in a patient with CREST syndrome. ( Berenguer, J; Gálvez, C; Garrigues, V; Ponce, J; Valverde, J, 1996) |
| "Cisapride was effective in reducing the delayed intestinal transit time to within the normal range (delta solids = -115 +/- 25 min; delta liquids = -146 +/- 71 min; p less than 0." | 1.27 | Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride. ( Brown, ML; Camilleri, M; Malagelada, JR, 1986) |
| " All patients not responding to treatment in the first hour were given a repeat dosage and observed for the following 3 hours." | 1.27 | Treatment of postoperative gastrointestinal atony. ( Boghaert, A; de Coster, M; Dehertog, P; Michiels, G; Verlinden, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.83) | 18.7374 |
| 1990's | 13 (54.17) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Carroll, W | 2 |
| Green, J | 2 |
| Gilchrist, FJ | 2 |
| Bove, A | 1 |
| Bellini, M | 1 |
| Battaglia, E | 1 |
| Bocchini, R | 1 |
| Gambaccini, D | 1 |
| Bove, V | 1 |
| Pucciani, F | 1 |
| Altomare, DF | 1 |
| Dodi, G | 1 |
| Sciaudone, G | 1 |
| Falletto, E | 1 |
| Piloni, V | 1 |
| Jones, R | 1 |
| Franklin, K | 1 |
| Spicer, R | 1 |
| Berry, J | 1 |
| Roberts, JP | 1 |
| Benson, MJ | 1 |
| Rogers, J | 1 |
| Deeks, JJ | 1 |
| Wingate, DL | 1 |
| Williams, NS | 1 |
| Steinebach, MA | 1 |
| Cole, D | 1 |
| Garrigues, V | 1 |
| Ponce, J | 1 |
| Gálvez, C | 1 |
| Valverde, J | 1 |
| Berenguer, J | 1 |
| Gerring, EL | 1 |
| King, JN | 1 |
| Resnick, J | 1 |
| Greenwald, DA | 1 |
| Brandt, LJ | 1 |
| Lander, A | 1 |
| Redkar, R | 1 |
| Nicholls, G | 1 |
| Lawson, A | 1 |
| Choudhury, SR | 1 |
| Corkery, JJ | 1 |
| Gornall, P | 1 |
| Buick, RG | 1 |
| Booth, IW | 1 |
| Dart, AJ | 1 |
| Hodgson, DR | 1 |
| Valk, N | 1 |
| Doherty, TJ | 1 |
| Blackford, JT | 1 |
| Abraha, TW | 1 |
| Frazier, DL | 1 |
| Shibata, Y | 1 |
| Toyoda, S | 1 |
| Vandenplas, Y | 1 |
| De Winter, BY | 1 |
| Boeckxstaens, GE | 1 |
| De Man, JG | 1 |
| Moreels, TG | 1 |
| Schuurkes, JA | 1 |
| Peeters, TL | 1 |
| Herman, AG | 1 |
| Pelckmans, PA | 1 |
| Davies, MW | 1 |
| Sunil, S | 1 |
| Sinha, S | 1 |
| Cheetham, M | 1 |
| Hallerbäck, B | 1 |
| Bergman, B | 1 |
| Bong, H | 1 |
| Ekström, P | 1 |
| Glise, H | 1 |
| Lundgren, K | 1 |
| Risberg, O | 1 |
| Koletzko, S | 1 |
| Corey, M | 1 |
| Ellis, L | 1 |
| Spino, M | 1 |
| Stringer, DA | 1 |
| Durie, PR | 1 |
| Springall, RG | 1 |
| Spitz, L | 1 |
| Boghaert, A | 2 |
| Haesaert, G | 1 |
| Mourisse, P | 1 |
| Verlinden, M | 2 |
| Camilleri, M | 1 |
| Brown, ML | 1 |
| Malagelada, JR | 1 |
| Michiels, G | 1 |
| de Coster, M | 1 |
| Dehertog, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Caffeine Ingestion in Prevention of Postoperative Ileus After Caesarean Section: A Randomized Controlled Trial[NCT03815877] | 600 participants (Actual) | Interventional | 2018-01-17 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for cisapride and Intestinal Obstruction
| Article | Year |
|---|---|
Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.
Topics: Cisapride; Constipation; Cystic Fibrosis; Humans; Intestinal Obstruction; Quality of Life; Randomize | 2021 |
Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.
Topics: Adolescent; Adult; Cisapride; Cystic Fibrosis; Gastrointestinal Agents; Humans; Intestinal Obstructi | 2018 |
Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: part II.
Topics: Abdomen; Cisapride; Dopamine Antagonists; Erythromycin; Gastric Emptying; Gastrointestinal Agents; H | 1997 |
Role of prokinetic drugs for treatment of postoperative ileus in the horse.
Topics: Adrenergic Antagonists; Anesthetics, Local; Animals; Anti-Bacterial Agents; Cholinergic Agonists; Ci | 1998 |
Clinical use of cisapride and its risk-benefit in paediatric patients.
Topics: Child; Child, Preschool; Cisapride; Constipation; Cystic Fibrosis; Drug Interactions; Dyspepsia; Fec | 1998 |
7 trials available for cisapride and Intestinal Obstruction
| Article | Year |
|---|---|
Effect of cisapride on distal colonic motility in the early postoperative period following left colonic anastomosis.
Topics: Aged; Aged, 80 and over; Anastomosis, Surgical; Cisapride; Colon; Double-Blind Method; Drug Administ | 1995 |
Cisapride in the prophylaxis of equine post operative ileus.
Topics: Animals; Antiemetics; Cholinergic Agents; Cisapride; Domperidone; Dose-Response Relationship, Drug; | 1989 |
Cisapride reduces neonatal postoperative ileus: randomised placebo controlled trial.
Topics: Administration, Rectal; Cisapride; Double-Blind Method; Gastrointestinal Agents; Gastrointestinal Mo | 1997 |
Effect of cisapride on gastric emptying in horses following endotoxin treatment.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Area Under Curve; Cisapride; | 1998 |
Cisapride in the treatment of post-operative ileus.
Topics: Aged; Aged, 80 and over; Cisapride; Defecation; Double-Blind Method; Humans; Intestinal Obstruction; | 1991 |
Effects of cisapride in patients with cystic fibrosis and distal intestinal obstruction syndrome.
Topics: Adolescent; Adult; Chronic Disease; Cisapride; Cystic Fibrosis; Double-Blind Method; Female; Humans; | 1990 |
Placebo-controlled trial of cisapride in postoperative ileus.
Topics: Adult; Cisapride; Clinical Trials as Topic; Double-Blind Method; Female; Gastrointestinal Diseases; | 1987 |
12 other studies available for cisapride and Intestinal Obstruction
| Article | Year |
|---|---|
Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (part II: treatment).
Topics: Chronic Disease; Cisapride; Clinical Trials as Topic; Colectomy; Constipation; Dietary Fiber; Gastro | 2012 |
Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes.
Topics: Alginates; Aluminum Hydroxide; Amylases; Antacids; Anti-Ulcer Agents; Bromelains; Cisapride; Colon; | 1995 |
Use of cisapride in the resolution of pelvic flexure impaction in a horse.
Topics: Animals; Cisapride; Colonic Diseases; Fecal Impaction; Gastrointestinal Motility; Horse Diseases; Ho | 1995 |
Achalasia-like syndrome as the first manifestation in a patient with CREST syndrome.
Topics: Anti-Ulcer Agents; Cardia; Cisapride; Constipation; CREST Syndrome; Dilatation; Esophageal Achalasia | 1996 |
Effects of prostaglandin F2alpha and cisapride on small intestinal activity during the early postoperative period in humans.
Topics: Abdomen; Cisapride; Dinoprost; Female; Gastrointestinal Agents; Gastrointestinal Motility; Humans; I | 1998 |
Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats.
Topics: Animals; Cisapride; Dopamine Antagonists; Erythromycin; Gastrointestinal Agents; Granisetron; Intest | 1999 |
The use of cisapride in neonates.
Topics: Cisapride; Gastroesophageal Reflux; Gastrointestinal Agents; Humans; Infant, Newborn; Intestinal Obs | 2000 |
Postoperative ileus: a preventable event (Br J Surg 2000; 87: 1480-93).
Topics: Arrhythmias, Cardiac; Cisapride; Drug and Narcotic Control; Gastrointestinal Agents; Humans; Intesti | 2001 |
Postoperative ileus: a preventable event (Br J Surg 2000; 87: 1480-93).
Topics: Arrhythmias, Cardiac; Cisapride; Drug and Narcotic Control; Gastrointestinal Agents; Humans; Intesti | 2001 |
The prevention of post-operative adhesions using a gastrointestinal prokinetic agent.
Topics: Administration, Cutaneous; Anastomosis, Surgical; Animals; Cisapride; Disease Models, Animal; Female | 1989 |
Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride.
Topics: Adult; Cisapride; Eating; Female; Gastric Emptying; Gastrointestinal Motility; Humans; Intestinal Ob | 1986 |
Treatment of postoperative gastrointestinal atony.
Topics: Cisapride; Digestive System; Dose-Response Relationship, Drug; Female; Gastrointestinal Diseases; Ga | 1987 |