Page last updated: 2024-10-25

cisapride and Intestinal Obstruction

cisapride has been researched along with Intestinal Obstruction in 24 studies

Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.

Intestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.

Research Excerpts

ExcerptRelevanceReference
"In a double-blind, placebo-controlled, crossover trial, we investigated the effects of the prokinetic drug cisapride in patients with cystic fibrosis and chronic recurrent distal intestinal obstruction syndrome (DIOS)."9.06Effects of cisapride in patients with cystic fibrosis and distal intestinal obstruction syndrome. ( Corey, M; Durie, PR; Ellis, L; Koletzko, S; Spino, M; Stringer, DA, 1990)
"Cisapride was effective in reducing the delayed intestinal transit time to within the normal range (delta solids = -115 +/- 25 min; delta liquids = -146 +/- 71 min; p less than 0."5.27Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride. ( Brown, ML; Camilleri, M; Malagelada, JR, 1986)
"In a double-blind, placebo-controlled, crossover trial, we investigated the effects of the prokinetic drug cisapride in patients with cystic fibrosis and chronic recurrent distal intestinal obstruction syndrome (DIOS)."5.06Effects of cisapride in patients with cystic fibrosis and distal intestinal obstruction syndrome. ( Corey, M; Durie, PR; Ellis, L; Koletzko, S; Spino, M; Stringer, DA, 1990)
"This paper provides a comprehensive review of the current knowledge on cisapride in different clinical conditions in children: different manifestations of gastro-oesophageal reflux, such as (excessive) regurgitation, oesophagitis, chronic respiratory disease or uncontrolled asthma, cystic fibrosis, chronic dyspepsia, constipation and pseudo-obstruction, and as an aid to small bowel capsule-biopsy."4.80Clinical use of cisapride and its risk-benefit in paediatric patients. ( Vandenplas, Y, 1998)
"Treatment with cisapride did not shorten the duration of postoperative ileus after either upper gastrointestinal or colonic surgery."2.67Cisapride in the treatment of post-operative ileus. ( Bergman, B; Bong, H; Ekström, P; Glise, H; Hallerbäck, B; Lundgren, K; Risberg, O, 1991)
"Cisapride was significantly effective: bowel sounds were present in 43% and 50% within 1 hour after the first and second injection of 4 mg, respectively, and flatus in 36% and 43%."2.66Placebo-controlled trial of cisapride in postoperative ileus. ( Boghaert, A; Haesaert, G; Mourisse, P; Verlinden, M, 1987)
"A 46-year-old man with achalasia-like syndrome developed CREST syndrome 4 years later."1.29Achalasia-like syndrome as the first manifestation in a patient with CREST syndrome. ( Berenguer, J; Gálvez, C; Garrigues, V; Ponce, J; Valverde, J, 1996)
"Cisapride was effective in reducing the delayed intestinal transit time to within the normal range (delta solids = -115 +/- 25 min; delta liquids = -146 +/- 71 min; p less than 0."1.27Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride. ( Brown, ML; Camilleri, M; Malagelada, JR, 1986)
" All patients not responding to treatment in the first hour were given a repeat dosage and observed for the following 3 hours."1.27Treatment of postoperative gastrointestinal atony. ( Boghaert, A; de Coster, M; Dehertog, P; Michiels, G; Verlinden, M, 1987)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19905 (20.83)18.7374
1990's13 (54.17)18.2507
2000's3 (12.50)29.6817
2010's2 (8.33)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Carroll, W2
Green, J2
Gilchrist, FJ2
Bove, A1
Bellini, M1
Battaglia, E1
Bocchini, R1
Gambaccini, D1
Bove, V1
Pucciani, F1
Altomare, DF1
Dodi, G1
Sciaudone, G1
Falletto, E1
Piloni, V1
Jones, R1
Franklin, K1
Spicer, R1
Berry, J1
Roberts, JP1
Benson, MJ1
Rogers, J1
Deeks, JJ1
Wingate, DL1
Williams, NS1
Steinebach, MA1
Cole, D1
Garrigues, V1
Ponce, J1
Gálvez, C1
Valverde, J1
Berenguer, J1
Gerring, EL1
King, JN1
Resnick, J1
Greenwald, DA1
Brandt, LJ1
Lander, A1
Redkar, R1
Nicholls, G1
Lawson, A1
Choudhury, SR1
Corkery, JJ1
Gornall, P1
Buick, RG1
Booth, IW1
Dart, AJ1
Hodgson, DR1
Valk, N1
Doherty, TJ1
Blackford, JT1
Abraha, TW1
Frazier, DL1
Shibata, Y1
Toyoda, S1
Vandenplas, Y1
De Winter, BY1
Boeckxstaens, GE1
De Man, JG1
Moreels, TG1
Schuurkes, JA1
Peeters, TL1
Herman, AG1
Pelckmans, PA1
Davies, MW1
Sunil, S1
Sinha, S1
Cheetham, M1
Hallerbäck, B1
Bergman, B1
Bong, H1
Ekström, P1
Glise, H1
Lundgren, K1
Risberg, O1
Koletzko, S1
Corey, M1
Ellis, L1
Spino, M1
Stringer, DA1
Durie, PR1
Springall, RG1
Spitz, L1
Boghaert, A2
Haesaert, G1
Mourisse, P1
Verlinden, M2
Camilleri, M1
Brown, ML1
Malagelada, JR1
Michiels, G1
de Coster, M1
Dehertog, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Caffeine Ingestion in Prevention of Postoperative Ileus After Caesarean Section: A Randomized Controlled Trial[NCT03815877]600 participants (Actual)Interventional2018-01-17Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for cisapride and Intestinal Obstruction

ArticleYear
Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.
    The Cochrane database of systematic reviews, 2021, 12-22, Volume: 12

    Topics: Cisapride; Constipation; Cystic Fibrosis; Humans; Intestinal Obstruction; Quality of Life; Randomize

2021
Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.
    The Cochrane database of systematic reviews, 2018, 06-12, Volume: 6

    Topics: Adolescent; Adult; Cisapride; Cystic Fibrosis; Gastrointestinal Agents; Humans; Intestinal Obstructi

2018
Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: part II.
    The American journal of gastroenterology, 1997, Volume: 92, Issue:6

    Topics: Abdomen; Cisapride; Dopamine Antagonists; Erythromycin; Gastric Emptying; Gastrointestinal Agents; H

1997
Role of prokinetic drugs for treatment of postoperative ileus in the horse.
    Australian veterinary journal, 1998, Volume: 76, Issue:1

    Topics: Adrenergic Antagonists; Anesthetics, Local; Animals; Anti-Bacterial Agents; Cholinergic Agonists; Ci

1998
Clinical use of cisapride and its risk-benefit in paediatric patients.
    European journal of gastroenterology & hepatology, 1998, Volume: 10, Issue:10

    Topics: Child; Child, Preschool; Cisapride; Constipation; Cystic Fibrosis; Drug Interactions; Dyspepsia; Fec

1998

Trials

7 trials available for cisapride and Intestinal Obstruction

ArticleYear
Effect of cisapride on distal colonic motility in the early postoperative period following left colonic anastomosis.
    Diseases of the colon and rectum, 1995, Volume: 38, Issue:2

    Topics: Aged; Aged, 80 and over; Anastomosis, Surgical; Cisapride; Colon; Double-Blind Method; Drug Administ

1995
Cisapride in the prophylaxis of equine post operative ileus.
    Equine veterinary journal. Supplement, 1989, Issue:7

    Topics: Animals; Antiemetics; Cholinergic Agents; Cisapride; Domperidone; Dose-Response Relationship, Drug;

1989
Cisapride reduces neonatal postoperative ileus: randomised placebo controlled trial.
    Archives of disease in childhood. Fetal and neonatal edition, 1997, Volume: 77, Issue:2

    Topics: Administration, Rectal; Cisapride; Double-Blind Method; Gastrointestinal Agents; Gastrointestinal Mo

1997
Effect of cisapride on gastric emptying in horses following endotoxin treatment.
    Equine veterinary journal, 1998, Volume: 30, Issue:4

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Area Under Curve; Cisapride;

1998
Cisapride in the treatment of post-operative ileus.
    Alimentary pharmacology & therapeutics, 1991, Volume: 5, Issue:5

    Topics: Aged; Aged, 80 and over; Cisapride; Defecation; Double-Blind Method; Humans; Intestinal Obstruction;

1991
Effects of cisapride in patients with cystic fibrosis and distal intestinal obstruction syndrome.
    The Journal of pediatrics, 1990, Volume: 117, Issue:5

    Topics: Adolescent; Adult; Chronic Disease; Cisapride; Cystic Fibrosis; Double-Blind Method; Female; Humans;

1990
Placebo-controlled trial of cisapride in postoperative ileus.
    Acta anaesthesiologica Belgica, 1987, Volume: 38, Issue:3

    Topics: Adult; Cisapride; Clinical Trials as Topic; Double-Blind Method; Female; Gastrointestinal Diseases;

1987

Other Studies

12 other studies available for cisapride and Intestinal Obstruction

ArticleYear
Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (part II: treatment).
    World journal of gastroenterology, 2012, Sep-28, Volume: 18, Issue:36

    Topics: Chronic Disease; Cisapride; Clinical Trials as Topic; Colectomy; Constipation; Dietary Fiber; Gastro

2012
Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes.
    Lancet (London, England), 1995, Aug-19, Volume: 346, Issue:8973

    Topics: Alginates; Aluminum Hydroxide; Amylases; Antacids; Anti-Ulcer Agents; Bromelains; Cisapride; Colon;

1995
Use of cisapride in the resolution of pelvic flexure impaction in a horse.
    The Canadian veterinary journal = La revue veterinaire canadienne, 1995, Volume: 36, Issue:10

    Topics: Animals; Cisapride; Colonic Diseases; Fecal Impaction; Gastrointestinal Motility; Horse Diseases; Ho

1995
Achalasia-like syndrome as the first manifestation in a patient with CREST syndrome.
    European journal of gastroenterology & hepatology, 1996, Volume: 8, Issue:3

    Topics: Anti-Ulcer Agents; Cardia; Cisapride; Constipation; CREST Syndrome; Dilatation; Esophageal Achalasia

1996
Effects of prostaglandin F2alpha and cisapride on small intestinal activity during the early postoperative period in humans.
    Surgery today, 1998, Volume: 28, Issue:8

    Topics: Abdomen; Cisapride; Dinoprost; Female; Gastrointestinal Agents; Gastrointestinal Motility; Humans; I

1998
Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats.
    Gut, 1999, Volume: 45, Issue:5

    Topics: Animals; Cisapride; Dopamine Antagonists; Erythromycin; Gastrointestinal Agents; Granisetron; Intest

1999
The use of cisapride in neonates.
    Archives of disease in childhood. Fetal and neonatal edition, 2000, Volume: 83, Issue:1

    Topics: Cisapride; Gastroesophageal Reflux; Gastrointestinal Agents; Humans; Infant, Newborn; Intestinal Obs

2000
Postoperative ileus: a preventable event (Br J Surg 2000; 87: 1480-93).
    The British journal of surgery, 2001, Volume: 88, Issue:4

    Topics: Arrhythmias, Cardiac; Cisapride; Drug and Narcotic Control; Gastrointestinal Agents; Humans; Intesti

2001
Postoperative ileus: a preventable event (Br J Surg 2000; 87: 1480-93).
    The British journal of surgery, 2001, Volume: 88, Issue:4

    Topics: Arrhythmias, Cardiac; Cisapride; Drug and Narcotic Control; Gastrointestinal Agents; Humans; Intesti

2001
The prevention of post-operative adhesions using a gastrointestinal prokinetic agent.
    Journal of pediatric surgery, 1989, Volume: 24, Issue:6

    Topics: Administration, Cutaneous; Anastomosis, Surgical; Animals; Cisapride; Disease Models, Animal; Female

1989
Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride.
    Gastroenterology, 1986, Volume: 91, Issue:3

    Topics: Adult; Cisapride; Eating; Female; Gastric Emptying; Gastrointestinal Motility; Humans; Intestinal Ob

1986
Treatment of postoperative gastrointestinal atony.
    The British journal of surgery, 1987, Volume: 74, Issue:7

    Topics: Cisapride; Digestive System; Dose-Response Relationship, Drug; Female; Gastrointestinal Diseases; Ga

1987