Page last updated: 2024-10-25

cisapride and Gastric Diseases

cisapride has been researched along with Gastric Diseases in 28 studies

Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.

Research Excerpts

ExcerptRelevanceReference
"To investigate the therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation."7.73Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats. ( Wang, ZG; Xu, Y; Zhang, LY; Zhu, PF, 2005)
"A case of chronic intestinal pseudoobstruction secondary to systemic amyloidosis in a patient with multiple myeloma is described."5.28Intestinal pseudoobstruction secondary to amyloidosis responsive to cisapride. ( Arthur, JF; Fraser, AG; Hamilton, I, 1991)
"We conducted a 12-month trial of cisapride (10 mg three times a day) in 21 patients with gastric stasis due to clinically and manometrically diagnosed gastroparesis (N = 9; seven due to diabetes) or chronic intestinal pseudo-obstruction (N = 12)."5.07Long-term efficacy of oral cisapride in symptomatic upper gut dysmotility. ( Abell, TL; Camilleri, M; DiMagno, EP; Hench, VS; Malagelada, JR; Zinsmeister, AR, 1991)
"In a double blind crossover comparison with placebo, the effects of cisapride (10 mg tid for two weeks), a non-antidopaminergic gastrointestinal prokinetic drug, on gastric emptying times and on symptoms were evaluated in 12 patients with chronic idiopathic dyspepsia and gastroparesis."5.06Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis. ( Barbara, L; Corinaldesi, R; Raiti, C; Rea, E; Salgemini, R; Stanghellini, V, 1987)
"To investigate the therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation."3.73Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats. ( Wang, ZG; Xu, Y; Zhang, LY; Zhu, PF, 2005)
"Cisapride has an established prokinetic effect in patients with delayed gastric emptying."2.68The effect of a single rectal dose of cisapride on delayed gastric emptying. ( Brummer, RJ; Heidendal, GA; Kemerink, GJ; Sanders, DG; Schoenmakers, EA; Stockbrügger, RW, 1997)
"The aim of this study was to determine the optimal dosage regimen of cisapride for the treatment of idiopathic gastroparesis."2.67The effect of different dosage schedules of cisapride on gastric emptying in idiopathic gastroparesis. ( Barbara, L; Corbelli, C; Corinaldesi, R; Marengo, M; Monetti, N; Rea, E; Stanghellini, V; Tosetti, C, 1993)
" While both cisapride and metoclopramide normalized impaired solid emptying, cisapride at its highest dosage (10 mg) resulted in significantly faster gastric emptying (P = 0."2.67Cisapride vs metoclopramide. An acute study in diabetic gastroparesis. ( Diamant, NE; Lico, S; McHugh, S, 1992)
"Vomiting was the first cause of admission in diabetics."1.29Gastroparesis: an important cause of hospitalization in continuous ambulatory peritoneal dialysis patients and the role of erythromycin. ( Gallar, P; Guijo, G; Oliet, A; Ortega, O; Vigil, A, 1993)
"A case of chronic intestinal pseudoobstruction secondary to systemic amyloidosis in a patient with multiple myeloma is described."1.28Intestinal pseudoobstruction secondary to amyloidosis responsive to cisapride. ( Arthur, JF; Fraser, AG; Hamilton, I, 1991)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19905 (17.86)18.7374
1990's22 (78.57)18.2507
2000's1 (3.57)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, LY1
Wang, ZG1
Zhu, PF1
Xu, Y1
Dworkin, BM1
Rosenthal, WS1
Casellas, AR1
Girolomo, R1
Lebovics, E1
Freeman, S1
Clark, SB1
Kendall, BJ1
McCallum, RW3
Fraser, RJ1
Horowitz, M2
Maddox, AF1
Dent, J1
Rothstein, RD1
Alavi, A1
Reynolds, JC2
Corinaldesi, R2
Stanghellini, V2
Tosetti, C1
Rea, E2
Corbelli, C1
Marengo, M1
Monetti, N1
Barbara, L2
Hill, AD1
Walsh, TN1
Hamilton, D1
Freyne, P1
O'Hare, N1
Byrne, PJ1
Hennessy, TP1
Gallar, P1
Oliet, A1
Vigil, A1
Ortega, O1
Guijo, G1
Richards, RD1
Valenzuela, GA1
Davenport, KG1
Fisher, KL1
Kawagishi, T1
Nishizawa, Y1
Okuno, Y1
Sekiya, K1
Morii, H1
Sternberg, A1
Coscas, D1
Fireman, Z1
Czambor-Ksiazek, E1
Pokrzywnicki, W1
Grzeszczak, W1
Duda, G1
Brummer, RJ1
Schoenmakers, EA1
Kemerink, GJ1
Heidendal, GA1
Sanders, DG1
Stockbrügger, RW1
Vitola, J1
Vukanovic, J1
Roden, DM1
Hall, JA1
Washabau, RJ1
Chaabouni, H1
Cheikh, I1
el Mokhtar, M1
Ben Ammar, A1
Drenth, JP1
Engels, LG1
Jian, R1
McHugh, S1
Lico, S1
Diamant, NE1
Layer, P1
Goebell, H1
Fraser, AG1
Arthur, JF1
Hamilton, I1
Abell, TL1
Camilleri, M1
DiMagno, EP1
Hench, VS1
Zinsmeister, AR1
Malagelada, JR1
Roberts, AP1
Cullen, PT1
Campbell, FC1
Ricci, DA1
Vogelberg, KH1
Dalügge, A1
Raiti, C1
Salgemini, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622]Phase 23 participants (Actual)Interventional2014-07-31Terminated (stopped due to Lack of recruitment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for cisapride and Gastric Diseases

ArticleYear
Gastroparesis and the current use of prokinetic drugs.
    The Gastroenterologist, 1993, Volume: 1, Issue:2

    Topics: Cisapride; Domperidone; Gastric Emptying; Humans; Metoclopramide; Piperidines; Stomach Diseases

1993
[Disorders of gastric emptying in diabetes. II. Treatment].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1997, Volume: 50, Issue:1-3

    Topics: Cisapride; Diabetes Complications; Domperidone; Dopamine Agents; Erythromycin; Gastric Emptying; Hum

1997
Diagnosis and treatment of gastric motility disorders.
    The Veterinary clinics of North America. Small animal practice, 1999, Volume: 29, Issue:2

    Topics: Animals; Cat Diseases; Cats; Cisapride; Dog Diseases; Dogs; Erythromycin; Gastric Emptying; Gastroin

1999
Diabetic gastroparesis. A critical reappraisal of new treatment strategies.
    Drugs, 1992, Volume: 44, Issue:4

    Topics: Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cisapride; Diabetes

1992
[Disorders of gastric emptying].
    Presse medicale (Paris, France : 1983), 1992, Jun-20, Volume: 21, Issue:23

    Topics: Cisapride; Diabetes Complications; Domperidone; Dyspepsia; Gastric Emptying; Gastroesophageal Reflux

1992
Prokinetic agents: a key in the future of gastroenterology.
    Gastroenterology clinics of North America, 1989, Volume: 18, Issue:2

    Topics: Biomechanical Phenomena; Cisapride; Domperidone; Forecasting; Gastroenterology; Gastroesophageal Ref

1989
Diagnosis and treatment of delayed gastric emptying.
    Advances in internal medicine, 1988, Volume: 33

    Topics: Anemia, Pernicious; Anorexia Nervosa; Cisapride; Connective Tissue Diseases; Diabetes Complications;

1988

Trials

9 trials available for cisapride and Gastric Diseases

ArticleYear
Open label study of long-term effectiveness of cisapride in patients with idiopathic gastroparesis.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:7

    Topics: Adult; Anti-Ulcer Agents; Cisapride; Female; Gastric Emptying; Humans; Male; Paresis; Piperidines; S

1994
The effect of different dosage schedules of cisapride on gastric emptying in idiopathic gastroparesis.
    European journal of clinical pharmacology, 1993, Volume: 44, Issue:5

    Topics: Adult; Cisapride; Double-Blind Method; Drug Administration Schedule; Eating; Female; Gastric Emptyin

1993
Objective and subjective results of a randomized, double-blind, placebo-controlled trial using cisapride to treat gastroparesis.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:5

    Topics: Adolescent; Adult; Aged; Cisapride; Double-Blind Method; Female; Gastric Emptying; Humans; Male; Mid

1993
Effect of cisapride on gastric emptying of indigestible solids and plasma motilin concentration in diabetic autonomic neuropathy.
    The American journal of gastroenterology, 1993, Volume: 88, Issue:6

    Topics: Autonomic Nervous System Diseases; Cisapride; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2;

1993
The effect of a single rectal dose of cisapride on delayed gastric emptying.
    Alimentary pharmacology & therapeutics, 1997, Volume: 11, Issue:4

    Topics: Administration, Rectal; Adult; Aged; Cisapride; Cross-Over Studies; Double-Blind Method; Female; Gas

1997
Diabetic gastroparesis. A critical reappraisal of new treatment strategies.
    Drugs, 1992, Volume: 44, Issue:4

    Topics: Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cisapride; Diabetes

1992
Cisapride vs metoclopramide. An acute study in diabetic gastroparesis.
    Digestive diseases and sciences, 1992, Volume: 37, Issue:7

    Topics: Adult; Autonomic Nervous System Diseases; Cisapride; Diabetic Neuropathies; Dose-Response Relationsh

1992
Long-term efficacy of oral cisapride in symptomatic upper gut dysmotility.
    Digestive diseases and sciences, 1991, Volume: 36, Issue:5

    Topics: Administration, Oral; Adult; Body Weight; Chronic Disease; Cisapride; Double-Blind Method; Female; G

1991
Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis.
    Gut, 1987, Volume: 28, Issue:3

    Topics: Adult; Cisapride; Clinical Trials as Topic; Double-Blind Method; Dyspepsia; Female; Gastric Emptying

1987

Other Studies

13 other studies available for cisapride and Gastric Diseases

ArticleYear
Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats.
    Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2005, Volume: 8, Issue:2

    Topics: Animals; Cisapride; Disease Models, Animal; Gastric Emptying; Gastric Mucosa; Gastrointestinal Agent

2005
Postprandial antropyloroduodenal motility and gastric emptying in gastroparesis--effects of cisapride.
    Gut, 1994, Volume: 35, Issue:2

    Topics: Adult; Aged; Cisapride; Clinical Protocols; Duodenum; Female; Gastric Emptying; Gastrointestinal Mot

1994
Electrogastrography in patients with gastroparesis and effect of long-term cisapride.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:8

    Topics: Adult; Cisapride; Diabetes Mellitus, Type 1; Electromyography; Electrophysiology; Gastric Emptying;

1993
Erythromycin improves emptying of the denervated stomach after oesophagectomy.
    The British journal of surgery, 1993, Volume: 80, Issue:7

    Topics: Aged; Cisapride; Erythromycin; Esophageal Neoplasms; Esophagectomy; Female; Gastric Emptying; Humans

1993
Gastroparesis: an important cause of hospitalization in continuous ambulatory peritoneal dialysis patients and the role of erythromycin.
    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 1993, Volume: 13 Suppl 2

    Topics: Cisapride; Diabetes Mellitus, Type 1; Erythromycin; Female; Gastric Emptying; Hospitalization; Human

1993
[Gastric phytobezoar].
    Harefuah, 1996, Mar-01, Volume: 130, Issue:5

    Topics: Adult; Anti-Ulcer Agents; Bezoars; Cellulose; Cisapride; Dietary Fiber; Domperidone; Endoscopy; Frui

1996
Cisapride-induced torsades de pointes.
    Journal of cardiovascular electrophysiology, 1998, Volume: 9, Issue:10

    Topics: Adolescent; Anti-Bacterial Agents; Biotransformation; Cisapride; Electrocardiography; Female; Follow

1998
[Gastric motility disorders].
    La Tunisie medicale, 1999, Volume: 77, Issue:1

    Topics: Cisapride; Diagnosis, Differential; Gastric Emptying; Gastrointestinal Agents; Gastrointestinal Moti

1999
[Therapy of motility disorders of the stomach and small intestine].
    Deutsche medizinische Wochenschrift (1946), 1991, Feb-22, Volume: 116, Issue:8

    Topics: Cisapride; Constipation; Diarrhea; Domperidone; Dumping Syndrome; Gastric Emptying; Gastrointestinal

1991
Intestinal pseudoobstruction secondary to amyloidosis responsive to cisapride.
    Digestive diseases and sciences, 1991, Volume: 36, Issue:4

    Topics: Amyloidosis; Cisapride; Female; Humans; Intestinal Diseases; Intestinal Pseudo-Obstruction; Middle A

1991
Long-term efficacy of cisapride in diabetic gastroparesis.
    The American journal of medicine, 1990, Volume: 88, Issue:2

    Topics: Cisapride; Diabetes Mellitus, Type 1; Gastric Emptying; Humans; Male; Middle Aged; Piperidines; Sero

1990
Cisapride in postoperative gastroparesis.
    Lancet (London, England), 1987, Jan-03, Volume: 1, Issue:8523

    Topics: Acute Disease; Cisapride; Female; Humans; Middle Aged; Paralysis; Piperidines; Postoperative Complic

1987
[Sonographic studies during drug treatment of diabetic gastroparesis].
    Deutsche medizinische Wochenschrift (1946), 1988, Jun-16, Volume: 113, Issue:24

    Topics: Adult; Cisapride; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Gastric Emptying; Gastro

1988