cisapride has been researched along with Drug-Related Side Effects and Adverse Reactions in 16 studies
Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Drug-induced symptoms of functional dyspepsia are rare and do not contribute to the use of cisapride." | 3.70 | Drug-induced symptoms of functional dyspepsia and nausea. A symmetry analysis of one million prescriptions. ( Bytzer, P; Hallas, J, 2000) |
| " Incidents of adverse cardiac drug reactions are more common in patients with preexisting heart disease than the general population." | 1.39 | Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. ( Bers, DM; Diecke, S; Gong, T; Knowles, JW; Lan, F; Lee, AS; Liang, P; Nguyen, PK; Robbins, RC; Sallam, K; Sanchez-Freire, V; Wang, PJ; Wang, Y; Wu, JC, 2013) |
| "Discovering unknown adverse drug reactions (ADRs) in postmarketing surveillance as early as possible is of great importance." | 1.36 | A distributed, collaborative intelligent agent system approach for proactive postmarketing drug safety surveillance. ( Dews, P; Farber, MS; Ji, Y; Massanari, RM; Miller, RE; Yen, J; Ying, H, 2010) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (62.50) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pearlstein, R | 1 |
| Vaz, R | 1 |
| Rampe, D | 1 |
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Liang, P | 1 |
| Lan, F | 1 |
| Lee, AS | 1 |
| Gong, T | 1 |
| Sanchez-Freire, V | 1 |
| Wang, Y | 1 |
| Diecke, S | 1 |
| Sallam, K | 1 |
| Knowles, JW | 1 |
| Wang, PJ | 1 |
| Nguyen, PK | 1 |
| Bers, DM | 1 |
| Robbins, RC | 1 |
| Wu, JC | 1 |
| Healy, D | 1 |
| Howe, G | 1 |
| Mangin, D | 1 |
| Le Noury, J | 1 |
| Vos, MA | 1 |
| Hennessy, S | 1 |
| Leonard, CE | 1 |
| Palumbo, CM | 1 |
| Bilker, WB | 1 |
| Newcomb, C | 1 |
| Kimmel, SE | 1 |
| Dabhi, J | 1 |
| Mehta, A | 1 |
| Collins, KK | 1 |
| Sondheimer, JM | 1 |
| Ji, Y | 1 |
| Ying, H | 1 |
| Farber, MS | 1 |
| Yen, J | 1 |
| Dews, P | 1 |
| Miller, RE | 1 |
| Massanari, RM | 1 |
| Schwarzberg, MN | 1 |
| Shah, RR | 1 |
| Bytzer, P | 1 |
| Hallas, J | 1 |
| Smalley, W | 1 |
| Ricci, DA | 1 |
| McCallum, RW | 1 |
4 reviews available for cisapride and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
Topics: Cation Transport Proteins; DNA-Binding Proteins; Drug-Related Side Effects and Adverse Reactions; ER | 2003 |
Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability.
Topics: Animals; Aza Compounds; Cisapride; Dogs; Drug Evaluation, Preclinical; Drug-Related Side Effects and | 2008 |
Mechanistic basis of adverse drug reactions: the perils of inappropriate dose schedules.
Topics: Cisapride; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Drug Interactions; Drug-Rel | 2005 |
Diagnosis and treatment of delayed gastric emptying.
Topics: Anemia, Pernicious; Anorexia Nervosa; Cisapride; Connective Tissue Diseases; Diabetes Complications; | 1988 |
12 other studies available for cisapride and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Topics: Action Potentials; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic, Familial; Cell Differentia | 2013 |
Sudden cardiac death & the Reverse Dodo Verdict.
Topics: Antipsychotic Agents; Cisapride; Death, Sudden, Cardiac; Drug-Related Side Effects and Adverse React | 2014 |
Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research Database.
Topics: Arrhythmias, Cardiac; Cisapride; Cohort Studies; Databases, Factual; Death, Sudden, Cardiac; Domperi | 2008 |
QT prolongation and safety in the Indian population.
Topics: Astemizole; Cisapride; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Electroc | 2007 |
Domperidone-induced QT prolongation: add another drug to the list.
Topics: Animals; Cisapride; Domperidone; Dopamine Antagonists; Drug-Related Side Effects and Adverse Reactio | 2008 |
A distributed, collaborative intelligent agent system approach for proactive postmarketing drug safety surveillance.
Topics: Cisapride; Computer Communication Networks; Computer Simulation; Decision Making, Computer-Assisted; | 2010 |
Pro-kinetic medications as aids in imaging the small bowel by video-capsule.
Topics: Antiemetics; Capsules; Cisapride; Diagnostic Imaging; Diagnostic Uses of Chemicals; Drug-Related Sid | 2005 |
Drug-induced symptoms of functional dyspepsia and nausea. A symmetry analysis of one million prescriptions.
Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Antiemetics; Cisapride; Databases, Factual; Drug- | 2000 |
Drug safety: can simple interventions be effective in a complex world?
Topics: Cisapride; Contraindications; Drug Labeling; Drug Prescriptions; Drug-Related Side Effects and Adver | 2001 |