Page last updated: 2024-10-25

cisapride and Drop Attack

cisapride has been researched along with Drop Attack in 7 studies

Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.

Research Excerpts

ExcerptRelevanceReference
"Adverse cardiac events, typically long QT syndrome, have been reported in patients treated with the gastrointestinal prokinetic agent cisapride."8.81Spontaneous adverse event reports of serious ventricular arrhythmias, QT prolongation, syncope, and sudden death in patients treated with cisapride. ( Barbey, JT; Lazzara, R; Zipes, DP, 2002)
" Linkage to cisapride was probable, promoted by high dosage and cisapride metabolism inhibition by ranitidine, but its plasma concentration was not measured."5.30[Syncope with long QT interval in a 39 day-old infant treated with cisapride]. ( Autret, E; Champel, V; Jonville-Bera, AP; Olivier, C; Valdes, L, 1997)
"Adverse cardiac events, typically long QT syndrome, have been reported in patients treated with the gastrointestinal prokinetic agent cisapride."4.81Spontaneous adverse event reports of serious ventricular arrhythmias, QT prolongation, syncope, and sudden death in patients treated with cisapride. ( Barbey, JT; Lazzara, R; Zipes, DP, 2002)
" Continuous 24-h ECG recording detected a ventricular tachycardia in torsades de pointes inducing a syncopal convulsive attack that seemed to be related to oral Cisapride assumption for dyspepsia."3.74An anorexic woman with convulsive loss of consciousness. Syncope or epileptic fits? ( Argiriadou, V; Attanasio, A; Diomedi, M; Sandri, G, 2007)
"One patient died from ventricular arrhythmia 12 days after discontinuing cisapride."1.31Retrospective analysis of cisapride-induced QT changes in end-stage renal disease patients. ( Gunderson, BW; Hentges, MJ; Lewis, MJ, 2000)
" Linkage to cisapride was probable, promoted by high dosage and cisapride metabolism inhibition by ranitidine, but its plasma concentration was not measured."1.30[Syncope with long QT interval in a 39 day-old infant treated with cisapride]. ( Autret, E; Champel, V; Jonville-Bera, AP; Olivier, C; Valdes, L, 1997)
"To report a case of QT prolongation and syncopal episodes resulting from concomitant use of cisapride and agents known to inhibit its metabolism."1.30Syncopal episodes associated with cisapride and concurrent drugs. ( Gray, VS, 1998)
"Respiratory complications of gastroesophageal reflux disease that have been reported include hoarseness, wheezing, bronchospasm, stridor, laryngitis, and chronic cough."1.29Gastroesophageal reflux-induced cough syncope. ( Puetz, TR; Vakil, N, 1995)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Attanasio, A1
Argiriadou, V1
Sandri, G1
Diomedi, M1
Puetz, TR1
Vakil, N1
Valdes, L1
Champel, V1
Olivier, C1
Jonville-Bera, AP1
Autret, E1
Gray, VS1
Trinkle, R1
Hentges, MJ1
Gunderson, BW1
Lewis, MJ1
Barbey, JT1
Lazzara, R1
Zipes, DP1

Reviews

1 review available for cisapride and Drop Attack

ArticleYear
Spontaneous adverse event reports of serious ventricular arrhythmias, QT prolongation, syncope, and sudden death in patients treated with cisapride.
    Journal of cardiovascular pharmacology and therapeutics, 2002, Volume: 7, Issue:2

    Topics: Arrhythmias, Cardiac; Cisapride; Death, Sudden, Cardiac; Gastrointestinal Agents; Humans; Long QT Sy

2002

Other Studies

6 other studies available for cisapride and Drop Attack

ArticleYear
An anorexic woman with convulsive loss of consciousness. Syncope or epileptic fits?
    International journal of cardiology, 2007, Mar-20, Volume: 116, Issue:2

    Topics: Adult; Anorexia; Cisapride; Diagnosis, Differential; Dyspepsia; Epilepsy; Female; Gastrointestinal A

2007
Gastroesophageal reflux-induced cough syncope.
    The American journal of gastroenterology, 1995, Volume: 90, Issue:12

    Topics: Adult; Cisapride; Cough; Drug Therapy, Combination; Gastroesophageal Reflux; Humans; Male; Monitorin

1995
[Syncope with long QT interval in a 39 day-old infant treated with cisapride].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1997, Volume: 4, Issue:6

    Topics: Anti-Ulcer Agents; Cisapride; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gastroeso

1997
Syncopal episodes associated with cisapride and concurrent drugs.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:6

    Topics: Accidents, Traffic; Anti-Bacterial Agents; Anti-Ulcer Agents; Cisapride; Clarithromycin; Cytochrome

1998
Comment: syncopal episodes associated with cisapride.
    The Annals of pharmacotherapy, 1999, Volume: 33, Issue:2

    Topics: Cisapride; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Gastrointestinal Ag

1999
Retrospective analysis of cisapride-induced QT changes in end-stage renal disease patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:11

    Topics: Arrhythmias, Cardiac; Cisapride; Diabetic Nephropathies; Electrocardiography; Ethnicity; Female; Gas

2000