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cisapride and Diarrhea

cisapride has been researched along with Diarrhea in 8 studies

Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"A controlled multi-centre clinical trial was conducted for evaluating the efficacy and safety of cisapride in the treatment of 414 cases of functional dyspepsia with 169 cases as control."9.08[A controlled multi-centre clinical trial on cisapride in treatment of functional dyspepsia]. ( Jia, B; Liang, X; Wang, B, 1995)
"Cisapride has well-documented prokinetic effects and may be well suited for long-term therapy of GORD, but its effectiveness in purely symptomatic treatment is unknown."6.68The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux disease. ( Carling, L; Hatlebakk, JG; Johnsson, F; Thøgersen, T; Vilien, M; Wetterhus, S, 1997)
"A controlled multi-centre clinical trial was conducted for evaluating the efficacy and safety of cisapride in the treatment of 414 cases of functional dyspepsia with 169 cases as control."5.08[A controlled multi-centre clinical trial on cisapride in treatment of functional dyspepsia]. ( Jia, B; Liang, X; Wang, B, 1995)
"Cisapride has been reported to improve symptoms in patients with constipation-predominant irritable bowel syndrome."5.08Effects of oral cisapride on small bowel motility in irritable bowel syndrome. ( Bak, YT; Evans, PR; Kellow, JE, 1997)
"Cisapride has well-documented prokinetic effects and may be well suited for long-term therapy of GORD, but its effectiveness in purely symptomatic treatment is unknown."2.68The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux disease. ( Carling, L; Hatlebakk, JG; Johnsson, F; Thøgersen, T; Vilien, M; Wetterhus, S, 1997)
"Cisapride was a potent stimulant of gastric emptying in rats, 7 times more potent than metoclopramide."1.28General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride. ( Awouters, FH; Megens, AA; Niemegeers, CJ, 1991)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's7 (87.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, B1
Liang, X1
Jia, B1
Evans, PR1
Bak, YT1
Kellow, JE1
Hatlebakk, JG1
Johnsson, F1
Vilien, M1
Carling, L1
Wetterhus, S1
Thøgersen, T1
Fernández-Fernández, FJ1
González-González, C1
Castro-Alvariño, J1
Sesma, P1
Sanger, GJ1
Megens, AA1
Awouters, FH1
Niemegeers, CJ1
Layer, P1
Goebell, H1
Campbell, FC1
Storey, BE1
Cullen, PT1
Cuschieri, A1

Reviews

1 review available for cisapride and Diarrhea

ArticleYear
Hypersensitivity and hyperreactivity in the irritable bowel syndrome: An opportunity for drug discovery.
    Digestive diseases (Basel, Switzerland), 1999, Volume: 17, Issue:2

    Topics: Abdominal Pain; Afferent Pathways; Animals; Cisapride; Colonic Diseases, Functional; Constipation; D

1999

Trials

3 trials available for cisapride and Diarrhea

ArticleYear
[A controlled multi-centre clinical trial on cisapride in treatment of functional dyspepsia].
    Zhonghua nei ke za zhi, 1995, Volume: 34, Issue:3

    Topics: Abdominal Pain; Adolescent; Adult; Aged; Cisapride; Diarrhea; Dyspepsia; Female; Humans; Male; Middl

1995
Effects of oral cisapride on small bowel motility in irritable bowel syndrome.
    Alimentary pharmacology & therapeutics, 1997, Volume: 11, Issue:5

    Topics: Adult; Cisapride; Colonic Diseases, Functional; Constipation; Diarrhea; Eating; Female; Gastrointest

1997
The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux disease.
    Scandinavian journal of gastroenterology, 1997, Volume: 32, Issue:11

    Topics: Abdominal Pain; Cisapride; Constipation; Diarrhea; Drug Administration Schedule; Endoscopy; Esophagi

1997

Other Studies

4 other studies available for cisapride and Diarrhea

ArticleYear
[Cisapride in idiopathic megacolon-megarectum].
    Revista clinica espanola, 1999, Volume: 199, Issue:4

    Topics: Adolescent; Chronic Disease; Cisapride; Combined Modality Therapy; Diarrhea; Dilatation, Pathologic;

1999
General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:6

    Topics: Animals; Apomorphine; Bethanechol Compounds; Cisapride; Conditioning, Operant; Diarrhea; Dogs; Gastr

1991
[Therapy of motility disorders of the stomach and small intestine].
    Deutsche medizinische Wochenschrift (1946), 1991, Feb-22, Volume: 116, Issue:8

    Topics: Cisapride; Constipation; Diarrhea; Domperidone; Dumping Syndrome; Gastric Emptying; Gastrointestinal

1991
Surface vibration analysis (SVA): a new non-invasive monitor of gastrointestinal activity.
    Gut, 1989, Volume: 30, Issue:1

    Topics: Adult; Cisapride; Diarrhea; Digestive System; Digestive System Physiological Phenomena; Gastrointest

1989