cisapride has been researched along with Diabetic Neuropathies in 16 studies
Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether cisapride accelerates gastric emptying in the long term or improves diabetes control in patients with diabetic gastroparesis." | 9.10 | Long-term cisapride treatment improves diabetic gastroparesis but not glycaemic control. ( Braden, B; Caspary, WF; Enghofer, M; Lembcke, B; Schaub, M; Usadel, KH, 2002) |
| "The motor mechanisms that underlie both slow gastric emptying in diabetic gastroparesis and its acceleration by cisapride are poorly understood." | 9.09 | Evaluation of gastric emptying and motility in diabetic gastroparesis with magnetic resonance imaging: effects of cisapride. ( Boesiger, P; Borovicka, J; Crelier, G; Fraser, R; Fried, M; Kreiss, C; Kunz, P; Lehmann, R; Schwizer, W; Spinas, GA, 1999) |
| " Chronic administration of a prokinetic drug resulted in improved solid gastric emptying (percentage residual) at 120 min (p=0." | 6.71 | Glucose control is not improved by accelerating gastric emptying in patients with type 1 diabetes mellitus and gastroparesis. a pilot study with cisapride as a model drug. ( Feinle, C; Fried, M; Honegger, RA; Lehmann, R; Schwizer, W; Spinas, GA, 2003) |
| "To investigate whether cisapride accelerates gastric emptying in the long term or improves diabetes control in patients with diabetic gastroparesis." | 5.10 | Long-term cisapride treatment improves diabetic gastroparesis but not glycaemic control. ( Braden, B; Caspary, WF; Enghofer, M; Lembcke, B; Schaub, M; Usadel, KH, 2002) |
| "The motor mechanisms that underlie both slow gastric emptying in diabetic gastroparesis and its acceleration by cisapride are poorly understood." | 5.09 | Evaluation of gastric emptying and motility in diabetic gastroparesis with magnetic resonance imaging: effects of cisapride. ( Boesiger, P; Borovicka, J; Crelier, G; Fraser, R; Fried, M; Kreiss, C; Kunz, P; Lehmann, R; Schwizer, W; Spinas, GA, 1999) |
| " Chronic administration of a prokinetic drug resulted in improved solid gastric emptying (percentage residual) at 120 min (p=0." | 2.71 | Glucose control is not improved by accelerating gastric emptying in patients with type 1 diabetes mellitus and gastroparesis. a pilot study with cisapride as a model drug. ( Feinle, C; Fried, M; Honegger, RA; Lehmann, R; Schwizer, W; Spinas, GA, 2003) |
| " While both cisapride and metoclopramide normalized impaired solid emptying, cisapride at its highest dosage (10 mg) resulted in significantly faster gastric emptying (P = 0." | 2.67 | Cisapride vs metoclopramide. An acute study in diabetic gastroparesis. ( Diamant, NE; Lico, S; McHugh, S, 1992) |
| "Cisapride is a prokinetic drug of the gastrointestinal tract and acts by releasing acetylcholine from cholinergic nerve endings." | 1.31 | Cisapride improves gallbladder emptying in patients with type 2 diabetes mellitus. ( Arke, L; Bhansali, A; Chawla, YK; Dhiman, RK; Gupta, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Braden, B | 1 |
| Enghofer, M | 1 |
| Schaub, M | 1 |
| Usadel, KH | 1 |
| Caspary, WF | 2 |
| Lembcke, B | 2 |
| Lehmann, R | 2 |
| Honegger, RA | 1 |
| Feinle, C | 2 |
| Fried, M | 2 |
| Spinas, GA | 2 |
| Schwizer, W | 2 |
| Kawagishi, T | 2 |
| Nishizawa, Y | 2 |
| Okuno, Y | 2 |
| Sekiya, K | 2 |
| Morii, H | 2 |
| Prassler, R | 1 |
| Huchzermeyer, H | 1 |
| Stacher, G | 1 |
| Schernthaner, G | 1 |
| Francesconi, M | 1 |
| Kopp, HP | 1 |
| Bergmann, H | 1 |
| Stacher-Janotta, G | 1 |
| Weber, U | 1 |
| Borovicka, J | 1 |
| Kunz, P | 1 |
| Fraser, R | 1 |
| Kreiss, C | 1 |
| Crelier, G | 1 |
| Boesiger, P | 1 |
| von Ehrlich, B | 1 |
| Dhiman, RK | 1 |
| Arke, L | 1 |
| Bhansali, A | 1 |
| Gupta, S | 1 |
| Chawla, YK | 1 |
| Horowitz, M | 1 |
| O'Donovan, D | 1 |
| Jones, KL | 1 |
| Rayner, CK | 1 |
| Samsom, M | 1 |
| Bergmann, JF | 1 |
| Chassany, O | 1 |
| Guillausseau, PJ | 1 |
| Bayle, M | 1 |
| Chagnon, S | 1 |
| Caulin, C | 1 |
| Sallenave, JR | 1 |
| McHugh, S | 1 |
| Lico, S | 1 |
| Diamant, NE | 1 |
| Wehrmann, T | 1 |
| de Caestecker, JS | 1 |
| Ewing, DJ | 1 |
| Tothill, P | 1 |
| Clarke, BF | 1 |
| Heading, RC | 1 |
| Champion, MC | 1 |
| Vogelberg, KH | 1 |
| Dalügge, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Preoperative Oral Carbohydrate on Recovery in Diabetic Patients After Gastrointestinal Surgery: a Pilot Randomized Controlled Trial[NCT03204344] | 65 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622] | Phase 2 | 3 participants (Actual) | Interventional | 2014-07-31 | Terminated (stopped due to Lack of recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cisapride and Diabetic Neuropathies
| Article | Year |
|---|---|
Gastric emptying in diabetes: clinical significance and treatment.
Topics: Blood Glucose; Cisapride; Diabetes Mellitus; Diabetic Neuropathies; Domperidone; Gastric Emptying; G | 2002 |
Management of idiopathic, diabetic and miscellaneous gastroparesis with cisapride.
Topics: Cisapride; Clinical Trials as Topic; Diabetic Neuropathies; Domperidone; Gastric Emptying; Humans; M | 1989 |
10 trials available for cisapride and Diabetic Neuropathies
| Article | Year |
|---|---|
Long-term cisapride treatment improves diabetic gastroparesis but not glycaemic control.
Topics: Aged; Blood Glucose; Breath Tests; Cisapride; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Drug | 2002 |
Glucose control is not improved by accelerating gastric emptying in patients with type 1 diabetes mellitus and gastroparesis. a pilot study with cisapride as a model drug.
Topics: Adult; Age of Onset; Blood Glucose; Body Constitution; Cisapride; Diabetes Mellitus, Type 1; Diabeti | 2003 |
Effect of cisapride on gastric emptying of indigestible solids and plasma motilin concentration in diabetic autonomic neuropathy.
Topics: Autonomic Nervous System Diseases; Cisapride; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; | 1993 |
Cisapride versus placebo for 8 weeks on glycemic control and gastric emptying in insulin-dependent diabetes: a double blind cross-over trial.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Glucose; Cardiovascular System; Cisapride; Cro | 1999 |
Evaluation of gastric emptying and motility in diabetic gastroparesis with magnetic resonance imaging: effects of cisapride.
Topics: Adult; Cisapride; Cross-Over Studies; Diabetic Neuropathies; Double-Blind Method; Female; Gastric Em | 1999 |
Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times. Use in studying the actions of cisapride in diabetic patients.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Cisapride; Diabetic Neuropathies; Double-Blind Metho | 1992 |
Cisapride vs metoclopramide. An acute study in diabetic gastroparesis.
Topics: Adult; Autonomic Nervous System Diseases; Cisapride; Diabetic Neuropathies; Dose-Response Relationsh | 1992 |
Influence of cisapride on antroduodenal motor function in healthy subjects and diabetics with autonomic neuropathy.
Topics: Adult; Autonomic Nervous System Diseases; Cisapride; Diabetes Mellitus, Type 1; Diabetic Neuropathie | 1991 |
Evaluation of oral cisapride and metoclopramide in diabetic autonomic neuropathy: an eight-week double-blind crossover study.
Topics: Adult; Autonomic Nervous System Diseases; Blood Glucose; Cisapride; Diabetic Neuropathies; Double-Bl | 1989 |
Management of idiopathic, diabetic and miscellaneous gastroparesis with cisapride.
Topics: Cisapride; Clinical Trials as Topic; Diabetic Neuropathies; Domperidone; Gastric Emptying; Humans; M | 1989 |
5 other studies available for cisapride and Diabetic Neuropathies
| Article | Year |
|---|---|
[Possibilities of ultrasonography of gastric emptying].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cisapride; Diabetic Neuropathies; Dyspepsia; Female; Gas | 1996 |
[Peripheral neuropathy in diabetes mellitus from the perspective of internist].
Topics: Cisapride; Diabetic Neuropathies; Drug and Narcotic Control; Drug Interactions; Gastrointestinal Age | 2000 |
Cisapride improves gallbladder emptying in patients with type 2 diabetes mellitus.
Topics: Acetylcholine; Administration, Oral; Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Cis | 2001 |
Segmental gut transit in diabetes mellitus: effect of cisapride.
Topics: Administration, Oral; Adult; Cisapride; Colon; Contrast Media; Diabetes Mellitus; Diabetic Nephropat | 1992 |
[Sonographic studies during drug treatment of diabetic gastroparesis].
Topics: Adult; Cisapride; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Gastric Emptying; Gastro | 1988 |