cisapride has been researched along with Complication, Postoperative in 30 studies
Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.
| Excerpt | Relevance | Reference |
|---|---|---|
| "with cisapride long-lasting symptomatic relief and improved transit is achieved in about 40% of patients with the Roux-en-Y syndrome." | 7.68 | Cisapride in treatment of Roux-en-Y syndrome. ( Beekhuis, H; Bleichrodt, RP; Kleibeuker, JH; van der Mijle, HC, 1991) |
| " These pharmacological differences have clinical relevance: metoclopramide and domperidon could not consistently prove efficacy in functional dyspepsia and GORD." | 4.79 | [Pharmacologic and clinical differentiation of prokinetic drugs]. ( Greving, I; May, B, 1996) |
| "with cisapride long-lasting symptomatic relief and improved transit is achieved in about 40% of patients with the Roux-en-Y syndrome." | 3.68 | Cisapride in treatment of Roux-en-Y syndrome. ( Beekhuis, H; Bleichrodt, RP; Kleibeuker, JH; van der Mijle, HC, 1991) |
| "Long-standing gastroesophageal reflux disease (GERD) is frequently associated with impaired esophageal body motility." | 2.69 | [Prokinetic medication after surgical therapy of reflux patients with disorders of esophageal peristalsis: a randomized clinical study]. ( Gadenstätter, M; Klocker, J; Weiss, H; Wetscher, GJ, 2000) |
| "Treatment with cisapride did not shorten the duration of postoperative ileus after either upper gastrointestinal or colonic surgery." | 2.67 | Cisapride in the treatment of post-operative ileus. ( Bergman, B; Bong, H; Ekström, P; Glise, H; Hallerbäck, B; Lundgren, K; Risberg, O, 1991) |
| " The postoperative transit time after cisapride dosing was still longer than before the operation but was significantly (p = 0." | 2.66 | Effect of cisapride on the post-cholecystectomy upper gastrointestinal transit time. ( Creve, U; Hubens, A; Van Rooy, F; Verlinden, M, 1988) |
| "Cisapride was significantly effective: bowel sounds were present in 43% and 50% within 1 hour after the first and second injection of 4 mg, respectively, and flatus in 36% and 43%." | 2.66 | Placebo-controlled trial of cisapride in postoperative ileus. ( Boghaert, A; Haesaert, G; Mourisse, P; Verlinden, M, 1987) |
| "The cisapride protocol was largely well tolerated." | 1.51 | Effects of preoperative cisapride on postoperative aspiration pneumonia in dogs with laryngeal paralysis. ( Ogden, J; Ovbey, D; Saile, K, 2019) |
| " All patients not responding to treatment in the first hour were given a repeat dosage and observed for the following 3 hours." | 1.27 | Treatment of postoperative gastrointestinal atony. ( Boghaert, A; de Coster, M; Dehertog, P; Michiels, G; Verlinden, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (30.00) | 18.7374 |
| 1990's | 17 (56.67) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ogden, J | 1 |
| Ovbey, D | 1 |
| Saile, K | 1 |
| Zeinali, F | 1 |
| Stulberg, JJ | 1 |
| Delaney, CP | 1 |
| Lytras, D | 1 |
| Paraskevas, KI | 1 |
| Avgerinos, C | 1 |
| Manes, C | 1 |
| Touloumis, Z | 1 |
| Paraskeva, KD | 1 |
| Dervenis, C | 1 |
| Lindahl, H | 1 |
| Rintala, R | 1 |
| Roberts, JP | 1 |
| Benson, MJ | 1 |
| Rogers, J | 1 |
| Deeks, JJ | 1 |
| Wingate, DL | 1 |
| Williams, NS | 1 |
| May, B | 1 |
| Greving, I | 1 |
| Gerring, EL | 1 |
| King, JN | 1 |
| Resnick, J | 1 |
| Greenwald, DA | 1 |
| Brandt, LJ | 1 |
| Lander, A | 1 |
| Redkar, R | 1 |
| Nicholls, G | 1 |
| Lawson, A | 1 |
| Choudhury, SR | 1 |
| Corkery, JJ | 1 |
| Gornall, P | 1 |
| Buick, RG | 1 |
| Booth, IW | 1 |
| Dart, AJ | 1 |
| Hodgson, DR | 1 |
| Hep, A | 1 |
| Prásek, J | 1 |
| Filipínský, J | 1 |
| Navrátil, P | 1 |
| David, L | 1 |
| Dolina, J | 1 |
| Dítĕ, P | 1 |
| Valk, N | 1 |
| Doherty, TJ | 1 |
| Blackford, JT | 1 |
| Abraha, TW | 1 |
| Frazier, DL | 1 |
| Shibata, Y | 1 |
| Toyoda, S | 1 |
| Brown, TA | 1 |
| McDonald, J | 1 |
| Williard, W | 1 |
| De Winter, BY | 1 |
| Boeckxstaens, GE | 1 |
| De Man, JG | 1 |
| Moreels, TG | 1 |
| Schuurkes, JA | 1 |
| Peeters, TL | 1 |
| Herman, AG | 1 |
| Pelckmans, PA | 1 |
| Gadenstätter, M | 1 |
| Klocker, J | 1 |
| Weiss, H | 1 |
| Wetscher, GJ | 1 |
| Jian, R | 1 |
| van der Mijle, HC | 1 |
| Beekhuis, H | 1 |
| Bleichrodt, RP | 1 |
| Kleibeuker, JH | 1 |
| Hallerbäck, B | 1 |
| Bergman, B | 1 |
| Bong, H | 1 |
| Ekström, P | 1 |
| Glise, H | 1 |
| Lundgren, K | 1 |
| Risberg, O | 1 |
| Tollesson, PO | 1 |
| Cassuto, J | 1 |
| Rimbäck, G | 1 |
| Faxén, A | 1 |
| Bergman, L | 1 |
| Mattsson, E | 1 |
| Farup, PG | 1 |
| Tjora, S | 1 |
| Tholfsen, JK | 1 |
| Vanderwinden, JM | 1 |
| Dassonville, M | 1 |
| Van der Veken, E | 1 |
| Cadranel, S | 1 |
| De Laet, MH | 1 |
| Johnson, AG | 1 |
| Springall, RG | 1 |
| Spitz, L | 2 |
| Sparnon, AL | 1 |
| Cullen, PT | 1 |
| Campbell, FC | 1 |
| Van Rooy, F | 1 |
| Creve, U | 1 |
| Verlinden, M | 3 |
| Hubens, A | 1 |
| Boghaert, A | 2 |
| Haesaert, G | 1 |
| Mourisse, P | 1 |
| von Ritter, C | 1 |
| Hunter, S | 1 |
| Hinder, RA | 1 |
| Michiels, G | 1 |
| de Coster, M | 1 |
| Dehertog, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery[NCT02056405] | Phase 4 | 90 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for cisapride and Complication, Postoperative
| Article | Year |
|---|---|
Pharmacological management of postoperative ileus.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Therapeutic strategies for the management of delayed gastric emptying after pancreatic resection.
Topics: Cisapride; Enteral Nutrition; Gastric Emptying; Gastrointestinal Agents; Humans; Intubation, Gastroi | 2007 |
[Pharmacologic and clinical differentiation of prokinetic drugs].
Topics: Adult; Antiemetics; Child; Cisapride; Clinical Trials as Topic; Domperidone; Dopamine Antagonists; D | 1996 |
Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: part II.
Topics: Abdomen; Cisapride; Dopamine Antagonists; Erythromycin; Gastric Emptying; Gastrointestinal Agents; H | 1997 |
Role of prokinetic drugs for treatment of postoperative ileus in the horse.
Topics: Adrenergic Antagonists; Anesthetics, Local; Animals; Anti-Bacterial Agents; Cholinergic Agonists; Ci | 1998 |
[Disorders of gastric emptying].
Topics: Cisapride; Diabetes Complications; Domperidone; Dyspepsia; Gastric Emptying; Gastroesophageal Reflux | 1992 |
The effects of cisapride on antroduodenal co-ordination and gastric emptying.
Topics: Cisapride; Dyspepsia; Gastric Emptying; Gastrointestinal Motility; Humans; Piperidines; Postoperativ | 1989 |
13 trials available for cisapride and Complication, Postoperative
| Article | Year |
|---|---|
Effect of cisapride on distal colonic motility in the early postoperative period following left colonic anastomosis.
Topics: Aged; Aged, 80 and over; Anastomosis, Surgical; Cisapride; Colon; Double-Blind Method; Drug Administ | 1995 |
Cisapride in the prophylaxis of equine post operative ileus.
Topics: Animals; Antiemetics; Cholinergic Agents; Cisapride; Domperidone; Dose-Response Relationship, Drug; | 1989 |
Cisapride reduces neonatal postoperative ileus: randomised placebo controlled trial.
Topics: Administration, Rectal; Cisapride; Double-Blind Method; Gastrointestinal Agents; Gastrointestinal Mo | 1997 |
[Cisapride (Prepulsid) in the prevention of postoperative gastrointestinal atony].
Topics: Cisapride; Female; Gastrointestinal Agents; Gastrointestinal Motility; Gastroparesis; Humans; Male; | 1998 |
Effect of cisapride on gastric emptying in horses following endotoxin treatment.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Area Under Curve; Cisapride; | 1998 |
A prospective, randomized, double-blinded, placebo-controlled trial of cisapride after colorectal surgery.
Topics: Aged; Cisapride; Colorectal Surgery; Diet; Double-Blind Method; Female; Gastrointestinal Agents; Gas | 1999 |
[Prokinetic medication after surgical therapy of reflux patients with disorders of esophageal peristalsis: a randomized clinical study].
Topics: Adult; Aged; Cisapride; Esophageal Motility Disorders; Female; Follow-Up Studies; Fundoplication; Ga | 2000 |
Cisapride in the treatment of post-operative ileus.
Topics: Aged; Aged, 80 and over; Cisapride; Defecation; Double-Blind Method; Humans; Intestinal Obstruction; | 1991 |
Treatment of postoperative paralytic ileus with cisapride.
Topics: Cholecystectomy; Cisapride; Colonic Diseases; Double-Blind Method; Female; Gastrointestinal Motility | 1991 |
Effect of cisapride on symptoms and biliary drainage in patients with postcholecystectomy syndrome.
Topics: Adult; Aged; Cholangiopancreatography, Endoscopic Retrograde; Cholecystectomy; Cholestasis; Cisaprid | 1991 |
Effect of cisapride on the post-cholecystectomy upper gastrointestinal transit time.
Topics: Adult; Aged; Aged, 80 and over; Breath Tests; Cholecystectomy; Cisapride; Clinical Trials as Topic; | 1988 |
Placebo-controlled trial of cisapride in postoperative ileus.
Topics: Adult; Cisapride; Clinical Trials as Topic; Double-Blind Method; Female; Gastrointestinal Diseases; | 1987 |
Cisapride does not reduce postoperative paralytic ileus.
Topics: Cisapride; Clinical Trials as Topic; Double-Blind Method; Humans; Intestinal Pseudo-Obstruction; Pip | 1987 |
10 other studies available for cisapride and Complication, Postoperative
| Article | Year |
|---|---|
Effects of preoperative cisapride on postoperative aspiration pneumonia in dogs with laryngeal paralysis.
Topics: Animals; Cisapride; Dog Diseases; Dogs; Pneumonia, Aspiration; Postoperative Complications; Retrospe | 2019 |
Long-term complications in cases of isolated esophageal atresia treated with esophageal anastomosis.
Topics: Anastomosis, Surgical; Anti-Ulcer Agents; Cisapride; Constriction, Pathologic; Endoscopy, Digestive | 1995 |
Effects of prostaglandin F2alpha and cisapride on small intestinal activity during the early postoperative period in humans.
Topics: Abdomen; Cisapride; Dinoprost; Female; Gastrointestinal Agents; Gastrointestinal Motility; Humans; I | 1998 |
Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats.
Topics: Animals; Cisapride; Dopamine Antagonists; Erythromycin; Gastrointestinal Agents; Granisetron; Intest | 1999 |
Cisapride in treatment of Roux-en-Y syndrome.
Topics: Adult; Aged; Anastomosis, Roux-en-Y; Cisapride; Female; Gastric Emptying; Humans; Jejunum; Male; Mid | 1991 |
Post-necrotising enterocolitis pseudo-obstruction treated with Cisapride.
Topics: Cisapride; Colonic Pseudo-Obstruction; Enteral Nutrition; Enterocolitis, Pseudomembranous; Follow-Up | 1990 |
The prevention of post-operative adhesions using a gastrointestinal prokinetic agent.
Topics: Administration, Cutaneous; Anastomosis, Surgical; Animals; Cisapride; Disease Models, Animal; Female | 1989 |
Pharmacological manipulation of postoperative intestinal adhesions.
Topics: Animals; Cisapride; Female; Gastrointestinal Motility; Intestinal Diseases; Intestinal Pseudo-Obstru | 1989 |
Cisapride in postoperative gastroparesis.
Topics: Acute Disease; Cisapride; Female; Humans; Middle Aged; Paralysis; Piperidines; Postoperative Complic | 1987 |
Treatment of postoperative gastrointestinal atony.
Topics: Cisapride; Digestive System; Dose-Response Relationship, Drug; Female; Gastrointestinal Diseases; Ga | 1987 |