cisapride has been researched along with Cholera Infantum in 49 studies
Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This paper provides a comprehensive review of the current knowledge on cisapride in different clinical conditions in children: different manifestations of gastro-oesophageal reflux, such as (excessive) regurgitation, oesophagitis, chronic respiratory disease or uncontrolled asthma, cystic fibrosis, chronic dyspepsia, constipation and pseudo-obstruction, and as an aid to small bowel capsule-biopsy." | 4.80 | Clinical use of cisapride and its risk-benefit in paediatric patients. ( Vandenplas, Y, 1998) |
| "Life-threatening arrhythmias and prolonged QT interval have been reported in adults and children using cisapride, a medication structurally similar to procainamide." | 3.70 | QT interval in children and infants receiving cisapride. ( Dinari, G; Fogelman, R; Levine, A; Shamir, R; Sirota, L; Zangen, Z, 1998) |
| "Several cases of QT prolongation and ventricular tachyarrhythmia have been reported with domperidone, a gastrokinetic and antiemetic agent available worldwide but still under investigation in the United States." | 3.70 | Domperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders. ( Cardinal, R; Daleau, P; Drolet, B; Rousseau, G; Turgeon, J, 2000) |
| "Cisapride was significantly effective: bowel sounds were present in 43% and 50% within 1 hour after the first and second injection of 4 mg, respectively, and flatus in 36% and 43%." | 2.66 | Placebo-controlled trial of cisapride in postoperative ileus. ( Boghaert, A; Haesaert, G; Mourisse, P; Verlinden, M, 1987) |
| "The nonselective 5-HT(4) receptor agonists, cisapride and tegaserod have been associated with cardiovascular adverse events (AEs)." | 2.48 | Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. ( Camilleri, M; Chang, L; Chey, WD; De Maeyer, JH; Galligan, JJ; Lacy, BE; Müller-Lissner, S; Quigley, EM; Schuurkes, J; Stanghellini, V; Tack, J, 2012) |
| "Functional gastrointestinal disorders are best understood by applying a bio-psycho-social model." | 2.40 | Today's therapy of functional gastrointestinal disorders--does it help? ( Berstad, A, 1998) |
| "Cisapride is an orally administered prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract." | 2.39 | Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders. ( Faulds, D; Wiseman, LR, 1994) |
| "Cisapride is a substituted benzamide compound that stimulates motor activity in all segments of the gastrointestinal tract by enhancing the release of acetylcholine from the enteric nervous system." | 2.39 | A risk-benefit assessment of cisapride in the treatment of gastrointestinal disorders. ( Coremans, G; Janssens, J; Tack, J, 1995) |
| "Cisapride is a prokinetic agent which restores motility of the gastrointestinal tract in conditions of decreased bowel transit." | 2.39 | Cisapride. Drug interactions of clinical significance. ( Bedford, TA; Rowbotham, DJ, 1996) |
| "Domperidone, which has also been shown to stimulate gastric motility and to possess antiemetic properties, improves symptoms in patients suffering from diabetic gastroparesis." | 2.38 | Use of metoclopramide, domperidone, and cisapride in the management of diabetic gastroparesis. ( Brown, CK; Khanderia, U, 1990) |
| "Premature infants less than 1 month of age could be at higher risk for cardiac side effects of cisapride when used in the same dosage as in older infants." | 1.31 | The effect of cisapride on the corrected QT interval and QT dispersion in premature infants. ( Benatar, A; Bougatef, A; Cools, F; Vandenplas, Y, 2001) |
| "Ventricular arrhythmias have been associated with both cisapride and hemodialysis (HD)." | 1.31 | Retrospective analysis of the effects of cisapride on the QT interval and QT dispersion in chronic hemodialysis patients. ( Barone, JA; Costeas, C; Mathis, AS, 2001) |
| "Cisapride was well tolerated and thus appears to be a useful option in the treatment of functional digestive disorders in a general practice setting." | 1.29 | Functional dyspepsia versus other functional gastrointestinal disorders: a practical approach in Belgian general practices. ( Cardon, E; Jaecques, N; Lebrun, F; Meurant, JP; Rombouts, J; Spaepen, W; Verhaeghe, J, 1993) |
| " All patients not responding to treatment in the first hour were given a repeat dosage and observed for the following 3 hours." | 1.27 | Treatment of postoperative gastrointestinal atony. ( Boghaert, A; de Coster, M; Dehertog, P; Michiels, G; Verlinden, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (14.29) | 18.7374 |
| 1990's | 30 (61.22) | 18.2507 |
| 2000's | 10 (20.41) | 29.6817 |
| 2010's | 2 (4.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McKinnell, RM | 1 |
| Armstrong, SR | 1 |
| Beattie, DT | 1 |
| Choi, SK | 1 |
| Fatheree, PR | 1 |
| Gendron, RA | 1 |
| Goldblum, A | 1 |
| Humphrey, PP | 1 |
| Long, DD | 1 |
| Marquess, DG | 1 |
| Shaw, JP | 1 |
| Smith, JA | 1 |
| Turner, SD | 1 |
| Vickery, RG | 1 |
| Quigley, EM | 2 |
| Tack, J | 2 |
| Camilleri, M | 2 |
| Chang, L | 1 |
| Chey, WD | 1 |
| Galligan, JJ | 1 |
| Lacy, BE | 1 |
| Müller-Lissner, S | 2 |
| Schuurkes, J | 1 |
| De Maeyer, JH | 1 |
| Stanghellini, V | 1 |
| De Ponti, F | 1 |
| Crema, F | 1 |
| Poncet, CM | 1 |
| Dupre, GP | 1 |
| Freiche, VG | 1 |
| Bouvy, BM | 1 |
| Hanauer, SB | 1 |
| Wiseman, LR | 1 |
| Faulds, D | 1 |
| Ryss, ES | 1 |
| Fishzon-Ryss, IuI | 1 |
| Hep, A | 1 |
| Prásek, J | 1 |
| Dítĕ, P | 1 |
| Räihä, I | 1 |
| Sourander, L | 1 |
| Balm, RK | 1 |
| Zinsmeister, AR | 1 |
| Ljubich, P | 1 |
| Parkman, HP | 1 |
| Fisher, RS | 1 |
| Sorokin, JJ | 1 |
| Conaway, DC | 1 |
| Carone, R | 1 |
| Vercelli, D | 1 |
| Bertapelle, P | 1 |
| Verhaeghe, J | 1 |
| Jaecques, N | 1 |
| Rombouts, J | 1 |
| Spaepen, W | 1 |
| Cardon, E | 1 |
| Lebrun, F | 1 |
| Meurant, JP | 1 |
| Coremans, G | 1 |
| Janssens, J | 1 |
| Cucchiara, S | 1 |
| Doxey, DL | 2 |
| Milne, EM | 2 |
| Harter, A | 1 |
| Bedford, TA | 1 |
| Rowbotham, DJ | 1 |
| Woodman, MP | 1 |
| Cuddeford, D | 1 |
| Pearson, RA | 1 |
| Brignoli, R | 1 |
| Watkins, P | 1 |
| Halter, F | 1 |
| Levine, A | 1 |
| Fogelman, R | 1 |
| Sirota, L | 1 |
| Zangen, Z | 1 |
| Shamir, R | 1 |
| Dinari, G | 1 |
| Vandenplas, Y | 2 |
| Berstad, A | 1 |
| Lander, A | 1 |
| Desai, A | 1 |
| Shulman, RJ | 1 |
| Boyle, JT | 1 |
| Colletti, RB | 1 |
| Friedman, RA | 1 |
| Heyman, MB | 1 |
| Kearns, G | 1 |
| Kirschner, BS | 1 |
| Levy, J | 1 |
| Mitchell, AA | 1 |
| Van Hare, G | 1 |
| Newell, SJ | 2 |
| Cairns, P | 1 |
| Evans, JS | 1 |
| Huffman, S | 1 |
| Drolet, B | 1 |
| Rousseau, G | 1 |
| Daleau, P | 1 |
| Cardinal, R | 1 |
| Turgeon, J | 1 |
| Mathew, A | 1 |
| Alimchandani, A | 1 |
| Pai-dhungat, JV | 1 |
| Shinawi, M | 1 |
| Brik, R | 1 |
| Berkowitz, D | 1 |
| Cools, F | 1 |
| Benatar, A | 1 |
| Bougatef, A | 1 |
| Mathis, AS | 1 |
| Costeas, C | 1 |
| Barone, JA | 1 |
| Hellström, P | 1 |
| Menezes, O | 1 |
| Hawkey, CJ | 1 |
| Brown, CK | 1 |
| Khanderia, U | 1 |
| Hyman, PE | 1 |
| Napolitano, JA | 1 |
| Diego, A | 1 |
| Patel, S | 1 |
| Flores, AF | 1 |
| Grill, BB | 1 |
| Reddy, SN | 1 |
| Garvey, TQ | 1 |
| Tomomasa, T | 1 |
| Klauser, A | 1 |
| McCallum, RW | 2 |
| Prakash, C | 1 |
| Campoli-Richards, DM | 1 |
| Goa, KL | 1 |
| Boghaert, A | 2 |
| Haesaert, G | 1 |
| Mourisse, P | 1 |
| Verlinden, M | 2 |
| Horowitz, M | 1 |
| Maddern, GJ | 1 |
| Maddox, A | 1 |
| Wishart, J | 1 |
| Chatterton, BE | 1 |
| Shearman, DJ | 1 |
| Michiels, G | 1 |
| de Coster, M | 1 |
| Dehertog, P | 1 |
16 reviews available for cisapride and Cholera Infantum
| Article | Year |
|---|---|
Cisapride: what can we learn from the rise and fall of a prokinetic?
Topics: Cisapride; Gastroesophageal Reflux; Gastrointestinal Diseases; Gastrointestinal Motility; Gastropare | 2011 |
Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.
Topics: Cardiovascular Diseases; Cisapride; Gastrointestinal Agents; Gastrointestinal Diseases; Humans; Indo | 2012 |
Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders.
Topics: Animals; Anti-Ulcer Agents; Cisapride; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; | 1994 |
[Cisapride and other prokinetic agents in the treatment of gastroenterological diseases].
Topics: Cisapride; Female; Gastrointestinal Agents; Gastrointestinal Diseases; Gastrointestinal Motility; Hu | 1995 |
A risk-benefit assessment of cisapride in the treatment of gastrointestinal disorders.
Topics: Anti-Ulcer Agents; Cisapride; Gastric Emptying; Gastrointestinal Diseases; Gastrointestinal Motility | 1995 |
Cisapride therapy for gastrointestinal disease.
Topics: Adult; Animals; Child; Cisapride; Constipation; Esophageal Motility Disorders; Gastrointestinal Dise | 1996 |
Cisapride. Drug interactions of clinical significance.
Topics: Cisapride; Drug Interactions; Gastrointestinal Diseases; Humans; Piperidines; Sympathomimetics | 1996 |
Clinical use of cisapride and its risk-benefit in paediatric patients.
Topics: Child; Child, Preschool; Cisapride; Constipation; Cystic Fibrosis; Drug Interactions; Dyspepsia; Fec | 1998 |
Today's therapy of functional gastrointestinal disorders--does it help?
Topics: Antacids; Benzyl Compounds; Cisapride; Clinical Trials as Topic; Colonic Diseases, Functional; Dyspe | 1998 |
The use of cisapride in children. The North American Society for Pediatric Gastroenterology and Nutrition.
Topics: Arrhythmias, Cardiac; Aryl Hydrocarbon Hydroxylases; Cisapride; Cytochrome P-450 CYP3A; Cytochrome P | 1999 |
Update on medications used to treat gastrointestinal disease in children.
Topics: Anti-Bacterial Agents; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Child; Cisapride; Dru | 1999 |
[Prokinetic drugs].
Topics: Cisapride; Gastrointestinal Agents; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Me | 1992 |
The place of cisapride in therapeutics: an interim verdict.
Topics: Animals; Cisapride; Gastrointestinal Diseases; Humans; Piperidines; Serotonin Antagonists | 1991 |
Use of metoclopramide, domperidone, and cisapride in the management of diabetic gastroparesis.
Topics: Cisapride; Diabetes Complications; Domperidone; Gastric Emptying; Gastrointestinal Diseases; Humans; | 1990 |
[What is assured in therapy of gastrointestinal diseases with drugs acting on motility?].
Topics: Atropine; Calcium Channel Blockers; Cisapride; Dopamine; Dopamine Antagonists; Gastrointestinal Dise | 1989 |
Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders.
Topics: Cisapride; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Piperidines | 1988 |
7 trials available for cisapride and Cholera Infantum
| Article | Year |
|---|---|
Determinants of response to a prokinetic agent in neuropathic chronic intestinal motility disorder.
Topics: Adult; Autonomic Nervous System; Autonomic Nervous System Diseases; Chronic Disease; Cisapride; Doub | 1994 |
An evaluation of the use of cisapride in horses with chronic grass sickness (equine dysautonomia)
Topics: Animals; Anti-Ulcer Agents; Autonomic Nervous System Diseases; Chronic Disease; Cisapride; Female; G | 1996 |
The Omega-Project--a comparison of two diagnostic strategies for risk- and cost-oriented management of dyspepsia.
Topics: Adult; Cisapride; Costs and Cost Analysis; Domperidone; Dopamine Antagonists; Double-Blind Method; D | 1997 |
A study of gastric emptying in chronic renal failure.
Topics: Adolescent; Adult; Aged; Cisapride; Cross-Over Studies; Double-Blind Method; Erythromycin; Female; G | 1997 |
[Treatment of chronic-obstructive upper abdominal complaints. Outlook. Further hypothetical indications].
Topics: Cisapride; Clinical Trials as Topic; Constipation; Dyspepsia; Gastroesophageal Reflux; Gastrointesti | 1990 |
Placebo-controlled trial of cisapride in postoperative ileus.
Topics: Adult; Cisapride; Clinical Trials as Topic; Double-Blind Method; Female; Gastrointestinal Diseases; | 1987 |
Effects of cisapride on gastric and esophageal emptying in progressive systemic sclerosis.
Topics: Adult; Cisapride; Esophagus; Female; Gastric Emptying; Gastrointestinal Diseases; Humans; Male; Midd | 1987 |
26 other studies available for cisapride and Cholera Infantum
| Article | Year |
|---|---|
A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists.
Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cell Line; Dogs; Drug Design; | 2009 |
Treatment functional GI disease: the complex pharmacology of serotonergic drugs.
Topics: Buspirone; Cisapride; Gastrointestinal Diseases; Humans; Serotonin Agents; Serotonin Receptor Agonis | 2002 |
[With evidence-based phytotherapy. Takes away gastric and intestinal irritation].
Topics: Antiemetics; Cisapride; Clinical Trials as Topic; Dopamine Antagonists; Evidence-Based Medicine; Gas | 2003 |
Long-term results of upper respiratory syndrome surgery and gastrointestinal tract medical treatment in 51 brachycephalic dogs.
Topics: Airway Obstruction; Analysis of Variance; Animals; Anti-Ulcer Agents; Cisapride; Dog Diseases; Dogs; | 2006 |
Moving ahead or falling behind?
Topics: Cisapride; Constipation; Domperidone; Gastrointestinal Agents; Gastrointestinal Diseases; Gastrointe | 2007 |
[Functional disorders of the digestive tract and possibilities of therapy with Prepulside (cisapride)].
Topics: Cisapride; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Parasympathomimetics; Piper | 1995 |
GI motility disorders: diagnostic workup and use of prokinetic therapy.
Topics: Aging; Anti-Ulcer Agents; Autonomic Nervous System Diseases; Cisapride; Diet; Gastrointestinal Disea | 1993 |
Diffuse gastrointestinal dysmotility in a patient with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cisapride; Female; Gastrointestinal Diseases; Gastrointestinal Motility; Huma | 1993 |
Effects of cisapride on anorectal and vesicourethral function in spinal cord injured patients.
Topics: Anal Canal; Cisapride; Female; Gastrointestinal Diseases; Gastrointestinal Transit; Humans; Male; Pi | 1993 |
Functional dyspepsia versus other functional gastrointestinal disorders: a practical approach in Belgian general practices.
Topics: Adult; Aged; Belgium; Cisapride; Cluster Analysis; Constipation; Dyspepsia; Family Practice; Female; | 1993 |
Recovery of horses from dysautonomia (grass sickness).
Topics: Animals; Autonomic Nervous System Diseases; Chronic Disease; Cisapride; Female; Follow-Up Studies; G | 1995 |
QT interval in children and infants receiving cisapride.
Topics: Arrhythmias, Cardiac; Child; Cisapride; Electrocardiography; Gastrointestinal Agents; Gastrointestin | 1998 |
The risks and benefits of cisapride in premature neonates, infants, and children.
Topics: Age Factors; Child; Child, Preschool; Cisapride; Contraindications; Gastrointestinal Agents; Gastroi | 1998 |
The threat of therapeutic Nihilism.
Topics: Cisapride; Gastrointestinal Agents; Gastrointestinal Diseases; Humans; Legislation, Drug; Pediatrics | 1999 |
The risks and benefits of cisapride.
Topics: Cisapride; Gastrointestinal Agents; Gastrointestinal Diseases; Humans; Infant, Newborn; Infant, Prem | 1999 |
Domperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders.
Topics: Action Potentials; Animals; Antiemetics; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Cation Tr | 2000 |
Use of cisapride.
Topics: Child; Cisapride; Gastrointestinal Agents; Gastrointestinal Diseases; Humans; Infant, Newborn; Infan | 2000 |
Gastrointestinal tract cytomegalovirus infection with prolonged vomiting and fever in an immunocompetent child.
Topics: Cisapride; Cytomegalovirus; Cytomegalovirus Infections; Fever; Gastrointestinal Agents; Gastrointest | 2001 |
The effect of cisapride on the corrected QT interval and QT dispersion in premature infants.
Topics: Age Factors; Case-Control Studies; Cisapride; Cohort Studies; Electrocardiography; Gastrointestinal | 2001 |
Retrospective analysis of the effects of cisapride on the QT interval and QT dispersion in chronic hemodialysis patients.
Topics: Arrhythmias, Cardiac; Cisapride; Contraindications; Drug Interactions; Electrocardiography; Female; | 2001 |
Cisapride.
Topics: Cisapride; Contraindications; Drug Interactions; Gastroesophageal Reflux; Gastrointestinal Diseases; | 1991 |
Cisapride: its use in children.
Topics: Child; Cisapride; Gastroesophageal Reflux; Gastrointestinal Diseases; Gastrointestinal Motility; Hum | 1990 |
Antroduodenal manometry in the evaluation of chronic functional gastrointestinal symptoms.
Topics: Adolescent; Child; Child, Preschool; Cisapride; Duodenum; Fasting; Feeding Behavior; Female; Gastroi | 1990 |
[A new concept in the treatment of gastrointestinal diseases--Propulsin. Workshop, Beerse, Belgium, 16 June 1989].
Topics: Cisapride; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Piperidines | 1989 |
Treatment of postoperative gastrointestinal atony.
Topics: Cisapride; Digestive System; Dose-Response Relationship, Drug; Female; Gastrointestinal Diseases; Ga | 1987 |
Review of the current status of prokinetic agents in gastroenterology.
Topics: Benzamides; Chemical Phenomena; Chemistry; Cisapride; Dexamethasone; Digestive System; Domperidone; | 1985 |