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cisapride and ANS (Autonomic Nervous System) Diseases

cisapride has been researched along with ANS (Autonomic Nervous System) Diseases in 14 studies

Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
cisapride : The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.

Research Excerpts

ExcerptRelevanceReference
" While both cisapride and metoclopramide normalized impaired solid emptying, cisapride at its highest dosage (10 mg) resulted in significantly faster gastric emptying (P = 0."2.67Cisapride vs metoclopramide. An acute study in diabetic gastroparesis. ( Diamant, NE; Lico, S; McHugh, S, 1992)
"Cisapride is a prokinetic drug of the gastrointestinal tract and acts by releasing acetylcholine from cholinergic nerve endings."1.31Cisapride improves gallbladder emptying in patients with type 2 diabetes mellitus. ( Arke, L; Bhansali, A; Chawla, YK; Dhiman, RK; Gupta, S, 2001)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's11 (78.57)18.2507
2000's2 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gumurdulu, Y1
Yapar, Z1
Canataroglu, A1
Serin, E1
Gumurdulu, D1
Kibar, M1
Colakoglu, S1
Räihä, I1
Sourander, L1
Camilleri, M2
Balm, RK2
Zinsmeister, AR2
Kawagishi, T1
Nishizawa, Y1
Okuno, Y1
Sekiya, K1
Morii, H1
Doxey, DL3
Tothill, S1
Milne, EM3
Davis, Z1
Harter, A1
Woodman, MP1
Cuddeford, D1
Pearson, RA1
Stacher, G1
Schernthaner, G1
Francesconi, M1
Kopp, HP1
Bergmann, H1
Stacher-Janotta, G1
Weber, U1
Dhiman, RK1
Arke, L1
Bhansali, A1
Gupta, S1
Chawla, YK1
Bergmann, JF1
Chassany, O1
Guillausseau, PJ1
Bayle, M1
Chagnon, S1
Caulin, C1
Sallenave, JR1
McHugh, S1
Lico, S1
Diamant, NE1
Wehrmann, T1
Lembcke, B1
Caspary, WF1
de Caestecker, JS1
Ewing, DJ1
Tothill, P1
Clarke, BF1
Heading, RC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622]Phase 23 participants (Actual)Interventional2014-07-31Terminated (stopped due to Lack of recruitment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

9 trials available for cisapride and ANS (Autonomic Nervous System) Diseases

ArticleYear
Determinants of response to a prokinetic agent in neuropathic chronic intestinal motility disorder.
    Gastroenterology, 1994, Volume: 106, Issue:4

    Topics: Adult; Autonomic Nervous System; Autonomic Nervous System Diseases; Chronic Disease; Cisapride; Doub

1994
Effect of cisapride on gastric emptying of indigestible solids and plasma motilin concentration in diabetic autonomic neuropathy.
    The American journal of gastroenterology, 1993, Volume: 88, Issue:6

    Topics: Autonomic Nervous System Diseases; Cisapride; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2;

1993
Symptomatic improvement with one-year cisapride treatment in neuropathic chronic intestinal dysmotility.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:3

    Topics: Adult; Aged; Anti-Ulcer Agents; Autonomic Nervous System Diseases; Chronic Disease; Cisapride; Femal

1996
An evaluation of the use of cisapride in horses with chronic grass sickness (equine dysautonomia)
    The British veterinary journal, 1996, Volume: 152, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Autonomic Nervous System Diseases; Chronic Disease; Cisapride; Female; G

1996
Cisapride versus placebo for 8 weeks on glycemic control and gastric emptying in insulin-dependent diabetes: a double blind cross-over trial.
    The Journal of clinical endocrinology and metabolism, 1999, Volume: 84, Issue:7

    Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Glucose; Cardiovascular System; Cisapride; Cro

1999
Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times. Use in studying the actions of cisapride in diabetic patients.
    European journal of clinical pharmacology, 1992, Volume: 43, Issue:2

    Topics: Adult; Aged; Autonomic Nervous System Diseases; Cisapride; Diabetic Neuropathies; Double-Blind Metho

1992
Cisapride vs metoclopramide. An acute study in diabetic gastroparesis.
    Digestive diseases and sciences, 1992, Volume: 37, Issue:7

    Topics: Adult; Autonomic Nervous System Diseases; Cisapride; Diabetic Neuropathies; Dose-Response Relationsh

1992
Influence of cisapride on antroduodenal motor function in healthy subjects and diabetics with autonomic neuropathy.
    Alimentary pharmacology & therapeutics, 1991, Volume: 5, Issue:6

    Topics: Adult; Autonomic Nervous System Diseases; Cisapride; Diabetes Mellitus, Type 1; Diabetic Neuropathie

1991
Evaluation of oral cisapride and metoclopramide in diabetic autonomic neuropathy: an eight-week double-blind crossover study.
    Alimentary pharmacology & therapeutics, 1989, Volume: 3, Issue:1

    Topics: Adult; Autonomic Nervous System Diseases; Blood Glucose; Cisapride; Diabetic Neuropathies; Double-Bl

1989

Other Studies

5 other studies available for cisapride and ANS (Autonomic Nervous System) Diseases

ArticleYear
Gastric emptying time and the effect of cisapride in cirrhotic patients with autonomic neuropathy.
    Journal of clinical gastroenterology, 2003, Volume: 36, Issue:2

    Topics: Administration, Oral; Adult; Aged; Ascites; Autonomic Nervous System Diseases; Cisapride; Female; Ga

2003
GI motility disorders: diagnostic workup and use of prokinetic therapy.
    Geriatrics, 1993, Volume: 48, Issue:11

    Topics: Aging; Anti-Ulcer Agents; Autonomic Nervous System Diseases; Cisapride; Diet; Gastrointestinal Disea

1993
Patterns of feeding and behaviour in horses recovering from dysautonomia (grass sickness).
    The Veterinary record, 1995, Aug-19, Volume: 137, Issue:8

    Topics: Animal Feed; Animals; Appetitive Behavior; Autonomic Nervous System Diseases; Behavior, Animal; Cisa

1995
Recovery of horses from dysautonomia (grass sickness).
    The Veterinary record, 1995, Dec-02, Volume: 137, Issue:23

    Topics: Animals; Autonomic Nervous System Diseases; Chronic Disease; Cisapride; Female; Follow-Up Studies; G

1995
Cisapride improves gallbladder emptying in patients with type 2 diabetes mellitus.
    Journal of gastroenterology and hepatology, 2001, Volume: 16, Issue:9

    Topics: Acetylcholine; Administration, Oral; Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Cis

2001