Page last updated: 2024-10-25

ciprofloxacin and Tendinitis

ciprofloxacin has been researched along with Tendinitis in 39 studies

Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.
ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.

Tendinitis: Inflammation of TENDONS. It is characterized by the degeneration of tendons accompanied by an inflammatory repair response, fibroblastic proliferation, and formation of granulation tissue. Tendinitis is not a clinical diagnosis and can be confirmed only by histopathological findings.

Research Excerpts

ExcerptRelevanceReference
"We report a case of spontaneous non-traumatic bilateral rupture of the Achilles tendons following ciprofloxacin treatment."7.79[Bilateral rupture of the Achilles tendons after treatment with ciprofloxacin]. ( Attarzadeh, AP; Ryge, C, 2013)
"Bilateral achilles tendinitis developed in a 40-year-old man following treatment with Ciprofloxacin, 500 mg twice a day, for prostatis."7.69[Ciprofloxacin-associated bilateral acute achilles tendinitis]. ( Arlazoroff, A; Halperin, N; Mirovsky, Y; Pollack, L, 1995)
"Ciprofloxacin was stopped and her pain quickly resolved."5.40Ciprofloxacin-induced tendinopathy of the gluteal tendons. ( Aronowitz, P; Shimatsu, K; Sim, H; Subramaniam, S, 2014)
"Two patients with tendinitis by ciprofloxacin are described."4.79[Tendinitis due to fluoroquinolones. Description of 2 cases]. ( Collado, A; Hernández, MV; Muñoz-Gómez, J; Peris, P; Sierra, J, 1994)
"Fluoroquinolones, such as ciprofloxacin and levofloxacin, are broad-spectrum antibacterial agents that have historically been widely used for urinary tract infections, pneumonia, and intra-abdominal infections but are associated with several serious adverse reactions, including tendinopathy and tendon rupture, peripheral neuropathy, and aortic aneurysm."4.12A preventable, life-altering case of fluoroquinolone-associated tendonitis. ( Holmes, M; Wildermuth, A, 2022)
"Ciprofloxacin is recognized to have a deleterious relationship with tendons, particularly Achilles tendinopathy, which makes up most case reports."3.88Two Unique Cases of Ciprofloxacin-Associated Avulsion of Ligament and Tendon. ( Irwin, RW; Smith, JD; Wolff, ET, 2018)
"We report a case of spontaneous non-traumatic bilateral rupture of the Achilles tendons following ciprofloxacin treatment."3.79[Bilateral rupture of the Achilles tendons after treatment with ciprofloxacin]. ( Attarzadeh, AP; Ryge, C, 2013)
"Ciprofloxacin-induced tendinopathy and tendon rupture have been previously described, principally affecting the Achilles tendon."3.75Ciprofloxacin-mediated inhibition of tenocyte migration and down-regulation of focal adhesion kinase phosphorylation. ( Chen, HC; Hsu, CC; Hsu, YH; Lin, MS; Pang, JH; Tsai, WC; Wu, CW, 2009)
"To investigate the effect of ciprofloxacin on the proliferation and cell cycle progression of tendon cells, and to explore the potential molecular mechanism of ciprofloxacin-associated tendinopathy by analyzing the expression of cell cycle-related cyclin and cyclin-dependent kinase (CDK)."3.74Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. ( Chen, YC; Hsu, CC; Pang, JH; Tang, FT; Tsai, WC; Wong, AM, 2008)
"We present a case of Achilles tendinitis in a 77-year-old patient with renal dysfunction and a urinary tract infection (UTI) treated with ciprofloxacin 250 mg PO QD."3.74An elderly patient with fluoroquinolone-associated achilles tendinitis. ( Cinti, SK; Damuth, E; Heidelbaugh, J; Malani, PN, 2008)
"Bilateral achilles tendinitis developed in a 40-year-old man following treatment with Ciprofloxacin, 500 mg twice a day, for prostatis."3.69[Ciprofloxacin-associated bilateral acute achilles tendinitis]. ( Arlazoroff, A; Halperin, N; Mirovsky, Y; Pollack, L, 1995)
"Ciprofloxacin was stopped and her pain quickly resolved."1.40Ciprofloxacin-induced tendinopathy of the gluteal tendons. ( Aronowitz, P; Shimatsu, K; Sim, H; Subramaniam, S, 2014)
" The authors assessed the ability of PRP to prevent in vitro adverse effects of 2 drugs commonly linked to tendon rupture and tendinopathy, glucocorticoids and fluoroquinolone antibiotics."1.37Platelet-rich plasma protects tenocytes from adverse side effects of dexamethasone and ciprofloxacin. ( Franklin, SL; Hulley, PA; Poulsen, RC; Thompson, MS; Zargar Baboldashti, N, 2011)
"We report five cases of tendinitis induced by fluoroquinolones, three caused by levofloxacin and two by ciprofloxacin."1.34[Fluoroquinolone-induced tendon diseases]. ( Bruscas Izu, C; Mauri Llerda, JA; Medrano San Ildefonso, M, 2007)
" Tendon rupture occurred with a lower ciprofloxacin dosage than tendonitis and the mean recovery duration was significantly longer."1.31Achilles tendon disease in lung transplant recipients: association with ciprofloxacin. ( Chhajed, PN; Glanville, AR; Hopkins, PM; Malouf, MA; Plit, ML, 2002)
"We report on tendinitis and tendon rupture in six fluoroquinolone treated patients of our outpatient and dialysis service between 1995 and 1997."1.30[Fluoroquinolones as etiology of tendinopathy]. ( Gabutti, L; Marti, HP; Stoller, R, 1998)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (28.21)18.2507
2000's13 (33.33)29.6817
2010's12 (30.77)24.3611
2020's3 (7.69)2.80

Authors

AuthorsStudies
Wildermuth, A1
Holmes, M1
Huruba, M1
Farcas, A1
Leucuta, DC1
Bucsa, C1
Sipos, M1
Mogosan, C1
Koumou, GCG1
Pam, KPBB1
Arrayhani, M1
Houssaini, TS1
El Mrini, A1
Smith, JD1
Irwin, RW1
Wolff, ET1
Schjøtt, J1
Messner, T1
Attarzadeh, AP1
Ryge, C1
Zeidan, S1
Esposito, L1
Rostaing, L1
Kamar, N1
Shimatsu, K1
Subramaniam, S1
Sim, H1
Aronowitz, P1
Goyal, H1
Dennehy, J1
Barker, J1
Singla, U1
Smith, N1
Fackrell, R1
Henderson, E1
Nguyen, T1
Gelband, K1
Merschin, D1
Ekkernkamp, A1
Seifert, J1
Tsai, WC3
Hsu, CC2
Tang, FT1
Wong, AM1
Chen, YC1
Pang, JH3
Damuth, E1
Heidelbaugh, J1
Malani, PN1
Cinti, SK1
Chen, HC1
Hsu, YH1
Lin, MS2
Wu, CW1
Lowes, DA1
Wallace, C1
Murphy, MP1
Webster, NR1
Galley, HF1
Gültuna, S1
Köklü, S1
Arhan, M1
Aydin, F1
Mesci, P1
Usküdar, O1
Liang, VY1
Ghearing, GR1
Zivković, SA1
Zargar Baboldashti, N1
Poulsen, RC1
Franklin, SL1
Thompson, MS1
Hulley, PA1
Chang, HN1
Chen, CP1
Ko, PC1
Yang, YM1
Breck, RW1
Tomás, ME1
Pérez Carreras, M1
Morillasa, JD1
Castellano, G1
Solís, JA1
Khaliq, Y1
Zhanel, GG1
Fama, U1
Irace, S1
Frati, R1
de Gado, F1
Scuderi, N1
Shortt, P1
Wilson, R1
Erskine, I1
Karistinos, A1
Paulos, LE1
Medrano San Ildefonso, M1
Mauri Llerda, JA1
Bruscas Izu, C1
Hernández, MV1
Peris, P1
Sierra, J1
Collado, A1
Muñoz-Gómez, J1
Hugo-Persson, M1
Mirovsky, Y1
Pollack, L1
Arlazoroff, A1
Halperin, N1
Carrasco, JM1
García, B1
Andújar, C1
Garrote, F1
de Juana, P1
Bermejo, T1
Shinohara, YT1
Tasker, SA1
Wallace, MR1
Couch, KE1
Olson, PE1
Jagose, JT1
McGregor, DR1
Nind, GR1
Bailey, RR1
Movin, T1
Gad, A1
Güntner, P1
Földhazy, Z1
Rolf, C1
West, MB1
Gow, P1
Blanco Andrés, C1
Bravo Toledo, R1
Gabutti, L1
Stoller, R1
Marti, HP1
Harrell, RM1
Chhajed, PN1
Plit, ML1
Hopkins, PM1
Malouf, MA1
Glanville, AR1

Reviews

3 reviews available for ciprofloxacin and Tendinitis

ArticleYear
Fluoroquinolone-associated tendinopathy: a critical review of the literature.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Jun-01, Volume: 36, Issue:11

    Topics: Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Humans; Middle Aged; Pefloxacin; Risk Factors; Te

2003
[Tendinitis due to fluoroquinolones. Description of 2 cases].
    Medicina clinica, 1994, Sep-10, Volume: 103, Issue:7

    Topics: Adult; Bone Marrow Transplantation; Ciprofloxacin; Combined Modality Therapy; Female; Humans; Leukem

1994
Fluoroquinolone-induced tendinopathy: what do we know?
    Southern medical journal, 1999, Volume: 92, Issue:6

    Topics: Achilles Tendon; Adult; Anti-Infective Agents; Ciprofloxacin; Female; Humans; Tendinopathy

1999

Other Studies

36 other studies available for ciprofloxacin and Tendinitis

ArticleYear
A preventable, life-altering case of fluoroquinolone-associated tendonitis.
    JAAPA : official journal of the American Academy of Physician Assistants, 2022, Nov-01, Volume: 35, Issue:11

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Humans; Levofloxacin;

2022
A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders.
    Scientific reports, 2021, 07-13, Volume: 11, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Adverse Drug Reaction Reporting Systems; Arthralgia; Cip

2021
[Achilles tendinopathy in a hemodialysis patient complicated by rupture of the Achilles tendon due to self-medication with ciprofloxacin: about a case].
    The Pan African medical journal, 2021, Volume: 38

    Topics: Achilles Tendon; Aged; Anti-Bacterial Agents; Ciprofloxacin; Female; Humans; Renal Dialysis; Rupture

2021
Two Unique Cases of Ciprofloxacin-Associated Avulsion of Ligament and Tendon.
    American journal of physical medicine & rehabilitation, 2018, Volume: 97, Issue:5

    Topics: Ciprofloxacin; Collateral Ligaments; Diverticulitis; Female; Gastroenteritis; Hamstring Tendons; Hum

2018
Ciprofloxacin and acute aortic valve damage.
    Medical hypotheses, 2018, Volume: 121

    Topics: Aged; Aortic Valve; Arthroplasty, Replacement, Knee; Ciprofloxacin; Cloxacillin; Collagen; Fluoroqui

2018
[Bilateral rupture of the Achilles tendons after treatment with ciprofloxacin].
    Ugeskrift for laeger, 2013, Sep-23, Volume: 175, Issue:39

    Topics: Achilles Tendon; Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Glucocorticoids; H

2013
The Achilles tendon of preventing BK virus nephropathy.
    Transplant infectious disease : an official journal of the Transplantation Society, 2013, Volume: 15, Issue:6

    Topics: Achilles Tendon; Anti-Bacterial Agents; BK Virus; Ciprofloxacin; Humans; Kidney Diseases; Kidney Tra

2013
Ciprofloxacin-induced tendinopathy of the gluteal tendons.
    Journal of general internal medicine, 2014, Volume: 29, Issue:11

    Topics: Acute Disease; Adult; Anti-Bacterial Agents; Buttocks; Ciprofloxacin; Female; Humans; Magnetic Reson

2014
Achilles is not alone!!! Ciprofloxacin induced tendinopathy of gluteal tendons.
    QJM : monthly journal of the Association of Physicians, 2016, Volume: 109, Issue:4

    Topics: Aged; Anti-Bacterial Agents; Ciprofloxacin; Diabetes Mellitus, Type 2; Hip; Humans; Kidney Failure,

2016
Ciprofloxacin-associated bilateral iliopsoas tendon rupture: a case report.
    Age and ageing, 2016, Volume: 45, Issue:5

    Topics: Aged; Anti-Bacterial Agents; Ciprofloxacin; Female; Hip; Humans; Magnetic Resonance Imaging; Rupture

2016
A Case-Based Approach to Evaluate the Potential Risks Associated with Fluoroquinolones and Steroids.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2016, Nov-01, Volume: 31, Issue:11

    Topics: Aged, 80 and over; Anti-Bacterial Agents; Ciprofloxacin; Drug Interactions; Female; Humans; Polyphar

2016
[The Vulnerable Heel of Achilles: Intratendinous Abscess Following a Cat Bite].
    Zeitschrift fur Orthopadie und Unfallchirurgie, 2017, Volume: 155, Issue:3

    Topics: Abscess; Achilles Tendon; Aged, 80 and over; Animals; Bacillaceae Infections; Bacillus; Bacteroidace

2017
Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells.
    Arthritis and rheumatism, 2008, Volume: 58, Issue:6

    Topics: Achilles Tendon; Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Ciprofloxacin; Cyclin-Dep

2008
An elderly patient with fluoroquinolone-associated achilles tendinitis.
    The American journal of geriatric pharmacotherapy, 2008, Volume: 6, Issue:5

    Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Humans; Kidney Diseases; Male; Risk Factors; Tendinopath

2008
Ciprofloxacin-mediated inhibition of tenocyte migration and down-regulation of focal adhesion kinase phosphorylation.
    European journal of pharmacology, 2009, Apr-01, Volume: 607, Issue:1-3

    Topics: Achilles Tendon; Animals; Anti-Infective Agents; Blotting, Western; Cell Movement; Cell Proliferatio

2009
The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells.
    Free radical research, 2009, Volume: 43, Issue:4

    Topics: Achilles Tendon; Anti-Infective Agents; Antioxidants; Aza Compounds; Cell Survival; Cells, Cultured;

2009
Ciprofloxacin induced tendinitis.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2009, Volume: 15, Issue:4

    Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Humans; Male; Prostatitis; Tendinopathy; Treatment Outc

2009
Carpal tunnel syndrome after ciprofloxacin-induced tendinitis.
    Journal of clinical neuromuscular disease, 2010, Volume: 11, Issue:3

    Topics: Aged; Anti-Infective Agents; Carpal Tunnel Syndrome; Ciprofloxacin; Female; Humans; Tendinopathy; Ur

2010
Platelet-rich plasma protects tenocytes from adverse side effects of dexamethasone and ciprofloxacin.
    The American journal of sports medicine, 2011, Volume: 39, Issue:9

    Topics: Adult; Anti-Infective Agents; Cell Proliferation; Cells, Cultured; Cellular Senescence; Ciprofloxaci

2011
The effect of aging on migration, proliferation, and collagen expression of tenocytes in response to ciprofloxacin.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2012, Volume: 30, Issue:5

    Topics: Aging; Animals; Anti-Infective Agents; Cell Movement; Cell Proliferation; Ciprofloxacin; Collagen Ty

2012
"Ciprofloxacin: a warning for clinicians".
    Connecticut medicine, 2002, Volume: 66, Issue:10

    Topics: Achilles Tendon; Anti-Infective Agents; Ciprofloxacin; Haemophilus Infections; Haemophilus influenza

2002
[Rupture of the Achilles' tendon secondary to levofloxacin].
    Gastroenterologia y hepatologia, 2003, Volume: 26, Issue:1

    Topics: Achilles Tendon; Adult; Ceftriaxone; Ciprofloxacin; Crohn Disease; Drug Therapy, Combination; Humans

2003
Is it a real risk to take ciprofloxacin?
    Plastic and reconstructive surgery, 2004, Volume: 114, Issue:1

    Topics: Adult; Anthrax; Anti-Infective Agents; Ciprofloxacin; Humans; Male; Musculoskeletal Diseases; Tendin

2004
Tendinitis: the Achilles heel of quinolones!
    Emergency medicine journal : EMJ, 2006, Volume: 23, Issue:12

    Topics: Achilles Tendon; Aged; Anti-Infective Agents; Ciprofloxacin; Female; Humans; Middle Aged; Rupture, S

2006
"Ciprofloxacin-induced" bilateral rectus femoris tendon rupture.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 2007, Volume: 17, Issue:5

    Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Humans; Knee Injuries; Male; Middle Aged; Qu

2007
[Fluoroquinolone-induced tendon diseases].
    Anales de medicina interna (Madrid, Spain : 1984), 2007, Volume: 24, Issue:5

    Topics: Achilles Tendon; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary;

2007
[Rupture of the Achilles tendon after ciproxine therapy].
    Lakartidningen, 1996, Apr-17, Volume: 93, Issue:16

    Topics: Achilles Tendon; Aged; Anti-Infective Agents; Ciprofloxacin; Humans; Male; Rupture; Tendinopathy

1996
[Ciprofloxacin-associated bilateral acute achilles tendinitis].
    Harefuah, 1995, Dec-01, Volume: 129, Issue:11

    Topics: Achilles Tendon; Adult; Anti-Infective Agents; Ciprofloxacin; Humans; Male; Prostatitis; Tendinopath

1995
Tendinitis associated with ciprofloxacin.
    The Annals of pharmacotherapy, 1997, Volume: 31, Issue:1

    Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Female; Humans; Tendinopathy

1997
What is the risk of Achilles tendon rupture with ciprofloxacin?
    The Journal of rheumatology, 1997, Volume: 24, Issue:1

    Topics: Achilles Tendon; Anti-Infective Agents; Ciprofloxacin; Humans; Risk Factors; Rupture; Tendinopathy

1997
Achilles tendon rupture due to ciprofloxacin.
    The New Zealand medical journal, 1996, Dec-13, Volume: 109, Issue:1035

    Topics: Achilles Tendon; Aged; Ciprofloxacin; Humans; Kidney Transplantation; Male; Rupture; Tendinopathy

1996
Pathology of the Achilles tendon in association with ciprofloxacin treatment.
    Foot & ankle international, 1997, Volume: 18, Issue:5

    Topics: Achilles Tendon; Adult; Aged; Aged, 80 and over; Animals; Anti-Infective Agents; Ciprofloxacin; Fema

1997
Ciprofloxacin, bilateral Achilles tendonitis and unilateral tendon rupture--a case report.
    The New Zealand medical journal, 1998, Jan-23, Volume: 111, Issue:1058

    Topics: Achilles Tendon; Aged; Anti-Infective Agents; Ciprofloxacin; Female; Humans; Rupture; Tendinopathy

1998
[Bilateral tendinitis caused by ciprofloxacin].
    Atencion primaria, 1998, Feb-28, Volume: 21, Issue:3

    Topics: Achilles Tendon; Anti-Infective Agents; Ciprofloxacin; Female; Humans; Middle Aged; Tendinopathy

1998
[Fluoroquinolones as etiology of tendinopathy].
    Therapeutische Umschau. Revue therapeutique, 1998, Volume: 55, Issue:9

    Topics: Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Female; Fleroxacin; Humans; Male; Middle Aged; Ri

1998
Achilles tendon disease in lung transplant recipients: association with ciprofloxacin.
    The European respiratory journal, 2002, Volume: 19, Issue:3

    Topics: Achilles Tendon; Adult; Ciprofloxacin; Disease Susceptibility; Dose-Response Relationship, Drug; Fem

2002