Page last updated: 2024-10-25

ciprofloxacin and Mandibular Diseases

ciprofloxacin has been researched along with Mandibular Diseases in 4 studies

Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.
ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.

Mandibular Diseases: Diseases involving the MANDIBLE.

Research Excerpts

ExcerptRelevanceReference
"We demonstrate the use of Tc-99m ciprofloxacin imaging in a follow-up case of squamous cell carcinoma of the tongue post hemi-mandibulectomy with clinical suspicion of local recurrence of osteomyelitis."7.74Diagnosis of mandibular osteomyelitis in probable coexisting tumor recurrence: role of Tc-99m ciprofloxacin imaging. ( Bhatnagar, A; Bhattacharya, A; Gupta, KA; Mittal, BR; Prasad, V; Singh, AK; Singh, B, 2008)
"We demonstrate the use of Tc-99m ciprofloxacin imaging in a follow-up case of squamous cell carcinoma of the tongue post hemi-mandibulectomy with clinical suspicion of local recurrence of osteomyelitis."3.74Diagnosis of mandibular osteomyelitis in probable coexisting tumor recurrence: role of Tc-99m ciprofloxacin imaging. ( Bhatnagar, A; Bhattacharya, A; Gupta, KA; Mittal, BR; Prasad, V; Singh, AK; Singh, B, 2008)
"Osteomyelitis is a relatively frequent bacterial infection of the jaw bones."1.35Mandibular osteomyelitis due to Pseudomonas aeruginosa. Case report. ( Brutto, D; Cappello, V; Carlino, V; Consolo, G; Marescalco, M; Mauro, M; Pappalardo, S; Tanteri, L, 2008)
"Descending necrotizing mediastinitis is a potentially fatal condition which may occur seldom as a consequence of oral infections."1.32Mediastinitis caused by an infected mandibular cyst. ( Arslan, A; Basa, S; Metin, M; Sayan, MA; Sayar, A, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pappalardo, S1
Tanteri, L1
Brutto, D1
Marescalco, M1
Carlino, V1
Consolo, G1
Mauro, M1
Cappello, V1
Singh, B1
Prasad, V1
Bhattacharya, A1
Singh, AK1
Bhatnagar, A1
Mittal, BR1
Gupta, KA1
Delanian, S1
Chatel, C1
Porcher, R1
Depondt, J1
Lefaix, JL1
Basa, S1
Arslan, A1
Metin, M1
Sayar, A1
Sayan, MA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment[NCT03040778]Phase 3100 participants (Anticipated)Interventional2018-04-01Enrolling by invitation
Advances in the Management of Mandibular Osteoradionecrosis: Pentoxifylline and Tocopherol as Medical Treatment[NCT02368457]Phase 424 participants (Actual)Interventional2016-02-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Bone and/or Tissue Healing as Measured With the Classification of ORN Stages, Area of Bone Exposed (mm2) and Radiological Findings (OPG).

"Clinical healing assessment as measured with the classification of ORN stages, area of bone exposed (mm2) and radiological findings (OPG).~Intraoral bone exposure is measured in mm2." (NCT02368457)
Timeframe: From baseline to 1, 3, 6, and 9 months of starting treatment

,
Interventionmm2 (Mean)
1 month of starting treatment3 month of starting treatment6 month of starting treatment9 month of starting treatment
Control Group15151515
Pentoxifylline and Tocopherol141311.510

Clinical Symptoms Evaluation, Measured Using the LENT-SOMA Scale

"Evaluation of symptoms improvement using the LENT-SOMA scale (Late Effect Normal Tissue Task Force / Subjective, Objective, Management, Analytic scale).~To examine the LENT/SOMA scale prospectively using interviews and questionnaires~Assessments were made from baseline to 1, 3, 6 and 9 months of starting treatments. The acceptability and feasibility of using the scales was examined using compliance in completion of the questionnaires.~Maximum score: 36 Minimum score: 0~Questionnaires have been completed for 24 patients after treatment. Higher values represents worse outcome.~Scale categories:~Subjective: pain, nutritional problems, difficulty in mouth openning. Objective: bone exposure, trismus, Management: analgesic treatment, oral treatment, nutrition. Analytic: radiological findings." (NCT02368457)
Timeframe: From baseline to 1,3, 6, 9 months of starting treatment

,
Interventionunits on a scale (Mean)
1 month of starting treatment3 month of starting treatment6 month of starting treatment9 month of starting treatment
CONTROL15.515.515.515.5
Pentoxifylline and Tocopherol14.5141413.3

Trials

1 trial available for ciprofloxacin and Mandibular Diseases

ArticleYear
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
    International journal of radiation oncology, biology, physics, 2011, Jul-01, Volume: 80, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru

2011
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
    International journal of radiation oncology, biology, physics, 2011, Jul-01, Volume: 80, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru

2011
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
    International journal of radiation oncology, biology, physics, 2011, Jul-01, Volume: 80, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru

2011
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
    International journal of radiation oncology, biology, physics, 2011, Jul-01, Volume: 80, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru

2011

Other Studies

3 other studies available for ciprofloxacin and Mandibular Diseases

ArticleYear
Mandibular osteomyelitis due to Pseudomonas aeruginosa. Case report.
    Minerva stomatologica, 2008, Volume: 57, Issue:6

    Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Combined Modality Therapy; Debridement; Drug Resistance

2008
Diagnosis of mandibular osteomyelitis in probable coexisting tumor recurrence: role of Tc-99m ciprofloxacin imaging.
    Clinical nuclear medicine, 2008, Volume: 33, Issue:8

    Topics: Ciprofloxacin; Humans; Male; Mandibular Diseases; Middle Aged; Neoplasm Recurrence, Local; Organotec

2008
Mediastinitis caused by an infected mandibular cyst.
    International journal of oral and maxillofacial surgery, 2004, Volume: 33, Issue:6

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Clindamycin; Dentigerous Cyst; Drainage; Focal Infection, Dent

2004