Page last updated: 2024-10-25

ciprofloxacin and Hepatic Failure

ciprofloxacin has been researched along with Hepatic Failure in 8 studies

Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.
ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.

Research Excerpts

ExcerptRelevanceReference
" In the survival study, a dose-response effect of ciprofloxacin on survival was observed (ciprofloxacin: 10 mg/kg, 10%; 50 mg/kg, 26%; and 100 mg/kg, 35%) with the results in the 100-mg/kg-treated group being significant when compared with the 5% survival rate in saline-treated controls (P < ."5.30The beneficial effects of ciprofloxacin on survival and hepatic regenerative activity in a rat model of fulminant hepatic failure. ( Assy, N; Gauthier, T; Kaita, KD; Meyers, AF; Minuk, GY; Zhang, M, 1998)
" After intravenous dosing of ciprofloxacin (10-30 mg kg(-1)), ciprofloxacin levels in plasma and brain were measured in normal rats (Wistar, male, 10-week-old) and those with acute renal and hepatic injuries which were induced by uranyl nitrate and carbon tetrachloride (CCl4), respectively."5.30Distribution of ciprofloxacin into the central nervous system in rats with acute renal or hepatic failure. ( Hirano, H; Ichikawa, N; Iwamoto, K; Naora, K, 1999)
" Fluoroquinolones (norfloxacin and ciprofloxacin), third-generation cephalosporins (G3) (ceftriaxone and cefotaxime) and trimethoprim-sulfamethoxazole (SXT) are recommended for preventing infections in patients with cirrhosis or liver failure."4.12Evaluation of the current guidelines for antibacterial therapy strategies in patients with cirrhosis or liver failure. ( Dong, Y; Du, Q; Han, R; Shi, L; Sun, D; Teng, M; Wang, T; Wang, Y; Zhang, T; Zhang, Y; Zheng, G, 2022)
" Ciprofloxacin and dexamethasone were used to treat 11 patients diagnosed on blood culture as having typhoid fever."3.70Differentiation of typhoid fever from fulminant hepatic failure in patients presenting with jaundice and encephalopathy. ( Chakraborty, A; Jalihal, A; Kamath, PS, 2000)
" In the survival study, a dose-response effect of ciprofloxacin on survival was observed (ciprofloxacin: 10 mg/kg, 10%; 50 mg/kg, 26%; and 100 mg/kg, 35%) with the results in the 100-mg/kg-treated group being significant when compared with the 5% survival rate in saline-treated controls (P < ."1.30The beneficial effects of ciprofloxacin on survival and hepatic regenerative activity in a rat model of fulminant hepatic failure. ( Assy, N; Gauthier, T; Kaita, KD; Meyers, AF; Minuk, GY; Zhang, M, 1998)
" After intravenous dosing of ciprofloxacin (10-30 mg kg(-1)), ciprofloxacin levels in plasma and brain were measured in normal rats (Wistar, male, 10-week-old) and those with acute renal and hepatic injuries which were induced by uranyl nitrate and carbon tetrachloride (CCl4), respectively."1.30Distribution of ciprofloxacin into the central nervous system in rats with acute renal or hepatic failure. ( Hirano, H; Ichikawa, N; Iwamoto, K; Naora, K, 1999)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (50.00)18.2507
2000's2 (25.00)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Dong, Y2
Sun, D1
Wang, Y1
Du, Q1
Zhang, Y1
Han, R1
Teng, M1
Zhang, T1
Shi, L1
Zheng, G1
Wang, T1
San-Juan, R1
Aguado, JM1
Lumbreras, C1
Fortun, J1
Len, O1
Munoz, P1
Montejo, M1
Moreno, A1
Cordero, E1
Blanes, M1
Ramos, A1
Torre-Cisneros, J1
López-Medrano, F1
Carratala, J1
Moreno, E1
Kojima, H1
Kaita, KD2
Hawkins, K1
Uhanova, J1
Minuk, GY2
Fuchs, S1
Simon, Z1
Brezis, M1
Pfeiffer, M1
Reiter, C1
Assy, N1
Gauthier, T1
Zhang, M1
Meyers, AF1
Naora, K1
Ichikawa, N1
Hirano, H1
Iwamoto, K1
Kamath, PS1
Jalihal, A1
Chakraborty, A1

Trials

1 trial available for ciprofloxacin and Hepatic Failure

ArticleYear
Use of fluoroquinolones in patients with chronic hepatitis C virus-induced liver failure.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:10

    Topics: Alanine Transaminase; Anti-Infective Agents; Ciprofloxacin; Double-Blind Method; Hepatitis C, Chroni

2002

Other Studies

7 other studies available for ciprofloxacin and Hepatic Failure

ArticleYear
Evaluation of the current guidelines for antibacterial therapy strategies in patients with cirrhosis or liver failure.
    BMC infectious diseases, 2022, Jan-04, Volume: 22, Issue:1

    Topics: Anti-Bacterial Agents; Cefotaxime; Ciprofloxacin; Humans; Liver Cirrhosis; Liver Failure

2022
Selective intestinal decontamination with fluoroquinolones for the prevention of early bacterial infections after liver transplantation.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2011, Volume: 17, Issue:8

    Topics: Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Ciprofloxacin; Female; Fluoroquinolones; H

2011
Fatal hepatic failure associated with ciprofloxacin.
    Lancet (London, England), 1994, Mar-19, Volume: 343, Issue:8899

    Topics: Aged; Aged, 80 and over; Ciprofloxacin; Humans; Liver Failure; Male

1994
Who is withholding information?
    Lancet (London, England), 1994, May-07, Volume: 343, Issue:8906

    Topics: Adverse Drug Reaction Reporting Systems; Ciprofloxacin; Drug Industry; Germany; Humans; Liver Failur

1994
The beneficial effects of ciprofloxacin on survival and hepatic regenerative activity in a rat model of fulminant hepatic failure.
    Hepatology (Baltimore, Md.), 1998, Volume: 27, Issue:2

    Topics: Alanine Transaminase; Animals; Anti-Infective Agents; Ciprofloxacin; Disease Models, Animal; DNA; Im

1998
Distribution of ciprofloxacin into the central nervous system in rats with acute renal or hepatic failure.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:5

    Topics: Animals; Anti-Infective Agents; Central Nervous System; Ciprofloxacin; Liver Failure; Male; Rats; Ra

1999
Differentiation of typhoid fever from fulminant hepatic failure in patients presenting with jaundice and encephalopathy.
    Mayo Clinic proceedings, 2000, Volume: 75, Issue:5

    Topics: Adult; Aged; Alkaline Phosphatase; Anti-Infective Agents; Aspartate Aminotransferases; Ciprofloxacin

2000