ciprofloxacin has been researched along with Head and Neck Neoplasms in 6 studies
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.
ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The biopsy showed necrotic lymphadenitis." | 1.36 | [Rabbit fever--a neck tumor]. ( Høstmark, K; Moritz, J, 2010) |
| "Chemotherapeutic treatment of squamous cell carcinoma (SCC) of the head and neck has been largely ineffective because of tumor cell resistance." | 1.29 | Increased cytotoxicity of squamous cell carcinoma of the head and neck by combining cisplatin with VP-16 and ciprofloxacin. ( Burgess, R; Dawson, D; Haller, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Høstmark, K | 1 |
| Moritz, J | 1 |
| Delanian, S | 1 |
| Chatel, C | 1 |
| Porcher, R | 1 |
| Depondt, J | 1 |
| Lefaix, JL | 1 |
| Haller, J | 1 |
| Burgess, R | 1 |
| Dawson, D | 1 |
| Matthews, RH | 1 |
| Ercal, N | 1 |
| Amrikachi, M | 1 |
| Krishnan, B | 1 |
| Finch, CJ | 1 |
| Shahab, I | 1 |
| Appelbaum, PC | 1 |
| Spangler, SK | 1 |
| Strauss, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment[NCT03040778] | Phase 3 | 100 participants (Anticipated) | Interventional | 2018-04-01 | Enrolling by invitation | ||
| Advances in the Management of Mandibular Osteoradionecrosis: Pentoxifylline and Tocopherol as Medical Treatment[NCT02368457] | Phase 4 | 24 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Clinical healing assessment as measured with the classification of ORN stages, area of bone exposed (mm2) and radiological findings (OPG).~Intraoral bone exposure is measured in mm2." (NCT02368457)
Timeframe: From baseline to 1, 3, 6, and 9 months of starting treatment
| Intervention | mm2 (Mean) | |||
|---|---|---|---|---|
| 1 month of starting treatment | 3 month of starting treatment | 6 month of starting treatment | 9 month of starting treatment | |
| Control Group | 15 | 15 | 15 | 15 |
| Pentoxifylline and Tocopherol | 14 | 13 | 11.5 | 10 |
"Evaluation of symptoms improvement using the LENT-SOMA scale (Late Effect Normal Tissue Task Force / Subjective, Objective, Management, Analytic scale).~To examine the LENT/SOMA scale prospectively using interviews and questionnaires~Assessments were made from baseline to 1, 3, 6 and 9 months of starting treatments. The acceptability and feasibility of using the scales was examined using compliance in completion of the questionnaires.~Maximum score: 36 Minimum score: 0~Questionnaires have been completed for 24 patients after treatment. Higher values represents worse outcome.~Scale categories:~Subjective: pain, nutritional problems, difficulty in mouth openning. Objective: bone exposure, trismus, Management: analgesic treatment, oral treatment, nutrition. Analytic: radiological findings." (NCT02368457)
Timeframe: From baseline to 1,3, 6, 9 months of starting treatment
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| 1 month of starting treatment | 3 month of starting treatment | 6 month of starting treatment | 9 month of starting treatment | |
| CONTROL | 15.5 | 15.5 | 15.5 | 15.5 |
| Pentoxifylline and Tocopherol | 14.5 | 14 | 14 | 13.3 |
2 trials available for ciprofloxacin and Head and Neck Neoplasms
| Article | Year |
|---|---|
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru | 2011 |
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru | 2011 |
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru | 2011 |
Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.
Topics: Adult; Aged; Aged, 80 and over; Bone Density Conservation Agents; Ciprofloxacin; Clodronic Acid; Dru | 2011 |
Prevention of mucositis in irradiated head and neck cancer patients.
Topics: Ampicillin; Anti-Infective Agents; Ciprofloxacin; Clotrimazole; Drug Combinations; Gastrointestinal | 1996 |
4 other studies available for ciprofloxacin and Head and Neck Neoplasms
| Article | Year |
|---|---|
[Rabbit fever--a neck tumor].
Topics: Animal Husbandry; Animals; Anti-Infective Agents; Ciprofloxacin; Diagnosis, Differential; Francisell | 2010 |
Increased cytotoxicity of squamous cell carcinoma of the head and neck by combining cisplatin with VP-16 and ciprofloxacin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Survival; Ciprofloxac | 1993 |
Actinomyces and actinobacillus actinomycetemcomitans-Actinomyces-associated lymphadenopathy mimicking lymphoma.
Topics: Actinobacillus; Actinobacillus Infections; Actinomyces; Actinomycosis; Adult; Ampicillin; Anti-Infec | 2000 |
Reduction of oral flora with ciprofloxacin in healthy volunteers.
Topics: Adolescent; Adult; Aged; Bacteria; Bacterial Infections; Ciprofloxacin; Head and Neck Neoplasms; Hum | 1988 |