ciprofloxacin has been researched along with Endotoxemia in 7 studies
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.
ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this proof-of-principle intervention trial, 16 healthy young men received either no treatment or broad-spectrum antibiotics (ciprofloxacin, vancomycin and metronidazole) for 7 days, after which all were administered lipopolysaccharide intravenously to induce a transient sepsis-like syndrome." | 5.24 | Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study. ( Belzer, C; Cranendonk, DR; de Vos, AF; de Vos, WM; Lankelma, JM; van der Poll, T; Wiersinga, WJ, 2017) |
| "In cirrhotic rats, ciprofloxacin suppressed endotoxemia and the hepatic endocannabinoid system thus ameliorating hyperdynamic circulation and decreased intrahepatic resistance by preventing hepatic fibrogenesis and endothelial dysfunction." | 3.77 | The relationship between endotoxemia and hepatic endocannabinoids in cirrhotic rats with portal hypertension. ( Huang, CM; Huang, YT; Lee, FY; Lee, SD; Lin, HC; Liu, TT; Tsai, TH; Yang, YY, 2011) |
| " Transient adverse effects of mild to moderate severity included agitation, excitement and muscle fasciculation, followed by lethargy, cutaneous edema and loss of appetite developed in all seven horses after i." | 1.36 | Pharmacokinetics and toxicity of ciprofloxacin in adult horses. ( Edman, J; Papich, MG; Pusterla, N; Wiebe, VJ; Wilson, WD; Yamarik, TA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lankelma, JM | 1 |
| Cranendonk, DR | 1 |
| Belzer, C | 1 |
| de Vos, AF | 1 |
| de Vos, WM | 1 |
| van der Poll, T | 1 |
| Wiersinga, WJ | 1 |
| Ngure, R | 1 |
| Burke, J | 1 |
| Eckersall, PD | 1 |
| Jennings, FW | 1 |
| Mbai, FN | 1 |
| Murray, M | 1 |
| Yamarik, TA | 1 |
| Wilson, WD | 1 |
| Wiebe, VJ | 1 |
| Pusterla, N | 1 |
| Edman, J | 1 |
| Papich, MG | 1 |
| Lin, HC | 1 |
| Yang, YY | 1 |
| Tsai, TH | 1 |
| Huang, CM | 1 |
| Huang, YT | 1 |
| Lee, FY | 1 |
| Liu, TT | 1 |
| Lee, SD | 1 |
| Fukui, H | 1 |
| Schulze, C | 1 |
| Oesser, S | 1 |
| Hein, H | 1 |
| Seifert, J | 1 |
| Purswani, MU | 1 |
| Eckert, SJ | 1 |
| Arora, HK | 1 |
| Noel, GJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia[NCT02127749] | 16 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for ciprofloxacin and Endotoxemia
| Article | Year |
|---|---|
Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study.
Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Drug Monitoring; Endotoxemia; Escherichia coli; Gastroi | 2017 |
6 other studies available for ciprofloxacin and Endotoxemia
| Article | Year |
|---|---|
Secondary bacterial infection in plasma endotoxin levels and the acute-phase response of mice infected with Trypanosoma brucei brucei.
Topics: Acute-Phase Reaction; Animals; Anti-Bacterial Agents; Bacterial Infections; Ciprofloxacin; Endotoxem | 2009 |
Pharmacokinetics and toxicity of ciprofloxacin in adult horses.
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Colitis; Endotoxemia; Female; Half-Life; Horse Diseas | 2010 |
The relationship between endotoxemia and hepatic endocannabinoids in cirrhotic rats with portal hypertension.
Topics: Animals; Anti-Bacterial Agents; Cannabinoid Receptor Modulators; Ciprofloxacin; Disease Models, Anim | 2011 |
How leaky gut and endotoxemia induce bacterial infection in cirrhosis and gastrointestinal hemorrhage?
Topics: Administration, Oral; Anti-Bacterial Agents; Bacterial Infections; Bacterial Translocation; Cephalos | 2011 |
Risk of endotoxemia during the initial phase of gut decontamination with antimicrobial agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Translocation; Blood Pressure; Cipr | 2001 |
Effect of ciprofloxacin on lethal and sublethal challenge with endotoxin and on early cytokine responses in a murine in vivo model.
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Cytokines; Disease Models, Animal; Dose-Response Rela | 2002 |