Page last updated: 2024-10-25

ciprofloxacin and Bacterial Pneumonia

ciprofloxacin has been researched along with Bacterial Pneumonia in 103 studies

Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.
ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.

Research Excerpts

ExcerptRelevanceReference
"The authors determined the pharmacokinetic parameters of a new immediate-release ciprofloxacin suspension in tube-fed intensive care patients with bacterial pneumonia, to compare two dosage regimens: 500 mg b."9.10Pharmacokinetic parameters of ciprofloxacin (500 mg/5 mL) oral suspension in critically ill patients with severe bacterial pneumonia: a comparison of two dosages. ( Allaouchiche, B; Boselli, E; Breilh, D; Chassard, D; Debon, R; Duflo, F; Saux, MC, 2002)
"After enrollment in a Food and Drug Administration approved protocol, the pharmacokinetic profiles of ciprofloxacin (CIP) administered to 18 children with cystic fibrosis (ages 5 to 17 years) were studied at steady state after sequentially administered intravenous (10 mg/kg every 8 h) and oral (20 mg/kg every 12 h) doses."9.08Pharmacokinetic disposition of sequential intravenous/oral ciprofloxacin in pediatric cystic fibrosis patients with acute pulmonary exacerbation. ( Church, DA; Echols, RM; Kuhn, RJ; Lettieri, JT; Miles, MV; Rubio, TT, 1997)
" ceftazidime/tobramycin in hospitalized pediatric cystic fibrosis patients with an acute pulmonary exacerbation associated with P."9.08Sequential ciprofloxacin therapy in pediatric cystic fibrosis: comparative study vs. ceftazidime/tobramycin in the treatment of acute pulmonary exacerbations. The Cystic Fibrosis Study Group. ( Church, DA; Echols, RM; Haverstock, DC; Kanga, JF; Kuhn, RJ; Painter, BG; Perroncel, RY; Rubio, TT; Spohn, WA; Stevens, JC; Thurberg, BE, 1997)
"We report a rare case of torsade de pointes, a polymorphic ventricular tachycardia associated with QT interval prolongation, caused by intravenous ciprofloxacin given for pneumonia in a 22-year-old healthy Marine."7.73Ciprofloxacin-induced torsade de pointes. ( Flanagan, MC; Haigney, MC; Mitchell, ES, 2006)
"The efficacies of gatifloxacin and moxifloxacin were assessed in a BALB/c mouse model of pneumonic tularemia and compared with the efficacy of ciprofloxacin."7.73Treatment of murine pneumonic Francisella tularensis infection with gatifloxacin, moxifloxacin or ciprofloxacin. ( Brooks, TJ; Lever, MS; Piercy, T; Simpson, AJ; Steward, J, 2006)
"This study was performed to examine the ability of ciprofloxacin (CPFX) to suppress the inflammation associated with lipopolysaccharide (LPS) and an inflammatory cytokine in gram-negative bacterial pneumonia."7.73Effect of ciprofloxacin on levels of lipopolysaccharide and cytokines in experimentally induced gram-negative bacterial pneumonia in mice. ( Kamiya, S; Kawai, S; Kobayashi, O; Nakagawa, T; Sakayori, S, 2006)
"To assess the value of prophylactic ciprofloxacin in reducing the incidence of neutropenic fever in men receiving intensive chemotherapy for germ cell tumours, we reviewed the case notes of 88 consecutive patients treated between January 1986 and December 1992."7.69Chemotherapy for germ cell tumours: prophylactic ciprofloxacin reduces the incidence of neutropenic fever. ( Counsell, R; Pratt, J; Williams, MV, 1994)
" The purpose of this prospective study was to (i) develop a pharmacokinetic (PK) model to be utilized for therapeutic drug monitoring (TDM) of ciprofloxacin and (ii) evaluate current ciprofloxacin dosing regimens for pneumonias in cystic fibrosis (CF) patients."6.70Population pharmacokinetics and use of Monte Carlo simulation to evaluate currently recommended dosing regimens of ciprofloxacin in adult patients with cystic fibrosis. ( Aminimanizani, A; Beringer, PM; Gill, MA; Jelliffe, R; Louie, SG; Montgomery, MJ; Shapiro, BJ, 2001)
" Mild or moderate adverse events (AE) occurred in 13/153 (8."6.69Efficacy and safety of high dose intravenous ciprofloxacin in the treatment of bacterial pneumonia. Italian Ciprofloxacin Study Group. ( Curti, ME; Mazzei, T; Periti, P, 1998)
"The authors determined the pharmacokinetic parameters of a new immediate-release ciprofloxacin suspension in tube-fed intensive care patients with bacterial pneumonia, to compare two dosage regimens: 500 mg b."5.10Pharmacokinetic parameters of ciprofloxacin (500 mg/5 mL) oral suspension in critically ill patients with severe bacterial pneumonia: a comparison of two dosages. ( Allaouchiche, B; Boselli, E; Breilh, D; Chassard, D; Debon, R; Duflo, F; Saux, MC, 2002)
"The efficacy of ciprofloxacin was studied in the treatment of 22 patients with hospital infection of the lower respiratory tract: 10 patients with nosocomial pneumonia, 8 with exacerbation of chronic obstructive bronchitis, 3 with exacerbation of mucoviscidosis and 1 with bronchiectasis."5.08[Effectiveness of ciprofloxacin in the treatment of hospital infections of the lower respiratory tract]. ( Avdeev, SN; Belevskiĭ, AS; Chuchalin, AG; Novikov, IuK, 1997)
"After enrollment in a Food and Drug Administration approved protocol, the pharmacokinetic profiles of ciprofloxacin (CIP) administered to 18 children with cystic fibrosis (ages 5 to 17 years) were studied at steady state after sequentially administered intravenous (10 mg/kg every 8 h) and oral (20 mg/kg every 12 h) doses."5.08Pharmacokinetic disposition of sequential intravenous/oral ciprofloxacin in pediatric cystic fibrosis patients with acute pulmonary exacerbation. ( Church, DA; Echols, RM; Kuhn, RJ; Lettieri, JT; Miles, MV; Rubio, TT, 1997)
" ceftazidime/tobramycin in hospitalized pediatric cystic fibrosis patients with an acute pulmonary exacerbation associated with P."5.08Sequential ciprofloxacin therapy in pediatric cystic fibrosis: comparative study vs. ceftazidime/tobramycin in the treatment of acute pulmonary exacerbations. The Cystic Fibrosis Study Group. ( Church, DA; Echols, RM; Haverstock, DC; Kanga, JF; Kuhn, RJ; Painter, BG; Perroncel, RY; Rubio, TT; Spohn, WA; Stevens, JC; Thurberg, BE, 1997)
" For primary prophylaxis, short-term antibiotic treatment (oral norfloxacin or ciprofloxacin) is indicated in cirrhotic patients (with or without ascites) admitted with gastrointestinal haemorrhage (variceal or non-variceal)."4.84[Bacterial infections in liver cirrhosis]. ( Farkas, A; Papp, M; Tornai, I; Udvardy, M, 2007)
"We report a rare case of torsade de pointes, a polymorphic ventricular tachycardia associated with QT interval prolongation, caused by intravenous ciprofloxacin given for pneumonia in a 22-year-old healthy Marine."3.73Ciprofloxacin-induced torsade de pointes. ( Flanagan, MC; Haigney, MC; Mitchell, ES, 2006)
"The efficacies of gatifloxacin and moxifloxacin were assessed in a BALB/c mouse model of pneumonic tularemia and compared with the efficacy of ciprofloxacin."3.73Treatment of murine pneumonic Francisella tularensis infection with gatifloxacin, moxifloxacin or ciprofloxacin. ( Brooks, TJ; Lever, MS; Piercy, T; Simpson, AJ; Steward, J, 2006)
"This study was performed to examine the ability of ciprofloxacin (CPFX) to suppress the inflammation associated with lipopolysaccharide (LPS) and an inflammatory cytokine in gram-negative bacterial pneumonia."3.73Effect of ciprofloxacin on levels of lipopolysaccharide and cytokines in experimentally induced gram-negative bacterial pneumonia in mice. ( Kamiya, S; Kawai, S; Kobayashi, O; Nakagawa, T; Sakayori, S, 2006)
"To assess the value of prophylactic ciprofloxacin in reducing the incidence of neutropenic fever in men receiving intensive chemotherapy for germ cell tumours, we reviewed the case notes of 88 consecutive patients treated between January 1986 and December 1992."3.69Chemotherapy for germ cell tumours: prophylactic ciprofloxacin reduces the incidence of neutropenic fever. ( Counsell, R; Pratt, J; Williams, MV, 1994)
"The efficacy and safety of Cifran OD, a new dosage form of ciprofloxacin with prolonged action were studied in the treatment of patients with bronchopulmonary infection (n=23)."2.71[Therapy of bronchopulmonary infection in smokers]. ( Orlov, VA; Shenderovich, VA; Smirnova, LB; Sokolova, VI; Surkova, IuV, 2004)
" The purpose of this prospective study was to (i) develop a pharmacokinetic (PK) model to be utilized for therapeutic drug monitoring (TDM) of ciprofloxacin and (ii) evaluate current ciprofloxacin dosing regimens for pneumonias in cystic fibrosis (CF) patients."2.70Population pharmacokinetics and use of Monte Carlo simulation to evaluate currently recommended dosing regimens of ciprofloxacin in adult patients with cystic fibrosis. ( Aminimanizani, A; Beringer, PM; Gill, MA; Jelliffe, R; Louie, SG; Montgomery, MJ; Shapiro, BJ, 2001)
" Mild or moderate adverse events (AE) occurred in 13/153 (8."2.69Efficacy and safety of high dose intravenous ciprofloxacin in the treatment of bacterial pneumonia. Italian Ciprofloxacin Study Group. ( Curti, ME; Mazzei, T; Periti, P, 1998)
"These superinfections occurred in mechanically ventilated, postoperative cardiac surgical patients after 13 days in the intensive care unit (ICU)."2.69Outbreaks of Staphylococcus aureus infections during treatment of late onset pneumonia with ciprofloxacin in a prospective, randomized study. ( Brase, R; Heimesaat, M; Kljucar, S; Manhold, C; Timm, J; von Pritzbuer, E; von Rolbicki, U, 1998)
"ciprofloxacin was at least equivalent to imipenem in terms of bacteriological eradication and clinical response."2.69Clinical and economic evaluation of subsequent infection following intravenous ciprofloxacin or imipenem therapy in hospitalized patients with severe pneumonia. ( Caldwell, JW; Johnson, RH; Singh, S, 1999)
" The once daily dosage of fleroxacin [400 mg once daily intravenously (i."2.68Quinolones in everyday clinical practice: respiratory tract infections and nosocomial pneumonia. ( Marklein, G, 1996)
"The lower respiratory tract infections caused by E."2.68[The clinical manifestation and drug sensitive tests of lower respiratory tract infection by enterobacter cloacae. The Pulmonary Infection and Fibrosis Group, Thoracic Society Shanghai Medical Association]. ( , 1997)
"For levofloxacin-treated CAP patients with P."2.43Pneumonia due to Pseudomonas aeruginosa: the levofloxacin clinical trials experience. ( Davis, NB; Kahn, J; Tennenberg, AM; Wu, SC, 2006)
"Anthrax is a zoonotic disease caused by Bacillus anthracis."2.40[Pulmonary anthrax]. ( Debord, T; Vidal, D, 1998)
"The aims of the study were to develop a population pharmacokinetic model of ciprofloxacin (CPX) in the elderly patients and to examine the impact of patient-dependent variables on pharmacokinetic parameter values of this drug."1.40Population pharmacokinetic analysis of ciprofloxacin in the elderly patients with lower respiratory tract infections. ( Cios, A; Grodzicki, T; Szymura-Oleksiak, J; Wyska, E, 2014)
"Tularemia is a worldwide zoonosis caused by Francisella tularensis."1.38Cavitary pneumonia and skin lesions. ( Alvela-Suárez, L; Belhassen-Garcia, M; Carpio-Pérez, A; Fraile-Alonso, Mdel C; Pardo-Lledias, J; Velasco-Tirado, V, 2012)
"Moxifloxacin is a respiratory fluoroquinolone with a community acquired pneumonia indication."1.35Fluoroquinolone resistance during 2000-2005: an observational study. ( Lindsell, C; Ryan, RJ; Sheehan, P, 2008)
"The present case showed once again that nocardiosis is not limited to patients with immunodeficiencies."1.34[Pulmonary nocardiosis with trimethoprime/sulphamethoxazole-resistant Nocardia paucivorans in a patient with no signs of immunosuppression]. ( Eder, W; Häussinger, K; Hoffmann, H; King, B; Markus, A; Morresi-Hauff, A; Philipp, E; Steffen, H; Weber, N; Wegerle, S, 2007)
" The probabilities of each drug and dosing regimen in achieving pharmacodynamic targets were calculated."1.33Pharmacodynamics of antimicrobials for the empirical treatment of nosocomial pneumonia: a report from the OPTAMA Program. ( Kuti, JL; Nicolau, DP; Sun, HK, 2005)
"The incidence of nosocomial infections in patients after ICAAS fell from 78."1.32Prevention of nosocomial lower respiratory tract infections in patients after intracranial artery aneurysm surgery with a short course of antimicrobials. ( Beovic, B; Bosnjak, R; Cizman, M; Hergouth-Krizan, V; Matos, B; Mueller-Premru, M; Seme, K, 2003)
" Dosing regimens were chosen to obtain a comparable area under the concentration-time curve from 0 to infinity/MIC ratio of 27."1.31Differential selection of multidrug efflux mutants by trovafloxacin and ciprofloxacin in an experimental model of Pseudomonas aeruginosa acute pneumonia in rats. ( Carbon, C; Chau, F; Dautrey, S; Faurisson, F; Join-Lambert, OF; Köhler, T; Michéa-Hamzehpour, M; Pechère, J; Vissuzaine, C, 2001)
"Ciprofloxacin was applied in four different diffusion sources (1, 3, 10 and 30 microg) on a single strip, the M-strip, and used."1.31MIC determination of fusidic acid and of ciprofloxacin using multidisk diffusion tests. ( Kronvall, G, 2000)

Research

Studies (103)

TimeframeStudies, this research(%)All Research%
pre-19904 (3.88)18.7374
1990's33 (32.04)18.2507
2000's48 (46.60)29.6817
2010's15 (14.56)24.3611
2020's3 (2.91)2.80

Authors

AuthorsStudies
Gou, S1
Li, B1
Ouyang, X1
Ba, Z1
Zhong, C1
Zhang, T1
Chang, L1
Zhu, Y1
Zhang, J1
Zhu, N1
Zhang, Y1
Liu, H1
Ni, J1
Lan, J1
Ma, Q1
Li, J1
Shao, C1
Shan, A1
Begbey, A1
Guppy, JH1
Mohan, C1
Webster, S1
Duhil de Bénazé, G1
Desselas, E1
Houdouin, V1
Mariani-Kurkdjian, P1
Kheniche, A1
Dauger, S1
Poncelet, G1
Gaschignard, J1
Levy, M1
Alhabshan, RN1
Mansour, TN1
Harent, S1
Vuotto, F1
Wallet, F1
Flateau, C1
Chopin, MC1
Faure, K1
Guery, B2
Domínguez-Herrera, J1
Velasco, C1
Docobo-Pérez, F2
Rodríguez-Martínez, JM2
López-Rojas, R1
Briales, A1
Pichardo, C2
Díaz-de-Alba, P1
Rodríguez-Baño, J1
Pascual, A2
Pachón, J2
Sun, Z1
Shi, J1
Liu, C1
Jin, Y1
Li, K1
Chen, R1
Jin, S1
Wu, W1
Cios, A1
Wyska, E1
Szymura-Oleksiak, J1
Grodzicki, T1
Wang, JY1
Lee, CH1
Yu, MC1
Lee, MC1
Lee, LN2
Wang, JT1
Marquart, JD1
Clifford, R1
Yayan, J1
Ghebremedhin, B1
Rasche, K1
García, I1
Pachón-Ibañez, ME1
Martínez-Martínez, L1
Chono, S1
Tanino, T1
Seki, T1
Morimoto, K1
Turtle, L1
Wey, E1
James, E1
Oztürk, O1
Akçam, Z1
Sahin, U1
Bircan, A1
Akkaya, A1
Yayli, G1
Nakamura, S1
Yanagihara, K2
Araki, N1
Morinaga, Y1
Izumikawa, K1
Seki, M1
Kakeya, H2
Yamamoto, Y1
Kamihira, S1
Kohno, S2
Sugimoto, S1
Yoshimura, Y1
Tachikawa, N1
Belhassen-Garcia, M1
Velasco-Tirado, V1
Alvela-Suárez, L1
Fraile-Alonso, Mdel C1
Carpio-Pérez, A1
Pardo-Lledias, J1
Papanicolas, LE1
Holds, JM1
Bak, N1
Issaoui, S1
Maoulainine, FM1
Elidrissi, NS1
Sorra, N1
Chabaa, L1
Aboussad, A1
Durdu, B1
Durdu, Y1
Güleç, N1
Islim, F1
Biçer, M1
Hall, RL1
Partridge, R1
Venkatraman, N1
Wiselka, M1
Breck, RW1
Vitkauskiene, A1
Sakalauskas, R1
Dudzevicius, V1
West, M1
Boulanger, BR1
Fogarty, C1
Tennenberg, A1
Wiesinger, B1
Oross, M1
Wu, SC2
Fowler, C1
Morgan, N1
Kahn, JB1
Tarr, PE1
Stock, F1
Cooke, RH1
Fedorko, DP1
Lucey, DR1
Beovic, B1
Matos, B1
Bosnjak, R1
Seme, K1
Mueller-Premru, M1
Hergouth-Krizan, V1
Cizman, M1
Finsterer, J1
Kotzailias, N1
Illinger, J1
Mohammedi, I1
Martin, O1
Argaud, L1
St Denis, M1
Robert, D1
Fujita, M1
Ishibashi, T1
Hara, N1
Yoshida, M1
Yamada, H1
Luyt, CE1
Chastre, J1
Fagon, JY1
Sokolova, VI1
Orlov, VA1
Surkova, IuV1
Shenderovich, VA1
Smirnova, LB1
Shorr, AF1
Susla, GB1
Kollef, MH2
Okimoto, N3
Yamato, K3
Honda, Y3
Kurihara, T3
Osaki, K3
Asaoka, N3
Fujita, K1
Ohba, H1
Cantón, R1
Cobos, N1
de Gracia, J1
Baquero, F1
Honorato, J1
Gartner, S1
Alvarez, A1
Salcedo, A1
Oliver, A1
García-Quetglas, E1
Sun, HK1
Kuti, JL1
Nicolau, DP1
Bassaris, HP1
Chrysanthopoulos, CJ1
Skouelis, AT1
Starakis, JC1
Brückner, O1
Trautmann, M1
Engelhardt, D1
Ruckdeschel, G1
Beuscart, C1
Leroy, O1
Chidiac, C2
Houriez, S1
Caillaux, M1
Beaucaire, G2
Mouton, Y1
Flanagan, MC1
Mitchell, ES1
Haigney, MC1
Mouzopoulos, G1
Stamatakos, M1
Vasiliadis, G1
Skandalakis, P1
Allan, RC1
Moghal, M1
Wijesuriya, V1
Melzer, M1
Steward, J1
Piercy, T1
Lever, MS1
Simpson, AJ1
Brooks, TJ1
Tennenberg, AM1
Davis, NB1
Kahn, J1
Kawai, S1
Nakagawa, T1
Sakayori, S1
Kobayashi, O1
Kamiya, S1
Wang, CY1
Chuang, YM1
Teng, LJ1
Yang, PC1
Kuo, SH1
Hsueh, PR1
Wegerle, S1
Markus, A1
Weber, N1
Steffen, H1
King, B1
Eder, W1
Philipp, E1
Morresi-Hauff, A1
Häussinger, K1
Hoffmann, H1
Papp, M1
Farkas, A1
Udvardy, M1
Tornai, I1
Leone, S1
Fiore, M1
Felaco, FM1
Esposito, S1
Rikimaru, T1
Yonemitu, J1
Koga, T1
Shimada, A1
Yokoyama, T1
Kawayama, T1
Kamimura, T1
Aizawa, H1
Nanba, F2
Kibayashi, T2
Kishimoto, M2
Tsifansky, MD1
Yeo, Y1
Evgenov, OV1
Bellas, E1
Benjamin, J1
Kohane, DS1
Ryan, RJ1
Lindsell, C1
Sheehan, P1
Yu, L1
Chen, YL1
Zhu, YJ1
Wang, JX1
Liu, YN1
Dunn, M1
Wunderink, RG1
Roussel-Delvallez, M1
Lucena, MI1
Marquez, M1
Velasco, JL1
Andrade, RJ1
Ciofu, O1
Giwercman, B1
Pedersen, SS1
Høiby, N1
Wood, CA1
Counsell, R1
Pratt, J1
Williams, MV1
Siami, GA1
Wilkins, WT1
Bess, DT1
Christman, JW1
Asnis, DS1
Bresciani, AR1
Cohn, M1
Heurlin, N1
Bergström, SE1
Winiarski, J1
Ringden, O1
Ljungman, P1
Lönnqvist, B1
Andersson, J1
Alemany Francés, ML1
Romero Candeira, S1
Fernández Aracil, C1
Masuda, N1
Takahashi, Y1
Otsuki, M1
Ibuki, E1
Miyoshi, H1
Nishino, T1
Hachem, R1
Raad, I1
Rolston, KV1
Whimbey, E1
Katz, R1
Tarrand, J1
Libshitz, H1
Marklein, G1
Church, DA2
Kanga, JF1
Kuhn, RJ2
Rubio, TT2
Spohn, WA1
Stevens, JC1
Painter, BG1
Thurberg, BE1
Haverstock, DC1
Perroncel, RY1
Echols, RM2
Miles, MV1
Lettieri, JT1
Macías, J1
Pineda, JA1
Borderas, F1
Gallardo, JA1
Delgado, J1
Leal, M1
Sánchez-Quijano, A1
Lissen, E1
Bloch, KC1
Nadarajah, R1
Jacobs, R1
Hyatt, JM1
Luzier, AB1
Forrest, A1
Ballow, CH1
Schentag, JJ1
Chuchalin, AG1
Novikov, IuK1
Avdeev, SN1
Belevskiĭ, AS1
Vlasnik, J1
Sharpless, L1
Pasque, C1
Murphy, D1
Fraser, V1
Baraia-Etxaburu, J1
Malero, P1
Unzaga, MJ1
Teira, R1
Muñoz, J1
Cisterna, R1
Santamaría, JM1
Ernst, A1
Gordon, FD1
Hayek, J1
Silvestri, RC1
Koziel, H1
Periti, P1
Mazzei, T1
Curti, ME1
Manhold, C1
von Rolbicki, U1
Brase, R1
Timm, J1
von Pritzbuer, E1
Heimesaat, M1
Kljucar, S1
Debord, T1
Vidal, D1
Krumpe, PE1
Cohn, S1
Garreltes, J1
Ramirez, J1
Coulter, H1
Haverstock, D1
Echols, R1
Caldwell, JW1
Singh, S1
Johnson, RH1
Vikram, HR1
Shore, ET1
Venkatesh, PR1
Sefton, AM1
Maskell, JP1
Williams, JD1
Robert, R1
Grollier, G1
Doré, P1
Hira, M1
Ferrand, E1
Fauchère, JL1
Thadepalli, H1
Reddy, U1
Chuah, SK1
Hanna, N1
Rana, G1
Gollapudi, S1
Breen, D1
Schonell, M1
Au, T1
Reiss-Levy, E1
Pillai, A1
Mitchell, JL1
Hill, SL1
Stockley, RA1
Gruson, D1
Hilbert, G1
Vargas, F1
Valentino, R1
Bebear, C2
Allery, A1
Gbikpi-Benissan, G1
Cardinaud, JP1
Torres, A1
Bauer, TT1
León-Gil, C1
Castillo, F1
Alvarez-Lerma, F1
Martínez-Pellús, A1
Leal-Noval, SR1
Nadal, P1
Palomar, M1
Blanquer, J1
Ros, F1
Join-Lambert, OF1
Michéa-Hamzehpour, M1
Köhler, T1
Chau, F1
Faurisson, F1
Dautrey, S1
Vissuzaine, C1
Carbon, C1
Pechère, J1
Costa, SF1
Newbaer, M1
Santos, CR1
Basso, M1
Soares, I1
Levin, AS1
Kronvall, G1
Bakker-Woudenberg, IA1
ten Kate, MT1
Guo, L1
Working, P1
Mouton, JW1
Montgomery, MJ1
Beringer, PM1
Aminimanizani, A1
Louie, SG1
Shapiro, BJ1
Jelliffe, R1
Gill, MA1
Kaneko, Y1
Kuroki, M1
Ohi, H1
Miyazaki, Y1
Higashiyama, Y1
Hirakata, Y1
Tomono, K1
Kadota, JI1
Biechy, M1
Gálvez, E1
Salgueró, E1
Báñez, F1
Debon, R1
Breilh, D1
Boselli, E1
Saux, MC1
Duflo, F1
Chassard, D1
Allaouchiche, B1
Trübel, HK1
Meyer, HG1
Jahn, B1
Knuf, M1
Kamin, W1
Huth, RG1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter, Randomized, Open Label Study to Compare the Safety and Efficacy of Levofloxacin With That of Imipenem/Cilastatin in the Treatment of Nosocomial Pneumonia[NCT00236834]Phase 3438 participants (Actual)Interventional1997-12-31Completed
Impact of Aggressive Empiric Antibiotic Therapy and Duration of Therapy on the Emergence of Antimicrobial Resistance During the Treatment of Hospitalized Subjects With Pneumonia Requiring Mechanical Ventilation[NCT01570192]Phase 243 participants (Actual)Interventional2010-09-30Terminated (stopped due to NIAID terminated the study due to low subject enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinical Response

Percentage of patients with successful responses by efficacy endpoint, treatment group and population (n/N) (NCT01570192)
Timeframe: End of treatment - up to 28 days after enrollment

InterventionParticipants (Count of Participants)
ME Group - Meropenem Plus Aminoglycoside2
MEGroup - Meropenem Only8
m-MITT Group - Meropenem Plus Aminoglycoside2
m-MITT Group - Meropenem Only8

Clinical Response in Subjects Who Received Prior Antibiotics

Percentage of patients with successful responses by efficacy endpoint, treatment group and population (n/N) (NCT01570192)
Timeframe: End of treatment - up to 28 days after enrollment

InterventionParticipants (Count of Participants)
ME Group - Meropenem Plus Aminoglycoside1
ME Group - Meropenem Only2
m-MITT Group - Meropenem Plus Aminoglycoside1
m-MITT Group - Meropenem Only2

Mortality

Percentage of patients who died by efficacy endpoint, treatment group and population (n/N) (NCT01570192)
Timeframe: 14 days

InterventionParticipants (Count of Participants)
ME Group - Meropenem Plus Aminoglycoside1
ME Group - Meropenem Only0
m-MITT Group - Meropenem Plus Aminoglycoside2
m-MITT Group - Meropenem Only2

Mortality

Percentage of patients who died by efficacy endpoint, treatment group and population (n/N) (NCT01570192)
Timeframe: 28 days

InterventionParticipants (Count of Participants)
ME Group - Meropenem Plus Aminoglycoside2
ME Group - Meropenem Only1
m-MITT Group - Meropenem Plus Aminoglycoside3
m-MITT Group - Meropenem Only3

Occurrence of Repeat Negative Cultures

Percentage of patients with successful responses by efficacy endpoint, treatment group and population (n/N) (NCT01570192)
Timeframe: Day 5/Early Extubation

InterventionParticipants (Count of Participants)
ME Group - Meropenem Plus Aminoglycoside3
ME Group - Meropenem Only6
m-MITT Group - Meropenem Plus Aminoglycoside3
m-MITT Group - Meropenem Only7

Overall Microbiologic Response

Percentage of patients with successful responses by efficacy endpoint, treatment group and population (n/N) (NCT01570192)
Timeframe: End of treatment - up to 28 days after enrollment

InterventionParticipants (Count of Participants)
ME Group - Meropenem Plus Aminoglycoside2
ME Group - Meropenem Only6
m-MITT Group - Meropenem Plus Aminoglycoside2
m-MITT Group - Meropenem Only7

Pretreatment Pathogen Response

Percentage of patients with successful responses by efficacy endpoint, treatment group and population (n/N) (NCT01570192)
Timeframe: End of treatment - up to 28 days after enrollment

InterventionParticipants (Count of Participants)
ME Group - Meropenem Plus Aminoglycoside3
ME Group - Meropenem Only9
m-MITT Group - Meropenem Plus Aminoglycoside3
m-MITT Group - Meropenem Only11

Suppression of the Emergence of Resistance in Other Gram-negative Pathogens

Percentage of patients with successful responses by efficacy endpoint, treatment group and population (n/N) (NCT01570192)
Timeframe: Day 5/Early Extubation

InterventionParticipants (Count of Participants)
ME Group - Meropenem Plus Aminoglycoside1
ME Group - Meropenem Only1
m-MITT Group - Meropenem Plus Aminoglycoside1
m-MITT Group - Meropenem Only2

Number of Participants With Suppression and Emergence of Resistance

The emergence of resistance is defined as a change of meropenem MIC or aminoglycoside MIC by two tube dilutions (fourfold) from baseline when assessed at the second BAL procedure on day 5/early extubation. Patients are evaluable for this endpoint IF they had baseline BAL and Day 5/early extubation and if they had positive cultures on baseline and Day/EE. (NCT01570192)
Timeframe: up to 28 days after enrollment

Interventionparticipants (Number)
suppression of emergence of resistanceemergence of resistance
I.V. Meropenem51

Reviews

10 reviews available for ciprofloxacin and Bacterial Pneumonia

ArticleYear
[A case of repeated upper gastrointestinal bleeding secondary to Legionella pneumonia].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 2011, Volume: 85, Issue:3

    Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Female; Gastrointestinal Hemorrhage; Humans; Legionnaire

2011
Quinolones for treatment of nosocomial pneumonia: a meta-analysis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Feb-15, Volume: 40 Suppl 2

    Topics: Anti-Infective Agents; Cilastatin; Ciprofloxacin; Cross Infection; Humans; Imipenem; Levofloxacin; M

2005
Antimicrobial therapy for pulmonary pathogenic colonisation and infection by Pseudomonas aeruginosa in cystic fibrosis patients.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2005, Volume: 11, Issue:9

    Topics: Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Bronchopneumonia; Cefepime; Ceftazidime; Cep

2005
Pneumonia due to Pseudomonas aeruginosa: the levofloxacin clinical trials experience.
    Current medical research and opinion, 2006, Volume: 22, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Community-Acquired Infections; Cross Infection; Drug Re

2006
[Bacterial infections in liver cirrhosis].
    Orvosi hetilap, 2007, Mar-04, Volume: 148, Issue:9

    Topics: Administration, Oral; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Ascites;

2007
[Early and timely therapy: when to interrupt antibiotic therapy in nosocomial acquired pneumonia?].
    Le infezioni in medicina, 2007, Volume: 15, Issue:1

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Cohort Studies; Cross Infection; Drug Administration Schedule;

2007
Ventilator-associated pneumonia caused by Pseudomonas infection.
    Clinics in chest medicine, 1995, Volume: 16, Issue:1

    Topics: Aminoglycosides; Anti-Bacterial Agents; beta-Lactam Resistance; Ciprofloxacin; Drug Resistance, Micr

1995
Chryseobacterium meningosepticum: an emerging pathogen among immunocompromised adults. Report of 6 cases and literature review.
    Medicine, 1997, Volume: 76, Issue:1

    Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotics, Antitubercular; Breast Neoplasms; Ciprofloxacin; Dr

1997
Lung abcess complicating Legionella micdadei pneumonia in an adult liver transplant recipient: case report and review.
    Transplantation, 1998, Jan-15, Volume: 65, Issue:1

    Topics: Adult; Anti-Infective Agents; Bronchoalveolar Lavage Fluid; Ciprofloxacin; Diabetes Mellitus, Type 2

1998
[Pulmonary anthrax].
    Revue de pneumologie clinique, 1998, Volume: 54, Issue:6

    Topics: Anthrax; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Doxycycline; Humans; Pneumonia

1998

Trials

19 trials available for ciprofloxacin and Bacterial Pneumonia

ArticleYear
Levofloxacin compared with imipenem/cilastatin followed by ciprofloxacin in adult patients with nosocomial pneumonia: a multicenter, prospective, randomized, open-label study.
    Clinical therapeutics, 2003, Volume: 25, Issue:2

    Topics: Adult; Aged; Anti-Bacterial Agents; Cilastatin; Ciprofloxacin; Cross Infection; Drug Therapy, Combin

2003
Value of the clinical pulmonary infection score for the identification and management of ventilator-associated pneumonia.
    Intensive care medicine, 2004, Volume: 30, Issue:5

    Topics: Algorithms; Anti-Infective Agents; Bronchoscopy; Ciprofloxacin; Female; France; Humans; Intensive Ca

2004
[Therapy of bronchopulmonary infection in smokers].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2004, Volume: 49, Issue:3

    Topics: Adult; Aged; Anti-Bacterial Agents; Bronchitis, Chronic; Ciprofloxacin; Colony Count, Microbial; Com

2004
Clinical effect of intravenous ciprofloxacin on hospital-acquired pneumonia.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2005, Volume: 11, Issue:1

    Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Ciprofloxacin; Cross Infection; Drug Resistance, Bac

2005
[Clinical effects of intravenous ciprofloxacin on community-acquired pneumonia with positive Immunocard Mycoplasma test results].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2008, Volume: 46, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Biomarkers; Ciprofloxacin; Community-Acquired

2008
Comparison of ciprofloxacin with imipenem in the treatment of severe pneumonia in hospitalised geriatric patients.
    Drugs, 1995, Volume: 49 Suppl 2

    Topics: Aged; Anti-Infective Agents; APACHE; Ciprofloxacin; Double-Blind Method; Hospitalization; Humans; Im

1995
Quinolones in everyday clinical practice: respiratory tract infections and nosocomial pneumonia.
    Chemotherapy, 1996, Volume: 42 Suppl 1

    Topics: Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Cross Infection; Double-Blind Method; Female; Fle

1996
Sequential ciprofloxacin therapy in pediatric cystic fibrosis: comparative study vs. ceftazidime/tobramycin in the treatment of acute pulmonary exacerbations. The Cystic Fibrosis Study Group.
    The Pediatric infectious disease journal, 1997, Volume: 16, Issue:1

    Topics: Acute Disease; Adolescent; Anti-Infective Agents; Arthralgia; Ceftazidime; Child; Child, Preschool;

1997
Pharmacokinetic disposition of sequential intravenous/oral ciprofloxacin in pediatric cystic fibrosis patients with acute pulmonary exacerbation.
    The Pediatric infectious disease journal, 1997, Volume: 16, Issue:1

    Topics: Acute Disease; Administration, Oral; Adolescent; Anti-Infective Agents; Biological Availability; Chi

1997
Modeling the response of pneumonia to antimicrobial therapy.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:6

    Topics: Anti-Infective Agents; Cefmenoxime; Ceftazidime; Cephalosporins; Ciprofloxacin; Clinical Trials as T

1997
[Effectiveness of ciprofloxacin in the treatment of hospital infections of the lower respiratory tract].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1997, Volume: 42, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Infective Agents; Bronchiectasis; Bronchitis; Ch

1997
Efficacy and safety of high dose intravenous ciprofloxacin in the treatment of bacterial pneumonia. Italian Ciprofloxacin Study Group.
    International journal of antimicrobial agents, 1998, Volume: 10, Issue:3

    Topics: Anti-Infective Agents; Ciprofloxacin; Female; Humans; Injections, Intravenous; Male; Pneumonia, Bact

1998
Outbreaks of Staphylococcus aureus infections during treatment of late onset pneumonia with ciprofloxacin in a prospective, randomized study.
    Intensive care medicine, 1998, Volume: 24, Issue:12

    Topics: Adult; Anti-Infective Agents; APACHE; Ceftazidime; Cephalosporins; Ciprofloxacin; Cross Infection; D

1998
[The clinical manifestation and drug sensitive tests of lower respiratory tract infection by enterobacter cloacae. The Pulmonary Infection and Fibrosis Group, Thoracic Society Shanghai Medical Association].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1997, Volume: 20, Issue:4

    Topics: Adult; Aged; Amikacin; Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Enterobacter

1997
Intravenous and oral mono- or combination-therapy in the treatment of severe infections: ciprofloxacin versus standard antibiotic therapy. Ciprofloxacin Study Group.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 43 Suppl A

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Aminoglycosides; Anti-Bacterial Ag

1999
Clinical and economic evaluation of subsequent infection following intravenous ciprofloxacin or imipenem therapy in hospitalized patients with severe pneumonia.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 43 Suppl A

    Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Cost-Benefit Analysis; Cross Infection; Double-Blind Me

1999
Treatment of severe nosocomial pneumonia: a prospective randomised comparison of intravenous ciprofloxacin with imipenem/cilastatin.
    Thorax, 2000, Volume: 55, Issue:12

    Topics: Adult; Aged; Anti-Infective Agents; Cilastatin; Ciprofloxacin; Cross Infection; Drug Resistance, Mic

2000
Population pharmacokinetics and use of Monte Carlo simulation to evaluate currently recommended dosing regimens of ciprofloxacin in adult patients with cystic fibrosis.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:12

    Topics: Adult; Anti-Infective Agents; Area Under Curve; Ciprofloxacin; Cystic Fibrosis; Female; Genotype; Ha

2001
Pharmacokinetic parameters of ciprofloxacin (500 mg/5 mL) oral suspension in critically ill patients with severe bacterial pneumonia: a comparison of two dosages.
    Journal of chemotherapy (Florence, Italy), 2002, Volume: 14, Issue:2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Biological Availability

2002

Other Studies

74 other studies available for ciprofloxacin and Bacterial Pneumonia

ArticleYear
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
    Journal of medicinal chemistry, 2021, 08-12, Volume: 64, Issue:15

    Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Antineoplastic Agents; Cell Line; C

2021
Expression of T9W in Pichia pastoris and the protective roles of T9W in ICR Mice.
    Biotechnology letters, 2020, Volume: 42, Issue:1

    Topics: Animals; Anti-Infective Agents; Antimicrobial Cationic Peptides; Ciprofloxacin; Disease Models, Anim

2020
    BMJ case reports, 2020, Dec-31, Volume: 13, Issue:12

    Topics: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Ciprofloxacin; Cl

2020
Pneumonia with pleural empyema caused by Salmonella Typhi in an immunocompetent child living in a non-endemic country.
    Paediatrics and international child health, 2018, Volume: 38, Issue:3

    Topics: Adolescent; Anti-Bacterial Agents; Ceftriaxone; Ciprofloxacin; Drainage; Empyema, Pleural; Female; F

2018
Association between oral fluoroquinolone use and lateral canthal tendon rupture: case report.
    Orbit (Amsterdam, Netherlands), 2018, Volume: 37, Issue:5

    Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Blepharoplasty; Ciprofloxacin; Conjunctival Dise

2018
[Nocardia pseudobrasiliensis pneumonia in a heart transplant recipient].
    Medecine et maladies infectieuses, 2013, Volume: 43, Issue:2

    Topics: Acetamides; Adult; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Heart Transplantation; Human

2013
Impact of qnrA1, qnrB1 and qnrS1 on the efficacy of ciprofloxacin and levofloxacin in an experimental pneumonia model caused by Escherichia coli with or without the GyrA mutation Ser83Leu.
    The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Disease Models, Animal; DNA Gyrase; Drug Resistance,

2013
PrtR homeostasis contributes to Pseudomonas aeruginosa pathogenesis and resistance against ciprofloxacin.
    Infection and immunity, 2014, Volume: 82, Issue:4

    Topics: Acute Disease; Animals; Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Bronchoalveolar Lavage

2014
Population pharmacokinetic analysis of ciprofloxacin in the elderly patients with lower respiratory tract infections.
    Experimental gerontology, 2014, Volume: 57

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Ciprofloxacin; Community-Acquired Infections;

2014
Fluoroquinolone use delays tuberculosis treatment despite immediate mycobacteriology study.
    The European respiratory journal, 2015, Volume: 46, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Ciprofloxacin; Community-Acquired Infections;

2015
Pneumonic tularemia presenting with a vesicular eruption.
    Cutis, 2015, Volume: 95, Issue:4

    Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Female; Francisella tularensis; Humans; Pneumonia, Bact

2015
No development of ciprofloxacin resistance in the Haemophilus species associated with pneumonia over a 10-year study.
    BMC infectious diseases, 2015, Nov-13, Volume: 15

    Topics: Aged; Anti-Bacterial Agents; Ciprofloxacin; Cross Infection; Drug Resistance, Multiple, Bacterial; F

2015
Activity of ciprofloxacin and levofloxacin in experimental pneumonia caused by Klebsiella pneumoniae deficient in porins, expressing active efflux and producing QnrA1.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2008, Volume: 14, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Ciprofloxacin; Colony Count, Microbial; Drug Res

2008
Efficient drug delivery to alveolar macrophages and lung epithelial lining fluid following pulmonary administration of liposomal ciprofloxacin in rats with pneumonia and estimation of its antibacterial effects.
    Drug development and industrial pharmacy, 2008, Volume: 34, Issue:10

    Topics: Animals; Anti-Infective Agents; Bacteria; Ciprofloxacin; Epithelium; Liposomes; Lung; Macrophages, A

2008
Severe pneumonia caused by ciprofloxacin resistant panton-valentine leukocidin producing community acquired meticillin resistant Staphylococcus aureus.
    The Journal of infection, 2009, Volume: 58, Issue:1

    Topics: Aged, 80 and over; Anti-Bacterial Agents; Bacterial Toxins; Ciprofloxacin; Community-Acquired Infect

2009
[A rare agent of pneumonia: Brucella melitensis].
    Tuberkuloz ve toraks, 2008, Volume: 56, Issue:4

    Topics: Anti-Infective Agents; Brucella melitensis; Brucellosis; Ciprofloxacin; Cough; Diagnosis, Differenti

2008
In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube.
    International journal of antimicrobial agents, 2009, Volume: 34, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Bronchioles; Ciprofloxacin; Disease Models, Animal; Fluoroquinolones

2009
Cavitary pneumonia and skin lesions.
    Respiratory care, 2012, Volume: 57, Issue:3

    Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Ciprofloxacin; Female; H

2012
Meningitis and pneumonitis caused by pet rodents.
    The Medical journal of Australia, 2012, Feb-20, Volume: 196, Issue:3

    Topics: Adult; Animals; Anti-Bacterial Agents; C-Reactive Protein; Ceftriaxone; Ciprofloxacin; Female; Fusob

2012
[Neonatal infection with Stenotrophomonas maltophilia (2 case studies)].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2012, Volume: 19, Issue:4

    Topics: Amikacin; Anti-Bacterial Agents; Brain Abscess; Chloramphenicol; Ciprofloxacin; Cross Infection; Dru

2012
[A rare cause of pneumonia: Shewanella putrefaciens].
    Mikrobiyoloji bulteni, 2012, Volume: 46, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Bronchiectasis; Ceftazidime; Ceftriaxone; Cipro

2012
Invasive non-typhoidal salmonella infection with multifocal seeding in an immunocompetent host: an emerging disease in the developed world.
    BMJ case reports, 2013, Jan-30, Volume: 2013

    Topics: Abscess; Anti-Bacterial Agents; Ceftriaxone; Ciprofloxacin; Communicable Diseases, Emerging; Diagnos

2013
"Ciprofloxacin: a warning for clinicians".
    Connecticut medicine, 2002, Volume: 66, Issue:10

    Topics: Achilles Tendon; Anti-Infective Agents; Ciprofloxacin; Haemophilus Infections; Haemophilus influenza

2002
[The impact of antibiotic use on hospital-acquired pneumonia: data of etiology tests].
    Medicina (Kaunas, Lithuania), 2003, Volume: 39, Issue:3

    Topics: Acinetobacter; Acinetobacter Infections; Amikacin; Ampicillin; Anti-Bacterial Agents; Anti-Infective

2003
Multidrug-resistant Corynebacterium striatum pneumonia in a heart transplant recipient.
    Transplant infectious disease : an official journal of the Transplantation Society, 2003, Volume: 5, Issue:1

    Topics: Amphotericin B; Ciprofloxacin; Corynebacterium; Corynebacterium Infections; Drug Resistance, Multipl

2003
Prevention of nosocomial lower respiratory tract infections in patients after intracranial artery aneurysm surgery with a short course of antimicrobials.
    International journal of antimicrobial agents, 2003, Volume: 22, Issue:1

    Topics: Anti-Infective Agents; Ciprofloxacin; Cross Infection; Female; Humans; Intracranial Aneurysm; Male;

2003
Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.
    Platelets, 2003, Volume: 14, Issue:5

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Therapy, Combination; Humans; Male; Middle Aged; Penicill

2003
[Community-acquired Pseudomonas aeruginosa bacteremic pneumonia in a "healthy" subject].
    Presse medicale (Paris, France : 1983), 2003, Jul-12, Volume: 32, Issue:24

    Topics: Adult; Anti-Infective Agents; Bacteremia; Bronchoalveolar Lavage; Ciprofloxacin; Community-Acquired

2003
[The effect of intravenous ciprofloxacin for community acquired pneumonia in adults].
    The Japanese journal of antibiotics, 2003, Volume: 56, Issue:4

    Topics: Anti-Infective Agents; Ciprofloxacin; Community-Acquired Infections; Drug Administration Schedule; F

2003
Pharmacodynamics of antimicrobials for the empirical treatment of nosocomial pneumonia: a report from the OPTAMA Program.
    Critical care medicine, 2005, Volume: 33, Issue:10

    Topics: Anti-Bacterial Agents; Cefepime; Ceftazidime; Cephalosporins; Ciprofloxacin; Cross Infection; Dose-R

2005
Follow-up therapy with ciprofloxacin in severe infection, an alternative to parenteral treatment.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial I

1989
Efficacy and safety in the oral treatment of purulent chest disease and pneumonia with cefixime, ofloxacin, and ciprofloxacin.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Administration, Oral; Anti-Bacterial Agents; Bronchitis; Cefixime; Ciprofloxacin; Clinical Trials as

1989
Effect of combination therapy with ciprofloxacin and azlocillin in intensive care patients with pneumonia and/or sepsis.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Anti-Bacterial Agents; Azlocillin; Bacteria; Ciprofloxacin; Clinical Trials as Topic; Critical Care;

1989
Treatment of bronchopulmonary infections by ciprofloxacin in an intensive care unit. Correlation between serum and bronchial concentrations and bacteriological results.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Anti-Bacterial Agents; Bronchopneumonia; Ciprofloxacin; Humans; Intensive Care Units; Pneumonia, Bac

1989
Ciprofloxacin-induced torsade de pointes.
    International journal of cardiology, 2006, Nov-10, Volume: 113, Issue:2

    Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Defibrillators, Implantable; Electrocardiography; Follo

2006
Rupture of adductor longus tendon due to ciprofloxacin.
    Acta orthopaedica Belgica, 2005, Volume: 71, Issue:6

    Topics: Adult; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Stud

2005
University-acquired pneumonia.
    The Lancet. Infectious diseases, 2006, Volume: 6, Issue:3

    Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Cefuroxime; Ciprofloxacin; Community-Acquired Infections;

2006
Treatment of murine pneumonic Francisella tularensis infection with gatifloxacin, moxifloxacin or ciprofloxacin.
    International journal of antimicrobial agents, 2006, Volume: 27, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Aza Compounds; Ciprofloxacin; Female; Fluoroquinolones; Gatifloxacin

2006
Effect of ciprofloxacin on levels of lipopolysaccharide and cytokines in experimentally induced gram-negative bacterial pneumonia in mice.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2006, Volume: 12, Issue:3

    Topics: Animals; Anti-Infective Agents; Bronchoalveolar Lavage Fluid; Ciprofloxacin; Cytokines; Klebsiella I

2006
Bacteraemic pneumonia caused by Neisseria lactamica with reduced susceptibility to penicillin and ciprofloxacin in an adult with liver cirrhosis.
    Journal of medical microbiology, 2006, Volume: 55, Issue:Pt 8

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Base Sequence; Ceftriaxone; Ciprofl

2006
[Pulmonary nocardiosis with trimethoprime/sulphamethoxazole-resistant Nocardia paucivorans in a patient with no signs of immunosuppression].
    Pneumologie (Stuttgart, Germany), 2007, Volume: 61, Issue:1

    Topics: Amoxicillin-Potassium Clavulanate Combination; Ciprofloxacin; Drug Resistance, Bacterial; Drug Thera

2007
[Comparison of ciprofloxacin with biapenem in patients with moderate or severe pneumonia].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 2007, Volume: 81, Issue:3

    Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Female; Humans; Male; Pneumonia, Bacterial; Thienamycins

2007
[Study of the cases with multidrug-resistant Pseudomonas aeruginosa by sputum culture].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2007, Volume: 45, Issue:10

    Topics: Adult; Aged; Amikacin; Cilastatin; Cilastatin, Imipenem Drug Combination; Ciprofloxacin; Drug Combin

2007
Microparticles for inhalational delivery of antipseudomonal antibiotics.
    The AAPS journal, 2008, Volume: 10, Issue:2

    Topics: Administration, Inhalation; Anti-Bacterial Agents; Bronchitis; Ceftazidime; Chromatography, High Pre

2008
Fluoroquinolone resistance during 2000-2005: an observational study.
    BMC infectious diseases, 2008, May-24, Volume: 8

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Community-Acquired Infec

2008
[Clinical analysis of 60 cases of nosocomal pneumonias].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1994, Volume: 17, Issue:5

    Topics: Adult; Ciprofloxacin; Cross Infection; Humans; Klebsiella Infections; Klebsiella pneumoniae; Pneumon

1994
[Antibiotic treatment for pneumonia caused by Flavobacterium meningosepticum].
    Zhonghua nei ke za zhi, 1994, Volume: 33, Issue:9

    Topics: Aged; Aztreonam; Cefsulodin; Ciprofloxacin; Drug Therapy, Combination; Female; Flavobacterium; Gram-

1994
Should Pseudomonas aeruginosa isolates resistant to one of the fluorinated quinolones be tested for the others? Studies with an experimental model of pneumonia.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:3

    Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Lung; Male; Microbial Sen

1995
Acute renal failure attributable to ciprofloxacin in a patient with the acquired immunodeficiency syndrome.
    Archives of internal medicine, 1995, Jan-09, Volume: 155, Issue:1

    Topics: Acute Kidney Injury; Adult; AIDS-Related Opportunistic Infections; Ciprofloxacin; Humans; Male; Pneu

1995
Development of antibiotic resistance in Pseudomonas aeruginosa during two decades of antipseudomonal treatment at the Danish CF Center.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 1994, Volume: 102, Issue:9

    Topics: Anti-Bacterial Agents; beta-Lactamases; Carbenicillin; Ceftazidime; Ciprofloxacin; Cystic Fibrosis;

1994
Treatment of severe pneumonia with ciprofloxacin or imipenem.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:8

    Topics: Ciprofloxacin; Humans; Imipenem; Pneumonia, Bacterial

1994
Chemotherapy for germ cell tumours: prophylactic ciprofloxacin reduces the incidence of neutropenic fever.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1994, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Carbo

1994
Mycobacterium avium-intracellulare complex pneumonia in a non-HIV-infected individual: an increasingly recognized disease.
    Southern medical journal, 1996, Volume: 89, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Antitubercular Age

1996
Fungal pneumonia: the predominant lung infection causing death in children undergoing bone marrow transplantation.
    Acta paediatrica (Oslo, Norway : 1992), 1996, Volume: 85, Issue:2

    Topics: Adolescent; Amphotericin B; Antibodies, Monoclonal; Antifungal Agents; Aspergillus fumigatus; Bone M

1996
[Spontaneous bilateral pneumothorax].
    Archivos de bronconeumologia, 1996, Volume: 32, Issue:4

    Topics: Administration, Oral; Aged; Anti-Infective Agents; Bronchography; Ciprofloxacin; Female; Humans; Pne

1996
In vitro and in vivo antibacterial activities of CS-940, a new 6-fluoro-8-difluoromethoxy quinolone.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:5

    Topics: Animals; Anti-Infective Agents; Bacterial Infections; Ciprofloxacin; Drug Evaluation, Preclinical; F

1996
Cutaneous and pulmonary infections caused by Mycobacterium vaccae.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23, Issue:1

    Topics: Aged; Animals; Anti-Bacterial Agents; Cattle; Ciprofloxacin; Humans; Male; Middle Aged; Minocycline;

1996
Rhodococcus or mycobacterium? An example of misdiagnosis in HIV infection.
    AIDS (London, England), 1997, Volume: 11, Issue:2

    Topics: Actinomycetales Infections; Adult; AIDS-Related Opportunistic Infections; Ciprofloxacin; Clarithromy

1997
Scheduled change of antibiotic classes: a strategy to decrease the incidence of ventilator-associated pneumonia.
    American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:4 Pt 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bacteremia; Ceftazidime; Cephalos

1997
[Pneumonia caused by Rhodococcus equi in patients with AIDS: difficulty in defining the most appropriate initial treatment].
    Enfermedades infecciosas y microbiologia clinica, 1997, Volume: 15, Issue:5

    Topics: Actinomycetales Infections; Adult; AIDS-Related Opportunistic Infections; Ciprofloxacin; Clarithromy

1997
Community acquired Pseudomonas aeruginosa pneumonia.
    Connecticut medicine, 1999, Volume: 63, Issue:5

    Topics: Anti-Infective Agents; Ciprofloxacin; Community-Acquired Infections; Humans; Male; Middle Aged; Pneu

1999
Selection of resistant variants of respiratory pathogens by quinolones.
    International journal of antimicrobial agents, 1999, Volume: 12, Issue:2

    Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Haemophilus influenzae; Humans; Le

1999
Nosocomial pneumonia with isolation of anaerobic bacteria in ICU patients: therapeutic considerations and outcome.
    Journal of critical care, 1999, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bacteria, Anaerobic; Cefotaxime;

1999
Evaluation of trovafloxacin in the treatment of Klebsiella pneumoniae lung infection in tumour-bearing mice.
    The Journal of antimicrobial chemotherapy, 2000, Volume: 45, Issue:1

    Topics: Animals; Anti-Infective Agents; Antibiotics, Antineoplastic; Ciprofloxacin; Daunorubicin; Drug Evalu

2000
Pasteurella multocida: a case report of bacteremic pneumonia and 10-year laboratory review.
    Pathology, 2000, Volume: 32, Issue:2

    Topics: Aged; Animals; Ceftriaxone; Cephalosporins; Ciprofloxacin; Dogs; Humans; Male; Pasteurella Infection

2000
A case of Haemophilus parainfluenzae pneumonia.
    Thorax, 2000, Volume: 55, Issue:7

    Topics: Adult; Anti-Infective Agents; Antibodies, Bacterial; Blood Sedimentation; C-Reactive Protein; Ciprof

2000
Rotation and restricted use of antibiotics in a medical intensive care unit. Impact on the incidence of ventilator-associated pneumonia caused by antibiotic-resistant gram-negative bacteria.
    American journal of respiratory and critical care medicine, 2000, Volume: 162, Issue:3 Pt 1

    Topics: Aged; Antibiotic Prophylaxis; Ceftazidime; Ciprofloxacin; Critical Care; Cross Infection; Cross-Sect

2000
Differential selection of multidrug efflux mutants by trovafloxacin and ciprofloxacin in an experimental model of Pseudomonas aeruginosa acute pneumonia in rats.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:2

    Topics: Acute Disease; Animals; Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Drug Resis

2001
Nosocomial pneumonia: importance of recognition of aetiological agents to define an appropriate initial empirical therapy.
    International journal of antimicrobial agents, 2001, Volume: 17, Issue:2

    Topics: Anti-Bacterial Agents; Bacteria; Blood; Bronchoalveolar Lavage Fluid; Ciprofloxacin; Cross Infection

2001
MIC determination of fusidic acid and of ciprofloxacin using multidisk diffusion tests.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2000, Volume: 6, Issue:9

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Fusidic Acid; Gram-Negative Bacteria; G

2000
Improved efficacy of ciprofloxacin administered in polyethylene glycol-coated liposomes for treatment of Klebsiella pneumoniae pneumonia in rats.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:5

    Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Disease Models, Animal; Drug Carriers; Drug Delivery

2001
Effects of parenterally administered ciprofloxacin in a murine model of pulmonary Pseudomonas aeruginosa infection mimicking ventilator-associated pneumonia.
    Chemotherapy, 2001, Volume: 47, Issue:6

    Topics: Animals; Anti-Infective Agents; Area Under Curve; Cefozopran; Cephalosporins; Cilastatin; Ciprofloxa

2001
[Soft-tissue abscess caused by Rhodococcus equi in a patient on hemodialysis].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2001, Volume: 21, Issue:6

    Topics: Abscess; Actinomycetales Infections; Adrenal Cortex Hormones; Aged; Amikacin; Anti-Glomerular Baseme

2001
Complicated nosocomial pneumonia due to Legionella pneumophila in an immunocompromised child.
    Scandinavian journal of infectious diseases, 2002, Volume: 34, Issue:3

    Topics: Anti-Bacterial Agents; Child, Preschool; Ciprofloxacin; Clarithromycin; Cross Infection; Drug Resist

2002