ciprofloxacin has been researched along with Aging in 19 studies
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.
ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacokinetic characteristics of ciprofloxacin were studied in 10 children with cystic fibrosis, aged from 6 to 16 years, who had completed the standard regimen of intravenous ceftazidime and amikacin." | 9.08 | Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients. ( Fischer, C; Hampel, B; Kuhlmann, J; Schaad, UB; Schaefer, HG; Stass, H; Wedgwood, J, 1996) |
| "Cimetidine was a nonselective inhibitor of theophylline metabolic pathways in young men, but it exerted a greater inhibitory effect on N-demethylation pathways in the other groups." | 5.30 | Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers. ( Cusack, BJ; Loi, CM; Parker, BM; Vestal, RE, 1997) |
| "The pharmacokinetic characteristics of ciprofloxacin were studied in 10 children with cystic fibrosis, aged from 6 to 16 years, who had completed the standard regimen of intravenous ceftazidime and amikacin." | 5.08 | Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients. ( Fischer, C; Hampel, B; Kuhlmann, J; Schaad, UB; Schaefer, HG; Stass, H; Wedgwood, J, 1996) |
| "Temazepam clearance was lower in the elderly than in the young, but this difference was not statistically significant." | 2.67 | The influence of ciprofloxacin on the pharmacokinetics and pharmacodynamics of a single dose of temazepam in the young and elderly. ( Edwards, C; Herd, B; Kamali, F; Nicholson, E; Wynne, H, 1994) |
| "The purpose of this clinical study was to investigate the influence of concomitant drug therapy with ciprofloxacin and rifampin on the individual pharmacokinetic profile of each agent in elderly patients." | 2.67 | Multiple-dose pharmacokinetics of concurrent oral ciprofloxacin and rifampin therapy in elderly patients. ( Chandler, MH; Korvick, JA; Muder, RR; Rapp, RP; Toler, SM, 1990) |
| " Reformulation of marketed dosage forms, such as crunched tablets or opened capsules, by the hospital pharmacist may result in stability and bioavailability problems and therapeutic failures may be the consequence." | 2.39 | Biopharmaceutical aspects of anti-infective therapy at the extremes of age. ( Michaelis, J; Schaefer, HG, 1994) |
| "Ciprofloxacin has a slightly higher extent of metabolism, while temafloxacin probably has a higher transintestinal elimination." | 2.38 | Comparative pharmacokinetics of ciprofloxacin and temafloxacin in humans: a review. ( Kinzig, M; Mahr, G; Muth, P; Naber, KG; Sorgel, F, 1991) |
| "In many ways, the elderly are a more heterogeneous group than the young, yet most pharmacokinetic studies of a new drug are carried out in healthy young volunteers." | 2.37 | Pharmacokinetics in the elderly. Studies on ciprofloxacin. ( Bergeron, MG; Lebel, M, 1987) |
| "Enrofloxacin was metabolized to ciprofloxacin both by newborn and one-week-old calves, but the maximum concentration (Cmax) of ciprofloxacin was lower and the time when maximum concentration was reached (tmax) later in newborn calves." | 1.30 | Pharmacokinetics of enrofloxacin in newborn and one-week-old calves. ( Kaartinen, L; Moilanen, M; Pyörälä, S; Räisänen, S, 1997) |
| " A theophylline dosage individualized to obtain a mean theophylline concentration in plasma of 10 +/- 3 micrograms/ml was administered for 1 week to each subject." | 1.28 | Safety of fleroxacin coadministered with theophylline to young and elderly volunteers. ( LeBel, M; Parent, M; St-Laurent, M, 1990) |
| " The physiological aging of the kidneys resulted in a reduced renal clearance, while no significant changes in non-renal clearance, total clearance and terminal half-life were found in the elderly." | 1.28 | Pharmacokinetics of ciprofloxacin in the elderly: increased oral bioavailability and reduced renal clearance. ( Ljungberg, B; Nilsson-Ehle, I, 1989) |
| " After oral administration there is, furthermore, an increased AUC and Cmax, which are explained by a higher bioavailability of an oral dose in the elderly (72." | 1.28 | Influence of age on the pharmacokinetics of ciprofloxacin. ( Ljungberg, B; Nilsson-Ehle, I, 1989) |
| " Area under the plasma concentration-time curve, corrected for body weight, was on average 48% greater in the elderly, but the mean terminal elimination half-life was not significantly different, averaging 4." | 1.27 | Pharmacokinetics of ciprofloxacin in the elderly. ( Bayer, A; Gajewska, A; Pathy, J; Stark, JM; Stephens, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 13 (68.42) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, HN | 1 |
| Pang, JH | 1 |
| Chen, CP | 1 |
| Ko, PC | 1 |
| Lin, MS | 1 |
| Tsai, WC | 1 |
| Yang, YM | 1 |
| Gürer, US | 1 |
| Göçer, P | 1 |
| Erçağ, E | 1 |
| Erten, N | 1 |
| Rayaman, E | 1 |
| Gürbüz, B | 1 |
| Uzer, A | 1 |
| Karan, A | 1 |
| Cevikbaş, A | 1 |
| Schaefer, HG | 2 |
| Michaelis, J | 1 |
| Kamali, F | 1 |
| Herd, B | 1 |
| Edwards, C | 1 |
| Nicholson, E | 1 |
| Wynne, H | 1 |
| Hobden, JA | 1 |
| Hill, JM | 1 |
| Engel, LS | 1 |
| O'Callaghan, RJ | 1 |
| Anand, A | 1 |
| Stass, H | 1 |
| Wedgwood, J | 1 |
| Hampel, B | 1 |
| Fischer, C | 1 |
| Kuhlmann, J | 1 |
| Schaad, UB | 1 |
| Loi, CM | 1 |
| Parker, BM | 1 |
| Cusack, BJ | 1 |
| Vestal, RE | 1 |
| Fraile, LJ | 1 |
| Martinez, C | 1 |
| Aramayona, JJ | 1 |
| Abadía, AR | 1 |
| Bregante, MA | 1 |
| García, MA | 1 |
| Kaartinen, L | 1 |
| Pyörälä, S | 1 |
| Moilanen, M | 1 |
| Räisänen, S | 1 |
| Lopez-Gonzalez, MA | 1 |
| Delgado, F | 1 |
| Lucas, M | 1 |
| Sorgel, F | 1 |
| Naber, KG | 1 |
| Kinzig, M | 1 |
| Mahr, G | 1 |
| Muth, P | 1 |
| Waite, NM | 1 |
| Rybak, MJ | 1 |
| Krakovsky, DJ | 1 |
| Steinberg, JD | 1 |
| Warbasse, LH | 1 |
| Edwards, DJ | 1 |
| Parent, M | 1 |
| St-Laurent, M | 1 |
| LeBel, M | 2 |
| Chandler, MH | 1 |
| Toler, SM | 1 |
| Rapp, RP | 1 |
| Muder, RR | 1 |
| Korvick, JA | 1 |
| Ljungberg, B | 2 |
| Nilsson-Ehle, I | 2 |
| Bergeron, MG | 1 |
| Bayer, A | 1 |
| Gajewska, A | 1 |
| Stephens, M | 1 |
| Stark, JM | 1 |
| Pathy, J | 1 |
3 reviews available for ciprofloxacin and Aging
| Article | Year |
|---|---|
Biopharmaceutical aspects of anti-infective therapy at the extremes of age.
Topics: Administration, Oral; Aged; Aging; Anti-Infective Agents; Biopharmaceutics; Child; Ciprofloxacin; Hu | 1994 |
Comparative pharmacokinetics of ciprofloxacin and temafloxacin in humans: a review.
Topics: Aging; Anti-Infective Agents; Ciprofloxacin; Drug Interactions; Fluoroquinolones; Humans; Kidney Dis | 1991 |
Pharmacokinetics in the elderly. Studies on ciprofloxacin.
Topics: Adult; Aged; Aging; Ciprofloxacin; Female; Glomerular Filtration Rate; Humans; Intestinal Absorption | 1987 |
5 trials available for ciprofloxacin and Aging
| Article | Year |
|---|---|
The effects of some antibiotics on polymorphonuclear leukocyte functions of elderly patients in vitro before and after zinc supplementation.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Bacterial Agents; Candida albicans; Cefotaxime; Ciproflo | 2006 |
The influence of ciprofloxacin on the pharmacokinetics and pharmacodynamics of a single dose of temazepam in the young and elderly.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Ciprofloxacin; Drug Evaluation; Female; | 1994 |
Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients.
Topics: Administration, Oral; Adolescent; Aging; Anti-Infective Agents; Biotransformation; Blood Proteins; B | 1996 |
Influence of subject age on the inhibition of oxidative metabolism by ciprofloxacin.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antipyrine; Ciprofloxacin; Edaravone; Female; Humans; Male; O | 1991 |
Multiple-dose pharmacokinetics of concurrent oral ciprofloxacin and rifampin therapy in elderly patients.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Ciprofloxacin; Clinical Trials as Topic; Drug | 1990 |
11 other studies available for ciprofloxacin and Aging
| Article | Year |
|---|---|
The effect of aging on migration, proliferation, and collagen expression of tenocytes in response to ciprofloxacin.
Topics: Aging; Animals; Anti-Infective Agents; Cell Movement; Cell Proliferation; Ciprofloxacin; Collagen Ty | 2012 |
Age and therapeutic outcome of experimental Pseudomonas aeruginosa keratitis treated with ciprofloxacin, prednisolone, and flurbiprofen.
Topics: Aging; Animals; Aqueous Humor; Biological Assay; Ciprofloxacin; Cornea; Drug Therapy, Combination; F | 1993 |
Ciprofloxacin nephrotoxicity.
Topics: Acute Kidney Injury; Aged; Aging; Ciprofloxacin; Humans | 1993 |
Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers.
Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Biotransformation; Cimetidine; Ciprofloxacin; | 1997 |
Limited capacity of neonatal rabbits to eliminate enrofloxacin and ciprofloxacin.
Topics: Aging; Animals; Animals, Newborn; Animals, Suckling; Anti-Infective Agents; Blood Proteins; Ciproflo | 1997 |
Pharmacokinetics of enrofloxacin in newborn and one-week-old calves.
Topics: Aging; Animals; Animals, Newborn; Anti-Infective Agents; Area Under Curve; Cattle; Chromatography, H | 1997 |
Aminoglycosides activate oxygen metabolites production in the cochlea of mature and developing rats.
Topics: Aging; Animals; Animals, Newborn; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cochl | 1999 |
Safety of fleroxacin coadministered with theophylline to young and elderly volunteers.
Topics: Adult; Aged; Aging; Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Fleroxacin; Hum | 1990 |
Pharmacokinetics of ciprofloxacin in the elderly: increased oral bioavailability and reduced renal clearance.
Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Ciprofloxacin; Half-Life; Humans; | 1989 |
Influence of age on the pharmacokinetics of ciprofloxacin.
Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Ciprofloxacin; Humans; Injections | 1989 |
Pharmacokinetics of ciprofloxacin in the elderly.
Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Ciprofloxacin; Female; Half-Life; | 1987 |