cinobufagin has been researched along with Cancer-Pain* in 2 studies
2 other study(ies) available for cinobufagin and Cancer-Pain
| Article | Year |
|---|---|
The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors.
Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain especially cancer pain. The current study aimed to evaluate its antinociceptive effects in bone cancer pain and explore the underlying mechanisms.. Rat bone cancer model was used in this study. The withdrawal threshold evoked by stimulation of the hindpaw was determined using a 2290 CE electrical von Frey hair. The β-endorphin and IL-10 levels were measured in the spinal cord and cultured primary microglia, astrocytes, and neurons.. Our results illustrate that cinobufagin produces mechanical antiallodynia in bone cancer pain through spinal microglial expression of IL-10 and subsequent β-endorphin following activation of α7-nAChRs. Our results also highlight the broad significance of the recently uncovered spinal microglial IL-10/β-endorphin pathway in antinociception. Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; beta-Endorphin; Bone Neoplasms; Bufanolides; Cancer Pain; Female; Hyperalgesia; Interleukin-10; Male; Microglia; Rats; Rats, Wistar; Spinal Cord | 2020 |
[Effect of cinobufagin on transient outward potassium current in dorsal root ganglion cells of rats with cancer-induced bone pain].
To observe the effect of cinobufagin on transient outward potassium current (. Whole cell patch clamp technique was used to examine the effect of cionbufagin on. The DRG cells from rats with CIBP showed obviously decreased Topics: Analgesics; Animals; Bufanolides; Cancer Pain; Cells, Cultured; Ganglia, Spinal; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley | 2019 |