cinnarizine and Rhinitis--Allergic--Seasonal

In this single-blind study, the efficacy and safety of Disophrol Syrup was compared to Rinomar Syrup in seventy-eight paediatric patients with seasonal allergic rhinitis. Patients took 5-10 ml of the randomly assigned medication three to four times daily for a 2-week period. Severity of nasal obstruction, nasal secretion and mucosal swelling was graded and patient response to each week of therapy evaluated. An overall favourable response to Disophrol Syrup was observed in thirty-one out of thirty-five (89%) patients and in thirty out of thirty-five (86%) patients in the Rinomar group. No statistically significant difference in patient response to therapy between treatment groups was noted and no mentionable adverse reactions were reported.

Topics: Brompheniramine; Child; Child, Preschool; Cinnarizine; Drug Combinations; Drug Evaluation; Ephedrine; Female; Humans; Male; Phenylpropanolamine; Piperazines; Pyridines; Rhinitis, Allergic, Seasonal

The new antiallergic drug oxatomide was evaluated in 40 schoolchildren suffering from severe allergic seasonal rhinoconjunctivitis. Antihistamine drugs had earlier given insufficient symptomatic relief. Double-blind technique was used. There was no significant difference in effect between oxatomide, the antihistamine cinnarizine in combination with phenylpropanolamine and placebo. The results do not support the hypothesis that oxatomide is superior to antihistamine drugs in the treatment of severe seasonal rhinoconjunctivitis.

Topics: Adolescent; Child; Child, Preschool; Cinnarizine; Clinical Trials as Topic; Conjunctivitis; Double-Blind Method; Female; Humans; Hypersensitivity; Male; Phenylpropanolamine; Piperazines; Placebos; Poaceae; Pollen; Rhinitis, Allergic, Seasonal; Trees