cinnarizine and Muscle-Rigidity

We performed a clinical report based, descriptive and retrospective study, aimed at comparing Flunarizine/Cinnarizine-induced parkinsonism (FCIP) patients and Parkinson's disease (PD) patients. The FCIP group (n = 30) presented a lower frequency of rigidity and unilateral tremor than the PD group (n = 70). All FCIP patients improved, 13 after dopaminergic treatment. FCIP patients who improved spontaneously presented lower frequency of rigidity, compared with the other FCIP subgroup and PD group. FCIP patients who did not improve spontaneously showed a clinical pattern similar to PD patients.

Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Cinnarizine; Dopamine Agonists; Female; Flunarizine; Humans; Male; Middle Aged; Muscle Rigidity; Parkinson Disease; Parkinsonian Disorders; Retrospective Studies; Statistics, Nonparametric; Treatment Outcome; Tremor