cinnarizine and Depressive-Disorder

cinnarizine has been researched along with Depressive-Disorder* in 3 studies

Trials

1 trial(s) available for cinnarizine and Depressive-Disorder

Article	Year
[Clinical double blind study with the calcium antagonist flunarizine cerebral circulatory disturbances]. Arzneimittel-Forschung, 1985, Volume: 35, Issue:8 In a clinically controlled double-blind study the effect of flunarizine (Sibelium) was compared with that of placebo in patients with involutional depression (WHO's International Classification of Diseases (ICD No. 296.0) and with cerebral circulatory disturbances (ICD No. 293.1). Effectiveness was objectified with the aid of the Clinical Global Impression test (CGI), the Hamilton Depression Scale (HAMD), the Nurses' Observation Scale for Inpatient Evaluation (NOSIE), and the "wellbeing tests" Bf-S and Bf-S'. Duration of treatment was 6 weeks. 32 patients were available for the final evaluation. In a combination of the good to excellent results considered as effective and the moderate to unsatisfactory results considered as ineffective the 82% rate of improvement in favour of the cerebral Ca2+ antagonist flunarizine was significantly superior to the 26% reached in the placebo group. The correlation with the psychopathometric tests has been proved. The medication was shown to be well tolerated. Side-effects did not appear. The mechanisms of action of the cerebral Ca2+ antagonist are discussed. Topics: Adult; Aged; Cerebrovascular Disorders; Cinnarizine; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Flunarizine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Random Allocation	1985

Article

Year

[Clinical double blind study with the calcium antagonist flunarizine cerebral circulatory disturbances].

Arzneimittel-Forschung, 1985, Volume: 35, Issue:8

In a clinically controlled double-blind study the effect of flunarizine (Sibelium) was compared with that of placebo in patients with involutional depression (WHO's International Classification of Diseases (ICD No. 296.0) and with cerebral circulatory disturbances (ICD No. 293.1). Effectiveness was objectified with the aid of the Clinical Global Impression test (CGI), the Hamilton Depression Scale (HAMD), the Nurses' Observation Scale for Inpatient Evaluation (NOSIE), and the "wellbeing tests" Bf-S and Bf-S'. Duration of treatment was 6 weeks. 32 patients were available for the final evaluation. In a combination of the good to excellent results considered as effective and the moderate to unsatisfactory results considered as ineffective the 82% rate of improvement in favour of the cerebral Ca2+ antagonist flunarizine was significantly superior to the 26% reached in the placebo group. The correlation with the psychopathometric tests has been proved. The medication was shown to be well tolerated. Side-effects did not appear. The mechanisms of action of the cerebral Ca2+ antagonist are discussed.

Topics: Adult; Aged; Cerebrovascular Disorders; Cinnarizine; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Flunarizine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Random Allocation

1985

Other Studies

2 other study(ies) available for cinnarizine and Depressive-Disorder

Article	Year
Extrapyramidal and depressive side reactions with flunarizine and cinarizine. Journal of neurology, neurosurgery, and psychiatry, 1989, Volume: 52, Issue:2 Topics: Aged; Basal Ganglia Diseases; Cinnarizine; Depressive Disorder; Female; Flunarizine; Follow-Up Studies; Humans; Male; Middle Aged	1989
Parkinsonism, tardive dyskinesia, akathisia, and depression induced by flunarizine. Lancet (London, England), 1986, Jun-07, Volume: 1, Issue:8493 12 subjects, 8 women and 4 men, presented with extrapyramidal motor signs and psychic depression after treatment with flunarizine for between 3 weeks and 15 months. One woman presented with severe symptoms and 20 months after stopping flunarizine she still had dyskinesia and akathisia. The other patients showed partial or complete improvement after withdrawal of the drug. Topics: Aged; Akathisia, Drug-Induced; Cinnarizine; Depressive Disorder; Dyskinesia, Drug-Induced; Female; Flunarizine; Humans; Male; Middle Aged; Parkinson Disease, Secondary; Psychoses, Substance-Induced	1986

Article

Year

Extrapyramidal and depressive side reactions with flunarizine and cinarizine.

Journal of neurology, neurosurgery, and psychiatry, 1989, Volume: 52, Issue:2

Topics: Aged; Basal Ganglia Diseases; Cinnarizine; Depressive Disorder; Female; Flunarizine; Follow-Up Studies; Humans; Male; Middle Aged

1989

Parkinsonism, tardive dyskinesia, akathisia, and depression induced by flunarizine.

Lancet (London, England), 1986, Jun-07, Volume: 1, Issue:8493

12 subjects, 8 women and 4 men, presented with extrapyramidal motor signs and psychic depression after treatment with flunarizine for between 3 weeks and 15 months. One woman presented with severe symptoms and 20 months after stopping flunarizine she still had dyskinesia and akathisia. The other patients showed partial or complete improvement after withdrawal of the drug.

Topics: Aged; Akathisia, Drug-Induced; Cinnarizine; Depressive Disorder; Dyskinesia, Drug-Induced; Female; Flunarizine; Humans; Male; Middle Aged; Parkinson Disease, Secondary; Psychoses, Substance-Induced

1986