cinnarizine has been researched along with Carotid-Artery-Thrombosis* in 1 studies
1 other study(ies) available for cinnarizine and Carotid-Artery-Thrombosis
| Article | Year |
|---|---|
Effect of dipfluzine on platelet aggregation and thrombus formation.
Dipfluzine (Dip) is a novel diphenylpiperazine calcium channel blocker first synthesized in China. Effects of Dip on experimental thrombosis and platelet aggregation were studied in vitro and in vivo compared with cinnarizine (Cin). Dip 1 and 2 mg.kg-1 i.v. and incubated in 1-100 mumol.L-1 in vitro inhibited dose- or concentration-dependent rabbit platelet aggregation induced by ADP and by arachidonic acid (AA), respectively. Dip 2.5-10 mg.kg-1 i.v. and 50-100 mg.kg-1 ip inhibited the thrombosis in rats. Dip 10 mg.kg-1 i.v. and 200 mumol.L-1 depressed the in vitro thrombosis. These results suggest that attenuation of disturbed platelet-vessel wall reaction associated with platelet activation and vasoconstriction may be a main factor involved in the antithrombotic action of Dip, and that the effects of Dip were more potent than those of Cin. Topics: Animals; Carotid Artery Thrombosis; Cinnarizine; Dose-Response Relationship, Drug; Female; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Wistar; Thrombosis | 1994 |