cinidon-ethyl and Alzheimer-Disease

Alzheimer's disease (AD) is an age-related neurodegenerative disease and is featured by cognitive impairment. Procyanidins have been shown to have a potential protective effect against neurodegenerative diseases, but the underlying mechanism is not comprehensive enough.. To further investigate the effects of procyanidins from lotus seedpod (LSPC) on cognition in AD.. LSPC significantly ameliorated cognitive dysfunction, reduced Aβ deposition and reversed the remarkable reduction of the phosphorylation of CREB and the expression of BDNF, and then enhanced the effect of LTP in. These results revealed that LSPC could ameliorate cognitive impairment through the CREB-BDNF pathway that mediates the enhancement of LTP in

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Lotus; Maze Learning; Mice; Mice, Transgenic; Neurodegenerative Diseases; Proanthocyanidins; Seeds