cinepazet and Hypertension

cinepazet has been researched along with Hypertension* in 1 studies

Other Studies

1 other study(ies) available for cinepazet and Hypertension

Article	Year
Cinepazet relaxation of aortic strips from normal and spontaneously hypertensive rats. Research communications in chemical pathology and pharmacology, 1980, Volume: 29, Issue:1 The vasodilator cinepazet (Vascoril) was tested for its ability to relax potassium-contracted aortic strips obtained from normal and spontaneously hypertensive rats (SHR). Cinepazet caused a dose-dependent relaxation of the isolated aortic strip preparations which had been contracted with 60 mM KCl. The ED50 for this relaxant effect was 200 microgram/ml. No differences in relaxation response to cinepazet were found between tissues from SHR and normal animals. The drug is 2 x 10(4) less potent than verapamil on a weight basis in this action on rat aortic tissue. The results suggest that the excitation-contraction mechanism associated with KCl-induced membrane depolarization is equally affected by cinepazet in aortae from SHR and WKY. Topics: Animals; Aorta, Thoracic; Female; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Piperazines; Potassium Chloride; Rats; Vasodilator Agents; Verapamil	1980

Article

Year

Cinepazet relaxation of aortic strips from normal and spontaneously hypertensive rats.

Research communications in chemical pathology and pharmacology, 1980, Volume: 29, Issue:1

The vasodilator cinepazet (Vascoril) was tested for its ability to relax potassium-contracted aortic strips obtained from normal and spontaneously hypertensive rats (SHR). Cinepazet caused a dose-dependent relaxation of the isolated aortic strip preparations which had been contracted with 60 mM KCl. The ED50 for this relaxant effect was 200 microgram/ml. No differences in relaxation response to cinepazet were found between tissues from SHR and normal animals. The drug is 2 x 10(4) less potent than verapamil on a weight basis in this action on rat aortic tissue. The results suggest that the excitation-contraction mechanism associated with KCl-induced membrane depolarization is equally affected by cinepazet in aortae from SHR and WKY.

Topics: Animals; Aorta, Thoracic; Female; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Piperazines; Potassium Chloride; Rats; Vasodilator Agents; Verapamil

1980