Page last updated: 2024-10-25

cimetidine and Wounds and Injuries

cimetidine has been researched along with Wounds and Injuries in 13 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.

Research Excerpts

ExcerptRelevanceReference
"Critically ill trauma patients were entered in a prospective, randomized trial to determine the role of gastric colonization in the development of pneumonia."2.67Role of gastric colonization in the development of pneumonia in critically ill trauma patients: results of a prospective randomized trial. ( Burchard, KW; DeMaria, E; McDonald, L; Peterson, D; Robinson, A; Simms, HH, 1991)
" A side effect encountered was sinus tachycardia in 4 of 27 patients treated with pirenzepine."2.66[Prevention of gastroduodenal stress lesions with secretion inhibitors in accident patients needing intensive care: incidence of lesions and adverse effects; consequences]. ( Barandun, J; Frutiger, A; Kobler, E; Leutenegger, A; Rüedi, T, 1985)
"Cimetidine was highly effective in preventing stress ulceration in severe polytrauma patients, but mortality was the same in the cimetidine and in the placebo group."2.65[A randomized clinical study of stress ulcer prophylaxis with cimeytidine in severe multiple injuries]. ( Fischer, M; Lorenz, W; Rohde, H, 1980)
"Cimetidine has been effective in the treatment of peptic ulcer disease because of its ability to elevate gastric pH."2.65Cimetidine for the prophylaxis of potential gastric acid aspiration pneumonitis in trauma patients. ( Markovchick, VJ; Moore, EE; Strain, JD; Van Duzer-Moore, S, 1981)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-199011 (84.62)18.7374
1990's2 (15.38)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barandun, J2
Leutenegger, A2
Frutiger, A2
Rüedi, T2
Kobler, E2
Myrick, SW1
Chang, FC1
Rohde, H2
Lorenz, W2
Fischer, M2
Troidl, H1
Reimann, HJ1
Ohmann, C1
Strain, JD1
Moore, EE1
Markovchick, VJ1
Van Duzer-Moore, S1
Fabian, TC1
Boucher, BA1
Croce, MA1
Kuhl, DA1
Janning, SW1
Coffey, BC1
Kudsk, KA1
Martin, LF1
Staloch, DK1
Simonowitz, DA1
Dellinger, EP1
Max, MH1
Herrmann, V1
Kaminski, DL1
Simms, HH1
DeMaria, E1
McDonald, L1
Peterson, D1
Robinson, A1
Burchard, KW1
Zapata-Sirvent, R1
Hansbrough, JF2
Bartle, EJ1
Zapata-Sirvent, RL1
Shackford, SR1
Hoyt, D1
Carter, WH1
Ivatury, RR1
Khan, MB1
Nallathambi, M1
Davis, K1
Stahl, WM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit[NCT00633035]Phase 460 participants (Actual)Interventional2007-09-30Completed
Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis in Patients After Major Abdominal Surgery[NCT00839488]Phase 46 participants (Actual)Interventional2008-04-30Terminated (stopped due to the chief of GS left the hopsital and the successor did't want to keep on this study)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

8 trials available for cimetidine and Wounds and Injuries

ArticleYear
[Incidence of gastro-duodenal stress lesions in trauma patients requiring intensive care, treated with secretory inhibitors. A double blind study].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1984, Sep-18, Volume: 73, Issue:38

    Topics: Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Critical Care; Double-Blind Method; Histami

1984
[A randomized clinical study of stress ulcer prophylaxis with cimeytidine in severe multiple injuries].
    Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:6

    Topics: Cimetidine; Clinical Trials as Topic; Guanidines; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Ran

1980
Histamine and stress ulcer: new components in organizing a sequential trial on cimetidine prophylaxis in seriously ill patients and definition of a special group at risk (severe polytrauma).
    Klinische Wochenschrift, 1980, Jul-01, Volume: 58, Issue:13

    Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Ethics, Medical; Guanidines; Humans; Pept

1980
Cimetidine for the prophylaxis of potential gastric acid aspiration pneumonitis in trauma patients.
    The Journal of trauma, 1981, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Anesthesia; Cimetidine; Female; Gastric Acid; Gastric Juice; Guanidines; Humans;

1981
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
    Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I

1993
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
    Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I

1993
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
    Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I

1993
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
    Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I

1993
Evaluation of intragastric pH in acutely ill patients.
    Archives of surgery (Chicago, Ill. : 1960), 1979, Volume: 114, Issue:4

    Topics: Adult; Aged; Antacids; Cimetidine; Clinical Trials as Topic; Female; Gastric Juice; Guanidines; Huma

1979
Role of gastric colonization in the development of pneumonia in critically ill trauma patients: results of a prospective randomized trial.
    The Journal of trauma, 1991, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Antacids; Bacteria; Cimetidine; Cross Infection; Gastric Juice; Humans; Hydrogen-

1991
[Prevention of gastroduodenal stress lesions with secretion inhibitors in accident patients needing intensive care: incidence of lesions and adverse effects; consequences].
    Schweizerische medizinische Wochenschrift, 1985, Jul-20, Volume: 115, Issue:29

    Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Critical Care; Double-Bli

1985

Other Studies

5 other studies available for cimetidine and Wounds and Injuries

ArticleYear
Cimetidine for trauma.
    The Journal of the Kansas Medical Society, 1980, Volume: 81, Issue:9

    Topics: Cimetidine; Gastrointestinal Hemorrhage; Guanidines; Humans; Prospective Studies; Wounds and Injurie

1980
Failure of cimetidine prophylaxis in the critically ill.
    Archives of surgery (Chicago, Ill. : 1960), 1979, Volume: 114, Issue:4

    Topics: Acute Kidney Injury; Bacterial Infections; Child; Cimetidine; Female; Gastric Juice; Guanidines; Hum

1979
Prevention of posttraumatic alterations in lymphocyte subpopulations in mice by immunomodulating drugs.
    Archives of surgery (Chicago, Ill. : 1960), 1986, Volume: 121, Issue:1

    Topics: Animals; Cimetidine; Corticosterone; Cyclophosphamide; Female; Ibuprofen; Leukocyte Count; Lymphocyt

1986
Immunomodulating drugs increase resistance against sepsis in traumatized mice.
    The Journal of trauma, 1986, Volume: 26, Issue:7

    Topics: Adjuvants, Immunologic; Animals; Cimetidine; Cyclophosphamide; Female; Ibuprofen; Immune Tolerance;

1986
Cimetidine and hepatic blood flow in polytrauma patients.
    Critical care medicine, 1985, Volume: 13, Issue:5

    Topics: Adult; Aged; Cardiac Output; Cimetidine; Humans; Indocyanine Green; Injections, Intravenous; Liver C

1985