cimetidine has been researched along with Wounds and Injuries in 13 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Critically ill trauma patients were entered in a prospective, randomized trial to determine the role of gastric colonization in the development of pneumonia." | 2.67 | Role of gastric colonization in the development of pneumonia in critically ill trauma patients: results of a prospective randomized trial. ( Burchard, KW; DeMaria, E; McDonald, L; Peterson, D; Robinson, A; Simms, HH, 1991) |
| " A side effect encountered was sinus tachycardia in 4 of 27 patients treated with pirenzepine." | 2.66 | [Prevention of gastroduodenal stress lesions with secretion inhibitors in accident patients needing intensive care: incidence of lesions and adverse effects; consequences]. ( Barandun, J; Frutiger, A; Kobler, E; Leutenegger, A; Rüedi, T, 1985) |
| "Cimetidine was highly effective in preventing stress ulceration in severe polytrauma patients, but mortality was the same in the cimetidine and in the placebo group." | 2.65 | [A randomized clinical study of stress ulcer prophylaxis with cimeytidine in severe multiple injuries]. ( Fischer, M; Lorenz, W; Rohde, H, 1980) |
| "Cimetidine has been effective in the treatment of peptic ulcer disease because of its ability to elevate gastric pH." | 2.65 | Cimetidine for the prophylaxis of potential gastric acid aspiration pneumonitis in trauma patients. ( Markovchick, VJ; Moore, EE; Strain, JD; Van Duzer-Moore, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (84.62) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barandun, J | 2 |
| Leutenegger, A | 2 |
| Frutiger, A | 2 |
| Rüedi, T | 2 |
| Kobler, E | 2 |
| Myrick, SW | 1 |
| Chang, FC | 1 |
| Rohde, H | 2 |
| Lorenz, W | 2 |
| Fischer, M | 2 |
| Troidl, H | 1 |
| Reimann, HJ | 1 |
| Ohmann, C | 1 |
| Strain, JD | 1 |
| Moore, EE | 1 |
| Markovchick, VJ | 1 |
| Van Duzer-Moore, S | 1 |
| Fabian, TC | 1 |
| Boucher, BA | 1 |
| Croce, MA | 1 |
| Kuhl, DA | 1 |
| Janning, SW | 1 |
| Coffey, BC | 1 |
| Kudsk, KA | 1 |
| Martin, LF | 1 |
| Staloch, DK | 1 |
| Simonowitz, DA | 1 |
| Dellinger, EP | 1 |
| Max, MH | 1 |
| Herrmann, V | 1 |
| Kaminski, DL | 1 |
| Simms, HH | 1 |
| DeMaria, E | 1 |
| McDonald, L | 1 |
| Peterson, D | 1 |
| Robinson, A | 1 |
| Burchard, KW | 1 |
| Zapata-Sirvent, R | 1 |
| Hansbrough, JF | 2 |
| Bartle, EJ | 1 |
| Zapata-Sirvent, RL | 1 |
| Shackford, SR | 1 |
| Hoyt, D | 1 |
| Carter, WH | 1 |
| Ivatury, RR | 1 |
| Khan, MB | 1 |
| Nallathambi, M | 1 |
| Davis, K | 1 |
| Stahl, WM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit[NCT00633035] | Phase 4 | 60 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis in Patients After Major Abdominal Surgery[NCT00839488] | Phase 4 | 6 participants (Actual) | Interventional | 2008-04-30 | Terminated (stopped due to the chief of GS left the hopsital and the successor did't want to keep on this study) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for cimetidine and Wounds and Injuries
| Article | Year |
|---|---|
[Incidence of gastro-duodenal stress lesions in trauma patients requiring intensive care, treated with secretory inhibitors. A double blind study].
Topics: Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Critical Care; Double-Blind Method; Histami | 1984 |
[A randomized clinical study of stress ulcer prophylaxis with cimeytidine in severe multiple injuries].
Topics: Cimetidine; Clinical Trials as Topic; Guanidines; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Ran | 1980 |
Histamine and stress ulcer: new components in organizing a sequential trial on cimetidine prophylaxis in seriously ill patients and definition of a special group at risk (severe polytrauma).
Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Ethics, Medical; Guanidines; Humans; Pept | 1980 |
Cimetidine for the prophylaxis of potential gastric acid aspiration pneumonitis in trauma patients.
Topics: Adolescent; Adult; Anesthesia; Cimetidine; Female; Gastric Acid; Gastric Juice; Guanidines; Humans; | 1981 |
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I | 1993 |
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I | 1993 |
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I | 1993 |
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I | 1993 |
Evaluation of intragastric pH in acutely ill patients.
Topics: Adult; Aged; Antacids; Cimetidine; Clinical Trials as Topic; Female; Gastric Juice; Guanidines; Huma | 1979 |
Role of gastric colonization in the development of pneumonia in critically ill trauma patients: results of a prospective randomized trial.
Topics: Adolescent; Adult; Antacids; Bacteria; Cimetidine; Cross Infection; Gastric Juice; Humans; Hydrogen- | 1991 |
[Prevention of gastroduodenal stress lesions with secretion inhibitors in accident patients needing intensive care: incidence of lesions and adverse effects; consequences].
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Critical Care; Double-Bli | 1985 |
5 other studies available for cimetidine and Wounds and Injuries
| Article | Year |
|---|---|
Cimetidine for trauma.
Topics: Cimetidine; Gastrointestinal Hemorrhage; Guanidines; Humans; Prospective Studies; Wounds and Injurie | 1980 |
Failure of cimetidine prophylaxis in the critically ill.
Topics: Acute Kidney Injury; Bacterial Infections; Child; Cimetidine; Female; Gastric Juice; Guanidines; Hum | 1979 |
Prevention of posttraumatic alterations in lymphocyte subpopulations in mice by immunomodulating drugs.
Topics: Animals; Cimetidine; Corticosterone; Cyclophosphamide; Female; Ibuprofen; Leukocyte Count; Lymphocyt | 1986 |
Immunomodulating drugs increase resistance against sepsis in traumatized mice.
Topics: Adjuvants, Immunologic; Animals; Cimetidine; Cyclophosphamide; Female; Ibuprofen; Immune Tolerance; | 1986 |
Cimetidine and hepatic blood flow in polytrauma patients.
Topics: Adult; Aged; Cardiac Output; Cimetidine; Humans; Indocyanine Green; Injections, Intravenous; Liver C | 1985 |