Page last updated: 2024-10-25

cimetidine and Thrombopenia

cimetidine has been researched along with Thrombopenia in 31 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
" In October 1994, thrombocytopenia gradually progressed, and we halted the administration of cimetidine to ranitidine."7.69[Hemolytic anemia and thrombocytopenia induced by cimetidine: recurrence with ranitidine administration]. ( Kura, T; Mogi, Y; Niitsu, Y; Takimoto, R, 1997)
"We report the case of a patient with peptic ulcer disease who developed cimetidine-induced thrombocytopenia."7.68Cimetidine and ranitidine may not cross-react to cause thrombocytopenia. ( Seror, D; Shalev, O, 1991)
"A rare case of thrombocytopenia associated with ranitidine is described."7.67Thrombocytopenia associated with hypersensitivity to ranitidine: possible cross-reactivity with cimetidine. ( Gafter, U; Komlos, L; Levi, J; Livni, E; Zevin, D, 1989)
"Combined use of cimetidine and phenytoin among 1512 neurosurgical patients has led to severe thrombocytopenia in 4 patients."7.67Severe thrombocytopenia due to combined cimetidine and phenytoin therapy. ( Chan, KH; Mann, KS; Yue, CP, 1987)
"A 67-year-old man developed a sudden onset of severe isolated thrombocytopenia (platelet count, 1000/mm3) after 10 days of phenytoin administration as a prophylactic measure prior to craniotomy."7.67Severe thrombocytopenia associated with phenytoin and cimetidine therapy. ( Brown, FD; Lichtor, T; Wong, YY, 1985)
"A case of thrombocytopenia associated with cimetidine administration in a 65-year-old white female with recurrent adenocarcinoma is reported."7.66Cimetidine-associated thrombocytopenia. ( Delaney, JP; Mann, HJ; Miller, JB; Schneider, JR, 1983)
"This report described a case of cimetidine-induced thrombocytopenia documented by accidental rechallenge."7.66Cimetidine-induced thrombocytopenia. ( Glotzbach, RE, 1982)
" In October 1994, thrombocytopenia gradually progressed, and we halted the administration of cimetidine to ranitidine."3.69[Hemolytic anemia and thrombocytopenia induced by cimetidine: recurrence with ranitidine administration]. ( Kura, T; Mogi, Y; Niitsu, Y; Takimoto, R, 1997)
"We report the case of a patient with peptic ulcer disease who developed cimetidine-induced thrombocytopenia."3.68Cimetidine and ranitidine may not cross-react to cause thrombocytopenia. ( Seror, D; Shalev, O, 1991)
"A rare case of thrombocytopenia associated with ranitidine is described."3.67Thrombocytopenia associated with hypersensitivity to ranitidine: possible cross-reactivity with cimetidine. ( Gafter, U; Komlos, L; Levi, J; Livni, E; Zevin, D, 1989)
"Combined use of cimetidine and phenytoin among 1512 neurosurgical patients has led to severe thrombocytopenia in 4 patients."3.67Severe thrombocytopenia due to combined cimetidine and phenytoin therapy. ( Chan, KH; Mann, KS; Yue, CP, 1987)
"A 67-year-old man developed a sudden onset of severe isolated thrombocytopenia (platelet count, 1000/mm3) after 10 days of phenytoin administration as a prophylactic measure prior to craniotomy."3.67Severe thrombocytopenia associated with phenytoin and cimetidine therapy. ( Brown, FD; Lichtor, T; Wong, YY, 1985)
"A case of thrombocytopenia associated with cimetidine administration in a 65-year-old white female with recurrent adenocarcinoma is reported."3.66Cimetidine-associated thrombocytopenia. ( Delaney, JP; Mann, HJ; Miller, JB; Schneider, JR, 1983)
"This report described a case of cimetidine-induced thrombocytopenia documented by accidental rechallenge."3.66Cimetidine-induced thrombocytopenia. ( Glotzbach, RE, 1982)
"A 67-year-old man with a bleeding ulcer developed fever, thrombocytopenia, and neutropenia with eosinophilia coincidental to receiving 3600 mg of cimetidine."3.66Cimetidine and hematologic suppression: things are not always as they appear. ( Castell, DO; Gerhardt, DC; Pasquale, DN; Richter, JE, 1980)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199022 (70.97)18.7374
1990's8 (25.81)18.2507
2000's1 (3.23)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mann, HJ1
Schneider, JR1
Miller, JB1
Delaney, JP1
Reddy, J1
Bailey, RR1
Isaacs, AJ1
Collen, MJ1
Glotzbach, RE1
Mar, DD1
Brandstetter, RD1
Miskovitz, PF1
Fotino, M1
Chandrasekhara, KL1
Iyer, SK1
Macchia, RJ1
Denis, J1
Thierman-Duffaud, D1
Opolon, P1
Levy, VG1
Selker, HP1
Rosenbloom, BE1
Weinstein, IM1
Yates, VM1
Kerr, RE1
Richter, JE1
Gerhardt, DC1
Pasquale, DN1
Castell, DO1
Gurzó, M1
Varga, G1
Dobos, K1
Náfrádi, J1
Petri, A1
Arbiser, JL1
Goldstein, AM1
Gordon, D1
Hatton, J1
Lu, WY1
Rhoney, DH1
Tibbs, PA1
Dempsey, RJ1
Young, B1
Takimoto, R1
Mogi, Y1
Kura, T1
Niitsu, Y1
Gentilini, G1
Curtis, BR1
Aster, RH1
Wade, EE1
Rebuck, JA1
Healey, MA1
Rogers, FB1
James, C1
Prout, BJ1
Idvall, J1
McDaniel, JL1
Stein, JJ1
Rate, R1
Bonnell, M1
Chervenak, C1
Pavinich, G1
Raya Sánchez, JM1
Jorge Hernández, JA1
Santolaria Fernández, FJ1
Hernández Nieto, L1
Shalev, O1
Seror, D1
Bourghol, A1
Rindone, JP1
Gafter, U1
Zevin, D1
Komlos, L1
Livni, E1
Levi, J1
Harats, N1
Oren, R1
Heyman, A1
Naparstek, Y1
Habel, A1
Murray, N1
Yue, CP1
Mann, KS1
Chan, KH1
Ogawa, T1
Tanaka, M1
Araki, N1
Yogo, H1
Naito, K1
Yamada, I1
Wong, YY1
Lichtor, T1
Brown, FD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit[NCT00633035]Phase 460 participants (Actual)Interventional2007-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for cimetidine and Thrombopenia

ArticleYear
H(2) antagonist-induced thrombocytopenia: is this a real phenomenon?
    Intensive care medicine, 2002, Volume: 28, Issue:4

    Topics: Cimetidine; Critical Care; Famotidine; Histamine H2 Antagonists; Humans; Peptic Ulcer; Ranitidine; R

2002

Other Studies

30 other studies available for cimetidine and Thrombopenia

ArticleYear
Cimetidine-associated thrombocytopenia.
    Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2

    Topics: Aged; Cimetidine; Female; Guanidines; Humans; Platelet Count; Thrombocytopenia; Time Factors

1983
Cimetidine and thrombocytopenia.
    The New Zealand medical journal, 1980, Mar-26, Volume: 91, Issue:656

    Topics: Cimetidine; Female; Graft Rejection; Guanidines; Humans; Kidney Transplantation; Middle Aged; Thromb

1980
Cimetidine and thrombocytopenia.
    British medical journal, 1980, Feb-02, Volume: 280, Issue:6210

    Topics: Adult; Cimetidine; Guanidines; Humans; Male; Platelet Count; Sarcoidosis; Thrombocytopenia

1980
Cimetidine-associated thrombocytopenia and leukopenia.
    The Western journal of medicine, 1980, Volume: 132, Issue:3

    Topics: Cimetidine; Guanidines; Humans; Leukopenia; Male; Middle Aged; Thrombocytopenia

1980
Cimetidine-induced thrombocytopenia.
    Southern medical journal, 1982, Volume: 75, Issue:2

    Topics: Blood Platelets; Cimetidine; Guanidines; Humans; Male; Middle Aged; Serotonin; Stomach Ulcer; Thromb

1982
Cimetidine-induced, immune-mediated leukopenia and thrombocytopenia.
    Southern medical journal, 1982, Volume: 75, Issue:10

    Topics: Agglutination Tests; Agglutinins; Cimetidine; Female; Guanidines; Humans; Leukocytes; Leukopenia; Mi

1982
[Thrombocytopenia during cimetidine therapy].
    Ugeskrift for laeger, 1982, Sep-06, Volume: 144, Issue:36

    Topics: Aged; Cimetidine; Female; Guanidines; Humans; Male; Middle Aged; Thrombocytopenia

1982
Leucopenia and thrombocytopenia with cimetidine.
    Journal of the National Medical Association, 1981, Volume: 73, Issue:2

    Topics: Cimetidine; Female; Guanidines; Humans; Leukopenia; Middle Aged; Thrombocytopenia

1981
[Thrombopenia induced by cimetidine].
    La Nouvelle presse medicale, 1981, Jul-04, Volume: 10, Issue:29

    Topics: Cimetidine; Guanidines; Humans; Male; Middle Aged; Thrombocytopenia

1981
Cimetidine and cytopenia.
    The Western journal of medicine, 1981, Volume: 135, Issue:4

    Topics: Aged; Agranulocytosis; Bone Marrow Cells; Cimetidine; Female; Guanidines; Humans; In Vitro Technique

1981
Cimetidine and thrombocytopenia.
    British medical journal, 1980, Jun-14, Volume: 280, Issue:6229

    Topics: Aged; Cimetidine; Guanidines; Humans; Male; Psoriasis; Thrombocytopenia

1980
Cimetidine and hematologic suppression: things are not always as they appear.
    Digestive diseases and sciences, 1980, Volume: 25, Issue:12

    Topics: Aged; Agranulocytosis; Blood Transfusion; Cimetidine; Duodenal Ulcer; Eosinophilia; Fever; Guanidine

1980
[Therapeutic possibilities in the management of gastrointestinal bleeding in thrombocytopenic patients].
    Orvosi hetilap, 1994, Apr-10, Volume: 135, Issue:15

    Topics: Aged; Blood Coagulation Disorders; Blood Transfusion; Cimetidine; Ethamsylate; Gastrointestinal Hemo

1994
Thrombocytopenia following administration of phenytoin, dexamethasone and cimetidine: a case report and a potential mechanism.
    Journal of internal medicine, 1993, Volume: 234, Issue:1

    Topics: Aged; Aged, 80 and over; Cimetidine; Dexamethasone; Drug Interactions; Female; Humans; Phenytoin; Th

1993
A step-wise protocol for stress ulcer prophylaxis in the neurosurgical intensive care unit.
    Surgical neurology, 1996, Volume: 46, Issue:5

    Topics: Adult; Cimetidine; Clinical Protocols; Critical Care; Drug Therapy, Combination; Gastric Acid; Gastr

1996
[Hemolytic anemia and thrombocytopenia induced by cimetidine: recurrence with ranitidine administration].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1997, Volume: 38, Issue:2

    Topics: Aged; Anemia, Hemolytic; Anti-Ulcer Agents; Cimetidine; Drug Interactions; Female; Histamine H2 Anta

1997
An antibody from a patient with ranitidine-induced thrombocytopenia recognizes a site on glycoprotein IX that is a favored target for drug-induced antibodies.
    Blood, 1998, Oct-01, Volume: 92, Issue:7

    Topics: Aged; Animals; Anti-Ulcer Agents; Antibodies, Monoclonal; Antibody Specificity; Antigen-Antibody Rea

1998
Marrow suppression and intravenous cimetidine.
    Lancet (London, England), 1978, May-06, Volume: 1, Issue:8071

    Topics: Adult; Bone Marrow; Cimetidine; Guanidines; Humans; Injections, Intravenous; Leukopenia; Male; Throm

1978
Cimetidine-associated thrombocytopenia.
    Lancet (London, England), 1979, Jul-21, Volume: 2, Issue:8134

    Topics: Aged; Blood Platelets; Cimetidine; Guanidines; Humans; Male; Middle Aged; Thrombocytopenia

1979
Thrombocytopenia with cimetidine therapy.
    The New England journal of medicine, 1979, Apr-12, Volume: 300, Issue:15

    Topics: Aged; Cimetidine; Female; Guanidines; Humans; Thrombocytopenia

1979
Cimetidine and hematologic effects.
    Annals of internal medicine, 1979, Volume: 91, Issue:5

    Topics: Agranulocytosis; Anemia, Hemolytic; Cimetidine; Female; Guanidines; Humans; Middle Aged; Thrombocyto

1979
[Severe thrombocytopenia associated with cimetidine. A new case].
    Anales de medicina interna (Madrid, Spain : 1984), 1992, Volume: 9, Issue:3

    Topics: Aged; Cimetidine; Humans; Male; Thrombocytopenia

1992
Cimetidine and ranitidine may not cross-react to cause thrombocytopenia.
    Journal of internal medicine, 1991, Volume: 230, Issue:1

    Topics: Aged; Cimetidine; Duodenal Ulcer; Humans; Male; Peptic Ulcer Hemorrhage; Ranitidine; Thrombocytopeni

1991
Cimetidine-associated thrombocytopenia.
    DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:10

    Topics: Aged; Cimetidine; Humans; Male; Thrombocytopenia

1990
Thrombocytopenia associated with hypersensitivity to ranitidine: possible cross-reactivity with cimetidine.
    The American journal of gastroenterology, 1989, Volume: 84, Issue:5

    Topics: Cell Migration Inhibition; Cimetidine; Cross Reactions; Drug Hypersensitivity; Humans; Immunoglobuli

1989
Cimetidine-induced thrombocytopenia in a cirrhotic patient.
    DICP : the annals of pharmacotherapy, 1989, Volume: 23, Issue:2

    Topics: Cimetidine; Female; Fibrosis; Humans; Middle Aged; Thrombocytopenia

1989
Ranitidine in the newborn.
    Archives of disease in childhood, 1988, Volume: 63, Issue:8

    Topics: Cimetidine; Humans; Infant, Newborn; Infant, Premature, Diseases; Male; Ranitidine; Thrombocytopenia

1988
Severe thrombocytopenia due to combined cimetidine and phenytoin therapy.
    Neurosurgery, 1987, Volume: 20, Issue:6

    Topics: Adult; Aged; Bone Marrow Diseases; Cimetidine; Humans; Male; Phenytoin; Thrombocytopenia

1987
[A case of cimetidine-induced thrombocytopenia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1986, Volume: 27, Issue:3

    Topics: Adult; Cimetidine; Humans; Male; Stomach Ulcer; Thrombocytopenia

1986
Severe thrombocytopenia associated with phenytoin and cimetidine therapy.
    Surgical neurology, 1985, Volume: 23, Issue:2

    Topics: Aged; Cimetidine; Humans; Male; Phenytoin; Thrombocytopenia

1985