cimetidine has been researched along with Symptom Cluster in 32 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study showed that both drug regimens are significantly effective in preventing febrile attacks in PFAPA syndrome, and the presence of a MEFV gene mutation might not be the only significant risk factor for a response to colchicine." | 9.51 | Colchicine versus cimetidine: the better choice for Periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome prophylaxis, and the role of MEFV gene mutations. ( Asna Ashari, K; Mousavi T, M; Raeeskarami, SR; Sadeghi, P; Vahedi, M; Ziaee, V, 2022) |
| "To determine whether oral cimetidine, which reportedly improves symptoms in 60-70% of patients with painful bladder syndrome/interstitial cystitis has a similar mechanism of action on the human bladder and involving a similar peptidergic pathway as it has in human stomach, where it alters histamine-gastrin reactions mediated via H2 receptors and a proton pump." | 7.71 | Cimetidine in painful bladder syndrome: a histopathological study. ( Blackford, HN; Dasgupta, P; Dennis, P; Sharma, SD; Womack, C, 2001) |
| "Cimetidine, as an immunomodulating agent, appears to be beneficial in the in-depth treatment of (P)FAPA syndrome." | 7.70 | [(P)FAPA syndrome: value of cimetidine]. ( Ansoborlo, S; Carrère, A; Guillard, JM; Perel, Y; Pillet, P, 2000) |
| "Successful treatment with cimetidine of a case of severe metabolic alkalosis secondary to gastric hypersecretion in the short bowel syndrome has been presented." | 7.66 | Cimetidine in the treatment of severe metabolic alkalosis secondary to short bowel syndrome. ( Doherty, NJ; Matsumoto, T; Pavlides, CA; Sufian, S, 1978) |
| "The term fasciitis-panniculitis syndrome (FPS) is proposed as a novel compilation encompassing several disorders, common to which is subcutaneous induration caused by cicatrizing fasciitis as well as septal and lobular panniculitis and perimysial fibrosis." | 6.38 | The fasciitis-panniculitis syndrome: clinical spectrum and response to cimetidine. ( Boss, JH; Missellevitch, I; Naschitz, JE; Rosner, I; Shajrawi, I; Yeshurun, D; Zuckerman, E, 1992) |
| "This study showed that both drug regimens are significantly effective in preventing febrile attacks in PFAPA syndrome, and the presence of a MEFV gene mutation might not be the only significant risk factor for a response to colchicine." | 5.51 | Colchicine versus cimetidine: the better choice for Periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome prophylaxis, and the role of MEFV gene mutations. ( Asna Ashari, K; Mousavi T, M; Raeeskarami, SR; Sadeghi, P; Vahedi, M; Ziaee, V, 2022) |
| "Treatment with cimetidine caused the remission of cutaneous manifestations and the extracutaneous abnormalities, such as nailfold capillary disturbances and the presence of antithyroid antibodies, improved." | 5.28 | Treatment with cimetidine of atypical fasciitis panniculitis syndrome. ( Abrahamson, JE; Boss, JH; Misselevitch, I; Naschitz, JE; Rosner, I; Yeshurun, D, 1990) |
| "The use of antibiotics and cimetidine in PFAPA syndrome are ineffective." | 4.86 | PFAPA syndrome in children: A meta-analysis on surgical versus medical treatment. ( Athanasopoulos, I; Houlakis, M; Koudoumnakis, E; Parpounas, K; Peridis, S; Pilgrim, G, 2010) |
| "To determine whether oral cimetidine, which reportedly improves symptoms in 60-70% of patients with painful bladder syndrome/interstitial cystitis has a similar mechanism of action on the human bladder and involving a similar peptidergic pathway as it has in human stomach, where it alters histamine-gastrin reactions mediated via H2 receptors and a proton pump." | 3.71 | Cimetidine in painful bladder syndrome: a histopathological study. ( Blackford, HN; Dasgupta, P; Dennis, P; Sharma, SD; Womack, C, 2001) |
| "Cimetidine, as an immunomodulating agent, appears to be beneficial in the in-depth treatment of (P)FAPA syndrome." | 3.70 | [(P)FAPA syndrome: value of cimetidine]. ( Ansoborlo, S; Carrère, A; Guillard, JM; Perel, Y; Pillet, P, 2000) |
| "A 35-yr-old man with moderate hypertriglyceridemia, associated with a positive family history for hyperlipidemia, developed chylomicronemia with abdominal pain, muscle pain, and splenomegaly while being treated with cimetidine for a duodenal ulcer." | 3.67 | Chylomicronemia induced by cimetidine. ( Brunzell, JD; Iverius, PH, 1985) |
| "Successful treatment with cimetidine of a case of severe metabolic alkalosis secondary to gastric hypersecretion in the short bowel syndrome has been presented." | 3.66 | Cimetidine in the treatment of severe metabolic alkalosis secondary to short bowel syndrome. ( Doherty, NJ; Matsumoto, T; Pavlides, CA; Sufian, S, 1978) |
| "Mesenteric traction syndrome is described as sudden tachycardia, hypotension and flush." | 2.70 | Histamine release in mesenteric traction syndrome during abdominal aortic aneurysm surgery: prophylaxis with H1 and H2 antihistamines. ( Celik, I; Duda, D; Lorenz, W, 2002) |
| "Cimetidine therapy was associated with the resolution of the fevers in 7/26 (27%) patients; tonsillectomy was associated with the resolution of the fevers in 11/11 (100%) patients." | 2.46 | A clinical review of 105 patients with PFAPA (a periodic fever syndrome). ( Feder, HM; Salazar, JC, 2010) |
| "PFAPA or Marshall's syndrome is characterized by abrupt onset of periodic episodes of high fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis, often associated with headache and / or abdominal or joint pain." | 2.44 | Oral aphthous-like lesions, PFAPA syndrome: a review. ( Buonaiuto, C; Cirillo, N; Femiano, F; Gombos, F; Lanza, A, 2008) |
| "Idiopathic FPS, that is, eosinophilic fasciitis, was diagnosed in 14 patients." | 2.39 | The fasciitis-panniculitis syndromes. Clinical and pathologic features. ( Boss, JH; Misselevich, I; Naschitz, JE; Rosner, I; Yeshurun, D, 1996) |
| "The term fasciitis-panniculitis syndrome (FPS) is proposed as a novel compilation encompassing several disorders, common to which is subcutaneous induration caused by cicatrizing fasciitis as well as septal and lobular panniculitis and perimysial fibrosis." | 2.38 | The fasciitis-panniculitis syndrome: clinical spectrum and response to cimetidine. ( Boss, JH; Missellevitch, I; Naschitz, JE; Rosner, I; Shajrawi, I; Yeshurun, D; Zuckerman, E, 1992) |
| " The intimate relationship of the bioavailability of cimetidine and its effect in primary hyperparathyroidism is clearly demonstrated." | 2.37 | Hyperparathyroid crisis reviewed: a role for parenteral cimetidine? ( Ackroyd, FW; Garcia, M; Glick, H; Goldstone, RJ; Minervini, D; Sherwood, JK, 1986) |
| "Pharyngitis is the most frequent symptom associated with fever." | 1.72 | Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome: Clinical characteristics and treatment outcomes - a single center study in Japan. ( Kawano, Y; Ohnishi, T; Sato, S; Suganuma, E; Uejima, Y, 2022) |
| " If an underlying problem requires long-term immunosuppressive medication, it is wiser to choose cimetidine rather than increasing the steroid dosage to resolve atypical PFAPA." | 1.30 | PFAPA syndrome (Periodic Fever, Aphthous stomatitis, Pharyngitis, Adenitis). ( Chen, LC; Huang, JL; Lee, KF; Lee, WI; Lin, SJ; Yang, MH; Yeh, KW, 1999) |
| "Treatment with cimetidine caused the remission of cutaneous manifestations and the extracutaneous abnormalities, such as nailfold capillary disturbances and the presence of antithyroid antibodies, improved." | 1.28 | Treatment with cimetidine of atypical fasciitis panniculitis syndrome. ( Abrahamson, JE; Boss, JH; Misselevitch, I; Naschitz, JE; Rosner, I; Yeshurun, D, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (40.63) | 18.7374 |
| 1990's | 7 (21.88) | 18.2507 |
| 2000's | 6 (18.75) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Raeeskarami, SR | 1 |
| Sadeghi, P | 1 |
| Vahedi, M | 1 |
| Asna Ashari, K | 1 |
| Mousavi T, M | 1 |
| Ziaee, V | 1 |
| Ohnishi, T | 1 |
| Sato, S | 1 |
| Uejima, Y | 1 |
| Kawano, Y | 1 |
| Suganuma, E | 1 |
| Amarilyo, G | 1 |
| Rothman, D | 1 |
| Manthiram, K | 1 |
| Edwards, KM | 1 |
| Li, SC | 1 |
| Marshall, GS | 1 |
| Yildirim-Toruner, C | 1 |
| Haines, K | 1 |
| Ferguson, PJ | 1 |
| Lionetti, G | 1 |
| Cherian, J | 1 |
| Zhao, Y | 1 |
| DeLaMora, P | 1 |
| Syverson, G | 1 |
| Nativ, S | 1 |
| Twilt, M | 1 |
| Michelow, IC | 1 |
| Stepanovskiy, Y | 1 |
| Thatayatikom, A | 1 |
| Harel, L | 1 |
| Akoghlanian, S | 1 |
| Tucker, L | 1 |
| Marques, MC | 1 |
| Srinivasalu, H | 1 |
| Propst, EJ | 1 |
| Licameli, GR | 1 |
| Dedeoglu, F | 1 |
| Lapidus, S | 1 |
| Kutsuna, S | 1 |
| Ohmagari, N | 1 |
| Tanizaki, R | 1 |
| Hagino, N | 1 |
| Nishikomori, R | 1 |
| Ujiie, M | 1 |
| Takeshita, N | 1 |
| Hayakawa, K | 1 |
| Kato, Y | 1 |
| Kanagawa, S | 1 |
| Feder, HM | 2 |
| Salazar, JC | 1 |
| Peridis, S | 1 |
| Pilgrim, G | 1 |
| Koudoumnakis, E | 1 |
| Athanasopoulos, I | 1 |
| Houlakis, M | 1 |
| Parpounas, K | 1 |
| Duda, D | 1 |
| Lorenz, W | 1 |
| Celik, I | 1 |
| Pinto, A | 1 |
| Lindemeyer, RG | 1 |
| Sollecito, TP | 1 |
| Kolokotronis, A | 1 |
| Markopoulos, A | 1 |
| Voutas, S | 1 |
| Mataftsi, A | 1 |
| Ikonomidis, P | 1 |
| Antoniades, D | 1 |
| Schorderet, DF | 1 |
| Femiano, F | 1 |
| Lanza, A | 1 |
| Buonaiuto, C | 1 |
| Gombos, F | 1 |
| Cirillo, N | 1 |
| Friesen, SR | 1 |
| Hermreck, AS | 1 |
| Brackett, CE | 1 |
| Schimke, RN | 1 |
| Aram, H | 1 |
| Qvist, N | 1 |
| Storm, K | 1 |
| Iordanov, K | 1 |
| Dimitrov, A | 1 |
| Naschitz, JE | 3 |
| Boss, JH | 3 |
| Misselevich, I | 1 |
| Yeshurun, D | 3 |
| Rosner, I | 3 |
| Lamadé, WR | 1 |
| Friedl, W | 1 |
| Schmid, B | 1 |
| Meeder, PJ | 1 |
| Pillet, P | 1 |
| Ansoborlo, S | 1 |
| Carrère, A | 1 |
| Perel, Y | 1 |
| Guillard, JM | 1 |
| Lee, WI | 1 |
| Yang, MH | 1 |
| Lee, KF | 1 |
| Chen, LC | 1 |
| Lin, SJ | 1 |
| Yeh, KW | 1 |
| Huang, JL | 1 |
| Dasgupta, P | 1 |
| Sharma, SD | 1 |
| Womack, C | 1 |
| Blackford, HN | 1 |
| Dennis, P | 1 |
| Husemeyer, RP | 1 |
| Davenport, HT | 1 |
| Rajasekaran, T | 1 |
| Cortot, A | 1 |
| Fleming, CR | 1 |
| Malagelada, JR | 1 |
| Bardhan, KD | 1 |
| Doherty, NJ | 1 |
| Sufian, S | 1 |
| Pavlides, CA | 1 |
| Matsumoto, T | 1 |
| Murphy, JP | 1 |
| King, DR | 1 |
| Dubois, A | 1 |
| Zuckerman, E | 1 |
| Shajrawi, I | 1 |
| Missellevitch, I | 1 |
| Camerini, S | 1 |
| Cantarelli, A | 1 |
| Spotti, M | 1 |
| Nolli, M | 1 |
| Abrahamson, JE | 1 |
| Misselevitch, I | 1 |
| Mandel, H | 1 |
| Tirosh, E | 1 |
| Berant, M | 1 |
| Sherwood, JK | 1 |
| Garcia, M | 1 |
| Ackroyd, FW | 1 |
| Glick, H | 1 |
| Minervini, D | 1 |
| Goldstone, RJ | 1 |
| Iverius, PH | 1 |
| Brunzell, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Human Lipoprotein Pathophysiology - Subproject: Genetics of Familial Combined Hyperlipidemia[NCT00005313] | 450 participants (Actual) | Observational | 2001-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for cimetidine and Symptom Cluster
| Article | Year |
|---|---|
A clinical review of 105 patients with PFAPA (a periodic fever syndrome).
Topics: Child, Preschool; Cimetidine; Female; Fever; Histamine H2 Antagonists; Humans; Lymphadenitis; Male; | 2010 |
PFAPA syndrome in children: A meta-analysis on surgical versus medical treatment.
Topics: Adenoidectomy; Anti-Bacterial Agents; Child; Cimetidine; Fever; Glucocorticoids; Histamine H2 Antago | 2010 |
The PFAPA syndrome in oral medicine: differential diagnosis and treatment.
Topics: Analgesics; Anti-Inflammatory Agents; Child; Child, Preschool; Cimetidine; Diagnosis, Differential; | 2006 |
Oral aphthous-like lesions, PFAPA syndrome: a review.
Topics: Child; Cimetidine; Cytokines; Diagnosis, Differential; Fever; Histamine H2 Antagonists; Humans; Lymp | 2008 |
Acquired ichthyosis and related conditions.
Topics: Aged; Cimetidine; Clofazimine; Female; Hodgkin Disease; Humans; Ichthyosis; Lymphoma; Male; Neoplasm | 1984 |
[Antacid prevention of Mendel'son's syndrome during anesthesia in obstetrics].
Topics: Anesthesia, General; Anesthesia, Obstetrical; Antacids; Cimetidine; Female; Gastric Acidity Determin | 1982 |
The fasciitis-panniculitis syndromes. Clinical and pathologic features.
Topics: Adipose Tissue; Adrenal Cortex Hormones; Cimetidine; Diagnosis, Differential; Fasciitis; Histamine H | 1996 |
The fasciitis-panniculitis syndrome: clinical spectrum and response to cimetidine.
Topics: Cimetidine; Eosinophilia; Fasciitis; Humans; Panniculitis; Syndrome | 1992 |
Hyperparathyroid crisis reviewed: a role for parenteral cimetidine?
Topics: Adult; Aged; Calcium; Cimetidine; Emergencies; Female; Humans; Hypercalcemia; Hyperparathyroidism; M | 1986 |
7 trials available for cimetidine and Symptom Cluster
| Article | Year |
|---|---|
Colchicine versus cimetidine: the better choice for Periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome prophylaxis, and the role of MEFV gene mutations.
Topics: Child; Cimetidine; Colchicine; Fever; Humans; Lymphadenitis; Lymphadenopathy; Mutation; Pharyngitis; | 2022 |
Histamine release in mesenteric traction syndrome during abdominal aortic aneurysm surgery: prophylaxis with H1 and H2 antihistamines.
Topics: Aortic Aneurysm, Abdominal; Blood Pressure; Cardiac Output; Cimetidine; Dimethindene; Double-Blind M | 2002 |
Cimethidine pre-anesthetic. A prophylactic method against Mendelson's syndrome in cesarean section.
Topics: Anesthesia, Obstetrical; Bronchial Spasm; Cesarean Section; Cimetidine; Clinical Trials as Topic; Do | 1983 |
Bone cement implantation syndrome. A prospective randomised trial for use of antihistamine blockade.
Topics: Bone Cements; Cimetidine; Clemastine; Double-Blind Method; Female; Hip Prosthesis; Histamine H1 Anta | 1995 |
Cimetidine as a single oral dose for prophylaxis against Mendelson's syndrome.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anesthesia, General; Cimetidine; Female; Guanidines; | 1978 |
Duodenal erosions during cimetidine therapy.
Topics: Cimetidine; Duodenal Ulcer; Esophagitis, Peptic; Guanidines; Humans; Recurrence; Syndrome | 1979 |
[Comparison of the efficacy of famotidine and cimetidine in in prophylaxis of Mendelson's syndrome in elective surgery].
Topics: Cimetidine; Famotidine; Female; Humans; Male; Middle Aged; Pneumonia, Aspiration; Postoperative Comp | 1991 |
16 other studies available for cimetidine and Symptom Cluster
| Article | Year |
|---|---|
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome: Clinical characteristics and treatment outcomes - a single center study in Japan.
Topics: Child; Cimetidine; Colchicine; Female; Fever; Humans; Infant, Newborn; Japan; Lymphadenitis; Lymphad | 2022 |
Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group.
Topics: Adrenal Cortex Hormones; Advisory Committees; Antipyretics; Child; Child, Preschool; Cimetidine; Col | 2020 |
The first case of adult-onset PFAPA syndrome in Japan.
Topics: Adult; Cimetidine; Cytoskeletal Proteins; Female; Fever; Glucocorticoids; Heterozygote; Humans; Japa | 2016 |
Conjunctivitis as a sign of PFAPA syndrome.
Topics: Abdominal Pain; Child; Cimetidine; Conjunctivitis; Fever; Histamine H2 Antagonists; Humans; Lymphade | 2007 |
Cimetidine and the acid-aspiration syndrome.
Topics: Anesthesia; Cimetidine; Female; Gastric Juice; Guanidines; Humans; Hydrogen-Ion Concentration; Male; | 1980 |
Case reports; Cimetidine in the management of synchronous crises of MEA I.
Topics: Adrenal Gland Neoplasms; Adult; Cimetidine; Female; Guanidines; Humans; Multiple Endocrine Neoplasia | 1980 |
[(P)FAPA syndrome: value of cimetidine].
Topics: Child; Child, Preschool; Cimetidine; Enzyme Inhibitors; Female; Fever; Humans; Infant; Lymphadenitis | 2000 |
PFAPA syndrome (Periodic Fever, Aphthous stomatitis, Pharyngitis, Adenitis).
Topics: Azathioprine; Child; Cimetidine; Fever; Humans; Immunosuppressive Agents; Infant; Lymphadenitis; Mal | 1999 |
Cimetidine in painful bladder syndrome: a histopathological study.
Topics: Cimetidine; Cystitis, Interstitial; Female; Follow-Up Studies; Histamine H2 Antagonists; Humans; Mal | 2001 |
Improved nutrient absorption after cimetidine in short-bowel syndrome with gastric hypersecretion.
Topics: Adult; Cimetidine; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Digestion; Double-Blind Me | 1979 |
Cimetidine in the treatment of severe metabolic alkalosis secondary to short bowel syndrome.
Topics: Adult; Alkalosis; Cimetidine; Female; Gastric Juice; Guanidines; Humans; Intestine, Small; Postopera | 1978 |
Treatment of gastric hypersecretion with cimetidine in the short-bowel syndrome.
Topics: Cimetidine; Gastric Emptying; Gastric Juice; Gastrins; Guanidines; Humans; Intestinal Absorption; In | 1979 |
Cimetidine treatment for periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis.
Topics: Adolescent; Child; Child, Preschool; Cimetidine; Fever; Humans; Lymphadenitis; Male; Periodicity; Ph | 1992 |
Treatment with cimetidine of atypical fasciitis panniculitis syndrome.
Topics: Adult; Aged; Cimetidine; Eosinophilia; Fasciitis; Female; Humans; Male; Middle Aged; Panniculitis; P | 1990 |
Sandifer syndrome reconsidered.
Topics: Antacids; Child; Child, Preschool; Cimetidine; Domperidone; Dystonia; Female; Gastroesophageal Reflu | 1989 |
Chylomicronemia induced by cimetidine.
Topics: Adult; Cholesterol; Chylomicrons; Cimetidine; Duodenal Ulcer; Humans; Hyperlipidemia, Familial Combi | 1985 |