cimetidine has been researched along with Spinal Cord Injuries in 8 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| " It is concluded that cimetidine on this dosage schedule is not effective in the prevention of gastric erosions in a cervical cord section rat model, whereas the ulceroprotective effects of 16,16-dmPGE2 and antacids are significant." | 1.26 | Effects of antacids, cimetidine, and 16,16-dimethyl prostaglandin E2 on acute gastric erosions in a spinal rat. ( Gillich, A; Sigman, HH, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Oprişoreanu, AM | 1 |
| Ryan, F | 1 |
| Richmond, C | 1 |
| Dzekhtsiarova, Y | 1 |
| Carragher, NO | 1 |
| Becker, T | 1 |
| David, S | 1 |
| Becker, CG | 1 |
| Sharma, HS | 2 |
| Patnaik, R | 1 |
| Muresanu, DF | 1 |
| Lafuente, JV | 1 |
| Ozkizilcik, A | 1 |
| Tian, ZR | 1 |
| Nozari, A | 1 |
| Sharma, A | 1 |
| Zäch, GA | 1 |
| Gyr, KE | 1 |
| von Alvensleben, E | 1 |
| Mills, JG | 1 |
| Stalder, GA | 1 |
| Dunn, SL | 1 |
| Bloom, S | 1 |
| Sigman, HH | 2 |
| Gillich, A | 2 |
| Begin, L | 1 |
| Epstein, N | 1 |
| Hood, DC | 1 |
| Ransohoff, J | 1 |
| Fabian, TC | 1 |
| Boucher, BA | 1 |
| Croce, MA | 1 |
| Kuhl, DA | 1 |
| Janning, SW | 1 |
| Coffey, BC | 1 |
| Kudsk, KA | 1 |
| Winkler, T | 1 |
| Stålberg, E | 1 |
| Olsson, Y | 1 |
| Nyberg, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit[NCT00633035] | Phase 4 | 60 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis in Patients After Major Abdominal Surgery[NCT00839488] | Phase 4 | 6 participants (Actual) | Interventional | 2008-04-30 | Terminated (stopped due to the chief of GS left the hopsital and the successor did't want to keep on this study) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for cimetidine and Spinal Cord Injuries
| Article | Year |
|---|---|
A double-blind randomized, controlled study to investigate the efficacy of cimetidine given in addition to conventional therapy in the prevention of stress ulceration and haemorrhage in patients with acute spinal injury.
Topics: Adolescent; Adult; Aged; Cimetidine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Dou | 1984 |
Gastrointestinal bleeding in patients with spinal cord trauma. Effects of steroids, cimetidine, and mini-dose heparin.
Topics: Adrenal Cortex Hormones; Cimetidine; Gastrointestinal Hemorrhage; Guanidines; Heparin; Humans; Methy | 1981 |
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I | 1993 |
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I | 1993 |
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I | 1993 |
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I | 1993 |
5 other studies available for cimetidine and Spinal Cord Injuries
| Article | Year |
|---|---|
Drug screening in zebrafish larvae reveals inflammation-related modulators of secondary damage after spinal cord injury in mice.
Topics: Animals; Cimetidine; Cytokines; Drug Evaluation, Preclinical; Inflammation; Larva; Mammals; Mice; Sp | 2023 |
Histaminergic Receptors Modulate Spinal Cord Injury-Induced Neuronal Nitric Oxide Synthase Upregulation and Cord Pathology: New Roles of Nanowired Drug Delivery for Neuroprotection.
Topics: Animals; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems | 2017 |
Treatment of established spinal injury-induced gastric erosions in rats with cimetidine and 16,16-dimethyl prostaglandin E2.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Cimetidine; Gastric Acid; Guanidines; Male; Prostaglandins | 1983 |
Effects of antacids, cimetidine, and 16,16-dimethyl prostaglandin E2 on acute gastric erosions in a spinal rat.
Topics: Acute Disease; Animals; Antacids; Anti-Inflammatory Agents; Cimetidine; Gastric Acidity Determinatio | 1982 |
Role of histamine in spinal cord evoked potentials and edema following spinal cord injury: experimental observations in the rat.
Topics: Animals; Cimetidine; Edema; Evoked Potentials; Histamine; Histamine H2 Antagonists; Male; Rats; Rats | 1995 |