cimetidine has been researched along with Skin Neoplasms in 17 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Skin Neoplasms: Tumors or cancer of the SKIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen evaluable patients with metastatic malignant melanoma who had received no prior chemotherapy were treated with high-dose cimetidine orally, 600 mg q." | 9.07 | Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial. ( Einhorn, LH; Mandanas, R; Schultz, S; Scullin, D, 1991) |
| "Cimetidine, an H2 histamine antagonist, was used in the clinical management of progressive, multifocal melanomatosis in 3 adult gray horses." | 7.68 | Cimetidine for treatment of melanomas in three horses. ( Goetz, TE; Johnson, PJ; Keegan, KG; Ogilvie, GK, 1990) |
| "Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma." | 7.67 | Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study. ( Langvad, E; Pedersen, L; Rose, C, 1987) |
| "With the aim of potentiating the anti-tumour effect of interferon in metastatic malignant melanoma by concomitant inhibition of suppressor T cells, oral cimetidine (histamine-2 receptor antagonist) medication was added to interferon (HuIFN-alpha(Le] therapy in a series of 20 patients." | 7.66 | Metastatic malignant melanoma: regression induced by combined treatment with interferon [HuIFN-alpha(Le)] and cimetidine. ( Borgström, S; Flodgren, P; Jönsson, PE; Lindström, C; Sjögren, HO, 1983) |
| "Fifteen evaluable patients with metastatic malignant melanoma who had received no prior chemotherapy were treated with high-dose cimetidine orally, 600 mg q." | 5.07 | Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial. ( Einhorn, LH; Mandanas, R; Schultz, S; Scullin, D, 1991) |
| "Cimetidine, an H2 histamine antagonist, was used in the clinical management of progressive, multifocal melanomatosis in 3 adult gray horses." | 3.68 | Cimetidine for treatment of melanomas in three horses. ( Goetz, TE; Johnson, PJ; Keegan, KG; Ogilvie, GK, 1990) |
| "Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma." | 3.67 | Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study. ( Langvad, E; Pedersen, L; Rose, C, 1987) |
| "With the aim of potentiating the anti-tumour effect of interferon in metastatic malignant melanoma by concomitant inhibition of suppressor T cells, oral cimetidine (histamine-2 receptor antagonist) medication was added to interferon (HuIFN-alpha(Le] therapy in a series of 20 patients." | 3.66 | Metastatic malignant melanoma: regression induced by combined treatment with interferon [HuIFN-alpha(Le)] and cimetidine. ( Borgström, S; Flodgren, P; Jönsson, PE; Lindström, C; Sjögren, HO, 1983) |
| "Cimetidine was fed to one group during a 70 day period of chronic UVR (5 days/week for 10 weeks), to a second group from the end of this period to the end of the experiment at 286 days and a third group was fed a control diet only throughout the experiment." | 1.28 | The effect of the antihistamine cimetidine on ultraviolet-radiation-induced tumorigenesis in the hairless mouse. ( Matheson, MJ; Reeve, VE, 1991) |
| "N-Nitrosocimetidine (NCM) is a derivative of the drug cimetidine, a methylguanidine derivative used in the treatment of peptic ulcer, and is known to be inactive as a complete mouse skin carcinogen, even when given in repeated high doses for a long period." | 1.28 | N-nitrosocimetidine as an initiator of murine skin tumors with associated H-ras oncogene activation. ( Anderson, LM; Enomoto, T; Giner-Sorolla, A; Kovatch, RM; Perantoni, AO; Reed, CD; Rice, JM; Riggs, CW, 1989) |
| "N-Nitrosocimetidine (NCM) is a nitrosation product of cimetidine, a commonly-prescribed pharmaceutical agent." | 1.27 | N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice. ( Anderson, LM; Giner-Sorolla, A; Hagiwara, A; Kovatch, RM; Rehm, S; Rice, JM; Riggs, CW, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mamus, SW | 1 |
| Mladenovic, J | 1 |
| Hordinsky, MK | 1 |
| Dahl, MV | 1 |
| Kay, NE | 1 |
| Aram, H | 1 |
| Flodgren, P | 1 |
| Borgström, S | 1 |
| Jönsson, PE | 1 |
| Lindström, C | 1 |
| Sjögren, HO | 1 |
| Fitzsimons, C | 1 |
| Molinari, B | 1 |
| Duran, H | 1 |
| Palmieri, M | 1 |
| Davio, C | 1 |
| Cricco, G | 1 |
| Bergoc, R | 1 |
| Rivera, E | 1 |
| Hellstrand, K | 1 |
| Hermodsson, S | 1 |
| Naredi, P | 1 |
| Mellqvist, UH | 1 |
| Brune, M | 1 |
| Schmidt, H | 1 |
| Geertsen, PF | 1 |
| Fode, K | 1 |
| Rytter, C | 1 |
| Bastholt, L | 1 |
| von der Maase, H | 1 |
| Creagan, ET | 1 |
| Ahmann, DL | 1 |
| Frytak, S | 1 |
| Long, HJ | 1 |
| Chang, MN | 1 |
| Itri, LM | 1 |
| Matheson, MJ | 1 |
| Reeve, VE | 1 |
| Mandanas, R | 1 |
| Schultz, S | 1 |
| Scullin, D | 1 |
| Einhorn, LH | 1 |
| Fischer, SM | 1 |
| Patrick, KE | 1 |
| Patamalai, B | 1 |
| Slaga, TJ | 1 |
| Goetz, TE | 1 |
| Ogilvie, GK | 1 |
| Keegan, KG | 1 |
| Johnson, PJ | 1 |
| Harland, CC | 1 |
| Saihan, EM | 1 |
| Anderson, LM | 2 |
| Enomoto, T | 1 |
| Perantoni, AO | 1 |
| Riggs, CW | 2 |
| Kovatch, RM | 2 |
| Reed, CD | 1 |
| Giner-Sorolla, A | 2 |
| Rice, JM | 2 |
| Sterry, W | 1 |
| Hansen, G | 1 |
| Krüger, A | 1 |
| Christophers, E | 1 |
| Steiner, A | 1 |
| Wolf, C | 1 |
| Pehamberger, H | 1 |
| Hagiwara, A | 1 |
| Rehm, S | 1 |
| Pedersen, L | 1 |
| Rose, C | 1 |
| Langvad, E | 1 |
2 reviews available for cimetidine and Skin Neoplasms
| Article | Year |
|---|---|
Acquired ichthyosis and related conditions.
Topics: Aged; Cimetidine; Clofazimine; Female; Hodgkin Disease; Humans; Ichthyosis; Lymphoma; Male; Neoplasm | 1984 |
Histamine and cytokine therapy.
Topics: Animals; Antineoplastic Agents; Cimetidine; Combined Modality Therapy; Histamine; Humans; Immunother | 1998 |
3 trials available for cimetidine and Skin Neoplasms
| Article | Year |
|---|---|
Subcutaneous interleukin-2 and interferon-alpha plus cisplatin with and without prophylactic cimetidine in patients with metastatic malignant melanoma: a phase II study.
Topics: Adjuvants, Immunologic; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; | 2000 |
Three consecutive phase II studies of recombinant interferon alfa-2a in advanced malignant melanoma. Updated analyses.
Topics: Adjuvants, Immunologic; Antibodies; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Prot | 1987 |
Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Cimetidine; Drug Administration Schedule; Drug | 1991 |
12 other studies available for cimetidine and Skin Neoplasms
| Article | Year |
|---|---|
Cimetidine-induced remission of mycosis fungoides.
Topics: Cimetidine; Humans; Male; Middle Aged; Mycosis Fungoides; Skin Neoplasms | 1984 |
Metastatic malignant melanoma: regression induced by combined treatment with interferon [HuIFN-alpha(Le)] and cimetidine.
Topics: Adult; Aged; Cimetidine; Combined Modality Therapy; Female; Humans; Interferon Type I; Lung Neoplasm | 1983 |
Atypical association of H1 and H2 histamine receptors with signal transduction pathways during multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Count; Cimetidine; Cyclic AMP; Female; Histamine H1 | 1997 |
The effect of the antihistamine cimetidine on ultraviolet-radiation-induced tumorigenesis in the hairless mouse.
Topics: Animals; Antineoplastic Agents; Cimetidine; Female; Mice; Mice, Hairless; Neoplasms, Radiation-Induc | 1991 |
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capillary Permeability; Cimetidine; Diphenhydramine; Fema | 1990 |
Cimetidine for treatment of melanomas in three horses.
Topics: Animals; Cimetidine; Horse Diseases; Horses; Male; Melanoma; Skin Neoplasms | 1990 |
Regression of cutaneous metastatic malignant melanoma with topical diphencyprone and oral cimetidine.
Topics: Administration, Oral; Administration, Topical; Aged; Cimetidine; Cyclopropanes; Drug Administration | 1989 |
N-nitrosocimetidine as an initiator of murine skin tumors with associated H-ras oncogene activation.
Topics: Animals; Carcinogens; Cimetidine; Cocarcinogenesis; Dose-Response Relationship, Drug; Gene Expressio | 1989 |
Progression of mycosis fungoides during cimetidine therapy.
Topics: Aged; Cimetidine; Female; Humans; Male; Mycosis Fungoides; Skin Neoplasms | 1985 |
Comparison of the effects of three different treatment regimens of recombinant interferons (r-IFN alpha, r-IFN gamma, and r-IFN alpha + cimetidine) in disseminated malignant melanoma.
Topics: Cimetidine; Drug Evaluation; Drug Therapy, Combination; Fatigue; Female; Fever; Humans; Interferon T | 1987 |
N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cimetidine; Cocarcinogenesis; Lung Neoplasms; Mice; Neopl | 1988 |
Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Drug Evaluation; | 1987 |