cimetidine has been researched along with Sepsis in 9 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "12 patients of an intensive care unit on respirator with peritonitis respectively septic complications were treated with 300 mg/die Ranitidine or 2000 mg Cimetidine/die administered via perfusor infusion under the conditions of a randomized double blind study." | 9.05 | [Control of the intragastric pH value in infection and peritonitis by ranitidine versus cimetidine. A double-blind study]. ( Hölscher, AH; Ketterl, R; Siewert, JR; Weiser, HF, 1984) |
| " Gastric pH was monitored hourly and the dosage of medication adjusted as required to maintain gastric pH above 4." | 6.65 | Failure of gastric pH control by antacids or cimetidine in the critically ill: a valid sign of sepsis. ( Martin, LF; Max, MH; Polk, HC, 1980) |
| "12 patients of an intensive care unit on respirator with peritonitis respectively septic complications were treated with 300 mg/die Ranitidine or 2000 mg Cimetidine/die administered via perfusor infusion under the conditions of a randomized double blind study." | 5.05 | [Control of the intragastric pH value in infection and peritonitis by ranitidine versus cimetidine. A double-blind study]. ( Hölscher, AH; Ketterl, R; Siewert, JR; Weiser, HF, 1984) |
| "Cyclo-oxygenase inhibition (with ibuprofen) combined with histamine (H1, H2) receptor antagonism (with diphenhydramine and cimetidine) attenuates microvascular leak injury in sepsis syndromes." | 3.69 | Multi-agent therapy in the treatment of sepsis-induced microvascular injury. ( Carey, PD; Fowler, AA; Sugerman, HJ; Walsh, CJ; Windsor, AC, 1994) |
| "Critically ill trauma patients were entered in a prospective, randomized trial to determine the role of gastric colonization in the development of pneumonia." | 2.67 | Role of gastric colonization in the development of pneumonia in critically ill trauma patients: results of a prospective randomized trial. ( Burchard, KW; DeMaria, E; McDonald, L; Peterson, D; Robinson, A; Simms, HH, 1991) |
| " Gastric pH was monitored hourly and the dosage of medication adjusted as required to maintain gastric pH above 4." | 2.65 | Failure of gastric pH control by antacids or cimetidine in the critically ill: a valid sign of sepsis. ( Martin, LF; Max, MH; Polk, HC, 1980) |
| "Especially patients with severe sepsis or septic shock are prone to develop lesions of the upper gastrointestinal tract with consecutive bleeding." | 1.35 | [Stress ulcer prophylaxis in septic patients. Evidence-based overview]. ( Elke, G; Schädler, D; Scholz, J; Weiler, N; Zick, G, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elke, G | 1 |
| Schädler, D | 1 |
| Zick, G | 1 |
| Scholz, J | 1 |
| Weiler, N | 1 |
| Ketterl, R | 1 |
| Hölscher, AH | 1 |
| Weiser, HF | 1 |
| Siewert, JR | 1 |
| Hillman, KM | 1 |
| Martin, LF | 1 |
| Max, MH | 1 |
| Polk, HC | 1 |
| Carey, PD | 1 |
| Windsor, AC | 1 |
| Walsh, CJ | 1 |
| Fowler, AA | 1 |
| Sugerman, HJ | 1 |
| Belliveau, P | 1 |
| Vas, S | 1 |
| Himal, HS | 1 |
| Simms, HH | 1 |
| DeMaria, E | 1 |
| McDonald, L | 1 |
| Peterson, D | 1 |
| Robinson, A | 1 |
| Burchard, KW | 1 |
| Garvey, BM | 1 |
| McCambley, JA | 1 |
| Tuxen, DV | 1 |
| Ho, JL | 1 |
| Shands, KN | 1 |
| Friedland, G | 1 |
| Eckind, P | 1 |
| Fraser, DW | 1 |
3 trials available for cimetidine and Sepsis
| Article | Year |
|---|---|
[Control of the intragastric pH value in infection and peritonitis by ranitidine versus cimetidine. A double-blind study].
Topics: Abscess; Adolescent; Adult; Aged; Cimetidine; Clinical Trials as Topic; Critical Care; Double-Blind | 1984 |
Failure of gastric pH control by antacids or cimetidine in the critically ill: a valid sign of sepsis.
Topics: Adolescent; Adult; Antacids; Cimetidine; Critical Care; Female; Gastric Juice; Gastritis; Gastrointe | 1980 |
Role of gastric colonization in the development of pneumonia in critically ill trauma patients: results of a prospective randomized trial.
Topics: Adolescent; Adult; Antacids; Bacteria; Cimetidine; Cross Infection; Gastric Juice; Humans; Hydrogen- | 1991 |
6 other studies available for cimetidine and Sepsis
| Article | Year |
|---|---|
[Stress ulcer prophylaxis in septic patients. Evidence-based overview].
Topics: Anti-Ulcer Agents; Cimetidine; Duodenal Ulcer; Evidence-Based Medicine; Gastric Acid; Gastrointestin | 2008 |
Colonisation of the gastric contents in critically ill patients.
Topics: Cimetidine; Critical Care; Cross Infection; Gastric Acidity Determination; Gastric Mucosa; Humans; S | 1983 |
Multi-agent therapy in the treatment of sepsis-induced microvascular injury.
Topics: Animals; Cell Membrane Permeability; Cimetidine; Diphenhydramine; Hemodynamics; Hypochlorous Acid; I | 1994 |
Septic induced acute gastric erosions: the role of cimetidine.
Topics: Animals; Bacteroides fragilis; Cimetidine; Disease Models, Animal; Dogs; Enterococcus faecalis; Guan | 1978 |
Effects of gastric alkalization on bacterial colonization in critically ill patients.
Topics: Adult; Aged; Antacids; Anti-Bacterial Agents; Bacterial Physiological Phenomena; Cimetidine; Critica | 1989 |
An outbreak of type 4b Listeria monocytogenes infection involving patients from eight Boston hospitals.
Topics: Aged; Antacids; Boston; Cimetidine; Cross Infection; Disease Outbreaks; Epidemiologic Methods; Femal | 1986 |