cimetidine has been researched along with Seizures in 13 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 7.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| " We report that cimetidine in doses that may cause pharmacokinetic interactions did not affect the concentration-effect relationship of either the stimulating action of theophylline or the depressant activity of ethanol." | 5.30 | The effect of cimetidine on the pharmacodynamics of theophylline-induced seizures and ethanol hypnotic activity. ( Gilhar, D; Habib, G; Hoffman, A; Perlstein, I; Pinto, E, 1999) |
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 3.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| "Electroconvulsions were evoked in Albino Swiss mice by a current delivered via ear-clip electrodes." | 1.43 | The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice. ( Barczyński, B; Czuczwar, SJ; Świąder, K; Świąder, MJ; Tomaszewski, M, 2016) |
| " We report that cimetidine in doses that may cause pharmacokinetic interactions did not affect the concentration-effect relationship of either the stimulating action of theophylline or the depressant activity of ethanol." | 1.30 | The effect of cimetidine on the pharmacodynamics of theophylline-induced seizures and ethanol hypnotic activity. ( Gilhar, D; Habib, G; Hoffman, A; Perlstein, I; Pinto, E, 1999) |
| "Naloxone was ineffective in antagonizing the analgesic effect of Rhazya stricta on tail-flick and abdominal constriction tests, possibly indicating that this effect occurs via non-opiate pathways." | 1.29 | Central nervous system activity of Rhazya stricta (Decne) in mice. ( Ali, BH; Banna, NR; Bashir, AK; Tanira, MO, 1995) |
| "Dose dependency of clonic and/or tonic convulsion was observed, and the ED50 values of convulsive occurrence for cimetidine, ranitidine, famotidine, and nizatidine were 997, 662, 23." | 1.29 | Neurotoxic convulsions induced by histamine H2 receptor antagonists in mice. ( Iga, T; Kawakami, J; Sawada, Y; Shimokawa, M; Yamamoto, K, 1996) |
| "Cimetidine was intravenously infused to ureter ligated (UL) and control rats, and cimetidine concentration in plasma, brain and cerebrospinal fluid (CSF) were compared." | 1.29 | Effect of acute renal failure on neurotoxicity of cimetidine in rats. ( Iga, T; Kawakami, J; Nakada, Y; Sawada, Y; Yamamoto, K, 1995) |
| "Pretreatment with cimetidine resulted in a significant, dose-dependent decrease in the CD50 of lidocaine, whereas ranitidine pretreatment did not significantly alter the lidocaine CD50." | 1.27 | Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice. ( Kim, KC; Tasch, MD, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Świąder, MJ | 1 |
| Barczyński, B | 1 |
| Tomaszewski, M | 1 |
| Świąder, K | 1 |
| Czuczwar, SJ | 1 |
| Wu, YH | 1 |
| Wu, ML | 1 |
| Lin, CC | 1 |
| Chu, WL | 1 |
| Yang, CC | 1 |
| Lin, RT | 1 |
| Deng, JF | 1 |
| Bauman, JH | 1 |
| Kimelblatt, BJ | 1 |
| Caraccio, TR | 1 |
| Silverman, HM | 1 |
| Simon, GI | 1 |
| Beck, GJ | 1 |
| Autret, E | 1 |
| Mercier, C | 1 |
| Marimbu, J | 1 |
| Ali, BH | 1 |
| Bashir, AK | 1 |
| Banna, NR | 1 |
| Tanira, MO | 1 |
| Amabeoku, GJ | 1 |
| Chikuni, O | 1 |
| Shimokawa, M | 1 |
| Yamamoto, K | 2 |
| Kawakami, J | 2 |
| Sawada, Y | 2 |
| Iga, T | 2 |
| Nakada, Y | 1 |
| Hoffman, A | 1 |
| Perlstein, I | 1 |
| Habib, G | 1 |
| Pinto, E | 1 |
| Gilhar, D | 1 |
| Grave, W | 1 |
| Nadorp, JN | 1 |
| Rutten, JJ | 1 |
| Edmonds, ME | 1 |
| Ashford, RF | 1 |
| Brenner, MK | 1 |
| Saunders, A | 1 |
| Kim, KC | 1 |
| Tasch, MD | 1 |
13 other studies available for cimetidine and Seizures
| Article | Year |
|---|---|
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Cimetidine; Drug Interactions; Electroshock; Male; M | 2016 |
Determination of caprolactam and 6-aminocaproic acid in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Topics: Adult; Aminocaproic Acid; Caprolactam; Chromatography, Liquid; Cimetidine; Drug Interactions; Drug S | 2012 |
Cimetidine-theophylline interaction: report of four patients.
Topics: Adrenergic beta-Agonists; Aged; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Lung Dise | 1982 |
[Convulsion and cimetidine].
Topics: Child; Cimetidine; Humans; Male; Seizures | 1984 |
Central nervous system activity of Rhazya stricta (Decne) in mice.
Topics: Abdomen; Analgesia; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Cimetidine; | 1995 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; M | 1993 |
Neurotoxic convulsions induced by histamine H2 receptor antagonists in mice.
Topics: Animals; Anticonvulsants; Brain; Cimetidine; Convulsants; Famotidine; GABA Agonists; Histamine H2 An | 1996 |
Effect of acute renal failure on neurotoxicity of cimetidine in rats.
Topics: Acute Kidney Injury; Animals; Cimetidine; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar | 1995 |
The effect of cimetidine on the pharmacodynamics of theophylline-induced seizures and ethanol hypnotic activity.
Topics: Animals; Anti-Ulcer Agents; Brain; Cimetidine; Drug Interactions; Ethanol; Female; Hypnosis; Posture | 1999 |
Cimetidine and renal failure.
Topics: Acute Kidney Injury; Aged; Cimetidine; Gastritis; Guanidines; Humans; Male; Postoperative Complicati | 1977 |
Cimetidine: does neurotoxicity occur? Report of three cases.
Topics: Aged; Blood-Brain Barrier; Brain; Cimetidine; Confusion; Female; Guanidines; Humans; Kidney Failure, | 1979 |
Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice.
Topics: Anesthetics, Local; Animals; Brain Diseases; Cimetidine; Dose-Response Relationship, Drug; Drug Inte | 1986 |