cimetidine has been researched along with Schizophrenia in 4 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is considerable interest in the role of serotonin (5-HT) in the pathophysiology of schizophrenia and in the mechanism of action of clozapine, an atypical antipsychotic agent and a potent dopamine (DA), 5-HT2/5-HT1C and histamine (H) antagonist." | 9.07 | The cimetidine-induced increase in prolactin secretion in schizophrenia: effect of clozapine. ( Lee, MA; Maes, M; Meltzer, HY, 1993) |
| "Cimetidine (400 mg) was initiated on the afternoon of day 15 and administered three times daily with every dose of quetiapine thereafter." | 5.31 | The effect of multiple doses of cimetidine on the steady-state pharmacokinetics of quetiapine in men with selected psychotic disorders. ( Keck, PE; Strakowski, SM; Thyrum, PT; Wong, YW; Yeh, C, 2002) |
| " Eventual discontinuation of cimetidine therapy led to a return of schizophrenic symptoms, which responded to an increase in chlorpromazine dosage to previous levels." | 5.28 | Adverse interaction between cimetidine and chlorpromazine in two cases of chronic schizophrenia. ( Byrne, A; O'Shea, B, 1989) |
| "There is considerable interest in the role of serotonin (5-HT) in the pathophysiology of schizophrenia and in the mechanism of action of clozapine, an atypical antipsychotic agent and a potent dopamine (DA), 5-HT2/5-HT1C and histamine (H) antagonist." | 5.07 | The cimetidine-induced increase in prolactin secretion in schizophrenia: effect of clozapine. ( Lee, MA; Maes, M; Meltzer, HY, 1993) |
| "The cyclic adenosine monophosphate (cAMP) responses to histamine, prostaglandin-E1, and isoproterenol in polymorphonuclear leukocytes from drug-free normal controls and patients with schizophrenia or major depressive disorder were compared." | 3.67 | Cyclic-AMP production by polymorphonuclear leukocytes in psychiatric disorders. ( Coccaro, EF; Davidson, M; Davis, KL; Johns, CA; Kanof, PD; Siever, LJ, 1989) |
| "Cimetidine (400 mg) was initiated on the afternoon of day 15 and administered three times daily with every dose of quetiapine thereafter." | 1.31 | The effect of multiple doses of cimetidine on the steady-state pharmacokinetics of quetiapine in men with selected psychotic disorders. ( Keck, PE; Strakowski, SM; Thyrum, PT; Wong, YW; Yeh, C, 2002) |
| " Eventual discontinuation of cimetidine therapy led to a return of schizophrenic symptoms, which responded to an increase in chlorpromazine dosage to previous levels." | 1.28 | Adverse interaction between cimetidine and chlorpromazine in two cases of chronic schizophrenia. ( Byrne, A; O'Shea, B, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meltzer, HY | 1 |
| Maes, M | 1 |
| Lee, MA | 1 |
| Strakowski, SM | 1 |
| Keck, PE | 1 |
| Wong, YW | 1 |
| Thyrum, PT | 1 |
| Yeh, C | 1 |
| Kanof, PD | 1 |
| Coccaro, EF | 1 |
| Johns, CA | 1 |
| Davidson, M | 1 |
| Siever, LJ | 1 |
| Davis, KL | 1 |
| Byrne, A | 1 |
| O'Shea, B | 1 |
1 trial available for cimetidine and Schizophrenia
| Article | Year |
|---|---|
The cimetidine-induced increase in prolactin secretion in schizophrenia: effect of clozapine.
Topics: Adult; Cimetidine; Clozapine; Female; Humans; Male; Prolactin; Receptors, Serotonin; Schizophrenia; | 1993 |
3 other studies available for cimetidine and Schizophrenia
| Article | Year |
|---|---|
The effect of multiple doses of cimetidine on the steady-state pharmacokinetics of quetiapine in men with selected psychotic disorders.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 | 2002 |
Cyclic-AMP production by polymorphonuclear leukocytes in psychiatric disorders.
Topics: Adult; Alprostadil; Chronic Disease; Cimetidine; Cyclic AMP; Depressive Disorder; Female; Humans; Is | 1989 |
Adverse interaction between cimetidine and chlorpromazine in two cases of chronic schizophrenia.
Topics: Chlorpromazine; Cimetidine; Drug Interactions; Esophagitis, Peptic; Female; Humans; Male; Middle Age | 1989 |