cimetidine has been researched along with Reperfusion Injury in 15 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Microdialysis was used to study how ischemia-evoked gastric mucosal injury affects rat stomach histamine, which resides in enterochromaffin-like (ECL) cells and mast cells." | 7.73 | Ischemia of rat stomach mobilizes ECL cell histamine. ( Bernsand, M; Haenuki, Y; Håkanson, R; Hasegawa, J; Kishimoto, Y; Kitano, M; Kudo, M; Norlén, P, 2005) |
| "This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia-reperfusion in the rat intestine." | 7.70 | Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Fukuyama, K; Iwakiri, R; Kojima, M; Noda, T; Okamoto, K; Yoshida, T, 2000) |
| "Cimetidine treatment completely or partially reversed all the IR-mediated changes, while ranitidine was ineffective." | 5.36 | Effects of cytochrome p450 inhibition by cimetidine on the warm hepatic ischemia-reperfusion injury in rats. ( Mehvar, R; Shaik, IH, 2010) |
| "Microdialysis was used to study how ischemia-evoked gastric mucosal injury affects rat stomach histamine, which resides in enterochromaffin-like (ECL) cells and mast cells." | 3.73 | Ischemia of rat stomach mobilizes ECL cell histamine. ( Bernsand, M; Haenuki, Y; Håkanson, R; Hasegawa, J; Kishimoto, Y; Kitano, M; Kudo, M; Norlén, P, 2005) |
| "To observe the gastric mucosal injury caused by hemorrhagic shock and reperfusion and to compare the effect between Salvia miltiorrhizae extract F (SEF) and cimetidine (CI) on it." | 3.73 | Gastric mucosal injury due to hemorrhagic reperfusion and efficacy of Salvia miltiorrhizae extract F and cimetidine. ( Gao, MQ; Li, HQ; Yao, CB; Zhang, LH, 2005) |
| "This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia-reperfusion in the rat intestine." | 3.70 | Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Fukuyama, K; Iwakiri, R; Kojima, M; Noda, T; Okamoto, K; Yoshida, T, 2000) |
| " However, expression and/or function of these proteins often fluctuate in pathological conditions, causing individual pharmacokinetic variability." | 2.52 | [Molecular Biological Analysis of Factors Influencing Pharmacokinetics to Achieve Personalized Pharmacotherapy]. ( Ikemura, K, 2015) |
| "Cimetidine treatment completely or partially reversed all the IR-mediated changes, while ranitidine was ineffective." | 1.36 | Effects of cytochrome p450 inhibition by cimetidine on the warm hepatic ischemia-reperfusion injury in rats. ( Mehvar, R; Shaik, IH, 2010) |
| "Model of hemorrhagic shock reperfusion injury was produced by Itoh method." | 1.31 | [Mucosal injury of gastric corpus by hemorrhage reperfusion and comparison between preventing and therapeutic effect of Salvia extract F and cimetidine]. ( Li, H; Yao, C; Zhang, L, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikemura, K | 2 |
| Nakagawa, E | 1 |
| Kurata, T | 1 |
| Iwamoto, T | 1 |
| Okuda, M | 1 |
| Shaik, IH | 1 |
| Mehvar, R | 1 |
| Tomita, M | 1 |
| Kishimoto, H | 1 |
| Takizawa, Y | 1 |
| Hayashi, M | 1 |
| Kitano, M | 3 |
| Bernsand, M | 1 |
| Kishimoto, Y | 3 |
| Norlén, P | 1 |
| Håkanson, R | 1 |
| Haenuki, Y | 1 |
| Kudo, M | 1 |
| Hasegawa, J | 1 |
| Zhang, LH | 1 |
| Yao, CB | 1 |
| Gao, MQ | 1 |
| Li, HQ | 1 |
| Kotani, T | 1 |
| Murashima, Y | 1 |
| Kobata, A | 1 |
| Amagase, K | 1 |
| Takeuchi, K | 1 |
| Tsunada, S | 1 |
| Fujimoto, K | 2 |
| Gotoh, Y | 1 |
| Sakai, T | 1 |
| Kang, M | 1 |
| Sakata, T | 1 |
| Granger, DN | 1 |
| Tso, P | 1 |
| Kaszaki, J | 1 |
| Boros, M | 1 |
| Szabó, A | 1 |
| Nagy, S | 1 |
| Wada, K | 2 |
| Kamisaki, Y | 2 |
| Nakamoto, K | 2 |
| Kawasaki, H | 2 |
| Itoh, T | 2 |
| Ashida, K | 1 |
| Cordeiro, PG | 1 |
| Lee, JJ | 1 |
| Mastorakos, D | 1 |
| Hu, QY | 1 |
| Pinto, JT | 1 |
| Santamaria, E | 1 |
| Yoshida, T | 1 |
| Iwakiri, R | 1 |
| Noda, T | 1 |
| Okamoto, K | 1 |
| Kojima, M | 1 |
| Fukuyama, K | 1 |
| Yao, C | 1 |
| Zhang, L | 1 |
| Li, H | 1 |
| Bysani, GK | 1 |
| Kennedy, TP | 1 |
| Ky, N | 1 |
| Rao, NV | 1 |
| Blaze, CA | 1 |
| Hoidal, JR | 1 |
1 review available for cimetidine and Reperfusion Injury
| Article | Year |
|---|---|
[Molecular Biological Analysis of Factors Influencing Pharmacokinetics to Achieve Personalized Pharmacotherapy].
Topics: Animals; Cimetidine; Cyclosporine; Drug Therapy; Glycoproteins; Humans; Liver; Liver Transplantation | 2015 |
14 other studies available for cimetidine and Reperfusion Injury
| Article | Year |
|---|---|
Altered pharmacokinetics of cimetidine caused by down-regulation of renal rat organic cation transporter 2 (rOCT2) after liver ischemia-reperfusion injury.
Topics: Animals; Antiporters; Chromans; Cimetidine; Down-Regulation; Liver; Male; Organic Anion Transporters | 2013 |
Effects of cytochrome p450 inhibition by cimetidine on the warm hepatic ischemia-reperfusion injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Catalase; Cimetidine; Cytochrome P-450 E | 2010 |
Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cimetidine; Cyclosp | 2009 |
Ischemia of rat stomach mobilizes ECL cell histamine.
Topics: Animals; Cimetidine; Enterochromaffin-like Cells; Gastric Mucosa; Histamine; Histamine H2 Antagonist | 2005 |
Gastric mucosal injury due to hemorrhagic reperfusion and efficacy of Salvia miltiorrhizae extract F and cimetidine.
Topics: Animals; Calcium Channel Blockers; Cimetidine; Drugs, Chinese Herbal; Gastric Mucosa; Histamine H2 A | 2005 |
Pathogenic importance of pepsin in ischemia/reperfusion-induced gastric injury.
Topics: Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Dose-Response Relationship, Drug; Male; Omeprazole | 2007 |
Role of histamine receptors in intestinal repair after ischemia-reperfusion in rats.
Topics: Animals; Biological Transport; Chlorpheniramine; Cimetidine; Dietary Fats; Histamine Antagonists; Hi | 1994 |
Role of histamine in the intestinal flow response following mesenteric ischemia.
Topics: Animals; Blood Flow Velocity; Cimetidine; Cromolyn Sodium; Dogs; Female; Guanidines; Histamine; Ileu | 1994 |
Effects of cimetidine on acute gastric mucosal injury induced by ischemia-reperfusion in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Erythrocyte Membrane; Famotidine; Gastric Mucosa; Histamine | 1997 |
The role of endogenous acid in the development of acute gastric ulcer induced by ischemia-reperfusion in the rat.
Topics: Acute Disease; Animals; Anti-Ulcer Agents; Cimetidine; Gastric Acid; Gastric Mucosa; Ischemia; Male; | 1998 |
Prevention of ischemia-reperfusion injury in a rat skin flap model: the role of mast cells, cromolyn sodium, and histamine receptor blockade.
Topics: Animals; Cell Count; Cimetidine; Cromolyn Sodium; Diphenhydramine; Female; Histamine Antagonists; Ma | 2000 |
Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion.
Topics: Animals; Apoptosis; Chlorpheniramine; Cimetidine; Guanidines; Histamine; Histamine Antagonists; Inte | 2000 |
[Mucosal injury of gastric corpus by hemorrhage reperfusion and comparison between preventing and therapeutic effect of Salvia extract F and cimetidine].
Topics: Animals; Cimetidine; Drugs, Chinese Herbal; Gastric Mucosa; Histamine H2 Antagonists; Male; Plant Ex | 2000 |
Role of cytochrome P-450 in reperfusion injury of the rabbit lung.
Topics: Animals; Capillary Permeability; Cimetidine; Cytochrome P-450 Enzyme System; Iron; Ischemia; Lung; M | 1990 |