cimetidine has been researched along with Renal Insufficiency in 5 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although mild elevation of serum creatinine level following the administration of cimetidine is relatively common, acute interstitial nephritis (AIN) is a rare hypersensitivity reaction." | 4.81 | Nephrotoxicity and hepatotoxicity of histamine H2 receptor antagonists. ( Fisher, AA; Le Couteur, DG, 2001) |
| " Cefaclor is not metabolized to a significant degree, but it degrades chemically in the body with an approximate half-life of 2 hours." | 2.40 | Pharmacokinetic profile of cefaclor. ( Derendorf, H; Schifferer, H; Sourgens, H, 1997) |
| "Morinidazole is a novel 5-nitroimidazole antimicrobial drug that undergoes extensive metabolism in humans via N(+)-glucuronidation (N(+)-glucuronide of S-morinidazole [M8-1] and N(+)-glucuronide of R-morinidazole [M8-2]) and sulfation (sulfate conjugate of morinidazole [M7])." | 1.40 | Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearance of the conjugated metabolites. ( Chen, X; Li, X; Xie, C; Zhang, Y; Zhong, D; Zhong, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhong, K | 1 |
| Li, X | 1 |
| Xie, C | 1 |
| Zhang, Y | 1 |
| Zhong, D | 1 |
| Chen, X | 1 |
| Idali, B | 1 |
| Miguil, M | 1 |
| Moutawakkil, S | 1 |
| Bouaggad, A | 1 |
| Guartit, A | 1 |
| Abassi, O | 1 |
| Ben Aguida, M | 1 |
| Sourgens, H | 1 |
| Derendorf, H | 1 |
| Schifferer, H | 1 |
| Andreev, E | 1 |
| Koopman, M | 1 |
| Arisz, L | 1 |
| Fisher, AA | 1 |
| Le Couteur, DG | 1 |
3 reviews available for cimetidine and Renal Insufficiency
| Article | Year |
|---|---|
Pharmacokinetic profile of cefaclor.
Topics: Aged; Antacids; Area Under Curve; Cefaclor; Cephalosporins; Child; Cimetidine; Drug Interactions; Ha | 1997 |
A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?
Topics: Adrenal Cortex Hormones; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvuls | 1999 |
Nephrotoxicity and hepatotoxicity of histamine H2 receptor antagonists.
Topics: Cimetidine; Creatinine; Duodenal Ulcer; Histamine; Histamine H2 Antagonists; Humans; Liver Failure; | 2001 |
2 other studies available for cimetidine and Renal Insufficiency
| Article | Year |
|---|---|
Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearance of the conjugated metabolites.
Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Cell Line; Cimetidine; Female; HEK293 Cells; Humans; | 2014 |
[Acute phostoxin poisoning].
Topics: Acute Disease; Adult; Aluminum Compounds; Cardiotonic Agents; Chemical and Drug Induced Liver Injury | 1995 |