cimetidine has been researched along with Rectal Neoplasms in 8 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Rectal Neoplasms: Tumors or cancer of the RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The histamine-2 receptor antagonist cimetidine (10(-5)M) and the prostaglandin synthesis inhibitor indomethacin (10(-8)M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma." | 3.67 | Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. ( Flodgren, P; Sjögren, HO, 1985) |
| "Four lines of human colorectal cancer were established and serially propagated as subcutaneous xenographs in immunosuppressed inbred CBA/Lac mice." | 1.26 | Influence of histamine and serotonin antagonists on the growth of xenografted human colorectal tumors. ( Barkla, DH; Tutton, PJ, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doldi, K | 1 |
| Manger, B | 1 |
| Koch, B | 1 |
| Riemann, J | 1 |
| Hermanek, P | 1 |
| Kalden, JR | 1 |
| Barkla, DH | 1 |
| Tutton, PJ | 2 |
| Matsumoto, S | 1 |
| Svendsen, LB | 1 |
| Ross, C | 1 |
| Knigge, U | 1 |
| Frederiksen, HJ | 1 |
| Graversen, P | 1 |
| Kjaergård, J | 1 |
| Luke, M | 1 |
| Stimpel, H | 1 |
| Sparsø, BH | 1 |
| Katsumoto, Y | 1 |
| Furukawa, J | 1 |
| Yoshioka, S | 1 |
| Shingai, T | 1 |
| Takekuni, K | 1 |
| Yukawa, M | 1 |
| Nakaguchi, K | 1 |
| Okajima, S | 1 |
| Sue, F | 1 |
| Hashimoto, T | 1 |
| Teshima, S | 1 |
| Steel, GG | 1 |
| Zhu, HM | 1 |
| Flodgren, P | 1 |
| Sjögren, HO | 1 |
2 trials available for cimetidine and Rectal Neoplasms
| Article | Year |
|---|---|
Cimetidine and survival with colorectal cancer.
Topics: CD8-Positive T-Lymphocytes; Cimetidine; Colonic Neoplasms; Combined Modality Therapy; Disease-Free S | 1995 |
Cimetidine as an adjuvant treatment in colorectal cancer. A double-blind, randomized pilot study.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Cimetidine; Colonic Neoplasm | 1995 |
6 other studies available for cimetidine and Rectal Neoplasms
| Article | Year |
|---|---|
Spontaneous suppressor cell activity in the peripheral blood of patients with malignant and chronic inflammatory bowel diseases.
Topics: Adenocarcinoma; Adult; Antigens, Surface; Cells, Cultured; Cimetidine; Colonic Neoplasms; Crohn Dise | 1984 |
Influence of histamine and serotonin antagonists on the growth of xenografted human colorectal tumors.
Topics: Amidines; Animals; Cimetidine; Colonic Neoplasms; Female; Guanidines; Humans; Kinetics; Male; Mice; | 1981 |
[A case of locally advanced rectal carcinoma with liver metastasis treated with a combination of CRT, HAI, and systemic chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Combined Modality | 2000 |
Influence of biogenic amines on the growth of xenografted human colorectal carcinomas.
Topics: Adrenergic Agonists; Animals; Biogenic Amines; Cimetidine; Colonic Neoplasms; Female; Humans; Mice; | 1979 |
[Short-term results of intratumor BCG injection for rectal carcinoma].
Topics: Adult; Aged; BCG Vaccine; Cimetidine; Combined Modality Therapy; Cyclophosphamide; Epithelioid Cells | 1990 |
Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.
Topics: Antibody-Dependent Cell Cytotoxicity; Carcinoma; Cimetidine; Colonic Neoplasms; Cytotoxicity, Immuno | 1985 |