Page last updated: 2024-10-25

cimetidine and Pruritus

cimetidine has been researched along with Pruritus in 32 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

Research Excerpts

ExcerptRelevanceReference
"The effect of oral Cimetidine compared to a classic antihistaminic and to a placebo was evaluated, under the double hypothesis of its anti-PTH and anti-pruritus action, in a population of patients recently included in Hemodialysis that were asked about the incidence and intensity of pruritus according to a scored questionnaire made for this purpose."9.05Dialysis pruritus: effect of cimetidine. ( Aguilera, J; Aubia, J; Garcia, C; LLorach, I; LLorach, M; LLoveras, J; Masramon, J; Rius, E, 1980)
" The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers."9.04The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus. ( Davies, MG; Horton, RJ; Marks, R; Storari, FE, 1979)
"We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr."7.67Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone. ( Farnam, J; Grant, JA; Guernsey, BG; Jorizzo, JL; Petrusa, ER, 1984)
"Intravenous cimetidine treatment was prescribed for patients suffering from anaphylaxis, urticaria, pruritus, and contact dermatitis."7.67Intravenous cimetidine as an effective treatment for systemic anaphylaxis and acute allergic skin reactions. ( Asano, M; Au-Yong, TF; Kimura, S; Mayumi, H; Shimokawa, T; Yayama, T, 1987)
"Thirty-four patients with polycythemia vera complicated by pruritus were treated with 900 mg of cimetidine daily for 30 days and their responses to treatment were evaluated."7.66The use of cimetidine for the treatment of pruritus in polycythemia vera. ( Cooperberg, AA; Donovan, PB; Dresch, C; Goldberg, JD; Najean, Y; Pisciotta, AV; Weick, JK, 1982)
"A 34-year-old woman who had had intractable pruritus for 2 years experienced dramatic relief from the symptom under treatment with cimetidine."7.66[Pruritus in Hodgkin's disease responding to cimetidine]. ( Graf, W; Stäubli, M; Straub, PW, 1981)
"Of the 35 patients with pruritus, all 12 receiving diphenhydramine placebo had clinically significant relief compared with six of ten (60%) receiving cimetidine plus placebo (P = ."5.07Histamine antagonists in the treatment of acute allergic reactions. ( Caravati, EM; Hartsell, SC; Martinez, JC; Runge, JW; Williamson, SG, 1992)
"The effect of oral Cimetidine compared to a classic antihistaminic and to a placebo was evaluated, under the double hypothesis of its anti-PTH and anti-pruritus action, in a population of patients recently included in Hemodialysis that were asked about the incidence and intensity of pruritus according to a scored questionnaire made for this purpose."5.05Dialysis pruritus: effect of cimetidine. ( Aguilera, J; Aubia, J; Garcia, C; LLorach, I; LLorach, M; LLoveras, J; Masramon, J; Rius, E, 1980)
" The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers."5.04The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus. ( Davies, MG; Horton, RJ; Marks, R; Storari, FE, 1979)
"We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr."3.67Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone. ( Farnam, J; Grant, JA; Guernsey, BG; Jorizzo, JL; Petrusa, ER, 1984)
"Intravenous cimetidine treatment was prescribed for patients suffering from anaphylaxis, urticaria, pruritus, and contact dermatitis."3.67Intravenous cimetidine as an effective treatment for systemic anaphylaxis and acute allergic skin reactions. ( Asano, M; Au-Yong, TF; Kimura, S; Mayumi, H; Shimokawa, T; Yayama, T, 1987)
"Thirty-four patients with polycythemia vera complicated by pruritus were treated with 900 mg of cimetidine daily for 30 days and their responses to treatment were evaluated."3.66The use of cimetidine for the treatment of pruritus in polycythemia vera. ( Cooperberg, AA; Donovan, PB; Dresch, C; Goldberg, JD; Najean, Y; Pisciotta, AV; Weick, JK, 1982)
"A 34-year-old woman who had had intractable pruritus for 2 years experienced dramatic relief from the symptom under treatment with cimetidine."3.66[Pruritus in Hodgkin's disease responding to cimetidine]. ( Graf, W; Stäubli, M; Straub, PW, 1981)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199026 (81.25)18.7374
1990's3 (9.38)18.2507
2000's2 (6.25)29.6817
2010's1 (3.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Sharma, N1
Kuraishi, Y1
Ohtsuka, E1
Nakano, T1
Kawai, S1
Andoh, T1
Nojima, H1
Kamimura, K1
Deutsch, PH1
Van Stee, EW1
Chee, YC1
Farnam, J1
Grant, JA1
Guernsey, BG1
Jorizzo, JL1
Petrusa, ER1
Thiers, B1
Weick, JK1
Donovan, PB1
Najean, Y1
Dresch, C1
Pisciotta, AV1
Cooperberg, AA1
Goldberg, JD1
Sandhu, BS1
Requena, R1
Greaves, MW1
Davies, MG2
Aubia, J1
Aguilera, J1
LLorach, I1
Garcia, C1
Rius, E1
LLoveras, J1
Masramon, J1
LLorach, M1
Stäubli, M1
Graf, W1
Straub, PW1
Aymard, JP1
Lederlin, P1
Witz, F1
Colomb, JN1
Herbeuval, R1
Weber, B1
Roberts, DL1
Aubert, M1
Quilicchini, R1
Carcassonne, Y1
Taillandier, J1
Bussone, A1
Manigand, G1
Inoue, A1
Teramae, H1
Hisa, T1
Taniguchi, S1
Chanoki, M1
Hamada, T1
Renz, C1
Lynch, J1
Thurn, J1
Moss, J1
Schapira, DV1
Bennett, JM1
Harrison, AR1
Littenberg, G1
Goldstein, L1
Kaplowitz, N1
Marks, R1
Horton, RJ2
Storari, FE1
Zappacosta, AR1
Hauss, D1
Easton, P1
Galbraith, PR1
Hess, CE1
Scott, GL1
Runge, JW1
Martinez, JC1
Caravati, EM1
Williamson, SG1
Hartsell, SC1
Massone, L1
Pestarino, A1
Borghi, S1
Isola, V1
Gambini, C1
Youngchaiyud, U1
Aram, H1
Mayumi, H1
Kimura, S1
Asano, M1
Shimokawa, T1
Au-Yong, TF1
Yayama, T1
Berild, D1
Hasselbalch, H1

Reviews

1 review available for cimetidine and Pruritus

ArticleYear
Cimetidine in dermatology.
    International journal of dermatology, 1987, Volume: 26, Issue:3

    Topics: Androgen Antagonists; Animals; Cimetidine; Humans; Immunity, Cellular; Neoplasms; Pruritus; Skin Dis

1987

Trials

6 trials available for cimetidine and Pruritus

ArticleYear
Dialysis pruritus: effect of cimetidine.
    Journal of dialysis, 1980, Volume: 4, Issue:4

    Topics: Cimetidine; Guanidines; Humans; Placebos; Pruritus; Renal Dialysis

1980
Histamine release during rapid vancomycin administration.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1

    Topics: Anti-Bacterial Agents; Cimetidine; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Exan

1998
Pruritus, cimetidine and polycythemia.
    The New England journal of medicine, 1979, 02-22, Volume: 300, Issue:8

    Topics: Cholestasis; Cimetidine; Clinical Trials as Topic; Guanidines; Humans; Pruritus

1979
The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus.
    Archives of dermatological research, 1979, Volume: 266, Issue:2

    Topics: Adult; Chlorpheniramine; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Co

1979
Histamine antagonists in the treatment of acute allergic reactions.
    Annals of emergency medicine, 1992, Volume: 21, Issue:3

    Topics: Adult; Anaphylaxis; Blood Pressure; Cimetidine; Diphenhydramine; Double-Blind Method; Drug Therapy,

1992
Comparison of the efficacy of four antihistamines in chronic urticaria.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1988, Volume: 71, Issue:10

    Topics: Adolescent; Adult; Chlorpheniramine; Chronic Disease; Cimetidine; Clemastine; Double-Blind Method; D

1988

Other Studies

25 other studies available for cimetidine and Pruritus

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Aquagenic pruritus.
    British journal of hospital medicine (London, England : 2005), 2008, Volume: 69, Issue:5

    Topics: Adult; Cimetidine; Hand Dermatoses; Histamine H2 Antagonists; Humans; Male; Pruritus; Treatment Outc

2008
Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.
    Journal of pharmacological sciences, 2007, Volume: 105, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Betamethasone Valerate; Bridged Bicyclo Compounds, Heterocycli

2007
Dermatographism treated with hydroxyzine and cimetidine and ranitidine.
    Annals of internal medicine, 1984, Volume: 101, Issue:4

    Topics: Adult; Cimetidine; Dermatitis, Atopic; Drug Therapy, Combination; Humans; Hydroxyzine; Male; Pruritu

1984
Alternative to corticosteroids in the management of pruritus in dogs.
    Veterinary medicine, small animal clinician : VM, SAC, 1981, Volume: 76, Issue:3

    Topics: Animals; Chlorpheniramine; Cimetidine; Dog Diseases; Dogs; Glucocorticoids; Guanidines; Histamine H1

1981
Effects of cimetidine, ranitidine and promethazine on histamine--induced dermal weals and pruritus--a case study.
    Singapore medical journal, 1983, Volume: 24, Issue:3

    Topics: Adult; Cimetidine; Drug Eruptions; Drug Therapy, Combination; Histamine; Humans; Male; Methyltestost

1983
Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone.
    The Journal of allergy and clinical immunology, 1984, Volume: 73, Issue:6

    Topics: Angioedema; Chlorpheniramine; Cimetidine; Double-Blind Method; Drug Therapy, Combination; Histamine;

1984
Therapeutic briefs. I.
    Journal of the American Academy of Dermatology, 1980, Volume: 3, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Aspirin; Child; Cimetidine; Cyclophosphamide; Dipyridamole; Female; Hu

1980
The use of cimetidine for the treatment of pruritus in polycythemia vera.
    Archives of internal medicine, 1982, Volume: 142, Issue:2

    Topics: Cimetidine; Guanidines; Humans; Polycythemia Vera; Pruritus

1982
Hypersensitivity to cimetidine.
    Annals of internal medicine, 1982, Volume: 97, Issue:1

    Topics: Adult; Angioedema; Cimetidine; Drug Hypersensitivity; Female; Guanidines; Humans; Pruritus

1982
Histamine receptors in human skin: indirect evidence.
    The British journal of dermatology, 1982, Volume: 107 Suppl 23

    Topics: Capillary Permeability; Chlorpheniramine; Cimetidine; Humans; Methylhistamines; Mitosis; Pruritus; R

1982
[Pruritus in Hodgkin's disease responding to cimetidine].
    Schweizerische medizinische Wochenschrift, 1981, May-16, Volume: 111, Issue:20

    Topics: Adult; Cimetidine; Female; Guanidines; Hodgkin Disease; Humans; Lomustine; Prednisone; Procarbazine;

1981
Cimetidine for pruritus in Hodgkin's disease.
    British medical journal, 1980, Jan-19, Volume: 280, Issue:6208

    Topics: Adult; Cimetidine; Guanidines; Hodgkin Disease; Humans; Male; Pruritus

1980
Cimetidine for pruritus related to systemic disorders.
    British medical journal, 1980, Feb-09, Volume: 280, Issue:6211

    Topics: Cimetidine; Guanidines; Humans; Pruritus

1980
[Trial treatment of the pruritus in Vaquez' disease with cimetidine].
    La Nouvelle presse medicale, 1980, Jul-05, Volume: 9, Issue:29

    Topics: Aged; Cimetidine; Female; Guanidines; Humans; Male; Middle Aged; Polycythemia Vera; Pruritus

1980
[Pruritus induced by cimetidine].
    La Nouvelle presse medicale, 1981, Jan-31, Volume: 10, Issue:4

    Topics: Aged; Cimetidine; Female; Guanidines; Humans; Male; Middle Aged; Pruritus

1981
Fixed drug eruption due to cimetidine.
    Acta dermato-venereologica, 1995, Volume: 75, Issue:3

    Topics: Cimetidine; Drug Eruptions; Erythema; Female; Hand Dermatoses; Humans; Middle Aged; Pruritus

1995
Cimetidine for pruritus.
    Lancet (London, England), 1979, Mar-31, Volume: 1, Issue:8118

    Topics: Aged; Anemia, Aplastic; Cimetidine; Female; Guanidines; Humans; Pruritus

1979
Cimetidine doesn't help pruritus of uremia.
    The New England journal of medicine, 1979, May-31, Volume: 300, Issue:22

    Topics: Cimetidine; Guanidines; Humans; Pruritus; Uremia

1979
Cimetidine treatment of pruritus in polycythemia vera.
    The New England journal of medicine, 1978, Nov-16, Volume: 299, Issue:20

    Topics: Cimetidine; Female; Guanidines; Humans; Middle Aged; Polycythemia Vera; Pruritus

1978
Cimetidine for the treatment of pruritus.
    The New England journal of medicine, 1979, Feb-15, Volume: 300, Issue:7

    Topics: Cimetidine; Guanidines; Humans; Myeloproliferative Disorders; Pruritus

1979
Pruritus, cimetidine and polycythemia.
    The New England journal of medicine, 1979, Feb-22, Volume: 300, Issue:8

    Topics: Aged; Cimetidine; Female; Guanidines; Humans; Polycythemia Vera; Pruritus

1979
[Hyperpigmented striae after bleomycin therapy].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1988, Volume: 123, Issue:5

    Topics: Aged; Bleomycin; Cimetidine; Hodgkin Disease; Humans; Male; Pigmentation Disorders; Pruritus

1988
Intravenous cimetidine as an effective treatment for systemic anaphylaxis and acute allergic skin reactions.
    Annals of allergy, 1987, Volume: 58, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Aged; Anaphylaxis; Child; Cimetidine; Dermatitis, Contact; Drug Ev

1987
[Itching of the skin in myeloproliferative disease treated with cimetidine].
    Ugeskrift for laeger, 1985, Apr-22, Volume: 147, Issue:17

    Topics: Aged; Cimetidine; Female; Humans; Male; Middle Aged; Myeloproliferative Disorders; Pruritus

1985