Page last updated: 2024-10-25

cimetidine and Pregnancy

cimetidine has been researched along with Pregnancy in 147 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" e) The gynaecomastia, galactorrhoea, amenorrhoea and impotence--reported only after long-term cimetidine treatment--can probably be attributed to the specific antiandrogen receptor property of CMT."4.77[Dysfunction of the hypothalamo-hypophyseal-gonadal axis induced by histamine H2 antagonists. Review of the literature and personal observations]. ( Biagi, P; Milani, G, 1985)
"Cimetidine, ranitidine, or water was administered to pregnant rats from the 12th day of pregnancy through weaning at 21 days of age."3.67Prenatal and neonatal exposure of male rat pups to cimetidine but not ranitidine adversely affects subsequent adult sexual functioning. ( Gavaler, JS; Parker, S; Pohl, CR; Schade, RR; Van Thiel, DH, 1984)
"Cumulative dose-response curves for histamine induced responses in mesometrial (ME) and antimesometrial (AME) regions of uterine horns isolated from rats at 7th, 16th and 22nd days of pregnancy, were constructed."3.67Is there a prostaglandin involvement in the positive inotropic action of histamine in isolated pregnant rat uterus, apparently mediated via H1-receptors activation? ( Dveksler, G; Franchi, AM; Gimeno, AL; Gimeno, MF; Viggiano, M, 1987)
" Similarly, the H2 receptor antagonists did not alter the plasma bupivacaine against time curves, half-life or bupivacaine clearance in the three groups studied."2.66H2 antagonists and bupivacaine clearance. ( Brighouse, D; Morgan, B; O'Sullivan, GM; Reynolds, F; Smith, M, 1988)
"The cimetidine-treated group received 300 mg cimetidine orally the evening before the operation and 300 mg intramuscularly between 1 and 3 h preoperatively."2.65Comparison of cimetidine (Tagamet) with antacid for safety and effectiveness in reducing gastric acidity before elective cesarean section. ( Coombs, DW; Gibbs, CP; Glassenberg, R; Hodgkinson, R; Joyce, TH; Ostheimer, GW, 1983)
" In the present article, the adverse effects of PPIs are reviewed, with special emphasis on those related to their continued administration and on the special circumstances of patients, as in the case of the elderly, those with liver failure, pregnant and breastfeeding mothers and children."2.43[Safety of proton pump inhibitors]. ( Esplugues, JV; Martí-Cabrera, M; Ponce, J, 2006)
" Coexisting disease states, such as renal or hepatic dysfunction, may require individualized dosing of these agents."2.37Individualization of calcium entry-blocker dosage for systemic hypertension. ( Piepho, RW, 1985)
"Cimetidine was used as an inhibitor for OCT-dependent active transfer."1.36The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta. ( Ekblad, U; Heikkinen, T; Laine, K; Rahi, M; Rönnemaa, T; Tertti, K, 2010)
"Cimetidine has been shown to induce gonadal and sexual dysfunction in men."1.31Effects of the prenatal administration of cimetidine on testicular descent and genital differentiation in rats. ( Kai, H; Suita, S; Takeshi, S, 2002)
"Cimetidine has been reported to cause antiandrogenic effects in male pups of female rats receiving cimetidine during gestation."1.29Development of secondary sex characteristics in male rats after fetal and perinatal cimetidine exposure. ( Hoie, EB; Leuschen, MP; Nelson, RM; Swigart, SA, 1994)
"Cimetidine treatment had no effect on milk lipid, solid, or protein content, but at 180 mg/kg/day, caused a significant increase in milk lactose."1.28Excretion of high concentrations of cimetidine and ranitidine into rat milk and their effects on milk composition and mammary gland nucleic acid content. ( Dostal, LA; Schwetz, BA; Weaver, RP, 1990)
"Cimetidine was administered in the mothers' drinking water at several levels reflecting both human and rat therapeutic-like doses from day 17 of gestation through day 7 of lactation."1.28Developmental levels and androgen responsiveness of hepatic mono-oxygenases of male rats perinatally exposed to maternally administered cimetidine. ( Bitar, MS; Shapiro, BH, 1991)
" Both p-HPPH and m-HPPH were much less developmentally toxic than DPH."1.28Use of Frog Embryo Teratogenesis Assay-Xenopus and an exogenous metabolic activation system to evaluate the developmental toxicity of diphenylhydantoin. ( Bantle, JA; Fort, DJ, 1990)
"With Cimetidine pretreatment the risk of aspiration and pneumonitis may be prevented."1.28Usefulness of acid and gastric juice secretion decreasing action of cimetidine in anaesthesia for the prevention of aspiration. ( Takács, G, 1989)
" In seven nonanesthetized sheep, maternal dosage produced mean steady-state plasma concentrations of 776 +/- 217 ng/ml in the mother and 32 +/- 15 ng/ml in the fetus."1.27Placental transfer and renal elimination of cimetidine in maternal and fetal sheep. ( Ching, MS; Hardy, KJ; Jones, DB; Mihaly, GW; Morgan, DJ; Smallwood, RA; Webster, LK, 1983)
"Cimetidine was effective in decreasing gastric volume and raising pH but the pH was still less than 2."1.27Cimetidine - antacid combination as premedication for elective Caesarean section. ( Bali, A; Motaweh, MM; Okasha, AS, 1983)
"Cimetidine was administered in the mothers' drinking water at several levels reflecting both human and rat therapeutic-like doses from day 17 of gestation through day 7 of lactation."1.27Prospective study on the sexual development of male and female rats perinatally exposed to maternally administered cimetidine. ( Babalola, GO; Bitar, MS; Hirst, SA; Shapiro, BH, 1988)
"Guanidine was transiently accumulated inside the vesicles against a concentration gradient in the presence of the H+ gradient."1.27Evidence for an organic cation-proton antiport system in brush-border membranes isolated from the human term placenta. ( Ganapathy, ME; Ganapathy, V; Leibach, FH; Mahesh, VB; Nair, CN, 1988)
"Cimetidine has weak antiandrogenic activity in rats, but does not affect fertility in male rats at daily doses up to 950 mg/kg."1.27Cimetidine does not demasculinize male rat offspring exposed in utero. ( Bond, BC; Bott, JH; Walker, TF, 1987)
"Cimetidine was administered as a bolus dose to either the maternal circuit alone (n = 4) or to both maternal and fetal circuits simultaneously (n = 3), to achieve initial concentrations of 4 micrograms/ml."1.27Low clearance of cimetidine across the human placenta. ( Ching, MS; Date, NM; Hardy, KJ; Mihaly, GW; Morgan, DJ; Smallwood, RA, 1987)
" The scheme successfully detected and quantified some already known adverse effects of cimetidine and did not detect any new effects."1.27Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report. ( Colin Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1985)
"Cimetidine was used as the routine antacid treatment for 1323 parturients."1.26A field trial of cimetidine as the sole oral antacid in obstetric anaesthesia. ( Dundee, JW; Johnston, JR; McCaughey, W; Moore, J, 1982)
"Cimetidine was given intravenously to fasting patients before elective Caesarean section."1.26Cimetidine in elective Caesarean section. Effect on gastric acidity. ( Dundee, JW; Howe, JP; McCaughey, W; Moore, J, 1981)
"Cimetidine was as effective as antacid in raising gastric pH but neither was completely reliable."1.26Cimetidine premedication in elective caesarean section. ( Cumming, M; Palahniuk, RJ; Pickering, BG, 1980)

Research

Studies (147)

TimeframeStudies, this research(%)All Research%
pre-1990105 (71.43)18.7374
1990's28 (19.05)18.2507
2000's10 (6.80)29.6817
2010's4 (2.72)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ikeda, K1
Ueda, C1
Yamada, K1
Nakamura, A1
Hatsuda, Y1
Kawanishi, S1
Nishii, S1
Ogawa, M1
Lee, CT1
Chen, J1
Hayashi, T1
Tsai, SY1
Sanchez, JF1
Errico, SL1
Amable, R1
Su, TP1
Lowe, RH1
Huestis, MA1
Shen, J1
Becker, KG1
Geller, HM1
Freed, WJ1
Gardiner, SJ1
Kirkpatrick, CM1
Zhang, M1
Begg, EJ1
Matok, I1
Gorodischer, R1
Koren, G2
Sheiner, E1
Wiznitzer, A1
Uziel, E1
Levy, A1
Tertti, K1
Ekblad, U1
Heikkinen, T1
Rahi, M1
Rönnemaa, T1
Laine, K1
Szukiewicz, D1
Szewczyk, G1
Mittal, TK1
Rongies, W1
Maslinski, S1
Bytautiene, E4
Vedernikov, YP3
Saade, GR4
Romero, R4
Garfield, RE4
Maul, H1
Vedernikov, Y1
Esplugues, JV1
Martí-Cabrera, M1
Ponce, J1
Cygalova, L1
Ceckova, M1
Pavek, P1
Staud, F1
Dundee, JW8
Moore, J11
Johnston, JR5
McCaughey, W7
Manchikanti, L1
Kraus, JW1
Edds, SP1
De Martiis, M1
D'Ottavi, R1
Patrizi, P1
Hoos, PC1
Hoffman, LH1
Parker, S1
Schade, RR1
Pohl, CR1
Gavaler, JS1
Van Thiel, DH2
Frank, M1
Evans, M1
Flynn, P1
Aun, C1
Qvist, N2
Storm, K2
Howard, PJ3
Toner, W1
McClean, E2
Simon, GL1
Gorbach, SL1
Bilynskiĭ, BT1
Shparik, IaV1
Bruguerolle, B1
Jadot, G1
Valli, M1
Bouyard, P1
Bacchi Modena, A1
Vadora, E1
Fiaschetti, D1
Micucci, G1
Lombardozzi, L1
Kaelin, AC1
Cummings, AJ1
Mihaly, GW4
Jones, DB2
Morgan, DJ5
Ching, MS4
Webster, LK1
Smallwood, RA5
Hardy, KJ4
Okasha, AS1
Motaweh, MM1
Bali, A1
Tryba, M1
Burkert, W1
Hüsch, M1
Zenz, M1
Berman, J1
Patel, S1
Moir, CL1
McMorland, GH1
Toung, TJ1
Cameron, JL2
Naftolin, F1
Imamura, I1
Maeyama, K1
Wada, H1
Watanabe, T1
Iordanov, K2
Dimitrov, A2
de Rosa, G1
Gulino, A1
de Rosa, E1
Satta, MA1
Aiello, A1
Makhoul, O1
Pasargiklian, E1
Cochrane, GW1
Swinhoe, JR1
Blakesley, ML1
Goodlin, R1
Woods, R1
Williams, N1
Moir, DD2
Hodgkinson, R1
Glassenberg, R1
Joyce, TH1
Coombs, DW1
Ostheimer, GW1
Gibbs, CP1
Messinis, IE2
Souvatzoglou, A1
Fais, N1
Lolis, D2
Ponce-Monter, H1
Hoyo-Vadillo, C1
Kubli-Garfias, C1
Stern, PH1
Snerling, S1
Baenziger, NL1
Force, LE1
Becherer, PR1
Witter, FR1
King, TM1
Blake, DA1
Ghishan, FK1
Pierce, E1
Farquharson, S1
Anand, S1
Garzon, B1
Ducroc, R1
Geloso, JP1
Iodice, M1
Lombardi, G1
Tommaselli, A1
Rossi, R1
Annunziato, L1
Minozzi, M1
Glade, G1
Saccar, CL1
Pereira, GR1
Howe, JP3
Hardesty, GA1
McGowan, WA2
Crawford, JS1
Nielsen, MS1
Pickering, BG1
Palahniuk, RJ1
Cumming, M1
Toung, T1
Baraka, A1
Shamma'a, M1
Husemeyer, RP1
Davenport, HT1
Gonzalez-Villapando, C1
Szabo, M1
Frohman, LA1
Osman, H1
Seaton, MJ1
Vesell, ES1
Hoie, EB1
Swigart, SA1
Nelson, RM1
Leuschen, MP1
Perney, P1
Diaz, D1
Bauret, P1
Larry, D1
Michel, H1
Gonzalez, R1
Reinicke, K1
Rudolph, GM1
Bassily, M1
Ghabrial, H1
Van der Aa, EM1
Wouterse, AC1
Copius Peereboom-Stegeman, JH1
Russel, FG1
Kuint, J1
Linder, N1
Reichman, B1
Anesini, C1
Genaro, A1
Cremaschi, G1
Zubillaga, M1
Boccio, J1
Sterin-Borda, L1
Borda, E1
Freeman, P1
Sturman, G1
Suhonen, AM1
Meade, HM1
Seeley, NA1
Luckman, SM1
Larsen, PJ1
Gené Badla, J1
Prieto Lozano, A1
Catalán Ramos, A1
Piura, B1
Meirovitz, M1
Kedar, I1
Matthiesen, L1
Berg, G1
Ernerudh, J1
Håkansson, L1
Zed, PJ1
Krenzelok, EP1
Ruigómez, A1
García Rodríguez, LA1
Cattaruzzi, C1
Troncon, MG1
Agostinis, L1
Wallander, MA1
Johansson, S1
Wessler, I1
Roth, E1
Deutsch, C1
Brockerhoff, P1
Bittinger, F1
Kirkpatrick, CJ1
Kilbinger, H1
Takeshi, S1
Kai, H1
Suita, S1
Eltze, M1
Voget, E1
Schollmeyer, P1
Zulli, P1
Di Nisio, Q1
Wienbeck, M1
Wollemann, M1
Papp, JG1
Bezuidenhout, DJ1
Karpow, S1
Gotz, V1
Lauper, RD1
Mogadam, M1
Zemlickis, DM1
Dostal, LA2
Weaver, RP1
Schwetz, BA1
Traĭkova, V1
Anastasov, D1
Nin'o, A1
Shapiro, BH2
Bitar, MS2
Cruz, MA2
González, C2
Sepúlveda, WH2
Rudolph, MI2
Czuba, MA1
Ormezzano, X2
Francois, TP1
Viaud, JY2
Bukowski, JG1
Bourgeonneau, MC2
Cottron, D1
Ganansia, MF2
Gregoire, FM2
Grinand, MR2
Wessel, PE2
Fort, DJ1
Bantle, JA1
Arnould, JF1
Bukowski, JC1
N'Guyen, NQ1
Burgess, RW1
Crowhurst, JA1
Jasson, J1
Armand, S1
Talafré, ML1
Mazuir, E1
Tallet, F1
Morisot, P1
Conseiller, C1
Flynn, RJ3
Collier, PS3
Kane, RE1
Lamott, J1
Franklin, MR1
Galinsky, RE1
Takács, G1
Acevedo, CG1
Dicke, JM1
Johnson, RF2
Henderson, GI2
Kuehl, TJ1
Schenker, S2
O'Sullivan, GM1
Smith, M1
Morgan, B1
Brighouse, D1
Reynolds, F1
Kwanashie, HO1
Osuide, G1
Wambebe, C1
Ikediobi, CO1
Emami, S1
Chastre, E1
Mulliez, N1
Gonzales, M1
Gespach, C1
Ganapathy, ME2
Leibach, FH2
Mahesh, VB2
Devoe, LD1
Ganapathy, V2
Kubota, T1
Kamada, S1
Tsuzuki, H1
Tei, A1
Saito, M1
Sondervan-Frank, BS1
Dailey, PA1
Hughes, SC1
Rosen, MA1
Healy, K1
Cheek, DB1
Shnider, SM1
Hirst, SA1
Babalola, GO1
Tsirkas, N1
Diamantis, K1
Vasakos, S1
Tsolas, O1
Nair, CN1
Pasanen, M1
Taskinen, T1
Sotaniemi, EA1
Kairaluoma, M1
Pelkonen, O1
Radev, RN1
Viggiano, M1
Franchi, AM1
Dveksler, G1
Gimeno, MF1
Gimeno, AL1
Walker, TF1
Bott, JH1
Bond, BC1
Pisoni, F1
Vimercati, C1
Pasquetti, G1
Moretti, MP1
Carnevali, M1
Thorburn, J1
Date, NM1
Nucete, HJ1
Bravo, M1
Somoza, B1
Kuhnert, BR1
Zuspan, KJ1
Kuhnert, PM1
Syracuse, CD1
Brashear, WT1
Brown, DE1
Jauhari, J1
Dicke, J1
Mor, LL1
Newman, B1
Lam, AM1
Abman, SH1
Wilkening, RB1
Ward, RM1
Accurso, FJ1
McAuley, DM1
Halliday, HL1
Stock, JG1
Sutherland, AD1
Piepho, RW1
Biagi, P1
Milani, G1
Lewis, JH1
Iba, MM1
Colin Jones, DG1
Langman, MJ1
Lawson, DH1
Vessey, MP1
Hamar, O1
Anderson, LM1
Giner-Sorolla, A1
Haller, IM1
Budinger, JM1
Holmskov, A1

Reviews

14 reviews available for cimetidine and Pregnancy

ArticleYear
[Safety of proton pump inhibitors].
    Medicina clinica, 2006, Nov-25, Volume: 127, Issue:20

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Adult; Age Factors; Aged; Animal

2006
Cimetidine and related drugs in anesthesia.
    Anesthesia and analgesia, 1982, Volume: 61, Issue:7

    Topics: Anesthesia, Obstetrical; Child; Cimetidine; Drug Administration Schedule; Emergencies; Female; Gastr

1982
Intestinal flora in health and disease.
    Gastroenterology, 1984, Volume: 86, Issue:1

    Topics: Adolescent; Adult; Aged; Bacteria, Anaerobic; Bacteriological Techniques; Cesarean Section; Child; C

1984
[Carcinogenicity of various drugs].
    Voprosy onkologii, 1984, Volume: 30, Issue:8

    Topics: Adult; Animals; Anti-Bacterial Agents; Arsenicals; Barbiturates; Brain Neoplasms; Carcinogens; Child

1984
[Antacid prevention of Mendel'son's syndrome during anesthesia in obstetrics].
    Akusherstvo i ginekologiia, 1982, Volume: 21, Issue:2

    Topics: Anesthesia, General; Anesthesia, Obstetrical; Antacids; Cimetidine; Female; Gastric Acidity Determin

1982
The effects of chronic gastrointestinal medication on the fetus and neonate.
    Obstetrics and gynecology, 1981, Volume: 58, Issue:5 Suppl

    Topics: Abnormalities, Drug-Induced; Antacids; Antiemetics; Cathartics; Cimetidine; Colonic Diseases, Functi

1981
Variables affecting nicotine metabolism.
    Pharmacology & therapeutics, 1993, Volume: 60, Issue:3

    Topics: Aging; Animals; Cimetidine; Dietary Proteins; Drug Interactions; Ethanol; Female; Genetic Variation;

1993
[Gastric protection in the treatment with NSAIDs].
    Atencion primaria, 1997, Mar-15, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cimetidi

1997
Treatment of acetaminophen overdose.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, Jun-01, Volume: 56, Issue:11

    Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anti-Ulcer Agents; Antidotes; Charco

1999
[The therapeutic importance of cimetidine (Tagamet) (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1978, Nov-03, Volume: 120, Issue:44

    Topics: Adult; Cimetidine; Diarrhea; Female; Galactorrhea; Gastritis; Guanidines; Gynecomastia; Headache; Hu

1978
[H2-receptor antagonists in obstetrical-gynecological anesthesiological work].
    Akusherstvo i ginekologiia, 1990, Volume: 29, Issue:2

    Topics: Anesthesia, Obstetrical; Cimetidine; Female; Gastric Mucosa; Histamine H2 Antagonists; Humans; Intra

1990
Cimetidine.
    IARC monographs on the evaluation of carcinogenic risks to humans, 1990, Volume: 50

    Topics: Animals; Carcinogens; Cimetidine; Dogs; Female; Male; Mice; Molecular Structure; Pregnancy; Rats; Re

1990
Individualization of calcium entry-blocker dosage for systemic hypertension.
    The American journal of cardiology, 1985, Dec-06, Volume: 56, Issue:16

    Topics: Adult; Age Factors; Aged; Calcium Channel Blockers; Child; Cimetidine; Diabetes Complications; Digox

1985
[Dysfunction of the hypothalamo-hypophyseal-gonadal axis induced by histamine H2 antagonists. Review of the literature and personal observations].
    Minerva medica, 1985, Mar-24, Volume: 76, Issue:12

    Topics: Amenorrhea; Androgens; Cimetidine; Erectile Dysfunction; Female; Follicle Stimulating Hormone; Galac

1985

Trials

16 trials available for cimetidine and Pregnancy

ArticleYear
Comparison of the prophylactic use of magnesium trisilicate mixture B.P.C., sodium citrate mixture or cimetidine in obstetrics.
    British journal of anaesthesia, 1984, Volume: 56, Issue:4

    Topics: Anesthesia, Obstetrical; Antacids; Cimetidine; Citrates; Citric Acid; Emergencies; Female; Humans; H

1984
Cimethidine pre-anesthetic. A prophylactic method against Mendelson's syndrome in cesarean section.
    Acta obstetricia et gynecologica Scandinavica, 1983, Volume: 62, Issue:2

    Topics: Anesthesia, Obstetrical; Bronchial Spasm; Cesarean Section; Cimetidine; Clinical Trials as Topic; Do

1983
Use of cimetidine as an oral antacid in obstetric anesthesia.
    Anesthesia and analgesia, 1983, Volume: 62, Issue:8

    Topics: Administration, Oral; Anesthesia, General; Anesthesia, Obstetrical; Antacids; Cimetidine; Citrates;

1983
[Effectiveness of cimetidine in the prevention of aspiration pneumonia in obstetrics].
    Fortschritte der Medizin, 1983, Oct-20, Volume: 101, Issue:39

    Topics: Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Gastric Acidity Determination; Humans

1983
Comparison of cimetidine (Tagamet) with antacid for safety and effectiveness in reducing gastric acidity before elective cesarean section.
    Anesthesiology, 1983, Volume: 59, Issue:2

    Topics: Adolescent; Adult; Aluminum Hydroxide; Anesthesia, General; Anesthesia, Obstetrical; Antacids; Cesar

1983
Ranitidine versus cimetidine prior to emergency obstetric anesthesia.
    Middle East journal of anaesthesiology, 1995, Volume: 13, Issue:2

    Topics: Anesthesia, Obstetrical; Apgar Score; Cimetidine; Emergencies; Female; Gastric Acid; Gastrointestina

1995
Effect of cimetidine on gastric pH in women undergoing elective Caesarean section [proceedings].
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:4

    Topics: Cesarean Section; Cimetidine; Female; Gastric Juice; Guanidines; Humans; Hydrogen-Ion Concentration;

1979
Aspiration pneumonitis prophylaxis in obstetric anaesthesia: comparison of effervescent cimetidine-sodium citrate mixture and sodium citrate.
    British journal of anaesthesia, 1990, Volume: 64, Issue:4

    Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Antacids; Cesarean Section; Cimetidine; Citrate

1990
Single dose oral H2-antagonists do not affect plasma lidocaine levels in the parturient.
    Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:7

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Drug Interactions; Fema

1989
Effect of intravenous cimetidine on lignocaine disposition during extradural caesarean section.
    Anaesthesia, 1989, Volume: 44, Issue:9

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Humans; Injecti

1989
H2 antagonists and bupivacaine clearance.
    Anaesthesia, 1988, Volume: 43, Issue:2

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Cimetidine; Fem

1988
Does pretreatment with cimetidine and ranitidine affect the disposition of bupivacaine?
    British journal of anaesthesia, 1989, Volume: 62, Issue:1

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Cimetidine; Fem

1989
Cimetidine in labour: absence of adverse effect on the high-risk fetus.
    British journal of obstetrics and gynaecology, 1985, Volume: 92, Issue:4

    Topics: Adult; Cimetidine; Clinical Trials as Topic; Female; Fetus; Gastric Acid; Humans; Infant, Newborn; M

1985
The role of H2 receptor antagonist premedication in pregnant day care patients.
    Canadian Anaesthetists' Society journal, 1985, Volume: 32, Issue:5

    Topics: Abortion, Therapeutic; Adult; Ambulatory Surgical Procedures; Anesthesia, General; Cimetidine; Clini

1985
Summary of the 29th meeting of the Gastrointestinal Drugs Advisory Committee, Food and Drug Administration--June 10, 1985.
    The American journal of gastroenterology, 1985, Volume: 80, Issue:9

    Topics: Abortion, Spontaneous; Animals; Anti-Ulcer Agents; Cimetidine; Clinical Trials as Topic; Double-Blin

1985
Cimetidine as pre-anesthetic agent for cesarean section: perinatal effects on the infant, the placental transfer of cimetidine and its elimination in the infants.
    Journal of perinatal medicine, 1985, Volume: 13, Issue:4

    Topics: Cesarean Section; Cimetidine; Double-Blind Method; Female; Humans; Infant, Newborn; Maternal-Fetal E

1985

Other Studies

117 other studies available for cimetidine and Pregnancy

ArticleYear
Carrier-mediated placental transport of cimetidine and valproic acid across differentiating JEG-3 cell layers.
    Die Pharmazie, 2015, Volume: 70, Issue:7

    Topics: Adult; Algorithms; Anticonvulsants; Carrier Proteins; Cell Line, Tumor; Chromatography, High Pressur

2015
A mechanism for the inhibition of neural progenitor cell proliferation by cocaine.
    PLoS medicine, 2008, Jun-10, Volume: 5, Issue:6

    Topics: Animals; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Cimetidine; Cocaine; Cyclin

2008
Cimetidine does not appear to influence the distribution of metformin into human milk.
    British journal of clinical pharmacology, 2008, Volume: 66, Issue:4

    Topics: Adult; Biological Transport, Active; Breast Feeding; Cimetidine; Drug Administration Schedule; Femal

2008
The safety of H(2)-blockers use during pregnancy.
    Journal of clinical pharmacology, 2010, Volume: 50, Issue:1

    Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Adolescent; Adult; Apgar Score; Cimetidine; Coho

2010
The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010, Jan-31, Volume: 39, Issue:1-3

    Topics: Antipyrine; Biological Transport, Active; Cimetidine; Female; Humans; Maternal-Fetal Exchange; Metfo

2010
Involvement of histamine and histamine H2 receptors in nicotinamide-induced differentiation of human amniotic epithelial cells into insulin-producing cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59 Suppl 2

    Topics: Adult; Amniotic Fluid; C-Peptide; Cell Differentiation; Cells, Cultured; Cimetidine; Epithelial Cell

2010
Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women.
    American journal of obstetrics and gynecology, 2003, Volume: 188, Issue:3

    Topics: Chlorpheniramine; Cimetidine; Dose-Response Relationship, Drug; Female; Histamine; Histamine H1 Anta

2003
Proteinase-activated receptor-2 activation induces uterine contractility in term pregnant rats that is not dependent on mast cell activation and cyclo-oxygenase products.
    American journal of obstetrics and gynecology, 2003, Volume: 188, Issue:6

    Topics: Animals; Chlorpheniramine; Cimetidine; Cromolyn Sodium; Dose-Response Relationship, Drug; Female; Hi

2003
Degranulation of uterine mast cell modifies contractility of isolated myometrium from pregnant women.
    American journal of obstetrics and gynecology, 2004, Volume: 191, Issue:5

    Topics: Cell Degranulation; Chlorpheniramine; Cimetidine; Cromolyn Sodium; Female; Histamine H1 Antagonists;

2004
Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat.
    Toxicology letters, 2008, May-30, Volume: 178, Issue:3

    Topics: Animals; Anti-Ulcer Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cas

2008
Cimetidine and the acid-aspiration syndrome.
    Lancet (London, England), 1980, Mar-01, Volume: 1, Issue:8166

    Topics: Anesthesia; Cimetidine; Female; Gastric Juice; Guanidines; Humans; Hydrogen-Ion Concentration; Male;

1980
Cimetidine and obstetric anaesthesia.
    Lancet (London, England), 1981, Aug-01, Volume: 2, Issue:8240

    Topics: Anesthesia, Obstetrical; Cimetidine; Female; Guanidines; Humans; Pregnancy

1981
[Relationship between cimetidine and prolactin].
    La Clinica terapeutica, 1982, Mar-15, Volume: 100, Issue:5

    Topics: Breast Diseases; Cimetidine; Female; Galactorrhea; Guanidines; Gynecomastia; Humans; Male; Pregnancy

1982
Effect of histamine receptor antagonists and indomethacin on implantation in the rabbit.
    Biology of reproduction, 1983, Volume: 29, Issue:4

    Topics: Aminopyridines; Animals; Capillary Permeability; Cimetidine; Drug Combinations; Drug Interactions; E

1983
Prenatal and neonatal exposure of male rat pups to cimetidine but not ranitidine adversely affects subsequent adult sexual functioning.
    Gastroenterology, 1984, Volume: 86, Issue:4

    Topics: Animals; Cimetidine; Evaluation Studies as Topic; Female; Gestational Age; Luteinizing Hormone; Male

1984
[Effects of cimetidine on estrus cycle in the rat].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1980, Volume: 173, Issue:6

    Topics: Animals; Cimetidine; Estrus; Female; Guanidines; Pregnancy; Rats; Vaginal Smears

1980
[Role of H2 receptors in controlling prolactin release. Decreased response to cimetidine in patients with prolactin-secreting adenoma and idiopathic hyperprolactinemia].
    Minerva ginecologica, 1984, Volume: 36, Issue:6

    Topics: Adenoma; Adult; Cimetidine; Female; Galactorrhea; Humans; Pituitary Neoplasms; Pregnancy; Prolactin;

1984
A study of monooxygenase activity in human placental homogenates: in vitro behaviour towards a number of substrates and inhibitors.
    Biochemical pharmacology, 1983, Aug-15, Volume: 32, Issue:16

    Topics: 7-Alkoxycoumarin O-Dealkylase; Cimetidine; Female; Humans; Mixed Function Oxygenases; Oxazoles; Oxyg

1983
Placental transfer and renal elimination of cimetidine in maternal and fetal sheep.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:2

    Topics: Animals; Cimetidine; Female; Fetal Blood; Kidney; Maternal-Fetal Exchange; Pregnancy; Sheep

1983
Cimetidine - antacid combination as premedication for elective Caesarean section.
    Canadian Anaesthetists' Society journal, 1983, Volume: 30, Issue:6

    Topics: Adult; Antacids; Cesarean Section; Cimetidine; Drug Therapy, Combination; Female; Gastric Juice; Hum

1983
Cimetidine--unresolved issues.
    Anesthesiology, 1984, Volume: 60, Issue:4

    Topics: Cesarean Section; Cimetidine; Female; Humans; Infant, Newborn; Pregnancy; Preoperative Care

1984
Potential interactions between cimetidine and amide local anesthetics in obstetrics.
    Anesthesiology, 1984, Volume: 60, Issue:5

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Cimetidine; Drug Interactions; Fe

1984
Cimetidine-antacid combination as premedication for elective cesarean section.
    Canadian Anaesthetists' Society journal, 1984, Volume: 31, Issue:3 Pt 1

    Topics: Antacids; Cesarean Section; Cimetidine; Female; Humans; Preanesthetic Medication; Pregnancy

1984
H2-receptor antagonists and sexual differentiation.
    Gastroenterology, 1984, Volume: 87, Issue:1

    Topics: Animals; Brain; Cimetidine; Female; Histamine Antagonists; Histamine H2 Antagonists; Male; Pregnancy

1984
Determination of imidazole acetic acid and its conjugate(s) levels in urine, serum and tissues of rats: studies on changes in their levels under various conditions.
    British journal of pharmacology, 1984, Volume: 82, Issue:3

    Topics: Animals; Cimetidine; Creatinine; Female; Fetus; Guanidines; Imidazoles; Male; Metabolic Clearance Ra

1984
[Effects of citicholine on pituitary gland function in normal subjects and in cases of idiopathic galactorrhea].
    La Clinica terapeutica, 1980, Aug-31, Volume: 94, Issue:4

    Topics: Adolescent; Adult; Choline; Cimetidine; Cytidine Diphosphate Choline; Female; Galactorrhea; Growth H

1980
Heartburn in pregnancy.
    British medical journal (Clinical research ed.), 1982, May-22, Volume: 284, Issue:6328

    Topics: Cimetidine; Female; Heartburn; Humans; Pregnancy; Pregnancy Complications

1982
Scombroid poisoning: prompt resolution of symptoms with cimetidine.
    Annals of emergency medicine, 1983, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Animals; Cimetidine; Female; Fishes; Food Preservation; Foodborne Diseases; Guani

1983
Cimetidine and the epigastric pain of preeclampsia.
    American journal of obstetrics and gynecology, 1983, Mar-01, Volume: 145, Issue:5

    Topics: Cimetidine; Female; Guanidines; Humans; Pain; Pre-Eclampsia; Pregnancy; Stomach

1983
Cimetidine, antacids, and pulmonary aspiration.
    Anesthesiology, 1983, Volume: 59, Issue:2

    Topics: Anesthesia, Obstetrical; Antacids; Cesarean Section; Cimetidine; Female; Gastric Acidity Determinati

1983
Effect of cimetidine on prolactin secretion in postpartum women.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1983, Volume: 15, Issue:7

    Topics: Adolescent; Adult; Bromocriptine; Cimetidine; Female; Guanidines; Humans; Postpartum Period; Pregnan

1983
Effects of histamine on the in vitro activity of the pregnant and non-pregnant uterus of the rat and guinea pig.
    Proceedings of the Western Pharmacology Society, 1983, Volume: 26

    Topics: Animals; Cimetidine; Diphenhydramine; Estrus; Female; Guinea Pigs; Histamine; In Vitro Techniques; P

1983
Cimetidine: lack of direct effects on bone in vitro.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1982, Volume: 14, Issue:10

    Topics: Animals; Bone and Bones; Calcitriol; Calcium; Cimetidine; Female; Fetus; Guanidines; Parathyroid Hor

1982
A field trial of cimetidine as the sole oral antacid in obstetric anaesthesia.
    Anaesthesia, 1982, Volume: 37, Issue:1

    Topics: Anesthesia, Obstetrical; Antacids; Apgar Score; Cesarean Section; Cimetidine; Female; Gastric Acidit

1982
Histamine stimulate prostacyclin synthesis in cultured human umbilical vein endothelial cells.
    Biochemical and biophysical research communications, 1980, Feb-27, Volume: 92, Issue:4

    Topics: Cimetidine; Dose-Response Relationship, Drug; Endothelium; Epoprostenol; Female; Histamine; Humans;

1980
Placental calcium transport: effect of cimetidine.
    American journal of obstetrics and gynecology, 1982, Apr-01, Volume: 142, Issue:7

    Topics: Animals; Biological Transport, Active; Body Weight; Calcium; Calcium Radioisotopes; Cimetidine; Fema

1982
Cimetidine as an oral antacid before elective Caesarean section.
    Anaesthesia, 1982, Volume: 37, Issue:1

    Topics: Adult; Anesthesia, Obstetrical; Antacids; Blood Glucose; Cesarean Section; Cimetidine; Female; Gastr

1982
Cimetidine in elective Caesarean section ineffective again.
    Anaesthesia, 1982, Volume: 37, Issue:3

    Topics: Cesarean Section; Cimetidine; Female; Guanidines; Humans; Hydrogen-Ion Concentration; Pregnancy; Pre

1982
Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult males.
    Science (New York, N.Y.), 1982, Oct-29, Volume: 218, Issue:4571

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Suckling; Cimetidine; Female; Guanidines; Male; Pregn

1982
Ontogenesis of gastric response to agonists and antagonists of acid secretion in fetal rat.
    Journal of developmental physiology, 1982, Volume: 4, Issue:3

    Topics: Acetylcholine; Animals; Body Weight; Cimetidine; Deoxyglucose; Female; Fetus; Gastric Acid; Histamin

1982
Agreement of prolactin response to cimetidine and nomifensine in patients with prolactin-secreting tumors and idiopathic hyperprolactinemia.
    Neuroendocrinology, 1982, Volume: 35, Issue:5

    Topics: Adolescent; Adult; Cimetidine; Female; Guanidines; Humans; Isoquinolines; Male; Nomifensine; Pituita

1982
Cimetidine in pregnancy: apparent transient liver impairment in the newborn.
    American journal of diseases of children (1960), 1980, Volume: 134, Issue:1

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cimetidine; Fema

1980
Cimetidine in elective Caesarean section. Effect on gastric acidity.
    Anaesthesia, 1981, Volume: 36, Issue:2

    Topics: Anesthesia, General; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Gastric Acidity

1981
Prevention of aspiration pneumonitis: preoperative preparation.
    AANA journal, 1981, Volume: 49, Issue:1

    Topics: Anesthesia, General; Antacids; Cimetidine; Female; Gastric Acidity Determination; Humans; Intubation

1981
The placental transfer of cimetidine.
    Anaesthesia, 1981, Volume: 36, Issue:4

    Topics: Cesarean Section; Cimetidine; Female; Fetal Blood; Guanidines; Humans; Infant, Newborn; Kinetics; La

1981
Cimetidine in elective Caesarean section.
    Anaesthesia, 1981, Volume: 36, Issue:6

    Topics: Anesthesia, Obstetrical; Antacids; Cesarean Section; Cimetidine; Female; Guanidines; Humans; Magnesi

1981
Possible dangers of the use of cimetidine in obstetric anaesthesia.
    Anaesthesia, 1981, Volume: 36, Issue:9

    Topics: Anesthesia, Obstetrical; Cimetidine; Female; Guanidines; Humans; Pregnancy

1981
Cimetidine premedication in elective caesarean section.
    Canadian Anaesthetists' Society journal, 1980, Volume: 27, Issue:1

    Topics: Adolescent; Adult; Anesthesia, General; Antacids; Cesarean Section; Cimetidine; Female; Gastric Juic

1980
Inefficiency of antacid in prevention of aspiration pneumonia.
    British journal of anaesthesia, 1980, Volume: 52, Issue:2

    Topics: Anesthesia, General; Anesthesia, Obstetrical; Antacids; Cimetidine; Female; Humans; Pneumonia, Aspir

1980
Control of gastric acidity in the parturient by cimetidine.
    Anaesthesia, 1980, Volume: 35, Issue:1

    Topics: Anesthesia, General; Anesthesia, Obstetrical; Cimetidine; Female; Gastric Juice; Guanidines; Humans;

1980
Prophylaxis for Mendelson's syndrome before elective caesarean section. A comparison of cimetidine and magnesium trisilicate mixture regimens.
    British journal of obstetrics and gynaecology, 1980, Volume: 87, Issue:7

    Topics: Anesthesia, General; Anesthesia, Obstetrical; Antacids; Cesarean Section; Cimetidine; Female; Gastri

1980
Central nervous system-mediated stimulation of prolactin secretion by cimetidine, a histamine H2-receptor antagonist: impaired responsiveness in patients with prolactin-secreting tumors and idiopathic hyperprolactinemia.
    The Journal of clinical endocrinology and metabolism, 1980, Volume: 51, Issue:6

    Topics: Adenoma; Adolescent; Adult; Animals; Carbidopa; Cimetidine; Female; Guanidines; Humans; Levodopa; Ma

1980
Development of secondary sex characteristics in male rats after fetal and perinatal cimetidine exposure.
    Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:1

    Topics: Animals; Cimetidine; Female; Fetus; Male; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Sexual

1994
[Icterus and irrepressible vomiting during pregnancy].
    Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:11

    Topics: Adult; Chlorpromazine; Cimetidine; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum

1993
Histamine H1 receptor binding sites in mouse uterine horns.
    General pharmacology, 1993, Volume: 24, Issue:1

    Topics: Animals; Cimetidine; Estrus; Female; Gonadal Steroid Hormones; Histamine; In Vitro Techniques; Kinet

1993
Determinants of placental drug transfer: studies in the isolated perfused human placenta.
    Journal of pharmaceutical sciences, 1995, Volume: 84, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cimetidine; Diclofenac; Female; Histamine H2 An

1995
Inhibition of choline uptake in syncytial microvillus membrane vesicles of human term placenta. Specificity and nature of interaction.
    Biochemical pharmacology, 1995, Nov-27, Volume: 50, Issue:11

    Topics: Atropine; Carrier Proteins; Choline; Cholinergic Antagonists; Cimetidine; Dose-Response Relationship

1995
Hypoxemia associated with cimetidine therapy in a newborn infant.
    American journal of perinatology, 1996, Volume: 13, Issue:5

    Topics: Adrenergic alpha-Antagonists; Adult; Cimetidine; Female; Fetal Diseases; Gastrointestinal Hemorrhage

1996
"In vivo" and "in vitro" antitumoral action of Larrea divaricata Cav.
    Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 1996, Volume: 46, Issue:1

    Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Cell Division; Cimetidi

1996
Effects of histamine H2-antagonists on pre- and post-natal development in the rat.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46 Suppl 1

    Topics: Animals; Cimetidine; Embryonic and Fetal Development; Female; Growth; Histamine H2 Antagonists; Preg

1997
Evidence for the involvement of histaminergic neurones in the regulation of the rat oxytocinergic system during pregnancy and parturition.
    The Journal of physiology, 1997, Jun-15, Volume: 501 ( Pt 3)

    Topics: Afferent Pathways; Animals; Cimetidine; Female; Histamine; Histamine Antagonists; Histidine Decarbox

1997
Long-term disease-free survival following surgery and active specific immunotherapy with allogeneic vaccine in a patient with high-risk malignant melanoma of the vulva.
    European journal of obstetrics, gynecology, and reproductive biology, 1998, Volume: 81, Issue:1

    Topics: Adult; Cancer Vaccines; Cimetidine; Disease-Free Survival; Female; Granulocyte-Macrophage Colony-Sti

1998
Lymphocyte subsets and mitogen stimulation of blood lymphocytes in preeclampsia.
    American journal of reproductive immunology (New York, N.Y. : 1989), 1999, Volume: 41, Issue:3

    Topics: Adult; Cells, Cultured; Cimetidine; Dexamethasone; Female; Flow Cytometry; Humans; Indomethacin; Int

1999
Use of cimetidine, omeprazole, and ranitidine in pregnant women and pregnancy outcomes.
    American journal of epidemiology, 1999, Sep-01, Volume: 150, Issue:5

    Topics: Abnormalities, Drug-Induced; Anti-Ulcer Agents; Cimetidine; Cohort Studies; Female; Humans; Infant,

1999
Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters.
    British journal of pharmacology, 2001, Volume: 134, Issue:5

    Topics: Acetylcholine; Amiloride; Cimetidine; Corticosterone; DNA, Antisense; Dose-Response Relationship, Dr

2001
Effects of the prenatal administration of cimetidine on testicular descent and genital differentiation in rats.
    Surgery, 2002, Volume: 131, Issue:1 Suppl

    Topics: Age Factors; Animals; Anti-Ulcer Agents; Cimetidine; Contraindications; Cryptorchidism; Female; Inci

2002
Endogenous mast cell degranulation modulates cervical contractility in the guinea pig.
    American journal of obstetrics and gynecology, 2002, Volume: 186, Issue:3

    Topics: Animals; Cell Degranulation; Cervix Uteri; Chlorpheniramine; Cimetidine; Dose-Response Relationship,

2002
Proestrus and metestrus rat uterus, a rapid and simple in vitro method for detecting histamine H2-receptor antagonism.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:8

    Topics: Animals; Cimetidine; Diphenhydramine; Estrus; Female; Histamine H2 Antagonists; In Vitro Techniques;

1979
Cimetidine treatment during pregnancy.
    Lancet (London, England), 1978, Oct-28, Volume: 2, Issue:8096

    Topics: Administration, Oral; Adult; Cimetidine; Duodenal Ulcer; Female; Guanidines; Humans; Infant, Newborn

1978
[The treatment of hepatic emergencies].
    Fortschritte der Medizin, 1979, Feb-01, Volume: 97, Issue:5

    Topics: Cimetidine; Female; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Humans; Lactulose; Liver Di

1979
Blockade by cimetidine of the effects of histamine on adenylate cyclase activity, spontaneous rate and contractility in the developing praenatal heart [proceedings].
    Agents and actions, 1979, Volume: 9, Issue:1

    Topics: Adenylyl Cyclases; Cimetidine; Female; Fetal Heart; Guanidines; Heart Rate; Histamine; Humans; In Vi

1979
Safety of cimetidine in obstetric patients.
    Journal of the Royal Society of Medicine, 1979, Volume: 72, Issue:12

    Topics: Adolescent; Adult; Cimetidine; Female; Fetal Blood; Fetal Heart; Guanidines; Heart Rate; Humans; Lab

1979
[Gynaecomastia during treatment with cimetidine].
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1978, Aug-12, Volume: 54, Issue:7

    Topics: Cimetidine; Female; Galactorrhea; Guanidines; Gynecomastia; Humans; Male; Middle Aged; Pregnancy

1978
Cimetidine.
    JAMA, 1978, Jan-30, Volume: 239, Issue:5

    Topics: Cimetidine; Duodenal Ulcer; Female; Guanidines; Humans; Maternal-Fetal Exchange; Milk, Human; Pregna

1978
Perspective as to pathogenesis and management of hyperemesis in pregnancy.
    The American journal of gastroenterology, 1992, Volume: 87, Issue:6

    Topics: Antacids; Cimetidine; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Ranitidine

1992
Outcome of pregnancy after first trimester exposure to H2 receptor antagonists.
    American journal of perinatology, 1991, Volume: 8, Issue:1

    Topics: Abnormalities, Drug-Induced; Cimetidine; Female; Histamine H2 Antagonists; Humans; Infant, Newborn;

1991
Excretion of high concentrations of cimetidine and ranitidine into rat milk and their effects on milk composition and mammary gland nucleic acid content.
    Toxicology and applied pharmacology, 1990, Mar-01, Volume: 102, Issue:3

    Topics: Aminopyrine N-Demethylase; Animals; Cimetidine; DNA; Female; Lactation; Liver; Male; Mammary Glands,

1990
Developmental levels and androgen responsiveness of hepatic mono-oxygenases of male rats perinatally exposed to maternally administered cimetidine.
    Toxicology letters, 1991, Volume: 55, Issue:1

    Topics: Aminopyrine N-Demethylase; Animals; Cimetidine; Female; Kinetics; Male; Maternal-Fetal Exchange; Mic

1991
Effect of histamine on human placental chorionic veins: interaction with serotonin.
    Pharmacology, 1991, Volume: 42, Issue:2

    Topics: Chorion; Cimetidine; Drug Interactions; Female; Histamine; Humans; In Vitro Techniques; Muscle Contr

1991
Ontogeny of fetal renal organic cation excretion: a study with cimetidine and ranitidine during the latter half of gestation in the pregnant ewe.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3

    Topics: Animals; Cimetidine; Embryonic and Fetal Development; Female; Fetal Organ Maturity; Gestational Age;

1990
Investigation of the mechanisms of the extensive excretion of cimetidine into rat milk.
    Biochemical pharmacology, 1990, Jan-01, Volume: 39, Issue:1

    Topics: Animals; Biological Transport, Active; Chemical Phenomena; Chemistry, Physical; Cimetidine; Female;

1990
Use of Frog Embryo Teratogenesis Assay-Xenopus and an exogenous metabolic activation system to evaluate the developmental toxicity of diphenylhydantoin.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1990, Volume: 14, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cimetidine; Cyclohexanes; Cyclohexenes; Dos

1990
[Prevention of aspiration pneumonia in obstetrical anesthesia with the effervescent combination of cimetidine and sodium citrate].
    Annales francaises d'anesthesie et de reanimation, 1990, Volume: 9, Issue:3

    Topics: Administration, Oral; Adult; Anesthesia, Obstetrical; Antacids; Cesarean Section; Cimetidine; Citrat

1990
Acid aspiration prophylaxis in Australian obstetric hospitals--a survey.
    Anaesthesia and intensive care, 1989, Volume: 17, Issue:4

    Topics: Anesthesia, General; Anesthesia, Obstetrical; Antacids; Australia; Cesarean Section; Cimetidine; Eme

1989
[Comparative study of the ingestion of a sodium citrate and cimetidine-citrate combination before emergency obstetrical anesthesia: effects of pH and volume of stomach contents].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8 Suppl

    Topics: Adult; Anesthesia, Obstetrical; Cimetidine; Citrates; Drug Combinations; Emergencies; Female; Gastri

1989
Perinatal cimetidine exposure has no apparent effect on hepatic drug oxidative or conjugative activity in adult male rat offspring.
    Developmental pharmacology and therapeutics, 1989, Volume: 12, Issue:2

    Topics: Acetaminophen; Animals; Arylsulfotransferase; Biotransformation; Chromatography, DEAE-Cellulose; Chr

1989
Usefulness of acid and gastric juice secretion decreasing action of cimetidine in anaesthesia for the prevention of aspiration.
    Therapia Hungarica (English edition), 1989, Volume: 37, Issue:1

    Topics: Adult; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Gastric Acid; Gastric Juice; H

1989
Effects of histamine and serotonin on the contractility of isolated pregnant and nonpregnant human myometrium.
    Gynecologic and obstetric investigation, 1989, Volume: 28, Issue:1

    Topics: Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Histamine; Humans; In Vitro

1989
A comparative evaluation of the transport of H2-receptor antagonists by the human and baboon placenta.
    The American journal of the medical sciences, 1988, Volume: 295, Issue:3

    Topics: Adolescent; Adult; Animals; Antipyrine; Biological Transport; Cimetidine; Famotidine; Female; Histam

1988
Effects of maternally administered cimetidine during lactation on the development of drug metabolizing enzymes in mouse pups.
    Biochemical pharmacology, 1989, Jan-01, Volume: 38, Issue:1

    Topics: Aminopyrine N-Demethylase; Animals; Animals, Newborn; Cimetidine; Female; Lactation; Male; Mice; Mic

1989
VIP and histamine H2 receptor activity in human fetal gastric glands.
    Experientia, 1986, Apr-15, Volume: 42, Issue:4

    Topics: Cimetidine; Cyclic AMP; Female; Fetus; Gastric Mucosa; Histamine; Humans; Pregnancy; Ranitidine; Rec

1986
Interaction of clonidine with human placental Na+ -H+ exchanger.
    Biochemical pharmacology, 1986, Nov-15, Volume: 35, Issue:22

    Topics: Amiloride; Carrier Proteins; Cimetidine; Clonidine; Female; Humans; In Vitro Techniques; Kinetics; M

1986
[Study on the neuroendocrinological control of prolactin release in early puerperium].
    Nihon Sanka Fujinka Gakkai zasshi, 1987, Volume: 39, Issue:7

    Topics: Bromocriptine; Cimetidine; Dopamine; Endorphins; Female; Histamine; Humans; Hypothalamo-Hypophyseal

1987
[Promoting lactation with the aid of drugs].
    Nederlands tijdschrift voor geneeskunde, 1987, Jun-27, Volume: 131, Issue:26

    Topics: Chlorpromazine; Cimetidine; Domperidone; Female; Humans; Lactation; Medroxyprogesterone; Metoclopram

1987
Effect of cimetidine and ranitidine on lidocaine concentrations during epidural anesthesia for cesarean section.
    Anesthesiology, 1988, Volume: 69, Issue:6

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Fetal Bl

1988
Prospective study on the sexual development of male and female rats perinatally exposed to maternally administered cimetidine.
    Toxicology letters, 1988, Volume: 44, Issue:3

    Topics: Androgens; Animals; Body Weight; Cimetidine; Estrus; Female; Male; Orchiectomy; Organ Size; Perinato

1988
Effect of cimetidine on maternal and fetal prolactin secretion during labor.
    Journal of endocrinological investigation, 1988, Volume: 11, Issue:11

    Topics: Cimetidine; Female; Fetus; Humans; Kinetics; Labor, Obstetric; Pregnancy; Prolactin; Umbilical Arter

1988
Evidence for an organic cation-proton antiport system in brush-border membranes isolated from the human term placenta.
    The Journal of biological chemistry, 1988, Apr-05, Volume: 263, Issue:10

    Topics: Carrier Proteins; Cations, Monovalent; Cimetidine; Clonidine; Female; Guanidine; Guanidines; Humans;

1988
Inhibitor panel studies of human hepatic and placental cytochrome P-450-associated monooxygenase activities.
    Pharmacology & toxicology, 1988, Volume: 62, Issue:5

    Topics: Aminoglutethimide; Animals; Benzoflavones; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enz

1988
[Prevention of the aspiration syndrome in obstetrical anesthesiology].
    Akusherstvo i ginekologiia, 1987, Issue:12

    Topics: Adult; Anesthesia, Obstetrical; Antacids; Cesarean Section; Cimetidine; Female; Humans; Pneumonia, A

1987
Is there a prostaglandin involvement in the positive inotropic action of histamine in isolated pregnant rat uterus, apparently mediated via H1-receptors activation?
    Prostaglandins, leukotrienes, and medicine, 1987, Volume: 28, Issue:3

    Topics: Alprostadil; Animals; Aspirin; Chlorpheniramine; Cimetidine; Dinoprost; Dinoprostone; Female; Histam

1987
Cimetidine does not demasculinize male rat offspring exposed in utero.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1987, Volume: 8, Issue:2

    Topics: Animals; Cimetidine; Female; Fertility; Male; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Inbred

1987
[Mendelson syndrome in obstetrics. The use of intravenous cimetidine in emergency cesarean sections].
    Minerva anestesiologica, 1986, Volume: 52, Issue:11

    Topics: Adult; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Gastric Acid; Humans; Preanest

1986
Antacid therapy for emergency caesarean section.
    Anaesthesia, 1987, Volume: 42, Issue:4

    Topics: Anesthesia, General; Anesthesia, Obstetrical; Antacids; Cesarean Section; Cimetidine; Citrates; Citr

1987
Low clearance of cimetidine across the human placenta.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:3

    Topics: Antipyrine; Cimetidine; Female; Humans; Leucine; Maternal-Fetal Exchange; Mathematics; Metabolic Cle

1987
[Prolactin: a function test with cimetidine].
    Acta cientifica venezolana, 1986, Volume: 37, Issue:2

    Topics: Adult; Cimetidine; Female; Galactorrhea; Humans; Injections, Intravenous; Lactation Disorders; Pregn

1986
Lack of influence of cimetidine on bupivacaine levels during parturition.
    Anesthesia and analgesia, 1987, Volume: 66, Issue:10

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Biotransformation; Bupivacaine; Cesarean Secti

1987
Gynaecomastia, galactorrhoea and impotence--the uncommon side effects of cimetidine therapy.
    The Journal of the Association of Physicians of India, 1987, Volume: 35, Issue:6

    Topics: Adult; Cimetidine; Erectile Dysfunction; Female; Galactorrhea; Gynecomastia; Humans; Lactation Disor

1987
Human placental transport of cimetidine.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:5

    Topics: Adolescent; Adult; Biological Transport; Chromatography, High Pressure Liquid; Cimetidine; Female; F

1987
Induced hypotension for clipping of a cerebral aneurysm during pregnancy: a case report and brief review.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Blood Pressure; Cimetidine; Female; Fetal Monitoring; Humans; Hypoten

1986
[Cimetidine or ranitidine?].
    Nederlands tijdschrift voor geneeskunde, 1986, Jul-26, Volume: 130, Issue:30

    Topics: Animals; Cimetidine; Female; Humans; Pregnancy; Ranitidine; Rats; Sex Differentiation

1986
Adaptation of fetal pulmonary blood flow to local infusion of tolazoline.
    Pediatric research, 1986, Volume: 20, Issue:11

    Topics: Animals; Blood Pressure; Cimetidine; Diphenhydramine; Female; Fetus; Heart Rate; Phentolamine; Pregn

1986
Decreased duration of pentobarbital anesthesia and increased pentobarbital metabolism in immature rats perinatally exposed to cimetidine.
    Biochemical pharmacology, 1986, Jan-15, Volume: 35, Issue:2

    Topics: Anesthesia; Animals; Animals, Newborn; Cimetidine; Cytochrome P-450 Enzyme System; Female; Fetus; Ma

1986
Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report.
    The Quarterly journal of medicine, 1985, Volume: 54, Issue:215

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cimetidine; Drug Interactions; Erectile Dysfunctio

1985
[Effect of cimetidine (Histodil) on stomach secretion and the pH value of gastric contents in cesarean section narcosis].
    Zentralblatt fur Gynakologie, 1985, Volume: 107, Issue:9

    Topics: Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Gastric Acid; Gastric Acidity Determi

1985
Effects of cimetidine, nitrite, cimetidine plus nitrite, and nitrosocimetidine on tumors in mice following transplacental plus chronic lifetime exposure.
    Cancer research, 1985, Volume: 45, Issue:8

    Topics: Animals; Body Weight; Cimetidine; Dose-Response Relationship, Drug; Female; Fetus; Lung Neoplasms; M

1985
Fetal exposure to cimetidine following chronic administration to pregnant sheep.
    Research communications in chemical pathology and pharmacology, 1985, Volume: 50, Issue:1

    Topics: Animals; Blood Proteins; Cimetidine; Female; Fetus; Kinetics; Maternal-Fetal Exchange; Pregnancy; Pr

1985