Compounds > cimetidine
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cimetidine and Peptic Ulcer Perforation

cimetidine has been researched along with Peptic Ulcer Perforation in 41 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Peptic Ulcer Perforation: Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.

Research Excerpts

ExcerptRelevanceReference
"Cimetidine is thought to have accelerated the reduction in elective peptic ulcer surgery but its effect on the incidence of perforated peptic ulcer has not been reported."7.66Cimetidine and perforated peptic ulcer. ( McArdle, CS; McKay, AJ, 1982)
"Since the introduction of cimetidine, multiple studies have documented that H2 antagonists will heal over 95 per cent of duodenal ulcers with 6 to 8 weeks of therapy."3.67Endoscopic follow-up of the perforated duodenal ulcer. ( Mansberger, JA, 1987)
"Cimetidine is thought to have accelerated the reduction in elective peptic ulcer surgery but its effect on the incidence of perforated peptic ulcer has not been reported."3.66Cimetidine and perforated peptic ulcer. ( McArdle, CS; McKay, AJ, 1982)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199040 (97.56)18.7374
1990's0 (0.00)18.2507
2000's1 (2.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bardhan, KD1
Nayyar, AK1
Royston, C1
McKay, AJ2
McArdle, CS2
Dreghorn, CR1
Moffat, LE1
Tolia, V1
Dubois, RS1
Sherlock, DJ1
Holl-Allen, RT1
Mitchell, WS1
Sturrock, RD1
MacLeod, IA1
Lee, FD1
Lewi, HJ1
Joffe, SN1
Previti, FW1
Holt, RW1
Stuart, FP1
Reckard, CR1
Schulak, JA1
Ketel, BL1
Monni, S1
Bianca, T1
Soro, P1
Padula, G1
Campus, GV1
Caragliano, V1
Wylie, CM1
Ahonen, J1
Eklund, B1
Lindfors, O1
Kuhlbäck, B1
Lindström, BL1
Hoste, P1
Ingels, J1
Elewaut, A1
Barbier, F1
Stark, FR1
Ninos, N1
Hutton, J1
Katz, R1
Butler, M1
Hassan, KE1
Browne, MK1
Buck, JP1
Murgatroyd, RE1
Boylston, AW1
Baron, JH1
Ahmad, S1
Ellis, DJ1
Hamer, JD1
Baker, SE1
Ball, JR1
Blum, AL1
Siewert, JR1
Halter, F1
Benichoux, R1
Martin, F1
Premont, M1
Poilleux, J1
Dazza, F1
Wallace, WA1
Orr, CM1
Bearn, AR1
Chan, KH1
Mann, KS1
Pedersen, JH1
Walter, S1
Andersen, JT1
Stadil, F1
Kolbasa, KP1
Lancaster, C1
Olafsson, AS1
Gilbertson, SK1
Robert, A1
Cherniavskiĭ, AA1
Zubeev, PS1
Simpson, CJ1
Lamont, G1
Macdonald, I1
Smith, IS1
Christensen, LA1
Schmidt, EB1
Nell, PA1
Gillen, P1
Ryan, W1
Peel, AL1
Devlin, HB1
Mansberger, JA1
Ribet, M1
Quandalle, P1
Chambon, JP1
Giard-Lefevre, S1
Pruvot, FR1
Pain, JA1
Collier, DS1
Huber, O1
Houriet, M1
Kobel, T1
Rohner, A1
Stürup, J1
Raahave, D1

Reviews

2 reviews available for cimetidine and Peptic Ulcer Perforation

ArticleYear
Side effects of cimetidine.
    Southern medical journal, 1979, Volume: 72, Issue:5

    Topics: Acute Disease; Aged; Agranulocytosis; Burns; Central Nervous System; Cimetidine; Female; Glucose; Gu

1979
[Treatment of recurrent ulcers after vagotomy].
    Vestnik khirurgii imeni I. I. Grekova, 1987, Volume: 138, Issue:1

    Topics: Cimetidine; Gastrectomy; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Peptic Ulcer Perforation; Po

1987

Trials

1 trial available for cimetidine and Peptic Ulcer Perforation

ArticleYear
Effect of cimetidine on prognosis after simple closure of perforated duodenal ulcer.
    The British journal of surgery, 1987, Volume: 74, Issue:2

    Topics: Aged; Aged, 80 and over; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Humans; Middle Aged;

1987

Other Studies

38 other studies available for cimetidine and Peptic Ulcer Perforation

ArticleYear
History in our lifetime: the changing nature of refractory duodenal ulcer in the era of histamine H2 receptor antagonists.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35, Issue:8

    Topics: Adult; Cimetidine; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; D

2003
Cimetidine and peptic ulcer.
    Lancet (London, England), 1981, Jul-18, Volume: 2, Issue:8238

    Topics: Cimetidine; Guanidines; Humans; Peptic Ulcer; Peptic Ulcer Perforation; Scotland; Statistics as Topi

1981
Changing patterns of gastric surgery in a district general hospital.
    Health bulletin, 1984, Volume: 42, Issue:5

    Topics: Adenocarcinoma; Cimetidine; Female; Hospitals, District; Humans; Male; Peptic Ulcer; Peptic Ulcer Pe

1984
Peptic ulcer disease in children and adolescents. A ten-year experience.
    Clinical pediatrics, 1983, Volume: 22, Issue:10

    Topics: Adolescent; Antacids; Child; Child, Preschool; Cimetidine; Female; Humans; Infant; Infant, Newborn;

1983
Duodenal ulcer perforation whilst on cimetidine therapy.
    The British journal of surgery, 1984, Volume: 71, Issue:8

    Topics: Adult; Aged; Chronic Disease; Cimetidine; Drainage; Duodenal Ulcer; Female; Humans; Male; Middle Age

1984
Ulcers and anti-inflammatory agents.
    British medical journal (Clinical research ed.), 1982, Mar-06, Volume: 284, Issue:6317

    Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cimetidine; Duodenal Ulcer; Female; Gu

1982
The effect of cimetidine and 15(S) 15-methyl prostaglandin E2 on the healing of laser-induced gastric mucosal damage.
    Gastrointestinal endoscopy, 1982, Volume: 28, Issue:3

    Topics: Animals; Cimetidine; Gastric Mucosa; Guanidines; Laser Therapy; Lasers; Male; Peptic Ulcer; Peptic U

1982
Failure of cimetidine prophylaxis in the critically ill patient: two fatal cases of duodenal perforation.
    The Journal of the Medical Society of New Jersey, 1980, Volume: 77, Issue:12

    Topics: Adult; Cimetidine; Duodenal Ulcer; Female; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer Perfo

1980
Gastroduodenal complications in kidney transplant recipients.
    Annals of surgery, 1981, Volume: 194, Issue:3

    Topics: Adult; Antacids; Cimetidine; Female; Gastric Juice; Graft Survival; Humans; Kidney Transplantation;

1981
Cimetidine and perforated peptic ulcer.
    The British journal of surgery, 1982, Volume: 69, Issue:6

    Topics: Cimetidine; Female; Guanidines; Humans; Male; Peptic Ulcer; Peptic Ulcer Perforation; Scotland

1982
[Long-term supervision of patients treated with simple suturing of perforated duodenal ulcer].
    Chirurgia italiana, 1980, Volume: 32, Issue:4

    Topics: Adolescent; Adult; Aged; Antacids; Child; Cimetidine; Duodenal Ulcer; Endoscopy; Female; Gastric Jui

1980
The complex wane of peptic ulcer. II. Trends in duodenal and gastric ulcer admissions to 790 hospitals, 1974-1979.
    Journal of clinical gastroenterology, 1981, Volume: 3, Issue:4

    Topics: Adolescent; Adult; Aged; Cimetidine; Duodenal Ulcer; Hospitalization; Humans; Length of Stay; Middle

1981
Peptic ulceration in kidney transplantation.
    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1977, Volume: 14

    Topics: Cimetidine; Duodenal Ulcer; Gastrins; Histamine H2 Antagonists; Humans; Kidney Transplantation; Pept

1977
Duodenal perforation after cimetidine.
    Lancet (London, England), 1978, Mar-25, Volume: 1, Issue:8065

    Topics: Adolescent; Cimetidine; Duodenal Ulcer; Guanidines; Humans; Male; Peptic Ulcer Hemorrhage; Peptic Ul

1978
Candida peritonitis and cimetidine.
    Lancet (London, England), 1978, Sep-30, Volume: 2, Issue:8092 Pt 1

    Topics: Aged; Candidiasis; Cimetidine; Female; Guanidines; Humans; Immunologic Deficiency Syndromes; Male; M

1978
Candida peritonitis and cimetidine.
    Lancet (London, England), 1978, Nov-11, Volume: 2, Issue:8098

    Topics: Candidiasis; Cimetidine; Duodenal Ulcer; Humans; Peptic Ulcer Perforation; Peritonitis

1978
Perforation of gastric carcinoma (at site of previous benign ulcer) after withdrawal of cimetidine.
    Lancet (London, England), 1979, Jul-07, Volume: 2, Issue:8132

    Topics: Adenocarcinoma; Cimetidine; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer Perforation; Stomach

1979
Perforation of chronic peptic ulcers after cimetidine.
    British medical journal, 1977, Oct-29, Volume: 2, Issue:6095

    Topics: Aged; Cimetidine; Guanidines; Humans; Male; Peptic Ulcer; Peptic Ulcer Perforation

1977
Perforation of chronic duodenal ulcer during treatment with cimetidine.
    British medical journal, 1977, Dec-10, Volume: 2, Issue:6101

    Topics: Aged; Cimetidine; Duodenal Ulcer; Guanidines; Humans; Male; Peptic Ulcer Perforation

1977
Hazards and benefits of cimetidine therapy.
    British medical journal, 1978, Jan-28, Volume: 1, Issue:6107

    Topics: Aged; Cimetidine; Duodenal Ulcer; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer Perforation

1978
[Ulcer therapy using cimetidine].
    Deutsche medizinische Wochenschrift (1946), 1978, Jan-27, Volume: 103, Issue:4

    Topics: Cimetidine; Duodenal Ulcer; Guanidines; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Peptic Ulcer

1978
[Conservative and surgical therapy of peptic ulcer].
    Deutsche medizinische Wochenschrift (1946), 1978, Apr-07, Volume: 103, Issue:14

    Topics: Antacids; Cimetidine; Duodenal Ulcer; Humans; Methods; Peptic Ulcer; Peptic Ulcer Hemorrhage; Peptic

1978
[Gastroduodenal perforation during cimetidine treatment].
    La Nouvelle presse medicale, 1978, Apr-01, Volume: 7, Issue:13

    Topics: Cimetidine; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer Perforation; Stomach Ulcer

1978
[Perforation of peptic ulcers and cimetidine (author's transl)].
    Chirurgie; memoires de l'Academie de chirurgie, 1978, Volume: 104, Issue:8

    Topics: Adult; Cimetidine; Female; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer Perfora

1978
Cimetidine and duodenal ulcer.
    British medical journal, 1979, Feb-10, Volume: 1, Issue:6160

    Topics: Adult; Aged; Cimetidine; Duodenal Ulcer; Guanidines; Humans; Male; Peptic Ulcer Perforation

1979
Perforation of chronic peptic ulcers after cimetidine.
    British medical journal, 1977, Oct-01, Volume: 2, Issue:6091

    Topics: Adult; Cimetidine; Duodenal Ulcer; Female; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer Perfo

1977
Perforation of peptic ulcer after withdrawal of cimetidine.
    British medical journal, 1977, Oct-15, Volume: 2, Issue:6093

    Topics: Aged; Cimetidine; Duodenal Ulcer; Guanidines; Humans; Male; Peptic Ulcer Perforation

1977
Failure of cimetidine prophylaxis in neurosurgery.
    The Australian and New Zealand journal of surgery, 1989, Volume: 59, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Brain Diseases; Cimetidine; Drug Evaluati

1989
Value of monitoring serum gastrin after renal transplantation.
    Danish medical bulletin, 1989, Volume: 36, Issue:5

    Topics: Cadaver; Cimetidine; Female; Gastrins; Gastrointestinal Hemorrhage; Graft Rejection; Humans; Immunos

1989
Indomethacin-induced gastric antral ulcers in hamsters.
    Gastroenterology, 1988, Volume: 95, Issue:4

    Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal

1988
Perforated peptic ulcer--a complication in acute salicylate intoxication.
    Acta medica Scandinavica, 1987, Volume: 222, Issue:2

    Topics: Acute Disease; Acute Kidney Injury; Aspirin; Cimetidine; Female; Humans; Middle Aged; Peptic Ulcer P

1987
A 15-year-old girl with a perforated gastric ulcer.
    Annals of allergy, 1986, Volume: 57, Issue:6

    Topics: Adolescent; Asthma; Cimetidine; Female; Humans; Peptic Ulcer Perforation; Stomach Ulcer; Theophyllin

1986
Duodenal ulcer perforation: the effect of H2 antagonists?
    Annals of the Royal College of Surgeons of England, 1986, Volume: 68, Issue:5

    Topics: Acute Disease; Aged; Chronic Disease; Cimetidine; Duodenal Ulcer; Female; Humans; Male; Middle Aged;

1986
Endoscopic follow-up of the perforated duodenal ulcer.
    The American surgeon, 1987, Volume: 53, Issue:1

    Topics: Cimetidine; Duodenal Ulcer; Duodenoscopy; Humans; Longitudinal Studies; Peptic Ulcer Perforation

1987
[Surgery of perforated duodenal ulcer. Treatment of the perforation or the ulcer?].
    Journal de chirurgie, 1985, Volume: 122, Issue:12

    Topics: Cimetidine; Duodenal Ulcer; Emergencies; Female; Humans; Male; Middle Aged; Peptic Ulcer Perforation

1985
Perforation on cimetidine.
    The British journal of surgery, 1985, Volume: 72, Issue:1

    Topics: Cimetidine; Humans; Peptic Ulcer Perforation

1985
[Emergency surgery of complicated gastroduodenal ulcers: risk factors and results].
    Schweizerische medizinische Wochenschrift, 1985, Jul-20, Volume: 115, Issue:29

    Topics: Age Factors; Aged; Cimetidine; Emergencies; Humans; Middle Aged; Peptic Ulcer; Peptic Ulcer Hemorrha

1985
Retroperitoneal perforation of duodenal ulcer.
    Annales chirurgiae et gynaecologiae, 1985, Volume: 74, Issue:6

    Topics: Abscess; Anti-Bacterial Agents; Cimetidine; Duodenal Ulcer; Female; Humans; Middle Aged; Peptic Ulce

1985