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cimetidine and Pancreatic Neoplasms

cimetidine has been researched along with Pancreatic Neoplasms in 9 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Research Excerpts

ExcerptRelevanceReference
"We present a first description of a pancreatic cancer patient treated with standard chemotherapy and TL-118, an anti-angiogenic combination of 4 drugs that target non-overlapping aspects of the angiogenic process (Provided by Tiltan Pharma Ltd for compassionate use)."1.39TL-118-anti-angiogenic treatment in pancreatic cancer: a case report. ( Appelbaum, L; Breuer, S; Hubert, A; Maimon, O; Peretz, T, 2013)
"New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies."1.39Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. ( Alston, N; Constantinides, PP; Huang, L; Mackenzie, GG; Mattheolabakis, G; Ouyang, N; Rigas, B; Vrankova, K, 2013)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19905 (55.56)18.7374
1990's1 (11.11)18.2507
2000's1 (11.11)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Breuer, S1
Maimon, O1
Appelbaum, L1
Peretz, T1
Hubert, A1
Mackenzie, GG1
Huang, L1
Alston, N1
Ouyang, N1
Vrankova, K1
Mattheolabakis, G1
Constantinides, PP1
Rigas, B1
Sürücü, O1
Middeke, M1
Höschele, I1
Kalder, J1
Hennig, S1
Dietz, C1
Celik, I1
Zollinger, RM1
Ellison, EC1
Fabri, PJ1
Johnson, J1
Sparks, J1
Carey, LC1
Becker, HD1
Klempa, I1
Encke, A1
Classen, M1
Feurle, GE1
Malesci, A1
Bonato, C1
Pisegna, JR1
Norton, JA1
Slimak, GG1
Metz, DC1
Maton, PN1
Gardner, JD1
Jensen, RT1
Luttwak, EM1
Saltz, NJ1

Reviews

1 review available for cimetidine and Pancreatic Neoplasms

ArticleYear
[Zollinger-Ellison syndrome].
    Wiener klinische Wochenschrift, 1984, Feb-17, Volume: 96, Issue:4

    Topics: Benzimidazoles; Calcium; Cimetidine; Diarrhea; Duodenal Ulcer; Female; Fluorouracil; Gastrectomy; Ga

1984

Trials

1 trial available for cimetidine and Pancreatic Neoplasms

ArticleYear
Effects of curative gastrinoma resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome.
    Gastroenterology, 1992, Volume: 102, Issue:3

    Topics: Adult; Aged; Cimetidine; Dose-Response Relationship, Drug; Duodenal Neoplasms; Famotidine; Female; F

1992

Other Studies

7 other studies available for cimetidine and Pancreatic Neoplasms

ArticleYear
TL-118-anti-angiogenic treatment in pancreatic cancer: a case report.
    Medical oncology (Northwood, London, England), 2013, Volume: 30, Issue:2

    Topics: Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Cyclophos

2013
Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cimetidine; Drug Synergism; Female; Hum

2013
Tumour growth inhibition of human pancreatic cancer xenografts in SCID mice by cimetidine.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2004, Volume: 53 Suppl 1

    Topics: Animals; Antineoplastic Agents; Cimetidine; Mice; Mice, SCID; Neoplasm Transplantation; Pancreatic N

2004
Primary peptic ulcerations of the jejunum associated with islet cell tumors. Twenty-five-year appraisal.
    Annals of surgery, 1980, Volume: 192, Issue:3

    Topics: Adenoma, Islet Cell; Cimetidine; Follow-Up Studies; Gastrectomy; Gastrins; Humans; Jejunal Diseases;

1980
[Zollinger-Ellison syndrome--changes in surgical therapy. Analysis of 27 patients].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1982, Volume: 53, Issue:4

    Topics: Adult; Aged; Cimetidine; Female; Gastrectomy; Gastrins; Histamine H2 Antagonists; Humans; Male; Midd

1982
[Smoke and stomach diseases].
    Minerva medica, 1982, Sep-22, Volume: 73, Issue:36

    Topics: Antacids; Cimetidine; Duodenal Ulcer; Female; Humans; Lung Neoplasms; Male; Pancreatic Neoplasms; Pe

1982
The progressive Zollinger-Ellison syndrome in multiple endocrine neoplasia.
    Surgery, gynecology & obstetrics, 1988, Volume: 167, Issue:5

    Topics: Adult; Apudoma; Cimetidine; Follow-Up Studies; Gastrectomy; Gastrinoma; Humans; Male; Middle Aged; M

1988