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cimetidine and Obesity

cimetidine has been researched along with Obesity in 19 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"To study the effect of cimetidine suspension compared with placebo suspension on weight loss in moderately obese patients taking a 5 MJ/day diet supplemented with dietary fibre."9.07Cimetidine suspension as adjuvant to energy restricted diet in treating obesity. ( Andersen, T; Breum, L; Gøtzsche, PC; Hilsted, J; Rasmussen, MH, 1993)
" Cimetidine dosage in clinical practice should therefore be calculated on the basis of IBW, which better reflects lean body mass, instead of total body weight, which reflects adipose tissue weight in addition to lean body mass."6.65Cimetidine disposition in obesity. ( Abernethy, DR; Greenblatt, DJ; Gugler, R; Matlis, R, 1984)
"Intake of cimetidine suspension 30 minutes before meals in overweight subjects may lead to reduced hunger, less food intake, and subsequent weight loss."5.07Effect of cimetidine suspension on appetite and weight in overweight subjects. ( Støa-Birketvedt, G, 1993)
"To study the effect of cimetidine suspension compared with placebo suspension on weight loss in moderately obese patients taking a 5 MJ/day diet supplemented with dietary fibre."5.07Cimetidine suspension as adjuvant to energy restricted diet in treating obesity. ( Andersen, T; Breum, L; Gøtzsche, PC; Hilsted, J; Rasmussen, MH, 1993)
"Forty-three overweight patients with Type 2 diabetes (age 18-65 y, body mass index (BMI) 27."2.69Cimetidine reduces weight and improves metabolic control in overweight patients with type 2 diabetes. ( Florholmen, J; Ganss, R; Ingebretsen, OC; Paus, PN; Støa-Birketvedt, G, 1998)
"Gastro-oesophageal reflux disease (GERD) is common in obese patients."2.41Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations. ( Barak, N; Ehrenpreis, ED; Harrison, JR; Sitrin, MD, 2002)
"Obesity is associated with considerable morbidity and decreased life expectancy."2.41Options for pharmacological management of obesity in patients treated with atypical antipsychotics. ( Sanders, TA; Taylor, D; Werneke, U, 2002)
"Obesity is a social disease and amounts to a real medical problem."1.29[Obesity: a multifactorial disorder with difficult long-term treatment]. ( Cotrozzi, G; Fontana, R; Relli, P, 1994)
" This same dosage in obese individuals with normal serum creatinine values should result in the same average steady-state serum concentrations."1.27Cimetidine clearance in the obese. ( Bauer, LA; Dellinger, EP; Edwards, WA; Ferreri, L; Jack, R; Raisys, V; Simonowitz, D; Wareing-Tran, C, 1985)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199010 (52.63)18.7374
1990's7 (36.84)18.2507
2000's2 (10.53)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barak, N1
Ehrenpreis, ED1
Harrison, JR1
Sitrin, MD1
Werneke, U1
Taylor, D1
Sanders, TA1
Manchikanti, L1
Kraus, JW1
Edds, SP1
de la Pierre, M1
Aricò, S1
Capussotti, L1
Dellepiane, M1
Marucci, M1
Gandini, G1
Imarisio, P1
Abernethy, DR1
Greenblatt, DJ1
Matlis, R1
Gugler, R1
Stull, DL1
Zinn, M1
Fales, JT1
Lanman, RC1
Burich, RL1
Wilson, SL1
Mantena, NR1
Halverson, JD1
Printen, KJ1
Scott, D1
Mason, EE1
Cotrozzi, G1
Relli, P1
Fontana, R1
Støa-Birketvedt, G2
Rasmussen, MH1
Andersen, T2
Breum, L1
Gøtzsche, PC1
Hilsted, J1
Garrow, J1
Mangtani, P1
Seed, P1
Paus, PN1
Ganss, R1
Ingebretsen, OC1
Florholmen, J1
Højby Rasmussen, M1
Lam, AM2
Grace, DM2
Manninen, PH1
Diamond, C1
Penny, FJ1
Vezina, WC1
Bauer, LA1
Wareing-Tran, C1
Edwards, WA1
Raisys, V1
Ferreri, L1
Jack, R1
Dellinger, EP1
Simonowitz, D1
Ramsey-Stewart, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Long Term Effects of Laparoscopic Roux-en-Y Gastric Bypass on Gastro-esophageal Reflux: Clinical Impact of Weakly Acidic Reflux[NCT02618044]86 participants (Actual)Observational2006-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for cimetidine and Obesity

ArticleYear
Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations.
    Obesity reviews : an official journal of the International Association for the Study of Obesity, 2002, Volume: 3, Issue:1

    Topics: Body Composition; Carcinoma; Cimetidine; Esophageal Neoplasms; Gastroesophageal Reflux; Hernia, Hiat

2002
Options for pharmacological management of obesity in patients treated with atypical antipsychotics.
    International clinical psychopharmacology, 2002, Volume: 17, Issue:4

    Topics: Amantadine; Antipsychotic Agents; Cimetidine; Cyclobutanes; Fluoxetine; Fructose; Humans; Lactones;

2002
Cimetidine and related drugs in anesthesia.
    Anesthesia and analgesia, 1982, Volume: 61, Issue:7

    Topics: Anesthesia, Obstetrical; Child; Cimetidine; Drug Administration Schedule; Emergencies; Female; Gastr

1982

Trials

6 trials available for cimetidine and Obesity

ArticleYear
Cimetidine disposition in obesity.
    The American journal of gastroenterology, 1984, Volume: 79, Issue:2

    Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Clinical Trials as Topic; Female; Half-Life

1984
Effect of cimetidine suspension on appetite and weight in overweight subjects.
    BMJ (Clinical research ed.), 1993, Apr-24, Volume: 306, Issue:6885

    Topics: Adolescent; Adult; Appetite; Blood Pressure; Body Constitution; Body Mass Index; Cimetidine; Diet; D

1993
Cimetidine suspension as adjuvant to energy restricted diet in treating obesity.
    BMJ (Clinical research ed.), 1993, Apr-24, Volume: 306, Issue:6885

    Topics: Adolescent; Adult; Blood Pressure; Body Constitution; Body Mass Index; Cimetidine; Combined Modality

1993
Cimetidine and weight loss.
    BMJ (Clinical research ed.), 1993, Jun-05, Volume: 306, Issue:6891

    Topics: Cimetidine; Humans; Obesity; Randomized Controlled Trials as Topic; Weight Loss

1993
Cimetidine reduces weight and improves metabolic control in overweight patients with type 2 diabetes.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1998, Volume: 22, Issue:11

    Topics: Adolescent; Adult; Appetite; Blood Glucose; Body Constitution; Cholecystokinin; Cholesterol, HDL; Ci

1998
The effects of cimetidine and ranitidine with and without metoclopramide on gastric volume and pH in morbidly obese patients.
    Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:6

    Topics: Adult; Cimetidine; Female; Gastric Acidity Determination; Gastric Emptying; Gastrointestinal Content

1986

Other Studies

10 other studies available for cimetidine and Obesity

ArticleYear
[Description of a case of Zollinger-Ellison syndrome].
    Minerva medica, 1984, May-07, Volume: 75, Issue:19

    Topics: Benzodiazepinones; Body Weight; Cimetidine; Diarrhea; Female; Gastrectomy; Gastric Acid; Humans; Mid

1984
The effectiveness of cimetidine as a preoperative medication in increasing gastric pH and decreasing gastric volume in obese patients.
    AANA journal, 1983, Volume: 51, Issue:4

    Topics: Adult; Aged; Animals; Cimetidine; Female; Gastric Acid; Humans; Hydrogen-Ion Concentration; Male; Mi

1983
Effects of atropine, glycopyrrolate, and cimetidine on gastric secretions in morbidly obese patients.
    Anesthesia and analgesia, 1981, Volume: 60, Issue:1

    Topics: Adult; Atropine; Cimetidine; Digestive System Surgical Procedures; Female; Gastric Juice; Glycopyrro

1981
Stomal ulcers after gastric bypass.
    Archives of surgery (Chicago, Ill. : 1960), 1980, Volume: 115, Issue:4

    Topics: Adult; Age Factors; Antacids; Cimetidine; Female; Gastroenterostomy; Humans; Male; Middle Aged; Obes

1980
[Obesity: a multifactorial disorder with difficult long-term treatment].
    La Clinica terapeutica, 1994, Volume: 145, Issue:11

    Topics: Adolescent; Adult; Albuterol; Appetite Depressants; Biguanides; Cimetidine; Diet, Reducing; Female;

1994
Does cimetidine cause weight loss?
    BMJ (Clinical research ed.), 1993, Apr-24, Volume: 306, Issue:6885

    Topics: Cimetidine; Clinical Trials as Topic; Denmark; Double-Blind Method; Humans; Norway; Obesity

1993
Cimetidine and obesity: conflicting evidence.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1999, Volume: 23, Issue:5

    Topics: Cimetidine; Histamine H2 Antagonists; Humans; Obesity; Randomized Controlled Trials as Topic; Weight

1999
Prophylactic intravenous cimetidine reduces the risk of acid aspiration in morbidly obese patients.
    Anesthesiology, 1986, Volume: 65, Issue:6

    Topics: Adult; Cimetidine; Female; Gastric Acid; Gastric Acidity Determination; Gastric Emptying; Humans; In

1986
Cimetidine clearance in the obese.
    Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:4

    Topics: Adult; Body Weight; Cimetidine; Creatinine; Female; Half-Life; Humans; Infusions, Parenteral; Kineti

1985
The perioperative management of morbidly obese patients (a surgeon's perspective).
    Anaesthesia and intensive care, 1985, Volume: 13, Issue:4

    Topics: Blood Pressure; Cardiovascular Diseases; Cimetidine; Fatty Acids, Nonesterified; Gastric Juice; Huma

1985