cimetidine has been researched along with Neutropenia in 13 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "If there is an association between cimetidine and neutropenia, it appears to be very small." | 7.69 | Is cimetidine associated with neutropenia? ( Carson, JL; Schinnar, R; Shaw, M; Strom, BL, 1995) |
| "We describe a case of quinidine-induced agranulocytosis in which in vitro marrow culture studies suggested immune inhibition of committed human granulocyte-macrophage progenitors (CFU-GM)." | 7.67 | Quinidine-induced neutropenia: report of a case with drug-dependent inhibition of granulocyte colony generation. ( Ascensao, JL; Flynn, PJ; Jacob, HS; Slungaard, A; Wachsman, W; Zanjani, ED, 1984) |
| "We studied the effect of the H2-receptor antagonists, cimetidine and metiamide, on in vitro myeloid colony formation by bone marrow cells from seven normal volunteers and two patients with a cimetidine-associated neutropenia." | 7.66 | Cimetidine and granulopoiesis: bone marrow culture studies in normal man and patients with cimetidine-associated neutropenia. ( Fitchen, JH; Koeffler, HP, 1980) |
| "Neutropenia associated with high-dose cimetidine therapy developed in a patient in whom earlier therapy, as well as rechallenge with low-dose cimetidine, did not result in neutropenia." | 7.66 | Cimetidine-induced neutropenia: a possible dose-related phenomenon. ( Graber, SE; Krantz, SB; Posnett, DN; Stein, RS, 1979) |
| "We describe a case of quinidine-induced agranulocytosis in which in vitro marrow culture studies suggested immune inhibition of committed human granulocyte-macrophage progenitors (CFU-GM)." | 3.67 | Quinidine-induced neutropenia: report of a case with drug-dependent inhibition of granulocyte colony generation. ( Ascensao, JL; Flynn, PJ; Jacob, HS; Slungaard, A; Wachsman, W; Zanjani, ED, 1984) |
| "We studied the effect of the H2-receptor antagonists, cimetidine and metiamide, on in vitro myeloid colony formation by bone marrow cells from seven normal volunteers and two patients with a cimetidine-associated neutropenia." | 3.66 | Cimetidine and granulopoiesis: bone marrow culture studies in normal man and patients with cimetidine-associated neutropenia. ( Fitchen, JH; Koeffler, HP, 1980) |
| "A 67-year-old man with a bleeding ulcer developed fever, thrombocytopenia, and neutropenia with eosinophilia coincidental to receiving 3600 mg of cimetidine." | 3.66 | Cimetidine and hematologic suppression: things are not always as they appear. ( Castell, DO; Gerhardt, DC; Pasquale, DN; Richter, JE, 1980) |
| "Neutropenia associated with high-dose cimetidine therapy developed in a patient in whom earlier therapy, as well as rechallenge with low-dose cimetidine, did not result in neutropenia." | 3.66 | Cimetidine-induced neutropenia: a possible dose-related phenomenon. ( Graber, SE; Krantz, SB; Posnett, DN; Stein, RS, 1979) |
| "Cimetidine may cause mental confusion and should be used with caution and in reduced dosage in the presence of hepatic or renal disease, or both, and in elderly patients." | 1.26 | Cimetidine: clinical uses and possible side effects. ( Babb, RR, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Legendre, C | 1 |
| Canaud, B | 1 |
| Beraud, JJ | 1 |
| Brunin, JL | 1 |
| Balmes, JL | 1 |
| Mirouze, J | 1 |
| Ascensao, JL | 1 |
| Flynn, PJ | 1 |
| Slungaard, A | 1 |
| Wachsman, W | 1 |
| Zanjani, ED | 1 |
| Jacob, HS | 1 |
| Babb, RR | 1 |
| Volkin, RL | 1 |
| Shadduck, RK | 1 |
| Winkelstein, A | 1 |
| Zeigler, ZR | 1 |
| Selker, RG | 1 |
| Dubost, JL | 1 |
| Chevallier, H | 1 |
| Sultan, R | 1 |
| Fallouh, H | 1 |
| Fitchen, JH | 1 |
| Koeffler, HP | 1 |
| Richter, JE | 1 |
| Gerhardt, DC | 1 |
| Pasquale, DN | 1 |
| Castell, DO | 1 |
| Strom, BL | 1 |
| Carson, JL | 1 |
| Schinnar, R | 1 |
| Shaw, M | 1 |
| Posnett, DN | 1 |
| Stein, RS | 1 |
| Graber, SE | 1 |
| Krantz, SB | 1 |
| Souza Lima, MS | 1 |
| Wiernik, PH | 1 |
| Schwartz, EL | 1 |
| Einzig, A | 1 |
| Strauman, JJ | 1 |
| Lipton, RB | 1 |
| Dutcher, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for cimetidine and Neutropenia
| Article | Year |
|---|---|
[Severe, recurrent and reversible neutropenia induced by cimetidine].
Topics: Agranulocytosis; Cimetidine; Female; Humans; Middle Aged; Neutropenia; Recurrence | 1984 |
Quinidine-induced neutropenia: report of a case with drug-dependent inhibition of granulocyte colony generation.
Topics: Agranulocytosis; Bone Marrow Examination; Cimetidine; Colony-Forming Units Assay; Granulocytes; Hema | 1984 |
Cimetidine: clinical uses and possible side effects.
Topics: Cimetidine; Confusion; Esophagitis, Peptic; Gastrointestinal Hemorrhage; Guanidines; Humans; Male; N | 1980 |
Potentiation of carmustine-cranial irradiation-induced myelosuppression by cimetidine.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Cimetidine; Drug Synergism; Female; Glioma; Guanidines; He | 1982 |
Alternative mechanisms for severe neutropenia.
Topics: Agranulocytosis; Carmustine; Cimetidine; Drug Interactions; Humans; Neutropenia | 1982 |
[Neutropenia in a patient treated with cimetidine].
Topics: Agranulocytosis; Cimetidine; Guanidines; Humans; In Vitro Techniques; Male; Middle Aged; Neutropenia | 1980 |
Cimetidine and granulopoiesis: bone marrow culture studies in normal man and patients with cimetidine-associated neutropenia.
Topics: Adult; Aged; Agranulocytosis; Bone Marrow; Cells, Cultured; Cimetidine; Colony-Forming Units Assay; | 1980 |
Cimetidine and hematologic suppression: things are not always as they appear.
Topics: Aged; Agranulocytosis; Blood Transfusion; Cimetidine; Duodenal Ulcer; Eosinophilia; Fever; Guanidine | 1980 |
Is cimetidine associated with neutropenia?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Child; Child, Preschool; Cimetidin | 1995 |
Leucopenia with cimetidine.
Topics: Adult; Cimetidine; Drug Evaluation; Duodenal Ulcer; Guanidines; Humans; Leukopenia; Male; Neutropeni | 1977 |
Cimetidine-induced neutropenia: a possible dose-related phenomenon.
Topics: Adult; Agranulocytosis; Cimetidine; Dose-Response Relationship, Drug; Gastrointestinal Hemorrhage; G | 1979 |
Transient neutropenia and cimetidine.
Topics: Agranulocytosis; Cimetidine; Duodenal Ulcer; Guanidines; Humans; Neutropenia | 1978 |
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphenhydramine; Drug Admin | 1987 |